A crossover comparison of progression of chronic renal failure: Ketoacids versus amino acids. Rates of progression of chronic renal failure were compared in patients receiving alternately an amino ...acid supplement (AA) and a ketoacid supplement (KA) to a very low protein (0.3 g/kg), low phosphorus (7 to 9 mg/kg) diet. The first supplement was randomly chosen. Bias due to carryover effects was minimized by delaying the regression analysis until one month after starting or changing supplements. In order to minimize possible bias caused by initiating the two supplements at differing levels of severity, a multiple crossover design was used (ABA, BAB, ABAB, or BABA) with at least four GFR's in each treatment period (except for three GFR's in one instance). Sixteen patients completed the protocol; five dropped out. Average starting GFR's were nearly identical for the two supplements (15.4 and 15.9 ml/min). For each patient, mean progression on KA was compared with mean progression on AA. Thirteen out of 16 patients progressed more slowly on KA than AA. On the average, progression on KA was significantly slower (95% confidence limits = -0.36 to 0.09 ml/min/month) than on AA (-0.91 to -0.41 ml/min/month; P = 0.024). There was no significant difference in estimated protein intake, phosphate excretion, or mean arterial pressure between KA and AA periods. Serum triglyceride concentration was significantly lower on KA (P = 0.0026). 17-hydroxycorticosteroid excretion was also lower (P = 0.031). We conclude that KA slow progression, relative to AA, independently of protein or phosphorus intake, in patients on this regimen.
Background: We evaluate the public health surveillance program, Screen, Test, and Protect (STP) designed to control and prevent COVID-19 at a large academic university in the United States. Methods: ...STP was established at the University of Florida in May 2020. This report details STP's full-time workforce, centralized database, and testing and vaccination programs. We evaluate the program's success in controlling COVID-19 during the 2020-2021 academic school year. Results: COVID-19 cases rose among the campus community in the first few weeks of campus reopening in Fall 2020. Test positivity levels returned to prefall semester levels within one month, however. A few additional, yet smaller, waves occurred during the 2020-2021 school year and were successfully controlled without any campus-wide closures. Conclusions: This program may serve as a framework for other institutions managing the ongoing COVID-19 crisis, in addition to setting the standard for programmatic management of future emerging infectious diseases at universities.
Progression of chronic renal failure is related to glucocorticoid production. Progression of chronic renal failure during 35 treatment periods in 27 patients was measured as the rate of change of ...bimonthy radioisotope GFR for an average of 15 months. Treatments were comprised of: (1) mild protein restriction; (2) more severe protein and phosphorus restriction plus essential amino acids; or (3) the same diet plus ketoacids. Progression was significantly (P < 0.025) correlated with urinary 17-hydroxycorticosteroid excretion in all three treatment groups; overall r was 0.78 (P < 0.0001). Multiple regression analysis showed that the following factors were not additional significant determinants of progression: urea N excretion, phosphate excretion, protein excretion, serum calcium times phosphorus product, serum alkaline phosphatase, serum uric acid, serum triglycerides, serum cholesterol, etiology, mean arterial pressure, or ehalapril treatment. However, when urinary 17-hydroxycorticosteroid excretion was factored by GFR (with which it was correlated), additional significant regressors appeared: serum triglycerides and polycystic kidney disease, which tended to be associated with more rapid progression, and ketoacid treatment, which tended to be associated with slower progression. Mean 17-hydroxycorticosteroid excretion differed significantly between the three treatment groups, in the order (1) > (2) > (3)(though not when factored by GFR). Changing from essential amino acids to ketoacids (or vice versa) without change in diet was associated with lower 17-hydroxycorticosteroid excretion on ketoacids (but not when factored by GFR). Therefore, progression of chronic renal failure is related to glucocorticoid production (and to triglyceridemia, which is correlated with it). Ketoacids appear to slow progression in part by suppressing production of glucocorticoids.
Neutral Higgs boson decays to squark pairs reanalyzed Accomando, E.; Chachamis, G.; Fugel, F. ...
