Diagnosis of Hodgkin lymphoma in the modern era Wang, Hao‐Wei; Balakrishna, Jayalakshmi P.; Pittaluga, Stefania ...
British journal of haematology,
January 2019, Letnik:
184, Številka:
1
Journal Article
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Summary
The Hodgkin lymphomas are a family of unique lymphoma subtypes, in which the nature of the neoplastic cell was enigmatic for many years. Much of the mystery has been solved, with all forms ...now considered to be of B‐cell origin, in most cases of germinal centre derivation. Today we recognize Hodgkin lymphoma as an eponym that encompasses multiple entities. One of the unifying themes is the major contribution from the tumour microenvironment. Both the character of the neoplastic cells and the nature of the immune environment are critical to accurate diagnosis. Moreover, an understanding of the molecular alterations that characterize both the neoplastic cells and their microenvironment have led to therapeutic advances, targeting both neoplastic and reactive components. Other conditions may foster a similar inflammatory milieu and lead to lymphoproliferations that mimic the Hodgkin lymphomas. In this review we provide an update on the diagnostic features of the various subtypes and include additional information relevant for prognostic evaluation and investigation of potential therapeutic targets. Additionally, we also discuss those conditions that often cause confusion in diagnosis and need to be distinguished from the Hodgkin lymphomas.
Summary
NAC transcription factors play important roles in plant growth, development and stress responses. Previously, we identified multiple NAC genes in soybean (Glycine max). Here, we identify the ...roles of two genes, GmNAC11 and GmNAC20, in stress responses and other processes. The two genes were differentially induced by multiple abiotic stresses and plant hormones, and their transcripts were abundant in roots and cotyledons. Both genes encoded proteins that localized to the nucleus and bound to the core DNA sequence CGTG/A. In the protoplast assay system, GmNAC11 acts as a transcriptional activator, whereas GmNAC20 functions as a mild repressor; however, the C‐terminal end of GmANC20 has transcriptional activation activity. Over‐expression of GmNAC20 enhances salt and freezing tolerance in transgenic Arabidopsis plants; however, GmNAC11 over‐expression only improves salt tolerance. Over‐expression of GmNAC20 also promotes lateral root formation. GmNAC20 may regulate stress tolerance through activation of the DREB/CBF–COR pathway, and may control lateral root development by altering auxin signaling‐related genes. GmNAC11 probably regulates DREB1A and other stress‐related genes. The roles of the two GmNAC genes in stress tolerance were further analyzed in soybean transgenic hairy roots. These results provide a basis for genetic manipulation to improve the agronomic traits of important crops.
•Focus on characteristics changes of geopolymer concrete after indoor/outdoor curing.•Compressive strength reach over 53 MPa after 180 days of indoor/outdoor curing.•Geopolymer concrete has excellent ...chloride resistance over prolonged curing time.
The purpose of this study is to focus on the durability of geopolymer concrete after nine months of an indoor and outdoor curing period. The geopolymer paste was prepared with fly ash and ground granulated blast furnace slag as raw materials and sodium silicate/sodium aluminate as an alkali activator. The geopolymer concrete was prepared with a 1:2.5:2.4 geopolymer:sand:gravel ratio. The influence of sodium aluminate, wollastonite additions and NaOH concentration on the microstructure, physical and mechanical properties were evaluated. The compressive strength of the geopolymer concrete can reach 67 MPa and 53 MPa after 180 days of indoor and outdoor curing, respectively. Rapid Chloride Ion Permeability Test (RCPT) shows the geopolymer concrete has excellent chloride resistance over prolonged curing time. After 180 days of accelerated wetting-drying cycles, the continued growth of compressive strength indicates the good weathering resistance of geopolymer concrete. According to the test results obtained during this study, the geopolymer has a high potential to be a key material for civil construction.
