Universal quantum computation1 is striking for its unprecedented capability in processing information, but its scalability is challenging in practice because of the inevitable environment noise. ...Although quantum error correction (QEC) techniques2–8 have been developed to protect stored quantum information from leading orders of error, the noise-resilient processing of the QEC-protected quantum information is highly demanded but remains elusive9. Here, we demonstrate phase gate operations on a logical qubit encoded in a bosonic oscillator in an error-transparent (ET) manner. Inspired by refs. 10,11, the ET gates are extended to the bosonic code and are able to tolerate errors on the logical qubit during gate operations, regardless of the random occurrence time of the error. With precisely designed gate Hamiltonians through photon-number-resolved a.c. Stark shifts, the ET condition is fulfilled experimentally. We verify that the ET gates outperform the non-ET gates with a substantial improvement of gate fidelity after an occurrence of the single-photon-loss error. Our ET gates in superconducting quantum circuits can be readily extended to multiple encoded qubits and a universal gate set is within reach, holding the potential for reliable quantum information processing.Error-transparent quantum gates that can tolerate certain error during the execution of quantum operations have been demonstrated. Substantial improvement of the gate fidelity sheds lights on large-scale universal quantum computation.
More than 20 monoclonal antibodies have been approved as therapeutic drugs by the US Food and Drug Administration, and it is quite likely that the number of approved antibodies will double in the ...next 7–10 years. Antibody drugs show several desirable characteristics, including good solubility and stability, long persistence in the body, high selectivity and specificity, and low risk for bioconversion to toxic metabolites. However, many antibody drugs demonstrate attributes that complicate drug development, including very poor oral bioavailability, incomplete absorption following intramuscular or subcutaneous administration, nonlinear distribution, and nonlinear elimination. In addition, antibody administration often leads to an endogenous antibody response, which may alter the pharmacokinetics and efficacy of the therapeutic antibody. Antibodies have been developed for a wide range of disease conditions, with effects produced through a complex array of mechanisms. This article attempts to provide a brief overview of the main determinants of antibody pharmacokinetics and pharmacodynamics.
Clinical Pharmacology & Therapeutics (2008); 84, 5, 548–558 doi:10.1038/clpt.2008.170
Despite the use of glasses for thousands of years, the nature of the glass transition is still mysterious. On approaching the glass transition, the growth of dynamic heterogeneity has long been ...thought to play a key role in explaining the abrupt slowdown of structural relaxation. However, it still remains elusive whether there is an underlying link between structural relaxation and dynamic heterogeneity. Here, we unravel the link by introducing a characteristic time scale hiding behind an identical dynamic heterogeneity for various model glass-forming liquids. We find that the time scale corresponds to the kinetic fragility of liquids. Moreover, it leads to scaling collapse of both the structural relaxation time and dynamic heterogeneity for all liquids studied, together with a characteristic temperature associated with the same dynamic heterogeneity. Our findings imply that studying the glass transition from the viewpoint of dynamic heterogeneity is more informative than expected.
Abstract
In this first paper in the SUPER GOODS series on powerfully star-forming galaxies in the two GOODS fields, we present a deep SCUBA-2 survey of the GOODS-N at both 850 and 450
μ
m (central ...rms noise of 0.28 mJy and 2.6 mJy, respectively). In the central region, the 850
μ
m observations cover the GOODS-N to near the confusion limit of ∼1.65 mJy, while over a wider 450 arcmin
2
region—well complemented by
Herschel
far-infrared imaging—they have a median
limit of 3.5 mJy. We present
catalogs of 186 850
μ
m and 31 450
μ
m selected sources. We use interferometric observations from the Submillimeter Array (SMA) and the Karl G. Jansky Very Large Array (VLA) to obtain precise positions for 114 SCUBA-2 sources (28 from the SMA, all of which are also VLA sources). We present new spectroscopic redshifts and include all existing spectroscopic or photometric redshifts. We also compare redshifts estimated using the 20 cm/850
μ
m and the 250 cm/850
μ
m flux ratios. We show that the redshift distribution increases with increasing flux, and we parameterize the dependence. We compute the star formation history and the star formation rate (SFR) density distribution functions in various redshift intervals, finding that they reach a peak at
before dropping to higher redshifts. We show that the number density per unit volume of
galaxies measured from the SCUBA-2 sample does not change much relative to that of lower SFR galaxies from UV selected samples over
, suggesting that, apart from changes in the normalization, the shape in the number density as a function of SFR is invariant over this redshift interval.
This paper examines the causal relationships between carbon dioxide emissions, energy consumption and real economic output using panel cointegration and panel vector error correction modeling ...techniques based on the panel data for 28 provinces in China over the period 1995–2007. Our empirical results show that CO2 emissions, energy consumption and economic growth have appeared to be cointegrated. Moreover, there exists bidirectional causality between CO2 emissions and energy consumption, and also between energy consumption and economic growth. It has also been found that energy consumption and economic growth are the long-run causes for CO2 emissions and CO2 emissions and economic growth are the long-run causes for energy consumption. The results indicate that China's CO2 emissions will not decrease in a long period of time and reducing CO2 emissions may handicap China's economic growth to some degree. Some policy implications of the empirical results have finally been proposed.
► We conduct a panel data analysis of the energy–CO2–economy nexus in China. ► CO2 emissions, energy use and economic growth appear to be cointegrated. ► There exists bidirectional causality between energy consumption and economic growth. ► Energy consumption and economic growth are the long-run causes for CO2 emissions.
