•Fatigue performance of powder bed fusion additive manufactured Ti-6Al-4V.•Effects of AM fabrication and post fabrication processes on fatigue performance.•Life predictions based on effective defect ...size from extreme value statistics.•Analysis and predictions of a link component as an illustrative application example.
Part I of these two-part paper series focused on the process and structure relationships, effect of powder feedstock, fabrication parameters, and post fabrication treatments on the resulting microstructure, defect characteristics, and surface quality of the fabricated Ti-6Al-4V parts. This second part extends the study by evaluating the effect of the aforementioned factors on axial, torsion, and multiaxial fatigue behavior of the additively manufactured (AM) Ti-6Al-4V specimens. Despite the advantages of additive manufacturing techniques discussed in Part I, they are still rarely used in fatigue critical load carrying applications, partly due to insufficient understanding of fatigue behavior and its dependence on variations in material microstructure and defects. This becomes even more challenging when other process characteristics of AM including build orientation, residual stresses, and surface roughness are considered. This paper discusses these effects, as well as machine-to-machine variability and the effects of specimen geometry and size, post heat treatment, and multiaxial stress state. Experimental uniaxial, torsion, and multiaxial fatigue test results recently generated by the authors for laser beam powder bed fusion- produced Ti-6Al-4V alloy are reviewed. The observed behaviors and the influence of the aforementioned effects are then related to the resulting microstructure and defect characteristics discussed in Part I. Fatigue life prediction results for specimens based on the effective defect size calculated by extreme value statistics (EVS) of the internal defects and surface roughness are also presented and compared with experimental data. The observed behaviors and specimen test results are then used for fatigue life analysis and predictions of a link component as an illustrative application example.
•High/low energy input during AM favors spherical pores/lack-of-fusion, respectively.•Lack-of-fusion defects are more detrimental to fatigue performance.•Post AM hot isostatic pressing cannot fully ...eliminate defects due to entrapped gas.•Reused powder can lead to reduced defect content and improved fatigue life.•Prior-beta morphology can be altered by tuning AM process and/or heat treatments.
Additive manufacturing provides an appealing means to process titanium alloy parts with new levels of conformability, complexity, and weight reduction. However, due to the heating/cooling rates and heat transfer associated with directed energy source material processing, the as-built AM parts contain unique material and microstructural features. In order to confidently manufacture fatigue critical additive manufactured (AM) Ti-6Al-4V parts, a better understanding of the interrelationships between powder feedstock, AM processes, structure of the processed parts, their resulting mechanical properties, and their performance under realistic loadings is necessary. Part I of this two-part collection focuses on the powder-process-structure relationships and how powder feedstock, manufacturing, and post-processing conditions can affect the microstructure and defect features that ultimately contribute to the fatigue performance of Ti-6Al-4V parts. The material and physical phenomena inherent to the AM process of Ti-6Al-4V are discussed in detail and related to the phase composition/structure, grain morphology, surface characteristics, defect size/distribution, and post-process treatments available for AM parts. This investigation is the foundation for the structure-performance relationships that will be discussed in detail in Part II.
Nutrient pollution from agriculture has been an ongoing challenge for decades, contributing to numerous negative environmental impacts. In the European Union policies have been developed to address ...nutrient pollution, including Nitrate Action Programmes under Council Directive 91/676/EEC. Although Member States report on progress on implementation, there have been few studies that explore how measures have been implemented; the environmental implications of any differences; and how they vary spatially on a European scale. This study aims to address this gap with respect to fertiliser closed periods (1155 different closed periods across 69 Nitrate Action Programmes). This included the development of an approach that can be applied using readily available spatial data. Each closed period was scored for its coverage of risk periods for losses of nitrate; organic material; nitrous oxide and ammonia. Closed periods were then matched to relevant combinations of spatial data for each environmental zone and fertiliser type. The scores for each combination were used to create maps and calculate spatial statistics. The results show that in addition to nitrate, closed periods also reduce the risk of organic material run-off, emissions of nitrous oxide and to a lesser extent ammonia. However, risk reduction is spatially variable across all the impacts and the scope for synergy is also variable (e.g. nitrate loss does not always correlate with nitrous oxide or ammonia risk reduction). Regions in the Atlantic, Lustanian and some areas within the Mediterranean zones appear to provide the greatest combined risk reduction, with other zones, especially in eastern Europe, having a lower combined risk reduction (due to a combination of different risk periods coupled with lower coverage of individual risks). The spatial analysis within this study is relatively simple; is based on a snapshot of closed periods during 2019–2020; and only explores one measure. However, it does provide some useful data and insights that could support policy development in the future. This includes scope for Member States and regions to learn from others where greater coverage of risk periods has been achieved; and highlighting how a more holistic perspective can be taken to the environmental management of nutrients. As we strive towards developing sustainable production systems, farmers and policy makers need to take a more integrated approach to incorporate additional environmental objectives; which increases the complexity of the challenge. Consequently, the demand for pragmatic approaches that take a more holistic approach is likely to increase in the future.
