The lateral right chest demonstrated intrapleural fluid, absence of true lung sliding or "comet tail" artifacts, and hepatic parenchymal movement against the parietal pleural surface along the fourth ...to fifth intercostal space in the anterior axillary line where lung parenchyma is normally expected (Fig. 1). The absence of normal lung sliding and visible comet tail artifacts in the right posterolateral hemithorax reflected the elevated liver position and loss of the diaphragmatic constraint, permitting hepatic movement in continuity with the parietal pleura.
Archaeological Fieldwork Reports Camardo, Domenico; Notomista, Mario; Court, Sarah ...
Papers of the British School at Rome,
11/2011, Letnik:
79
Journal Article
Recenzirano
Two key projects that took place in 2010 at Herculaneum Conservation Project are summarized.
This short text places the archaeological site of Herculaneum, Italy and the Herculaneum Conservation Project in context, and introduces the volume of articles on this subject. The author outlines ...the importance of the site, and the public/private partnership that was launched in order to tackle the problems of decay there.
The major biological effects of glucocorticoids are thought to be initiated through changes in the expression of cellular genes. However, the mechanisms involved in the suppression of some gene ...products by glucocorticoids are not well defined. ID13 mouse fibroblast cells were treated with the synthetic glucocorticoid dexamethasone (Dex) or with vehicle. Plus/minus (+Dex / −Dex) cDNAs were used to screen an ID13 cDNA library. Using this method, we found that the recently identified human protein adenovirus E4 promoter binding protein (E4BP4) mRNA was induced by Dex in the ID13 cell line. E4BP4 is a transcriptional repressor and binds to a specific DNA element. Further investigation indentified E4BP4-like DNA elements located in the promoters of glucocorticoid repressed genes Cox-2, iNOS, and cPLA2. These findings suggest that E4BP4 may play a role in the glucocorticoid repression of these and other genes.
The dissertation argues that sixteenth- and seventeenth-century imitations and appropriations of Virgil's Georgics constantly reflect on the poem's formal didacticism and on the institutional and ...pedagogical context in which educated readers would have first encountered it. The introduction surveys recent scholarship on Virgil's poem and establishes the range of problems and issues that collect under the rubric of a pedagogical version of georgic. Chapter One offers a reading of the attenuated act of instruction narrated in the epyllion that concludes the Fourth Georgic. It draws on the interpretative work of early editors and illustrators in order to argue that the epyllion genders the mechanics of instruction, and that the nymph Cyrene's interpretation of the song of Proteus tests the promise of Virgil's didactic poetics. Chapter Two tracks the Georgics and the educational issues I extract from the epyllion in the classrooms and curricula of Tudor and Stuart England. It argues that appropriations of the Georgics—for example, Sir Francis Bacon's description of The Advancement of Learning as a “Georgickes of the mind”—are guided not by a sense of the inherent dignity of georgic projects and intellectual labour, but by a fantasy of perfectly methodical instruction. Chapter Three reads Edmund Spenser's imitations of the Georgics in The Faerie Queene against the prominent position of georgic metaphors in humanist educational discourse. It argues that Spenser's didactic ambitions for his own heroic poem are bound up in his attempt to assess and reformulate the resources of Virgil's didactic poem on agricultural management. Chapter Four reads the English topographical tradition, which scholars have generally accepted as one face of georgic during the seventeenth century, in the context of Cyrene's act of mediation in the Aristaeus epyllion. It reads poems by Michael Drayton, Aemilia Lanyer, and Andrew Marvell against Cyrene's demiurgic decoding of the song of Proteus. The conclusion turns to a watershed text in the legacy of English georgic—Joseph Addison's 1697 “Essay on the Georgics”—in order to argue that the pedagogical georgic described here remained prominent in a document that sent georgic poetry in a completely different direction.
