Phthalates are a series of widely used chemicals that demonstrate to be endocrine disruptors and are detrimental to human health. Phthalates can be found in most products that have contact with ...plastics during producing, packaging, or delivering. Despite the short half-lives in tissues, chronic exposure to phthalates will adversely influence the endocrine system and functioning of multiple organs, which has negative long-term impacts on the success of pregnancy, child growth and development, and reproductive systems in both young children and adolescents. Several countries have established restrictions and regulations on some types of phthalates; however, we think that more countries should establish constraints or substitute measures for phthalates to reduce health risks. This article aims to summarize the adverse impacts of phthalates on human health, analyze the toxicity mechanism, assess the risks, and finally provide feasible strategies to reduce exposure of the public to phthalates.
In recent years, with the popularity of the Internet, more and more people like to comment on movies they have watched on the film platform after watching them. These reviews hide the reviewers' ...feedback on films. Mining the emotional orientation information in these reviews can provide consumers with shopping references and help businesses optimize film works and improve business strategies. Therefore, the emotional classification of film reviews has high research value because few emotion dictionaries and analysis tools are available for reference and use in film reviews. The accuracy of emotion classification still needs to be improved. This study introduces the attention mechanism and dual channel long short term memory (DC-LSTM) while building the emotion dictionary in the field of Chinese film review. It classifies Chinese film reviews in terms of topic-based fine-grained emotion. First, the emotion vector is constructed using the constructed movie review emotion lexicon. The semantic vector obtained by the Word2vector tool is input to LSTM to encode the comment text. Then, the topic attention module is used to decode. Finally, the final emotion classification result is obtained through the softmax function of the entire link layer and the output layer. The thematic attention modules constructed in this study are independent of each other for attention parameter adjustment and learning. One attention module corresponds to one film theme. In this study, eight themes, including "plot," "special effects," "original work," "music," "thought," "theme," "acting skills," and "joke," were extracted, and each theme was classified into three types of emotions: "positive," "neutral," and "negative." The experimental results on the crawled Chinese film review dataset show that the proposed algorithm is superior to some existing algorithms and models in accuracy, precision, recall and F1 measure. The DCLSTM based on the thematic attention mechanism (DCLSTM-TAM) model constructed in this study introduces the emotion vector into the network and adds the theme attention mechanism. It can not only classify the emotion for different topics of a film review but also effectively deal with film reviews with fuzzy emotional tendencies. It realizes the fine-grained emotion classification of film topics and improves the accuracy of emotion classification of film reviews. The emotion classification method and model proposed in this study have good transferability, and the change of training corpus is also applicable to other short text fields.
Porous yet densely packed carbon electrodes with high ion-accessible surface area and low ion transport resistance are crucial to the realization of high-density electrochemical capacitive energy ...storage but have proved to be very challenging to produce. Taking advantage of chemically converted graphene's intrinsic microcorrugated two-dimensional configuration and self-assembly behavior, we show that such materials can be readily formed by capillary compression of adaptive graphene gel films in the presence of a nonvolatile liquid electrolyte. This simple soft approach enables subnanometer scale integration of graphene sheets with electrolytes to form highly compact carbon electrodes with a continuous ion transport network. Electrochemical capacitors based on the resulting films can obtain volumetric energy densities approaching 60 watt-hours per liter.
Potential of zero charge (PZC) is a fundamental quantity that dictates the structure of the electrical double layer. Studies using single crystals suggest a polycrystalline surface should display an ...inhomogeneous distribution of PZC and electric field, which directly affects the electrochemical energy storage and conversion processes occurring at the electrode–electrolyte interface. Herein, we demonstrate the direct mapping of local PZC using scanning electrochemical cell microscopy (SECCM). The potential-dependent charging current upon the formation of the microscopic electrode–electrolyte interface is used to determine the PZC. Using polycrystalline Pt as a model system, correlative SECCM and electron backscatter diffraction (EBSD) images show the dependence of PZC on the local crystal grain orientation. The electrocatalytic activity can be mapped from the same SECCM experiment via local voltammetry, which demonstrates the variation of hydrogen evolution reaction (HER) activity across Pt grains. The method reported here can be readily applied to study other electrochemical interfaces, providing rich correlative information on the surface property and electrocatalytic activities.
With the global climate anomalies and the destruction of ecological balance, the water shortage has become a serious ecological problem facing all mankind, and drought has become a key factor ...restricting the development of agricultural production. Therefore, it is essential to study the drought tolerance of crops. Based on previous studies, we reviewed the effects of drought stress on plant morphology and physiology, including the changes of external morphology and internal structure of root, stem, and leaf, the effects of drought stress on osmotic regulation substances, drought-induced proteins, and active oxygen metabolism of plants. In this paper, the main drought stress signals and signal transduction pathways in plants are described, and the functional genes and regulatory genes related to drought stress are listed, respectively. We summarize the above aspects to provide valuable background knowledge and theoretical basis for future agriculture, forestry breeding, and cultivation.
Endostar, an anti-angiogenic drug, has been approved for treating non-small cell lung cancer (NSCLC). At present, endostar combined with radiotherapy or chemotherapy has achieved ideal results in the ...treatment of some tumors, but there is a lack of application and study in NSCLC. This study investigated the therapeutic effect and potential mechanism of endostar combined with cisplatin (EC) in NSCLC.
