The Vehicle Routing Problem (VRP) has been an especially active and fertile area of research. Over the past five to seven years, there have been numerous technological advances and exciting ...challenges that are of considerable interest to students, teachers, and researchers. The Vehicle Routing Problem: Latest Advances and New Challengeswill focus on a host of significant technical advances that have evolved over the past few years for modeling and solving vehicle routing problems and variants. New approaches for solving VRPs have been developed from important methodological advances. These developments have resulted in faster solutions algorithms, more accurate techniques, and an improvement in the ability to solve large-scale complex problems.
The economic and man-made resources that sustain human wellbeing are not distributed evenly across the world, but are instead heavily concentrated in cities. Poor access to opportunities and services ...offered by urban centres (a function of distance, transport infrastructure, and the spatial distribution of cities) is a major barrier to improved livelihoods and overall development. Advancing accessibility worldwide underpins the equity agenda of 'leaving no one behind' established by the Sustainable Development Goals of the United Nations. This has renewed international efforts to accurately measure accessibility and generate a metric that can inform the design and implementation of development policies. The only previous attempt to reliably map accessibility worldwide, which was published nearly a decade ago, predated the baseline for the Sustainable Development Goals and excluded the recent expansion in infrastructure networks, particularly in lower-resource settings. In parallel, new data sources provided by Open Street Map and Google now capture transportation networks with unprecedented detail and precision. Here we develop and validate a map that quantifies travel time to cities for 2015 at a spatial resolution of approximately one by one kilometre by integrating ten global-scale surfaces that characterize factors affecting human movement rates and 13,840 high-density urban centres within an established geospatial-modelling framework. Our results highlight disparities in accessibility relative to wealth as 50.9% of individuals living in low-income settings (concentrated in sub-Saharan Africa) reside within an hour of a city compared to 90.7% of individuals in high-income settings. By further triangulating this map against socioeconomic datasets, we demonstrate how access to urban centres stratifies the economic, educational, and health status of humanity.
Abstract
We used high-precision radial velocity measurements of FGKM stars to determine the occurrence of giant planets as a function of orbital separation spanning 0.03–30 au. Giant planets are more ...prevalent at orbital distances of 1–10 au compared to orbits interior or exterior of this range. The increase in planet occurrence at ∼1 au by a factor of ∼4 is highly statistically significant. A fall-off in giant planet occurrence at larger orbital distances is favored over models with flat or increasing occurrence. We measure
14.1
−
1.8
+
2.0
giant planets per 100 stars with semimajor axes of 2–8 au and
8.9
−
2.4
+
3.0
giant planets per 100 stars in the range 8–32 au, a decrease in occurrence with increasing orbital separation that is significant at the ∼2
σ
level. We find that the occurrence rate of sub-Jovian planets (0.1–1 Jupiter masses) is also enhanced for 1–10 au orbits. This suggests that lower-mass planets may share the formation or migration mechanisms that drive the increased prevalence near the water–ice line for their Jovian counterparts. Our measurements of cold gas giant occurrence are consistent with the latest results from direct imaging surveys and gravitational lensing surveys despite different stellar samples. We corroborate previous findings that giant planet occurrence increases with stellar mass and metallicity.
Abstract
We present a high-precision radial velocity (RV) survey of 719 FGKM stars, which host 164 known exoplanets and 14 newly discovered or revised exoplanets and substellar companions. This ...catalog updated the orbital parameters of known exoplanets and long-period candidates, some of which have decades-longer observational baselines than they did upon initial detection. The newly discovered exoplanets range from warm sub-Neptunes and super-Earths to cold gas giants. We present the catalog sample selection criteria, as well as over 100,000 RV measurements, which come from the Keck-HIRES, APF-Levy, and Lick-Hamilton spectrographs. We introduce the new RV search pipeline
RVSearch
(
https://california-planet-search.github.io/rvsearch/
) that we used to generate our planet catalog, and we make it available to the public as an open-source Python package. This paper is the first study in a planned series that will measure exoplanet occurrence rates and compare exoplanet populations, including studies of giant planet occurrence beyond the water ice line, and eccentricity distributions to explore giant planet formation pathways. We have made public all radial velocities and associated data that we use in this catalog.
Myc proteins (c-myc, Mycn and Mycl) target proliferative and apoptotic pathways vital for progression in cancer. Amplification of the MYCN gene has emerged as one of the clearest indicators of ...aggressive and chemotherapy-refractory disease in children with neuroblastoma, the most common extracranial solid tumor of childhood. Phosphorylation and ubiquitin-mediated modulation of Myc protein influence stability and represent potential targets for therapeutic intervention. Phosphorylation of Myc proteins is controlled in-part by the receptor tyrosine kinase/phosphatidylinositol 3-kinase/Akt/mTOR signaling, with additional contributions from Aurora A kinase. Myc proteins regulate apoptosis in part through interactions with the p53/Mdm2/Arf signaling pathway. Mutation in p53 is commonly observed in patients with relapsed neuroblastoma, contributing to both biology and therapeutic resistance. This review examines Myc function and regulation in neuroblastoma, and discusses emerging therapies that target Mycn.
