In order to address the global crisis in pear productivity, there has been increased attention given to advocating for the use of organic fertilizers. As part of this effort, researchers have been ...investigating the microbial properties of organic fertilizers to better understand their potential impact on fruit productivity. Our research focused specifically on the impact of four different ratios of sheep manure (SM) and chemical fertilizers (CF) on pear productivity. We found that replacing CF with SM resulted in a proliferation of gammaproteobacteria, Chlamydiae, Bastocatellia and Clostridia in the soil rhizosphere, which is the region around the roots of plants where most nutrient uptake occurs. Using redundancy analysis, we were able to determine that SM was particularly effective at promoting the growth of gammaproteobacteria and clostridia, which were associated with C:N ratios around 14:1 as well as the availability of K, Fe, Zn and Cu. This combination of factors was conducive to a transition from vegetative growth to reproductive growth, resulting in an increase in pear production from 43 to 56 tons per hectare. We also discovered that Blastociella acts as a buffering system in regulating soil acidity. Taken together, our findings indicate that a combination of SM and CF can improve the abundance of beneficial bacteria in the rhizosphere, leading to an increase in pear productivity.
Sheep Manure as good organic amendment that increased bacterial community diversity and OTU richness.Clostridia and Gammaproteobacteria leads to the SOM and AVL N acquisition in the soil, they were improved the pear tree included vegetative and reproductive growth significantly.Blastocatellia _ (Subgroup_4) driven by organic fertilizer as an effective buffer against as soil acidification.
Inspired by human brain and visual system, optoelectronic memristors-based neuromorphic computing has attracted the interests of researchers to overcome the limitation of traditional von Neumann ...architecture. With advantages of highly parallel computing and massive interconnection, the optical memristors could construct light-inspired artificial neural network for neuromorphic computing tasks. Besides, nonvolatile optoelectronic memristors provide a promising path for reconfigurable logic operations, greatly promoting the development of novel in-memory computing technology. In this work, the photoelectric perception, storage and in situ computing functions were integrated in optoelectronic memristors array, which could greatly decrease the footprint of multifunctional device and improve the work efficiency of chip. The neuromorphic computing capability of the photonic memristors was verified using face images of different people with accuracy of 86.7%. Moreover, with the advantages of photoelectric cooperative modulation, the reconfigurable logic functions including “AND” and “OR” were achieved by optoelectronic memristors. The present results demonstrate the attractive bio-inspired in-sensor computing behaviors of the optoelectronic memristors, opening up potential applications of optoelectronic memristors in next-generation reconfigurable sensing-memory-computing integrated paradigms.
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•Reconfigurable optoelectronic memristors array for artificial visual system was fabricated.•The optoelectronic memristors array exhibited highly integrated in situ sensing-memory-computing capabilities.•The Boolean logic computations of “AND/OR” gates were implemented successfully.•Neuromorphic computing tasks of face recognition with accuracy of 86.7% was demonstrated.
Given that many people suffer from large‐area skin damage, skin regeneration is a matter of high concern. Here, an available method is developed for the formation of large‐area robust skins through ...three stages: fabrication of a biodegradable sealant‐loaded nanofiber scaffold (SNS), skin tissue reconstruction, and skin regeneration. First, a microfluidic blow‐spinning strategy is proposed to fabricate a large‐scale nanofiber scaffold with an area of 140 cm × 40 cm, composed of fibrinogen‐loaded polycaprolactone/silk fibroin (PCL/SF) ultrafine core–shell nanofibers with mean diameter of 65 nm. Then, the SNS forms, where the gelling reaction of fibrin sealant occurs in situ between thrombin and fibrinogen on PCL/SF nanofiber surface, to promote the migration and proliferation of fibroblasts, accelerating skin regeneration. Through an in vivo study, it is shown that the SNS can rapidly repair acute tissue damage such as vascular bleeding and hepatic hemorrhage, and also promote angiogenesis, large‐area abdominal wall defect repair, and wound tissue regeneration for medical problems in the world. Besides, it avoids the risk of immune rejection and secondary surgery in clinical applications. This strategy offers a facile route to regenerate large‐scale robust skin, which shows great potential in abdominal wall defect repair.
