Zinc‐air batteries (ZABs) have attracted considerable attention for their high energy density, safety, low noise, and eco‐friendliness. However, the capacity of mechanically rechargeable ZABs was ...limited by the cumbersome procedure for replacing the zinc anode, while electrically rechargeable ZABs suffer from issues including low depth of discharge, zinc dendrite and dead zinc formation, and sluggish oxygen evolution reaction, etc. To address these issues, we report a hybrid redox‐mediated zinc‐air fuel cell (HRM‐ZAFC) utilizing 7,8‐dihydroxyphenazine‐2‐sulfonic acid (DHPS) as the anolyte redox mediator, which shifts the zinc oxidation reaction from the electrode surface to a separate fuel tank. This approach decouples fuel feeding and electricity generation, providing greater operation flexibility and scalability for large‐scale power generation applications. The DHPS‐mediated ZAFC exhibited a superior peak power density of 0.51 W/cm2 and a continuous discharge capacity of 48.82 Ah with ZnO as the discharge product in the tank, highlighting its potential for power generation.
A hybrid redox‐mediated zinc‐air fuel cell that liberates the zinc reaction from the electrode to a separate fuel tank was demonstrated, which enabled a facile zinc refueling in the tank and attained a record‐high power density of 0.51 W/cm2 and discharge capacity of 48.82 Ah by optimizing system kinetics. The zinc evolution mechanism during redox‐mediated reaction was unveiled for the first time using various in situ characterization techniques.
We conducted a case-control study to investigate the associations of functional single-nucleotide polymorphisms in the purinergic P2X7 receptor (P2X7R) gene (rs2393799, rs7958311, rs1718119, ...rs2230911, and rs3751143) with obesity and overweight in a population of Chinese postmenopausal women.
Our study included 180 obese women, 179 overweight women, and 204 controls. All participants were genotyped at the P2X7R rs2393799, rs7958311, rs1718119, rs2230911, and rs3751143 loci via allele-specific polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism procedures. The relationships between P2X7R genetic polymorphisms and their associated haplotypes with obesity (body mass index BMI ≥30 kg/m and overweight (25 kg/m ≤ BMI < 30 kg/m) were evaluated.
Our results showed that P2X7R rs2230911G and rs1718119A were associated with an increased risk of obesity; in particular, both carriers of the rs2230911G allele and GG/(CG + GG) genotypes (G vs C, P < 0.001, odds ratio OR 2.87, 95% confidence interval CI 1.98-4.16; GG vs CC, P < 0.001, OR 8.76, 95% CI 3.29-23.35; CG + GG vs CC, P < 0.001, OR 2.54, 95% CI 1.63-3.95) and carriers of the rs17181191A allele and GA/(GA + AA) genotypes (A vs G, P < 0.001, OR 2.97, 95% CI 1.86-4.74; GA vs GG, P = 0.001, OR 2.72, 95% CI 1.55-4.79; GA + AA vs GG, P < 0.001, OR 3.05, 95% CI 1.79-5.19) were at a higher risk of obesity. No association with obesity or overweight was observed for the other three P2X7R polymorphisms (rs2393799, rs7958311, and rs3751143). Haplotype analysis indicated that P2X7R rs1718119A-rs2230911G-rs3751143C appeared to be a significant risk haplotype with obesity (P = 0.0005, OR 2.37, 95% CI 1.45-3.90).
P2X7R functional genetic polymorphisms and their estimated haplotypes are associated with obesity in Chinese postmenopausal women.
Water-soluble fullerene derivatives have often been used as effective scavengers for reactive oxygen species. Three amphiphilic amino acid C
60 derivatives, β-alanine C
60 derivative, cystine C
60 ...derivative and arginine C
60 derivative have been synthesized and characterized. Because of the hydrophobic interaction, the amino acid C
60 derivatives could self-assemble to form spherical aggregates. Moreover, the cystine C
60 derivative and arginine C
60 derivative could further form multilayer vesicles because of hydrogen bonding. Experiments demonstrate that the aggregate morphology could impact the protective effect of amino acid C
60 derivatives on apoptosis. These compounds were able to penetrate the cell membrane and reduce the accumulation of reactive oxygen species and cellular damage caused by hydrogen peroxide in PC12 cells. The results suggest that amino acid C
60 derivatives have the potential to prevent oxidative stress-induced cell death without evident toxicity. Hence, we hypothesize that the protective effect of amino acid C
60 derivatives on hydrogen peroxide induced apoptosis is related to many factors, such as scavenger activity and morphology of the aggregate.
