Using the IRAM Plateau de Bure Interferometer, we report the detection of the 158 mu m CII emission line and underlying dust continuum in the host galaxy of the quasar ULAS J112001.48+064124.3 ...(hereafter J1120+0641) at z = 7.0842 + or - 0.0004. This is the highest redshift detection of the CII line to date, and allows us to put the first constraints on the physical properties of the host galaxy of J1120+0641. The CII line luminosity is 1.2 + or - 0.2 x 10 super(9) L sub(middot in circle), which is a factor ~4 lower than observed in a luminous quasar at z = 6.42 (SDSS J1148+5251). The underlying far-infrared (FIR) continuum has a flux density of 0.61 + or - 0.16 mJy, similar to the average flux density of z ~ 6 quasars that were not individually detected in the rest-frame FIR. Assuming that the FIR luminosity of L sub(FIR) = 5.8 x 10 super(11)-1.8 x 10 super(12) L sub(middot in circle) is mainly powered by star formation, we derive a star formation rate in the range 160-440 M sub(middot in cirlce) yr super(-1) and a total dust mass in the host galaxy of 6.7 x 107-5.7 x 10 super(8) M sub(middot in circle) (both numbers have significant uncertainties given the unknown nature of dust at these redshifts). The CII line width of sigma sub(V) = 100 + or - 15 km s super(-1) is among the smallest observed when compared to the molecular line widths detected in z ~ 6 quasars. Both the CII and dust continuum emission are spatially unresolved at the current angular resolution of 2.0 x 1.7 arcsec super(2) (corresponding to 10 x 9 kpc super(2) at the redshift of J1120+0641).
Treated effluent from municipal wastewater treatment plants (WWTPs) is a major source of contamination that can impact population size, community structure, and biodiversity of aquatic organisms. ...However, because the majority of field research occurs during warmer periods of the year, the impacts of wastewater effluent on aquatic communities during winter has largely been neglected. In this study, we assessed the impacts of wastewater effluent on aquatic benthic macroinvertebrate (benthos) communities along the effluent gradients of two WWTPs discharging into Hamilton Harbour, Canada, during summer and winter using artificial substrates incubated for 8 weeks. At the larger of the two plants, benthic macroinvertebrate abundance was higher and diversity was lower at sites downstream of the outfall compared to upstream sites in both seasons. Whereas at the smaller plant, the opposite was observed, abundance increased and diversity decreased with distance from the outfall in both seasons. While the impacts of wastewater on benthic communities were largely similar between seasons, we did detect several general seasonal trends – family diversity of macroinvertebrates was lower during winter at both WWTPs and total abundance was also lower during winter, but only significantly so at the smaller WWTP. Further, benthic macroinvertebrate community composition differed significantly along the effluent gradients, with sites closest and farthest from the outfall being the most dissimilar. Our contrasting results between the WWTPs demonstrate that plants, with different treatment capabilities and effluent-receiving environments (industrial/urban versus wetland), can dictate how wastewater effluent impacts benthic macroinvertebrate communities.
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•Minor seasonal differences in biodiversity responses to wastewater•Large, industrial-situated WWTP had higher abundance & lower diversity near outfall.•Small, wetland-situated WWTP had lower abundance & higher diversity near outfall.•WWTPs impaired water quality of downstream sites, especially in winter.•Benthic communities closest and farthest from the outfall were the most dissimilar.