An accessible method is proposed to enable large‐area skin regeneration from a biodegradable sealant‐loaded nanofiber scaffold (SNS) to skin tissue, showing great advantages and clinical significance in terms of wound healing, anti‐infection, and tissue regeneration (reepithelialization, epidermal thinning, and collagen alignment), solving the medical problems of large‐area abdominal trauma.
► Rhodococcus sp. CPZ24 was isolated from swine wastewater and identified. ► Rhodococcus sp. CPZ24 generates primarily inert N2 rather than N2O. ► Rhodococcus sp. CPZ24 performs simultaneous ...heterotrophic nitrification and aerobic denitrification.
Rhodococcus sp. CPZ24 was isolated from swine wastewater and identified. Batch (0.25L flask) experiments of nitrogen removal under aerobic growth conditions showed complete removal of 50mgL−1 ammonium nitrogen within 20h, while nitrate nitrogen removal reached 67%. A bioreactor (50L) was used to further assess the heterotrophic nitrification and aerobic denitrification abilities of Rhodococcus sp. CPZ24. The results showed that 85% of the ammonium nitrogen (100mgL−1) was transformed to nitrification products (NO3--N and NO2--N) (13%), intracellular nitrogen (24%), and gaseous denitrification products (48%) within 25h. The ammonium nitrogen removal rate was 3.4mg L−1h−1. The results indicate that the strain CPZ24 carries out simultaneous nitrification and denitrification, demonstrating a potential use of the strain for wastewater treatment.
Resistance to temozolomide (TMZ), the frontline chemotherapeutic agent for glioblastoma (GBM), has emerged as a formidable obstacle, underscoring the imperative to identify alternative therapeutic ...strategies to improve patient outcomes. In this study, we comprehensively evaluated a novel agent, O6-methyl-2'-deoxyguanosine-5'-triphosphate (O6-methyl-dGTP) for its anti-GBM activity both in vitro and in vivo. Notably, O6-methyl-dGTP exhibited pronounced cytotoxicity against GBM cells, including those resistant to TMZ and overexpressing O6-methylguanine-DNA methyltransferase (MGMT). Mechanistic investigations revealed that O6-methyl-dGTP could be incorporated into genomic DNA, disrupting nucleotide pools balance, and inducing replication stress, resulting in S-phase arrest and DNA damage. The compound exerted its anti-tumor properties through the activation of AIF-mediated apoptosis and the parthanatos pathway. In vivo studies using U251 and Ln229 cell xenografts supported the robust tumor-inhibitory capacity of O6-methyl-dGTP. In an orthotopic transplantation model with U87MG cells, O6-methyl-dGTP showcased marginally superior tumor-suppressive activity compared to TMZ. In summary, our research, for the first time, underscores the potential of O6-methyl-dGTP as an effective candidate against GBM, laying a robust scientific groundwork for its potential clinical adoption in GBM treatment regimens.
To assess the patient-level and societal burden of atopic dermatitis, we comprehensively reviewed the literature related to quality of life, social, economic, academic, and occupational impacts. ...Atopic dermatitis has profound impacts on patient and family quality of life. A conservative estimate of the annual costs of atopic dermatitis in the United States is $5.297 billion (in 2015 USD). People with atopic dermatitis may change their occupation because of their skin disease. Research gaps include quality of life assessments outside of tertiary care centers, impacts on partners and families of adult patients, and updated comprehensive cost estimates.
•Colloidal gold and time-resolved fluorescent nanobead for immunoassay.•On-site quantitation of imidacloprid in vegetable by two lateral flow immunoassays.•Comparison of two tracers for assay ...sensitivity at optimizing conditions.•Lateral flow immunoassay is an alternative to enzyme-linked immunosorbent assay.
Imidacloprid is a highly effective insecticide, but its potential hazards to the environment and ecosystems have limited its use in many regions. A fast and sensitive analytical method would aid monitoring imidacloprid residues. The monoclonal antibody 4D9, colloidal gold and time-resolved fluorescent nanobeads (CGN and TRFN, respectively) were applied to develop a lateral flow immunoassay (LFIA) for imidacloprid detection in the present work. Both the optimized TRFN-LFIA and CGN-LFIA had a similar limit of detection of approximately 0.02 ng/mL. Use of the portable optical scanner with the TRFN-LFIA or CGN-LFIA could quantitate concentrations of imidacloprid in vegetable as sensitively as the enzyme-linked immunosorbent assay (ELISA). The LFIAs quantitative results of imidacloprid in commercial Chinese leeks were verified by the liquid chromatography-mass spectrometry with a R2 of 0.91. The LFIAs are portable and simple and thus could fully replace the ELISA for onsite quantitation of imidacloprid residues in vegetables.