Abstract
The size of a planet is an observable property directly connected to the physics of its formation and evolution. We used precise radius measurements from the California-
Kepler
Survey to ...study the size distribution of 2025
Kepler
planets in fine detail. We detect a factor of ≥2 deficit in the occurrence rate distribution at 1.5–2.0
. This gap splits the population of close-in (
P
< 100 days) small planets into two size regimes:
and
, with few planets in between. Planets in these two regimes have nearly the same intrinsic frequency based on occurrence measurements that account for planet detection efficiencies. The paucity of planets between 1.5 and 2.0
supports the emerging picture that close-in planets smaller than Neptune are composed of rocky cores measuring 1.5
or smaller with varying amounts of low-density gas that determine their total sizes.
Probing the connection between a star's metallicity and the presence and properties of any associated planets offers an observational link between conditions during the epoch of planet formation and ...mature planetary systems. We explore this connection by analyzing the metallicities of Kepler target stars and the subset of stars found to host transiting planets. After correcting for survey incompleteness, we measure planet occurrence: the number of planets per 100 stars with a given metallicity M. Planet occurrence correlates with metallicity for some, but not all, planet sizes and orbital periods. For warm super-Earths having P = 10-100 days and = 1.0-1.7 , planet occurrence is nearly constant over metallicities spanning −0.4 to +0.4 dex. We find 20 warm super-Earths per 100 stars, regardless of metallicity. In contrast, the occurrence of warm sub-Neptunes ( = 1.7-4.0 ) doubles over that same metallicity interval, from 20 to 40 planets per 100 stars. We model the distribution of planets as , where β characterizes the strength of any metallicity correlation. This correlation steepens with decreasing orbital period and increasing planet size. For warm super-Earths β = , while for hot Jupiters β = . High metallicities in protoplanetary disks may increase the mass of the largest rocky cores or the speed at which they are assembled, enhancing the production of planets larger than 1.7 . The association between high metallicity and short-period planets may reflect disk density profiles that facilitate the inward migration of solids or higher rates of planet-planet scattering.
Zika virus was discovered in Uganda in 1947 and is transmitted by Aedes mosquitoes, which also act as vectors for dengue and chikungunya viruses throughout much of the tropical world. In 2007, an ...outbreak in the Federated States of Micronesia sparked public health concern. In 2013, the virus began to spread across other parts of Oceania and in 2015, a large outbreak in Latin America began in Brazil. Possible associations with microcephaly and Guillain-Barré syndrome observed in this outbreak have raised concerns about continued global spread of Zika virus, prompting its declaration as a Public Health Emergency of International Concern by the World Health Organization. We conducted species distribution modelling to map environmental suitability for Zika. We show a large portion of tropical and sub-tropical regions globally have suitable environmental conditions with over 2.17 billion people inhabiting these areas.
ABSTRACT We present high-resolution (0 16) 870 m Atacama Large Millimeter/submillimeter Array (ALMA) imaging of 16 luminous ( ) submillimeter galaxies (SMGs) from the ALESS survey of the Extended ...Chandra Deep Field South. This dust imaging traces the dust-obscured star formation in these galaxies on ∼1.3 kpc scales. The emission has a median effective radius of Re = 0 24 0 02, corresponding to a typical physical size of 1.8 0.2 kpc. We derive a median Sérsic index of n = 0.9 0.2, implying that the dust emission is remarkably disk-like at the current resolution and sensitivity. We use different weighting schemes with the visibilities to search for clumps on 0 12 (∼1.0 kpc) scales, but we find no significant evidence for clumping in the majority of cases. Indeed, we demonstrate using simulations that the observed morphologies are generally consistent with smooth exponential disks, suggesting that caution should be exercised when identifying candidate clumps in even moderate signal-to-noise ratio interferometric data. We compare our maps to comparable-resolution Hubble Space Telescope -band images, finding that the stellar morphologies appear significantly more extended and disturbed, and suggesting that major mergers may be responsible for driving the formation of the compact dust disks we observe. The stark contrast between the obscured and unobscured morphologies may also have implications for SED fitting routines that assume the dust is co-located with the optical/near-IR continuum emission. Finally, we discuss the potential of the current bursts of star formation to transform the observed galaxy sizes and light profiles, showing that the descendants of these SMGs are expected to have stellar masses, effective radii, and gas surface densities consistent with the most compact massive ( 1-2 × 1011 ) early-type galaxies observed locally.
Alternative splicing has critical roles in normal development and can promote growth and survival in cancer. Aberrant splicing, the production of noncanonical and cancer-specific mRNA transcripts, ...can lead to loss-of-function in tumor suppressors or activation of oncogenes and cancer pathways. Emerging data suggest that aberrant splicing products and loss of canonically spliced variants correlate with stage and progression in malignancy. Here, we review the splicing landscape of TP53, BARD1 and AR to illuminate roles for alternative splicing in cancer. We also examine the intersection between alternative splicing pathways and novel therapeutic approaches.
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