Spatial variability in the combined coverage of risk periods for nitrate loss, organic material, nitrous oxide and ammonia due to fertiliser closed periods in Europe. Display omitted
•A novel spatial analysis of the environmental impacts of fertiliser closed periods in Europe is developed and applied.•Risk reduction and scope for synergy varies spatially for losses of nitrate, organic material, nitrous oxide and ammonia.•Regions in the Atlantic, Lustanian and some Mediterranean zones appear to provide the greatest combined risk reduction.
Emerging technologies pose particularly strong challenges for risk governance when they have multidimensional and inequitable impacts, when there is scientific uncertainty about the technology and ...its risks, when there are strong value conflicts over the perceived benefits and risks, when decisions must be made urgently, and when the decision making environment is rife with mistrust. Shale gas development is one such emerging technology. Drawing on previous U.S. National Research Council committee reports that examined risk decision making for complex issues like these, we point to the benefits and challenges of applying the analytic-deliberative process recommened in those reports for stakeholder and public engagement in risk decision making about shale gas development in the United States. We discuss the different phases of such a process and conclude by noting the dangers of allowing controversy to ossify and the benefits of sound dialogue and learning among publics, stakeholders, industry, and regulatory decision makers.
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the formation of prostanoids by the enzyme cyclooxygenase (COX). Work in the past 15 years has shown that COX exists in two forms: COX1, which ...is largely associated with physiological functions, and COX2, which is largely associated with pathological functions. Heated debate followed the introduction of selective COX2 inhibitors around 5 years ago: do these drugs offer any advantages over the traditional NSAIDs theywere meant to replace, particularly in regard to gastrointestinal and cardiovascular side effects? Here we discuss the evidence and the latest recommendations for the use of selective inhibitors of COX2 as well as the traditional NSAIDs.
The Janus kinase (JAK) family of tyrosine kinases includes JAK1, JAK2, JAK3 and TYK2, and is required for signaling through Type I and Type II cytokine receptors. CP-690,550 is a potent and selective ...JAK inhibitor currently in clinical trials for rheumatoid arthritis (RA) and other autoimmune disease indications. In RA trials, dose-dependent decreases in neutrophil counts (PBNC) were observed with CP-690,550 treatment. These studies were undertaken to better understand the relationship between JAK selectivity and PBNC decreases observed with CP-690,550 treatment.
Potency and selectivity of CP-690,550 for mouse, rat and human JAKs was evaluated in a panel of in vitro assays. The effect of CP-690,550 on granulopoiesis from progenitor cells was also assessed in vitro using colony forming assays. In vivo the potency of orally administered CP-690,550 on arthritis (paw edema), plasma cytokines, PBNC and bone marrow differentials were evaluated in the rat adjuvant-induced arthritis (AIA) model.
CP-690,550 potently inhibited signaling through JAK1 and JAK3 with 5-100 fold selectivity over JAK2 in cellular assays, despite inhibiting all four JAK isoforms with nM potency in in vitro enzyme assays. Dose-dependent inhibition of paw edema was observed in vivo with CP-690,550 treatment. Plasma cytokines (IL-6 and IL-17), PBNC, and bone marrow myeloid progenitor cells were elevated in the context of AIA disease. At efficacious exposures, CP-690,550 returned all of these parameters to pre-disease levels. The plasma concentration of CP-690,550 at efficacious doses was above the in vitro whole blood IC50 of JAK1 and JAK3 inhibition, but not that of JAK2.
Results from this investigation suggest that CP-690,550 is a potent inhibitor of JAK1 and JAK3 with potentially reduced cellular potency for JAK2. In rat AIA, as in the case of human RA, PBNC were decreased at efficacious exposures of CP-690,550. Inflammatory end points were similarly reduced, as judged by attenuation of paw edema and cytokines IL-6 and IL-17. Plasma concentration at these exposures was consistent with inhibition of JAK1 and JAK3 but not JAK2. Decreases in PBNC following CP-690,550 treatment may thus be related to attenuation of inflammation and are likely not due to suppression of granulopoiesis through JAK2 inhibition.
Temperature data obtained by the Cryogenic Infrared Spectrometers and Telescopes for the Atmosphere (CRISTA) are analyzed for gravity waves (GWs). Amplitude, phase and vertical wavelength are ...determined from detrended temperature height profiles. The retrieved phases are utilized to estimate the horizontal wavelengths. At 25 km altitude an equatorial maximum of horizontal wavelength with a decrease toward mid and high latitudes is found. Simultaneous estimates of both horizontal and vertical wavelengths and temperature amplitudes allow the direct calculation of GW momentum flux (MF) from satellite observations for the first time. However, histograms of horizontal wavelength distributions indicate severe undersampling which prevents the retrieval of the propagation directions of the waves, and suggests our MF estimates may be too low, particularly at the high latitudes. Therefore an empirical aliasing correction has been applied. A world map of MF at 25 km altitude shows high variability and pronounced source regions and deviates in structure from a map of GW variances at the same altitude. Results from the Warner and McIntyre GW parameterization scheme (three‐part model) show better agreement with CRISTA MF estimates than with CRISTA squared GW amplitudes. Best agreement is found for low model launch levels. Large error ranges of the estimated MF values obtained in this paper could be substantially reduced by improved horizontal sampling in future satellite missions.
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