In search for a rational way to convert the information encoded in peptide structures into peptidomimetics, major progress could be made by coupling the power of selection methods, now enormously ...increased in number as a result of the development of combinatorial peptide libraries, with the rational design of structure-inducing templates for the selectable sequences. The availability of libraries of peptides with predetermined structure would enable selection-driven peptidomimetic design, whereby a conformational design, whereby a conformational model for the peptide pharmacophore would be directly derived from the screening, allowing the design of a suitable non-peptidic scaffold to replace the peptide backbone. We describe here the first example of a conformationally homogeneous combinatorial peptide library, which yields ligands with the expected structure upon selection. The library was built by randomising five positions in the α-helical portion of a 26 amino acid Cys|infer|2|2ru|His|infer|2 consensus “zinc-finger” motif. Since in zinc-fingers metal coordination and folding are coupled, in our library metal-dependent binding represents a built-in control against the selection of structurally undefined sequences. The α-helical library was produced as both fusion with the pVIII protein of filamentous phage and soluble peptides by chemical synthesis, the latter enabling the expansion of the selectable repertoire by the inclusion of non-coded amino acids.The two libraries were independently screened with the same receptor (a monoclonal IgA reactive against the lipopolysaccharide of the human pathogenShigella flexneri), yielding a very similar consensus. In particular, the peptides defined by both methods showed very strong, zinc-dependent binding to the IgA. The geometrical arrangement of the side-chains of the selected peptide pharmacophore was shown by circular dichroism, CO(II)-complex absorption and high-resolution NMR to be structurally invariant with respect to the parent zinc-finger.
The role of geographical area or place has long been central to some social policy strategies, initiatives and tensions. This chapter examines the enduring behaviourism which underpins much recent ...welfare and communities policy. It begins by briefly situating governmental discipline of individuals and communities within a broader agenda of neoliberal regulation, before proceeding to analyse the approaches of New Labour and the Coalition, and identifying the fresh agendas through which behaviour-shaping has been authorised and textured. Drawing on some primary research conducted within a recently 'empowered' residential community, the chapter then offers critical perspectives on these agendas and their weakness both as wider projects of societal discipline and as theories and practices of civic governance.
To gain a better understanding of the effects of medical schools related to transformations in medical practice, science, and public expectations, the Association of American Medical Colleges (AAMC) ...established the Advisory Panel on the Mission and Organization of Medical Schools (APMOMS) in 1994. Recognizing the privileges academic medicine enjoys as well as the power of and the strain on its special relationship with the American public, APMOMS formed the Working Group on Fulfilling the Social Contract. That group focused on the question: What are the roles and responsibilities involved in the social contract between medical schools and various interested communities and constituencies? This article reports the working group's findings. The group describes the historical and philosophical reasons supporting the concept of a social contract and asserts that medical schools have individual and collective social contracts with various subsets of the public, referred to as "stakeholders." Obligations derive implicitly from the generous public funding and other benefits medical school receive. Schools' primary obligation is to improve the nation's health. This obligation is carried out most directly by educating the next generation of physicians and biomedical scientists in a manner that instills appropriate professional attitudes, values, and skills. Group members identified 27 core stakeholders (e.g., government, patients, local residents, etc.) and outlined the expectations those stakeholders have of medical schools and the expectations medical schools have of those stakeholders. The group conducted a survey to test how leaders at medical schools responded to the notion of a social contract, to gather data on school leaders' perceptions of what groups they considered their schools' most important stakeholders, and to determine how likely it was that the schools' and the stakeholders expectations of each other were being met. Responses from 69 deans suggested that the survey provoked thinking about the broad issue of the social contract and stakeholders. Leaders on the same campuses disagreed about what groups were the most important stakeholders. Similarly, the responses revealed a lack of national consensus about the most important stakeholders, although certain groups were consistently included in the responses. The group concludes that medical school leaders should examine their assumptions and perspectives about their institutions' stakeholders and consider the interests of the stakeholders in activities such as strategic planning, policymaking, and program development.
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