Osteoporosis (OP) is a major public health problem worldwide. Genetic factors are considered to be major contributors to the pathogenesis of OP. The purinergic P2X7 receptor (P2X7R) has been shown to ...play a role in the regulation of osteoblast and osteoclast activity and has been considered as an important candidate gene for OP. A case–control study was performed to investigate the associations of functional single nucleotide polymorphisms (SNPs) in the P2X7R gene (rs2393799, rs7958311, rs1718119, rs2230911, and rs3751143) with susceptibility to OP in 400 Chinese OP patients and 400 controls. Results showed that rs3751143 was associated with OP; in particular, carriers of the C allele and CC/(AC + CC) genotypes were at a higher risk of OP, but no significant association of rs2230911, rs7958311, rs1718119, and rs2393799 with OP risk was observed. Analysis of the haplotypes revealed one haplotype (rs1718119G-rs2230911G-rs3751143C) that appeared to be a significant “risk” haplotype with OP. The rs3751143 polymorphism was associated with osteoclast apoptosis; ATP-induced caspase-1 activity of osteoclasts with AC and CC genotypes is lower than that of osteoclasts with AA genotype in vitro. The findings suggest that the P2X7R rs3751143 functional polymorphism might contribute to OP susceptibility in Chinese postmenopausal women.
This work aimed to synthesize a novel injectable alginate impression material and evaluate its accuracy.
Certain proportions of sodium alginate, trisodium phosphate dodecahydrate, potassium ...fluorotitanate, diatomaceous earth, and other ingredients were dissolved in water and mixed evenly with a planetary centrifugal mixer to obtain a certain viscosity base paste. Certain proportions of calcium sulfate hemihydrate, magnesium oxide, glycerin, and polyethylene glycol (PEG) 400 were mixed evenly with a planetary centrifugal mixer to obtain the reactor paste with the same viscosity as the base paste. The base and reactor pastes were poured into a two-cylinder cartridge at a 2∶1 volume ratio. A gun device was used to accomplish mixing by compressing materials into a mixing tip. The samples were divided into three groups: injectable alginate impression materials (IA group) as the experimental group, and Jeltrate alginate impression materials (JA group) and Silagum-putty/light addition silicone rubber impression materials (SI group) as the two control groups.
Scanning electron microscopy (SEM) showed that the injectable alginate impression materials had a denser structure and fewer bubbles than the commercial alginate impression material. The accuracy of the three kinds of impression materials was evaluated by 3D image superposition. The deviations between the three test group models and the standard model (trueness) were 49.58 μm±1.453 μm (IA group), 54.75 μm±7.264 μm (JA group), and 30.92 μm±1.013 μm (SI group). The deviations of the models within each test group (precision) were 85.79 μm±8.191 μm (IA group), 97.65 μm±11.060 μm (JA group), and 56.51 μm±4.995 μm (SI group). Significant differences in trueness and precision were found among the three kinds of impression materials (
<0.05).
The accuracy of the new injectable alginate impression material was better than that of the traditional powder-type alginate impression material but worse than that of the addition silicone rubber impression materials. The novel injec-table alginate impression material demonstrated good operation performance and impression accuracy, showing broad application prospect.
The Solar Upper Transition Region Imager (SUTRI) onboard the Space Advanced Technology demonstration satellite (SATech-01), which was launched to a sun-synchronous orbit at a height of 500 km in July ...2022, aims to test the on-orbit performance of our newly developed Sc-Si multi-layer reflecting mirror and the 2kx2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of 3 nm. SUTRI employs a Ritchey-Chretien optical system with an aperture of 18 cm. The on-orbit observations show that SUTRI images have a field of view of 41.6'x41.6' and a moderate spatial resolution of 8" without an image stabilization system. The normal cadence of SUTRI images is 30 s and the solar observation time is about 16 hours each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period. Approximately 15 GB data is acquired each day and made available online after processing. SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of 0.5 MK in the solar atmosphere, which has rarely been sampled by existing solar imagers. SUTRI observations will establish connections between structures in the lower solar atmosphere and corona, and advance our understanding of various types of solar activity such as flares, filament eruptions, coronal jets and coronal mass ejections.
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