Abstract
We present ALMA 870
μ
m and JCMT/SCUBA2 850
μ
m dust continuum observations of a sample of optically dark and strongly lensed galaxies in cluster fields. The ALMA and SCUBA2 observations ...reach a median rms of ∼0.11 mJy and 0.44 mJy, respectively, with the latter close to the confusion limit of the data at 850
μ
m. This represents one of the most sensitive searches for dust emission in optically dark galaxies. We detect the dust emission in 12 out of 15 galaxies at >3.8
σ
, corresponding to a detection rate of 80%. Thanks to the gravitational lensing, we reach a deeper limiting flux than previous surveys in blank fields by a factor of ∼3. We estimate delensed infrared luminosities in the range 2.9 × 10
11
–4.9 × 10
12
L
⊙
, which correspond to dust-obscured star formation rates of ∼30–520
M
⊙
yr
−1
. Stellar population fits to the optical-to-NIR photometric data yield a median redshift
z
= 4.26 and delensed stellar mass 6.0 × 10
10
M
⊙
. They contribute a lensing-corrected star formation rate density at least an order of magnitude higher than that of equivalently massive UV-selected galaxies at
z
> 3. The results suggest that there is a missing population of massive star-forming galaxies in the early Universe, which may dominate the SFR density at the massive end (
M
⋆
> 10
10.3
M
⊙
). Five optically dark galaxies are located within
r
< 50″ in one cluster field, representing a potential overdensity structure that has a physical origin at a confidence level >99.974% from Poisson statistics. Follow-up spectroscopic observations with ALMA and/or JWST are crucial to confirm whether it is associated with a protocluster at similar redshifts.
•BC pyrolyzed at 600°C significantly boosted H2 production from PSCB.•BC implemented selective enrichment and colonization of functional bacteria.•BC stimulated synergistic effect and activated EET ...between functional bacteria.•New insight in understanding improved AD performance by BC was proposed.
The influence of biochar (BC) on anerobic digestion (AD) of organic wastes have been widely studied. However, the effect of BC on rate-limiting step during AD of lignocellulosic waste, i.e. the hydrolysis and acidogenesis step, is rarely studied and the underlying mechanisms have not been investigated. In this study, the benefits of BC with respect to dark fermentative hydrogen production were explored in a fermentation system by a heat-shocked consortium from sewage sludge (SS) with pretreated sugarcane bagasse (PSCB) as carbon source. The results showed that biochar boosted biohydrogen production by 317.1% through stimulating bacterial growth, improving critical enzymatic activities, manipulating the ratio of NADH/NAD+ and enhancing electron transfer efficiency of fermentation system. Furthermore, cellulolytic Lachnospiraceae was efficiently enriched and electroactive bacteria were selectively colonized and the ecological niche was formed on the surface of biochar. Synergistic effect between functional bacteria and extracellular electron transfer (EET) in electroactive bacteria were assumed to be established and maintained by biochar amendment. This study shed light on the underlying mechanisms of improved performance of biohydrogen production from lignocellulosic waste during mesophilic dark fermentation by BC supplementation.
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We present sensitive 850 m imaging of the Cosmological Evolution Survey (COSMOS) field using 640 hr of new and archival observations taken with SCUBA-2 at the East Asian Observatory's James Clerk ...Maxwell Telescope. The SCUBA-2 COSMOS survey (S2COSMOS) achieves a median noise level of 850 m = 1.2 mJy beam−1 over an area of 1.6 sq. degree (main; Hubble Space Telescope/Advanced Camera for Surveys footprint), and 850 m = 1.7 mJy beam−1 over an additional 1 sq. degree of supplementary (supp) coverage. We present a catalog of 1020 and 127 sources detected at a significance level of >4 and >4.3 in the main and supp regions, respectively, corresponding to a uniform 2% false-detection rate. We construct the single-dish 850 m number counts at S850 > 2 mJy and show that these S2COSMOS counts are in agreement with previous single-dish surveys, demonstrating that degree-scale fields are sufficient to overcome the effects of cosmic variance in the S850 = 2-10 mJy population. To investigate the properties of the galaxies identified by S2COSMOS sources we measure the surface density of near-infrared-selected galaxies around their positions and identify an average excess of 2.0 0.2 galaxies within a 13″ radius (∼100 kpc at z ∼ 2). The bulk of these galaxies represent near-infrared-selected submillimeter galaxies and/or spatially correlated sources and lie at a median photometric redshift of z = 2.0 0.1. Finally, we perform a stacking analysis at submillimeter and far-infrared wavelengths of stellar-mass-selected galaxies (M = 1010-1012 M ) from z = 0-4, obtaining high-significance detections at 850 m in all subsets (signal-to-noise ratio, S/N = 4-30), and investigate the relation between far-infrared luminosity, stellar mass, and the peak wavelength of the dust spectral energy distribution. The publication of this survey adds a new deep, uniform submillimeter layer to the wavelength coverage of this well-studied COSMOS field.