HE staining, TUNEL staining, immunofluorescence, colony formation ability, and cell migration ability were used to evaluate the anti-tumor activity of EC. The expressions of FMOD, VEGF, FGF-2, and PDGF-B were detected by western blotting and qPCR. The target of combination therapy was analyzed by m6A sequencing and RNA sequencing. METTL3 knockdown and overexpressed A549 cells were constructed and co-cultured with HUVECs to further evaluate the effect of METLL3 on combination therapy.
Combination therapy significantly reduced the colony formation and migration ability of NSCLC cells, induced cell apoptosis, and inhibited the tube formation ability of HUVECs. The results of m6A sequencing and RNA sequencing showed that the EC could down-regulate the expression level of FMOD in tumor tissues, which might be related to the reduction of its m6A methylation modification regulatory enzyme METTL3. Restricting FMOD expression could reduce the expression of FGF2, TGF-β1, VEGF and PDGF-B. Moreover, overexpression of METTLE almost abolished the anti-tumor effect of EC and promoted angiogenesis.
Endostar combined with cisplatin might exert anti-tumor effects by down-regulating the expression of METTL3 and FMOD.
To meet various practical requirements and enhance human experience, hydrogels possessing multifunctionality are of great significance for flexible wearable sensors. Herein, a novel strategy has been ...developed to fabricate nanocomposite hydrogels with a combination of excellent stretchability, rapid recoverability, self-healing, and outstanding adhesiveness. The PAAc/SiO2-g-PAAm nanocomposite hydrogels were facilely prepared through the polymerization of acrylic acid (AAc) using SiO2-g-polyacrylamide core–shell hybrid nanoparticles (SiO2-g-PAAm) as the dynamic cross-linking center. The densely dynamic hydrogen bonds between PAAc matrices and grafted PAAm chains could reversibly be destructed and reconstructed to dissipate a large amount of energy. Due to this unique feature, the formulated hydrogels showed a wide spectrum of desirable properties, including skin-mimetic modulus, excellent stretchability (1600%), exceptional self-healing properties (96.5% at ambient temperature), and fast recoverability. The sensors fabricated with the prepared hydrogels exhibited a high detection sensitivity in the strain range from 50% to 500% with a gauge factor value of 5.86, rapid response time, and good antifatigue performance. Depending on the outstanding adhesiveness, this sensor could attach to different substrates to release the real-time motion monitoring. In the practical wearable sensing test, various human motions, including tiny-scaled swallowing, laughing, and speaking, as well as large-scaled wrist, elbow, and knee movements during basketball shooting, could be sensed. These demonstrations heralded the potential application of our sensor in accurate and long-term human motion monitoring.
Herein, we designed a new strategy for fabricating a renewable bioresource-derived N-doped hierarchical porous carbon-supported iron (Fe/NPC)-based oxidase mimic. The obtained results suggested that ...Fe/NPC possessed a large specific surface area (1144 m2/g) and pore volume (0.62 cm3/g) to afford extensive Fe-Nx active sites. Taking advantages of the remarkable oxidase-mimicking activity, outstanding stability, and reusability of Fe/NPC, a novel dual-channel biosensing system was strategically fabricated for sensitively determining acetylcholinesterase (AChE) through the integration of Fe/NPC and fluorescent silver nanoclusters (AgNCs) for the first time. The limits of detection for AChE can achieve as low as 0.0032 and 0.0073 U/L by the outputting fluorometric and colorimetric dual signals, respectively. Additionally, this dual-signal system was applied to analyze human erythrocyte AChE and its inhibitor with robust analytical performance. This work provides one sustainable and effective avenue to apply a bioresource for fabricating an Fe/NPC-based oxidase mimic with high catalytic performance and also gives new impetuses for developing novel biosensors by applying Fe/NPC-based enzyme mimics as substitutes for the natural enzyme.
The photodegradation of seven micropollutants commonly found in municipal wastewater, namely caffeine, carbamazepine, diuron, simazine, sulfamethoxazole, triclosan and 2,4-D, was investigated in pure ...water and secondary effluent to understand the direct and indirect photolysis of these compounds under natural sunlight irradiation. Sulfamethoxazole and triclosan were readily photodegraded with half-lives of 5.8 and 1.8 h, respectively, whilst the others were relatively resistant towards sunlight irradiation. Enhanced degradation was observed in secondary effluent compared with in the pure water matrix for all compounds, except for triclosan. It was confirmed that hydroxyl radicals played an important role in the photodegradation of the micropollutants while singlet oxygen may also play a role. The contribution of hydroxyl radical to the overall degradation of the five compounds that were resistant to direct sunlight accounted for 32%–70%. The impact of humic acid and nitrate, two known photosensitisers and wastewater components, on the photodegradation of the seven micropollutants in pure water was investigated under simulated solar radiation. The presence of nitrate promoted the photochemical loss of all seven micropollutants, however, humic acid caused promotion or inhibition, depending on the characteristics of the micropollutant. Humic acid enhanced the photolytic degradation of caffeine, sulfamethoxazole and diuron, while it hindered the photodegradation of the other four compounds by absorbing the available irradiation energy and/or reforming the parent compound. Furthermore, it was shown that there was only a small increase (up to 15%) in photodegradation of the compounds at 25 °C compared with that at 10 °C in the simulated system.
•CAF, CBZ, DUR, SMZ and 2,4-D primarily degraded via indirect photolysis.•Hydroxyl radicals had important role in the indirect photolysis of five compounds.•SMX and TCS primarily degraded via direct photolysis.•Nitrate promoted the photolysis of all compounds while affected TCS & SMX slightly.•Humic acid had differing effects on the photodegradation of the selected compounds.
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