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zadetkov: 21
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  • Saponin-based adjuvants ind... Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
    den Brok, Martijn H; Büll, Christian; Wassink, Melissa ... Nature communications, 11/2016, Letnik: 7, Številka: 1
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    Saponin-based adjuvants (SBAs) are being used in animal and human (cancer) vaccines, as they induce protective cellular immunity. Their adjuvant potency is a factor of inflammasome activation and ...
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  • Targeting aberrant sialylation in cancer cells using a fluorinated sialic acid analog impairs adhesion, migration, and in vivo tumor growth
    Büll, Christian; Boltje, Thomas J; Wassink, Melissa ... Molecular cancer therapeutics 12, Številka: 10
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    Cancer cells decorate their surface with a dense layer of sialylated glycans by upregulating the expression of sialyltransferases and other glycogenes. Although sialic acids play a vital role in many ...
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3.
  • Mechanical high-intensity f... Mechanical high-intensity focused ultrasound creates unique tumor debris enhancing dendritic cell-induced T cell activation
    van den Bijgaart, Renske J E; Mekers, Vera E; Schuurmans, Fabian ... Frontiers in immunology, 12/2022, Letnik: 13
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    tumor ablation releases a unique repertoire of antigens from a heterogeneous population of tumor cells. High-intensity focused ultrasound (HIFU) is a completely noninvasive ablation therapy that can ...
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  • Immune adjuvant efficacy of... Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells
    Nierkens, Stefan; den Brok, Martijn H; Garcia, Zacharias ... Cancer research, 10/2011, Letnik: 71, Številka: 20
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    The differences in function, location, and migratory pattern of conventional dendritic cells (cDC) and plasmacytoid DCs (pDC) not only point to specialized roles in immune responses but also signify ...
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5.
  • A transplantable TH‐MYCN tr... A transplantable TH‐MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma
    Kroesen, Michiel; Nierkens, Stefan; Ansems, Marleen ... International journal of cancer, 15 March 2014, Letnik: 134, Številka: 6
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    Current multimodal treatments for patients with neuroblastoma (NBL), including anti‐disialoganglioside (GD2) monoclonal antibody (mAb) based immunotherapy, result in a favorable outcome in around ...
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6.
  • Anti-GD2 antibody and Vorin... Anti-GD2 antibody and Vorinostat immunocombination therapy is highly effective in an aggressive orthotopic neuroblastoma model
    van den Bijgaart, Renske J E; Kroesen, Michiel; Brok, Ingrid C ... Oncoimmunology, 01/2020, Letnik: 9, Številka: 1
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    Neuroblastoma is a childhood malignancy and in the majority of patients, the primary tumor arises in one of the adrenal glands. Neuroblastoma cells highly express the disialoganglioside GD2, which is ...
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  • Tumor ablation plus co-admi... Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes
    Raaijmakers, Tonke K; van den Bijgaart, Renske J E; den Brok, Martijn H ... Journal for immunotherapy of cancer, 05/2020, Letnik: 8, Številka: 1
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    BackgroundTumor ablation techniques, like cryoablation, are successfully used in the clinic to treat tumors. The tumor debris remaining in situ after ablation is a major antigen depot, including ...
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9.
  • In vivo MR guided boiling h... In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology
    Hoogenboom, Martijn; Eikelenboom, Dylan; den Brok, Martijn H. ... NMR in biomedicine, 06/2016, Letnik: 29, Številka: 6
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    Boiling histotripsy (BH) is a new high intensity focused ultrasound (HIFU) ablation technique to mechanically fragmentize soft tissue into submicrometer fragments. So far, ultrasound has been used ...
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  • Anti-GD2 mAb and Vorinostat... Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma
    Kroesen, Michiel; Büll, Christian; Gielen, Paul R. ... Oncoimmunology, 06/2016, Letnik: 5, Številka: 6
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    Neuroblastoma (NBL) is a childhood malignancy of the sympathetic nervous system. For high-risk NBL patients, the mortality rate is still over 50%, despite intensive multimodal treatment. Anti-GD2 ...
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zadetkov: 21

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