Transport first became a significant source of air pollution after the problems of sooty smog from coal combustion had largely been solved in western European and North American cities. Since then, ...emissions from road, air, rail and water transport have been partly responsible for acid deposition, stratospheric ozone depletion and climate change. Most recently, road traffic exhaust emissions have been the cause of much concern about the effects of urban air quality on human health and tropospheric ozone production. This article considers the variety of transport impacts on the atmospheric environment by reviewing three examples: urban road traffic and human health, aircraft emissions and global atmospheric change, and the contribution of sulphur emissions from ships to acid deposition. Each example has associated with it a different level of uncertainty, such that a variety of policy responses to the problems are appropriate, from adaptation through precautionary emissions abatement to cost–benefit analysis and optimised abatement. There is some evidence that the current concern for road transport contribution to urban air pollution is justified, but aircraft emissions should also give cause for concern given that air traffic is projected to continue to increase. Emissions from road traffic are being reduced substantially by the introduction of technology especially three-way catalysts and also, most recently, by local traffic reduction measures especially in western European cities. In developing countries and Eastern Europe, however, there remains the possibility of great increase in car ownership and use, and it remains to be seen whether these countries will adopt measures now to prevent transport-related air pollution problems becoming severe later in the 21st Century.
Focal brain lesions are assumed to produce language deficits by two basic mechanisms: local cortical dysfunction at the lesion site, and remote cortical dysfunction due to disruption of the transfer ...and integration of information between connected brain regions. However, functional imaging studies investigating language outcome after aphasic stroke have tended to focus only on the role of local cortical function. In this positron emission tomography functional imaging study, we explored relationships between language comprehension performance after aphasic stroke and the functional connectivity of a key speech-processing region in left anterolateral superior temporal cortex. We compared the organization of left anterolateral superior temporal cortex functional connections during narrative speech comprehension in normal subjects with left anterolateral superior temporal cortex connectivity in a group of chronic aphasic stroke patients. We then evaluated the language deficits associated with altered left anterolateral superior temporal cortex connectivity in aphasic stroke. During normal narrative speech comprehension, left anterolateral superior temporal cortex displayed positive functional connections with left anterior basal temporal cortex, left inferior frontal gyrus and homotopic cortex in right anterolateral superior temporal cortex. As a group, aphasic patients demonstrated a selective disruption of the normal functional connection between left and right anterolateral superior temporal cortices. We observed that deficits in auditory single word and sentence comprehension correlated both with the degree of disruption of left-right anterolateral superior temporal cortical connectivity and with local activation in the anterolateral superior temporal cortex. Subgroup analysis revealed that aphasic patients with preserved positive intertemporal connectivity displayed better receptive language function; these patients also showed greater than normal left inferior frontal gyrus activity, suggesting a possible ‘top-down’ compensatory mechanism. These results demonstrate that functional connectivity between anterolateral superior temporal cortex and right anterior superior temporal cortex is a marker of receptive language outcome after aphasic stroke, and illustrate that language system organization after focal brain lesions may be marked by complex signatures of altered local and pathway-level function.
Purpose To characterize the effect of radial tears (RTs) of the lateral meniscus and their subsequent treatment (inside-out repair, partial meniscectomy) on joint contact mechanics during simulated ...gait. Methods Six human cadaveric knees were mounted on a simulator programmed to mimic human gait. A sensor was inserted below the lateral meniscus to measure peak joint contact pressure location, magnitude, and contact area. The following conditions were compared: intact meniscus, 30% RT (at the popliteal hiatus), 60% RT, 90% RT, repair, and partial meniscectomy. Data were analyzed in the midstance phase of gait (14% and 45%) when axial force was at its highest (2,100 N). Results Intact knees had peak contact pressures of 5.9 ± 0.9 MPa and 6.4 ± 1.1 MPa at 14% and 45% of gait, respectively. RTs of up to and including 60% had no effect on pressure magnitude or location. RTs of 90% resulted in significantly increased peak pressure (8.4 ± 1.1 MPa) in the postero-peripheral aspect of the tibial plateau and reduced contact area versus the intact knee, at 45% of gait. Repair resulted in a significant decrease in peak pressure (7.7 ± 1.0 MPa) relative to 90% RT but had no effect on contact area. Partial lateral meniscectomy resulted in areas and pressures that were not significantly different from 90% tears (8.7 ± 1.5 MPa). Conclusions Simulated large RTs of the lateral meniscus in the region of the popliteal hiatus show unfavorable dynamic contact mechanics that are not significantly different from those resulting from a partial lateral meniscectomy. Pressure was significantly reduced with inside-out repair but was not affected by partial meniscectomy; contact area was not restored to that of the intact condition for either procedure. Clinical Relevance Large RTs in the region of the popliteal hiatus show unfavorable dynamic contact mechanics.