Organic‐inorganic hybrid multifunctional materials have shown significant application in lighting and sensor fields, owing to their prominent performance and diversity structures. Herein, we ...synthesized two multifunctional compounds: (propyl‐quinuclidone)2CdBr4 (1) and (F‐butyl‐quinuclidone)2CdBr4 (2). By introducing light‐emitting organic cation with flexible long chain, 1 and 2 exhibit excellent transition properties and bright blue‐white fluorescence. Then, combine fluorescence lifetime and first‐principal calculation, providing evidence for the electron transfer emission. Subsequently, investigated the impact of substituent carbon chain length (methyl to butyl), structural rigidity (C−C to C−F) and halide framework (Cl to I) on the fluorescence properties. Results indicate that Cd⋅⋅⋅Cd distance and structural rigidity play an important role in fluorescence. Overall, our research provides valuable insight and example for chemical modifications enhance compound performance.
Two Cd‐based hybrid multifunctional compounds with dual‐stable behavior in dielectric, high transition temperature and bright fluorescence were reported. Then, investigated the impact of substituent carbon chain length (methyl to butyl), structural rigidity (C−C to C−F), and halide framework (Cl to I) on fluorescent properties.
High-performance earth-abundant electrocatalysts for oxygen and hydrogen evolutions are highly desired for renewable energy but remain challenging. Herein, we have developed ultrathin NiFeP ...nanosheets, and merged the NiFeP with a 3D support of sponge-like strutted graphenes (SG). The synthesized NiFeP/SG, a porous monolith, shows efficient electrocatalytic activities for oxygen and hydrogen evolutions in alkaline electrolyte with low overpotentials of 218 and 115 mV, respectively. Using NiFeP/SG as direct catalytic electrodes, the overall water splitting requires a low cell voltage of 1.54 V to achieve a current of 10 mA cm−2. The high performances result from the shifted-up d states caused by iron incorporation, the ultrathin NiFeP, and the 3D network structure of SG. Additionally, NiFeP/SG demonstrates excellent gravimetric catalytic activities, meaningful to aerospace and portables. The material opens the way to a universal robust lightweight catalytic electrode for a variety of applications in electrochemical energy storage and conversion.
Ultrathin NiFeP nanosheets are grown on 3D self-supported strutted-graphene foams. The lightweight porous monolith is directly applied as catalytic electrodes for bifunctionally efficient electrolysis of water. A low voltage of 1.54 V of the electrolyzer drives a current of 10 mA cm−2 for the overall water splitting in alkaline media. Display omitted
•A 3D strutted graphene foam is applied as the high-surface-area conductive stable lightweight support to load catalysts.•Ultrathin NiFeP nanosheets are grown on the graphene foam, serving as self-supported binder-free porous monolithic electrodes.•NiFeP/strutted-graphene shows excellent catalytic activities and remarkable gravimetric activities for both oxygen and hydrogen evolutions.•The catalytic electrode requires a low voltage of 1.54 V to deliver 10 mA cm−2 for overall water splitting in alkaline media.
Direct deprotonation represents an extremely simple, straightforward, and atom‐economic strategy to activate pronucleophiles bearing an acidic proton. However, the difficulty often arises in ...activating pronucleophiles with high pKa values by using conventional chiral tertiary amines. To overcome this challenge, a handful of novel chiral Brønsted superbases, including amidines, guanidines, cyclopropenimines, and iminophosphoranes, have been discovered in recent years. This minireview focuses on the application of these organo‐superbases in the catalytic asymmetric reactions of weakly acidic pronucleophiles, and highlights their comparison to the conventional tertiary amines, demonstrating the highly efficient deprotonation processes and stereoselectivity controlled conversions of the superbases. The advantage of these new superbases brings a great opportunity for developing more asymmetric transformations of weakly acidic pronucleophiles.
Superbase: This Minireview focuses on chiral organo‐superbases as catalysts in asymmetric reactions of pronucleophiles with high pKa values. The performance of the organo‐superbases, compared to conventional tertiary amine bases, is highlighted. The advantage of these new superbases lies in the opportunity to develop more asymmetric transformations of weakly acidic pronucleophiles.
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