Physical Review D (Particles, Fields, Gravitation and Cosmology),
01/2012, Letnik:
85, Številka:
1
Journal Article
We analyze neutral Higgs boson decays into squark pairs in the minimal supersymmetric extension of the standard model and improve previous analyses. In particular the treatment of potentially large ...higher-order corrections originating from the soft supersymmetry-breaking parameters Ab, the trilinear Higgs coupling to sbottoms, and mu , the Higgsino mass parameter, is investigated. The remaining theoretical uncertainties including the supersymmetric QCD corrections are analyzed quantitatively.
Atom interferometry represents a quantum leap in the technology for the ultra-precise monitoring of accelerations and rotations and, therefore, for all the science that relies on the latter ...quantities. These sensors evolved from a new kind of optics based on matter-waves rather than light-waves and might result in an advancement of the fundamental detection limits by several orders of magnitude. Matter-wave optics is still a young, but rapidly progressing science. The Space Atom Interferometer project (SAI), funded by the European Space Agency, in a multi-pronged approach aims to investigate both experimentally and theoretically the various aspects of placing atom interferometers in space: the equipment needs, the realistically expected performance limits and potential scientific applications in a micro-gravity environment considering all aspects of quantum, relativistic and metrological sciences. A drop-tower compatible prototype of a single-axis atom interferometry accelerometer is under construction. At the same time the team is studying new schemes, e.g. based on degenerate quantum gases as source for the interferometer. A drop-tower compatible atom interferometry acceleration sensor prototype has been designed, and the manufacturing of its subsystems has been started. A compact modular laser system for cooling and trapping rubidium atoms has been assembled. A compact Raman laser module, featuring outstandingly low phase noise, has been realized. Possible schemes to implement coherent atomic sources in the atom interferometer have been experimentally demonstrated.
Many real world problems have requirements and constraints which conflict with each other. One approach for dealing with such over-constrained problems is with constraint hierarchies. In the ...constraint hierarchy framework, constraints are classified into ranks, and appropriate solutions are selected using a comparator which takes into account the constraints and their ranks. In this paper, we present a local search solution to solving hierarchical constraint problems over finite domains (HCPs). This is an extension of local search for over-constrained integer programs WSAT(OIP) to constraint hierarchies and general finite domain constraints.The motivation for this work arose from solving large airport gate allocation problems. We show how gate allocation problems can be formulated as HCPs using typical gate allocation constraints. Using the gate allocation benchmarks, we investigate how constraint heirarchy selection strategies and the problem formulation using two models: a 0–1 linear constraint hierarchy model and a nonlinear finite domain constraint hierarchy model.
Spin and radiation in intense laser fields Walser, M. W.; Urbach, D. J.; Hatsagortsyan, K. Z. ...
Physical review. A, Atomic, molecular, and optical physics,
04/2002, Letnik:
65, Številka:
4
Journal Article
Adrenalectomy ameliorates ablative nephropathy in the rat independently of corticosterone maintenance level. The roles of the adrenal gland and of dietary protein level in ablative nephropathy in the ...rat were examined by comparing adrenalectomized rats, replaced with corticosterone at low physiological (1 and 2) or high physiological (3 and 4) levels with intact rats (5 and 6). All groups were subjected to 5/6 nephrectomy and followed 12 weeks on a regular diet (2, 4 and 6) or a reduced protein diet (1,3 and 5). Groups 1, 2, 5 and 6 all grew at the same rate but groups 3 and 4 grew less, though food intake was nearly the same in all. Higher dietary protein, higher corticosterone maintenance level, and the presence of intact adrenal glands all increased proteinuria significantly. Extracellular fluid volume (82Br space) was identical in all groups at 8 and 12 weeks, because the animals were given a choice of water or saline to drink. Mortality was highest (50%) in Group 6 and lowest (11%) in Group 1, but these differences were not significant. Final inulin clearance was significantly improved by adrenalectomy when non-survivors were scored as having zero clearance, but not if the analysis was limited to survivors. It was not affected by diet or by corticosterone level. Renal histopathological scores were also improved significantly by adrenalectomy and by protein restriction, but were not influenced by corticosterone level. Thus adrenalectomy and dietary protein restriction independently ameliorate ablative nephropathy, but corticosterone replacement level has no effects, except on proteinuria. The results indicate that the deleterious effects of dietary protein on renal histopathology persist in the absence of the adrenals, and suggest that some substance other than corticosterone produced by the adrenal (?cortisol) plays an even greater role in the progression of ablative nephropathy in the rat.
PDF