Castration-resistant prostate cancer (CRPC) continues to pose a significant clinical challenge with new generation second-line hormonal therapies affording limited improvement in disease outcome. As ...the androgen receptor (AR) remains a critical driver in CRPC, understanding the determinants of its transcriptional activity is important for developing new AR-targeted therapies. FOXA1 is a key component of the AR transcriptional complex yet its role in prostate cancer progression and the relationship between AR and FOXA1 are not completely resolved. It is well established that FOXA1 levels are elevated in advanced prostate cancer and metastases. We mimicked these conditions by overexpressing FOXA1 in the androgen-responsive LNCaP prostate cancer cell line and observed a significant increase in AR genomic binding at novel regions that possess increased chromatin accessibility. High levels of FOXA1 resulted in increased proliferation at both sub-optimal and high 5α-dihydrotestosterone (DHT) concentrations. Immunohistochemical staining for FOXA1 in a clinical prostate cancer cohort revealed that high FOXA1 expression is associated with shorter time to biochemical recurrence after radical prostatectomy (hazard ratio (HR) 5.0, 95% confidence interval (CI) 1.2-21.1, P=0.028), positive surgical margins and higher stage disease at diagnosis. The gene expression program that results from FOXA1 overexpression is enriched for PTEN, Wnt and other pathways typically represented in CRPC gene signatures. Together, these results suggest that in an androgen-depleted state, elevated levels of FOXA1 enhance AR binding at genomic regions not normally occupied by AR, which in turn facilitates prostate cancer cell growth.
Humans devote much time to the exchange of memories within the context of shared general and personal semantic knowledge. Our hypothesis was that functional imaging in normal subjects would ...demonstrate the convergence of speech comprehension and production on high-order heteromodal and amodal cortical areas implicated in declarative memory functions. Activity independent of speech phase (that is, comprehension and production) was most evident in the left and right lateral anterior temporal cortex. Significant activity was also observed in the posterior cortex, ventral to the angular gyri. The left and right hippocampus and adjacent inferior temporal cortex were active during speech comprehension, compatible with mnemonic encoding of narrative information, but activity was significantly less during the overt memory retrieval associated with speech production. Therefore, although clinical studies suggest that hippocampal function is necessary for the retrieval as well as the encoding of memories, the former appears to depend on much less net synaptic activity. In contrast, the retrosplenial/posterior cingulate cortex and the parahippocampal area, which are closely associated anatomically with the hippocampus, were equally active during both speech comprehension and production. The results demonstrate why a severe and persistent inability both to understand and produce meaningful speech in the absence of an impairment to process linguistic forms is usually only observed after bilateral, and particularly anterior, destruction of the temporal lobes, and emphasize the importance of retrosplenial/posterior cingulate cortex, an area known to be affected early in the course of Alzheimer's disease, in the processing of memories during communication.
Luminous K-band selected quasars from UKIDSS Maddox, Natasha; Hewett, Paul C.; Warren, S. J. ...
