In Vivo Gold Complex Catalysis within Live Mice Tsubokura, Kazuki; Vong, Kenward K. H.; Pradipta, Ambara R. ...
Angewandte Chemie International Edition,
March 20, 2017, Letnik:
56, Številka:
13
Journal Article
Recenzirano
Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin–AuIII complex was designed and developed that enables organ‐specific, ...localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5‐ and TAMRA‐linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.
The first metal‐catalyzed reaction that proceeds within live mice is based on a targeting approach with glycans. Glycoalbumin–AuIII complexes can be accumulated in specific organs where they catalyze amide bond formation between a propargyl ester probe and amine groups on nearby proteins. The selective targeting was confirmed by whole body fluorescence imaging and analysis of dissected tissues.
Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin-AuIII complex was designed and developed that enables organ-specific, ...localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.
In vivo gold complex catalysis in living mice is described by K. Tanaka and co‐workers in their Communication on page 3579 ff. When attached to a glycocluster, gold catalysts can be delivered to a ...target organ in a higher organism where they perform a chemical transformation. This approach could enable the use of organometallic catalysts in therapy or diagnostics as they could catalyze the uncaging of therapeutic enzymes or the generation of active drugs at a target organ.
Invivo gold complex catalysis in living mice is described by K. Tanaka and co-workers in their Communication on page3579ff. When attached to a glycocluster, gold catalysts can be delivered to a ...target organ in a higher organism where they perform a chemical transformation. This approach could enable the use of organometallic catalysts in therapy or diagnostics as they could catalyze the uncaging of therapeutic enzymes or the generation of active drugs at a target organ.
In Vivo Gold Complex Catalysis within Live Mice Tsubokura, Kazuki; Vong, Kenward K. H.; Pradipta, Ambara R. ...
Angewandte Chemie,
March 20, 2017, Letnik:
129, Številka:
13
Journal Article
Recenzirano
Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin–AuIII complex was designed and developed that enables organ‐specific, ...localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5‐ and TAMRA‐linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.
Die erste Metall‐katalysierte Reaktion in lebenden Mäusen basiert auf der Verwendung von Glycanen. Glycoalbumin‐AuIII‐Komplexe akkumulieren in spezifischen Organen, wo sie die Amidbildung zwischen einer Propargylestersonde und einem Amin eines nahen Proteins katalysieren. Die Organselektivität wurde durch Ganzkörperfluoreszenzbildgebung und die Analyse sezierter Gewebe bestätigt.
Goldkatalysierte Reaktionen ... in lebenden Mäusen werden von K. Tanaka etal. in der Zuschrift auf S.3633ff. beschrieben. Mit Glycoclustern modifizierte Goldkatalysatoren akkumulieren in spezifischen ...Organen in höheren Organismen und katalysieren dort chemische Umsetzungen. Dieser Ansatz könnte die Anwendung von metallorganischen Katalysatoren in der Therapie oder Diagnostik ermöglichen, indem sie die Freisetzung therapeutischer Enzyme oder die Bildung aktiver Wirkstoffe am Zielorgan katalysieren.
Goldkatalysierte Reaktionen …… in lebenden Mäusen werden von K. Tanaka et al. in der Zuschrift auf S. 3633 ff. beschrieben. Mit Glycoclustern modifizierte Goldkatalysatoren akkumulieren in ...spezifischen Organen in höheren Organismen und katalysieren dort chemische Umsetzungen. Dieser Ansatz könnte die Anwendung von metallorganischen Katalysatoren in der Therapie oder Diagnostik ermöglichen, indem sie die Freisetzung therapeutischer Enzyme oder die Bildung aktiver Wirkstoffe am Zielorgan katalysieren.
PDF