In vivo vagus nerve stimulation holds great promise in regulating food intake for obesity treatment. Here we present an implanted vagus nerve stimulation system that is battery-free and spontaneously ...responsive to stomach movement. The vagus nerve stimulation system comprises a flexible and biocompatible nanogenerator that is attached on the surface of stomach. It generates biphasic electric pulses in responsive to the peristalsis of stomach. The electric signals generated by this device can stimulate the vagal afferent fibers to reduce food intake and achieve weight control. This strategy is successfully demonstrated on rat models. Within 100 days, the average body weight is controlled at 350 g, 38% less than the control groups. This work correlates nerve stimulation with targeted organ functionality through a smart, self-responsive system, and demonstrated highly effective weight control. This work also provides a concept in therapeutic technology using artificial nerve signal generated from coordinated body activities.
The homojunction of oxygen/metal vacancies and its interfacial n–p effect on the physiochemical properties are rarely reported. Interfacial n–p homojunctions of TiO2 are fabricated by directly ...decorating interfacial p‐type titanium‐defected TiO2 around n‐type oxygen‐defected TiO2 nanocrystals in amorphous–anatase homogeneous nanostructures. Experimental measurements and theoretical calculations on the cell lattice parameters show that the homojunction of oxygen and titanium vacancies changes the charge density of TiO2; a strong EPR signal caused by oxygen vacancies and an unreported strong titanium vacancies signal of 2D 1H TQ‐SQ MAS NMR are present. Amorphous–anatase TiO2 shows significant performance regarding the photogeneration current, photocatalysis, and energy storage, owing to interfacial n‐type to p‐type conductivity with high charge mobility and less structural confinement of amorphous clusters. A new “homojunction of oxygen and titanium vacancies” concept, characteristics, and mechanism are proposed at an atomic‐/nanoscale to clarify the generation of oxygen vacancies and titanium vacancies as well as the interface electron transfer.
The homojunction of oxygen and titanium vacancies developed in the amorphous–anatase interface of nanostructured TiO2 results in a unique n–p electronic transmission, which is mostly preferred to the mobility of electronic charge carriers. It also contributes to significant performance regarding photogeneration current, photocatalysis, and energy storage.
As one paper in a series reporting on a large reverberation mapping campaign of super-Eddington accreting massive black holes (SEAMBHs) in active galactic nuclei (AGNs), we present the results of 10 ...SEAMBHs monitored spectroscopically during 2015-2017. Six of them are observed for the first time, and have generally higher 5100 luminosities than the SEAMBHs monitored in our campaign from 2012 to 2015; the remaining four are repeat observations to check if their previous lags change. Similar to the previous SEAMBHs, the Hβ time lags of the newly observed objects are shorter than the values predicted by the canonical RHβ-L5100 relation of sub-Eddington AGNs, by factors of ∼2-6, depending on the accretion rate. The four previously observed objects have lags consistent with previous measurements. We provide linear regressions for the RHβ-L5100 relation, solely for the SEAMBH sample and for low-accretion AGNs. We find that the relative strength of Fe ii and the profile of the Hβ emission line can be used as proxies of accretion rate, showing that the shortening of Hβ lags depends on accretion rates. The recent SDSS-RM discovery of shortened Hβ lags in AGNs with low accretion rates provides compelling evidence for retrograde accretion onto the black hole. These evidences show that the canonical RHβ-L5100 relation holds only in AGNs with moderate accretion rates. At low accretion rates, it should be revised to include the effects of black hole spin, whereas the accretion rate itself becomes a key factor in the regime of high accretion rates.
The output power of photovoltaic generation (PVG) varies with solar irradiance and temperature nonlinearly. Therefore, the maximum power point tracking (MPPT) is very important to operate PVG to ...harvest the maximum solar energy in real time. The perturbation and observation (P&O) method is one of the most commonly used MPPT methods. However, P&O MPPT suffers a tradeoff in selecting the perturbation step sizes of the control variables. This paper proposes a parameter-estimation-based MPPT for PVG. Based on the measured voltages and currents and the characteristic output function of PVG, the proposed MPPT uses parameter estimation to calculate the solar irradiance and temperature directly. The operating voltage of maximum power point can then be found out immediately. The proposed MPPT can effectively reduce the maximum power tracking time of conventional MPPT methods and increase the harvested energy during MPPT. Simulation and experimental results comparing the proposed MPPT to a P&O MPPT demonstrate the performance achieved by the proposed MPPT.
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