Glycogen synthase kinase 3 beta (GSK3β) is highly inactivated in epithelial cancers and is known to inhibit tumor migration and invasion. The zinc-finger-containing transcriptional repressor, Slug, ...represses E-cadherin transcription and enhances epithelial-mesenchymal transition (EMT). In this study, we find that the GSK3β-pSer9 level is associated with the expression of Slug in non-small cell lung cancer. GSK3β-mediated phosphorylation of Slug facilitates Slug protein turnover. Proteomic analysis reveals that the carboxyl terminus of Hsc70-interacting protein (CHIP) interacts with wild-type Slug (wtSlug). Knockdown of CHIP stabilizes the wtSlug protein and reduces Slug ubiquitylation and degradation. In contrast, nonphosphorylatable Slug-4SA is not degraded by CHIP. The accumulation of nondegradable Slug may further lead to the repression of E-cadherin expression and promote cancer cell migration, invasion and metastasis. Our findings provide evidence of a de novo GSK3β-CHIP-Slug pathway that may be involved in the progression of metastasis in lung cancer.
For glasses, the structural origin of their flow phenomena, such as elastic and plastic deformations especially the microscopic hidden flow before yield and glass-to-liquid transition (GLT), is ...unclear yet due to the lack of structural information. Here we investigate the evolution of the microscopic localized flow during GLT in a prototypical metallic glass combining with dynamical mechanical relaxations, temperature-dependent tensile experiments and stress relaxation spectra. We show that the unstable and high mobility nano-scale liquid-like regions acting as flow units persist in the glass and can be activated by either temperature or external stress. The activation of such flow units is initially reversible and correlated with β-relaxation. As the proportion of the flow units reaches a critical percolation value, a mechanical brittle-to-ductile transition or macroscopic GLT happens. A comprehensive picture on the hidden flow as well as its correlation with deformation maps and relaxation spectrum is proposed.
NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, has been reported to participate in inflammasome formation. Activation of ...inflammasome triggers a caspase-1–dependent programming cell death called pyroptosis. However, whether NLRP6 induces pyroptosis has not been investigated. In this study, we showed that NLRP6 overexpression activated caspase-1 and gasdermin-D and then induced pyroptosis of human gingival fibroblasts, resulting in release of proinflammatory mediators interleukin (IL)–1β and IL-18. Moreover, NLRP6 was highly expressed in gingival tissue of periodontitis compared with healthy controls. Porphyromonas gingivalis, which is a commensal bacterium and has periodontopathic potential, induced pyroptosis of gingival fibroblasts by activation of NLRP6. Together, we, for the first time, identified that NLRP6 could induce pyroptosis of gingival fibroblasts by activation of caspase-1 and may play a role in periodontitis.
Aim
Endothelial cell injury assumes a fundamental part in the pathogenesis of atherosclerosis, and endothelial cell autophagy has protective effects on the development of atherosclerosis, although ...the underlying molecular regulation mechanism is indistinct. This study aimed to investigate whether microRNA‐214‐3p (miR‐214‐3p) is involved in the endothelial cell autophagy regulation of atherosclerosis.
Methods
We utilized ApoE−/− mice provided with a high‐fat diet (HFD) as atherosclerosis model. We analysed the level of miR‐214‐3p and the levels of autophagy‐related protein 5 (ATG5) and autophagy‐related protein 12 (ATG12) in the purified CD31+ endothelial cells from mouse aorta. Bioinformatics analysis and a dual‐luciferase reporter assay were performed to confirm the binding target of miR‐214‐3p. In vitro study, human umbilical vein endothelial cells (HUVECs) were transfected with miR‐214‐3p mimics/inhibitor and stimulated with 100 μg/mL oxidized low‐density lipoprotein (ox‐LDL) for 12 hours to initiate a stress‐repairing autophagic process.
Results
In mouse models, we identified an inverse correlation between miR‐214‐3p, ATG5 and ATG12. We observed that in young HUVECs, ox‐LDL‐initiated autophagy was repressed by miR‐214‐3p overexpression, as evaluated by autophagic protein analysis, microtubule‐associated protein 1 light chain 3B‐II (LC3B‐II) immunofluorescence assay and transmission electron microscopy (TEM). Also, miR‐214‐3p promoted ox‐LDL accumulation in HUVECs and THP‐1 monocyte adhesion. Conversely, in old HUVECs, suppression of miR‐214‐3p preserved the ability to initiate a protective autophagy reaction to the ox‐LDL stimulation.
Conclusion
miR‐214‐3p regulates ox‐LDL‐initiated autophagy in HUVECs by directly targeting the 3′UTR of ATG5 and may have a suitable role in the pathogenesis of atherosclerosis.
The fracture of metallic glasses has received relatively little attention until recently. The development of bulk metallic glasses (BMGs) with more compositions, large sample sizes and diverse ...fracture behaviors provides a series of ideal model systems for the study of fracture in glassy materials. The fracture toughness of different BMGs varies significantly from approaching ideally brittle to the highest known damage tolerance. Diverse fracture patterns on the fracture surface, fracture modes and dynamic propagation of cracks have been observed in different BMGs. In this review paper, we present a comprehensive view of the state-of-the-art research on various aspects of the fracture of BMGs, including fracture behavior and characteristics, fracture mode, fracture criterion, fracture toughness, and fracture morphology. Accumulated experimental data on BMG fracture are presented and their possible theoretical connections with continuum fracture mechanics and the atomic-scale process are introduced and discussed. Modeling studies of the fracture of BMGs by various computational methods are also reviewed. The review also presents a number of perspectives, including the relation of BMG fracture study to other topics, and unsolved issues for future investigation.
PDF