Monthly notices of the Royal Astronomical Society,
05/2008, Letnik:
386, Številka:
3
Journal Article
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The largest K-band flux-limited sample of luminous quasars to date has been constructed from the UKIRT (UK Infrared Telescope) Infrared Deep Sky Survey (UKIDSS) Large Area Survey Early Data Release, ...covering an effective area of 12.8 deg2. Exploiting the K-band excess (KX) of all quasars with respect to foreground stars, including quasars experiencing dust reddening and objects with non-standard spectral energy distributions (SEDs), a list of targets suitable for spectroscopic follow-up observations with the AAOmega multi-object spectrograph is constructed, resulting in more than 200 confirmed active galactic nuclei (AGN). KX selection successfully identifies as quasar candidates objects that are excluded from the Sloan Digital Sky Survey (SDSS) quasar selection algorithm due to their colours being consistent with the stellar locus in optical colour space (with the space density of the excluded objects agreeing well with results from existing completeness analyses). Nearly half of the KX-selected quasars with K≤ 17.0 at z < 3 are too faint in the i band to have been targeted by the SDSS quasar selection algorithm, revealing a large population of quasars with red i−K colours. The majority of these objects have significant amounts of host galaxy light contributing to their K-band magnitudes, consistent with previous predictions. The remaining objects are morphologically stellar and have colours consistent with quasars experiencing Small Magellanic Cloud (SMC)-type reddening with 0.10 < E(B−V) < 0.25. The i−K colour distribution indicates that <10 per cent of the quasar population is missing from this K-band selected sample due to dust reddening, and comparisons with simulations strongly favour an obscured fraction of <20 per cent. Photometric redshifts and classifications are computed for the candidates that were not observed spectroscopically. For the extended objects whose colours are consistent with those of a reddened quasar, models of galaxy surface brightness profiles appropriate for each object are used to eliminate the possibility of the presence of a nuclear source bright enough for inclusion in a K≤ 17.0 quasar sample. The effectiveness of near-infrared colour selection of quasars has been demonstrated by this modest-sized sample, and it will only become more apparent as the amount of available data increases.
A method is disclosed for the convergent synthesis of multiply glycosylated peptides. The approach centers on a convergent technique for generating masked, complex glycopeptide-containing C-terminal ...acyl donors. Activation of the latent donor in situ and use directly in segment coupling with a second peptide bearing a complex carbohydrate produces a completely unprotected, bifunctional glycopeptide. The system demonstrates a minimum level of hydrolysis and epimerization at the C-terminal amino acid residue of the acyl donor during fully convergent segment coupling and is therefore a powerful tool for the synthesis of glycoproteins.
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•Pontogammarus roubustoides is an invader with a large complement of symbionts.•Symbiotic diversity spans 13 groups, including viruses.•Histopathology is used to explore potentially ...pathogenic symbionts.•With this baseline screen, we are better equipped to assess parasite introduction risk to other areas.
Biological invasions may act as conduits for pathogen introduction. To determine which invasive non-native species pose the biggest threat, we must first determine the symbionts (pathogens, parasites, commensals, mutualists) they carry, via pathological surveys that can be conducted in multiple ways (i.e., molecular, pathological, and histological). Whole animal histopathology allows for the observation of pathogenic agents (virus to Metazoa), based on their pathological effect upon host tissue. Where the technique cannot accurately predict pathogen taxonomy, it does highlight pathogen groups of importance. This study provides a histopathological survey of Pontogammarus robustoides (invasive amphipod in Europe) as a baseline for symbiont groups that may translocate to other areas/hosts in future invasions.
Pontogammarus robustoides (n = 1,141) collected throughout Poland (seven sites), were noted to include a total of 13 symbiotic groups: a putative gut epithelia virus (overall prevalence = 0.6%), a putative hepatopancreatic cytoplasmic virus (1.4%), a hepatopancreatic bacilliform virus (15.7%), systemic bacteria (0.7%), fouling ciliates (62.0%), gut gregarines (39.5%), hepatopancreatic gregarines (0.4%), haplosporidians (0.4%), muscle infecting microsporidians (6.4%), digeneans (3.5%), external rotifers (3.0%), an endoparasitic arthropod (putatively: Isopoda) (0.1%), and Gregarines with putative microsporidian infections (1.4%).
Parasite assemblages partially differed across collection sites. Co-infection patterns revealed strong positive and negative associations between five parasites. Microsporidians were common across sites and could easily spread to other areas following the invasion of P. robustoides. By providing this initial histopathological survey, we hope to provide a concise list of symbiont groups for risk-assessment in the case of a novel invasion by this highly invasive amphipod.
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