This paper revisits the macroeconomic effects of the large-scale asset purchase programmes launched by the Federal Reserve and the Bank of England from 2008. Using a Bayesian VAR, we investigate the ...macroeconomic impact of shocks to asset purchase announcements and assess changes in their effectiveness based on sub-sample analysis. The results suggest that the early asset purchase programmes had significant positive macroeconomic effects, while those of the subsequent ones were weaker and in part not significantly different from zero. The reduced effectiveness seems to reflect in part better anticipation of asset purchase programmes over time, since we find significant positive macroeconomic effects when we consider shocks to survey expectations of the Federal Reserve's last asset purchase programme. Finally, in all estimations we find a significant and persistent positive impact of asset purchase shocks on stock prices.
pathogenic variants are the major cause of X-linked retinitis pigmentosa. Here, we report the results from 1,033 clinical DNA tests that included sequencing of
. A total of 184
variants were ...identified: 78 pathogenic or likely pathogenic, 14 uncertain, and 92 likely benign or benign. Among the pathogenic and likely pathogenic variants, 23 were novel, and most were frameshift or nonsense mutations (87%) and enriched (67%) in
exon 15 (ORF15). Identical pathogenic variants found in different families were largely on different haplotype backgrounds, indicating relatively frequent, recurrent
mutations. None of the 16 mother/affected son pairs showed de novo mutations; all 16 mothers were heterozygous for the pathogenic variant. These last two observations support the occurrence of most
mutations in the male germline.
Africa is the source of all modern humans, but characterization of genetic variation and of relationships among populations across the continent has been enigmatic. We studied 121 African ...populations, four African American populations, and 60 non-African populations for patterns of variation at 1327 nuclear microsatellite and insertion/deletion markers. We identified 14 ancestral population clusters in Africa that correlate with self-described ethnicity and shared cultural and/or linguistic properties. We observed high levels of mixed ancestry in most populations, reflecting historical migration events across the continent. Our data also provide evidence for shared ancestry among geographically diverse hunter-gatherer populations (Khoesan speakers and Pygmies). The ancestry of African Americans is predominantly from Niger-Kordofanian (approximately 71%), European (approximately 13%), and other African (approximately 8%) populations, although admixture levels varied considerably among individuals. This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies.
Values theory posits that individuals have values and they are formed by upbringing and life's experiences and influence an individuals' cognitive processes, decisions, and behavior. Emerging onto ...the business scene is a new population group, the Millennials. This research seeks to explore Millennials' values from the viewpoint of their personal value orientation (PVO). Managerial PVO from the 1980s and 2010s are used as comparative populations. The Millennials' PVO is generally consistent with managerial PVO from past research. They tend toward a Personal, rather than Social, and Competence, rather than Moral, value orientation. Yet, some subtle differences emerged. Millennials are more self-focused and less other-focused than managers from the 1980s or 2010s. They emphasize competency skills more than today's managers but less than the managers of the 1980s and place more worth on moral values than managers of the 1980s but less than today's managers.
The genetic structure of Pacific Islanders Friedlaender, Jonathan S; Friedlaender, Françoise R; Reed, Floyd A ...
PLOS genetics,
01/2008, Letnik:
4, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Human genetic diversity in the Pacific has not been adequately sampled, particularly in Melanesia. As a result, population relationships there have been open to debate. A genome scan of autosomal ...markers (687 microsatellites and 203 insertions/deletions) on 952 individuals from 41 Pacific populations now provides the basis for understanding the remarkable nature of Melanesian variation, and for a more accurate comparison of these Pacific populations with previously studied groups from other regions. It also shows how textured human population variation can be in particular circumstances. Genetic diversity within individual Pacific populations is shown to be very low, while differentiation among Melanesian groups is high. Melanesian differentiation varies not only between islands, but also by island size and topographical complexity. The greatest distinctions are among the isolated groups in large island interiors, which are also the most internally homogeneous. The pattern loosely tracks language distinctions. Papuan-speaking groups are the most differentiated, and Austronesian or Oceanic-speaking groups, which tend to live along the coastlines, are more intermixed. A small "Austronesian" genetic signature (always <20%) was detected in less than half the Melanesian groups that speak Austronesian languages, and is entirely lacking in Papuan-speaking groups. Although the Polynesians are also distinctive, they tend to cluster with Micronesians, Taiwan Aborigines, and East Asians, and not Melanesians. These findings contribute to a resolution to the debates over Polynesian origins and their past interactions with Melanesians. With regard to genetics, the earlier studies had heavily relied on the evidence from single locus mitochondrial DNA or Y chromosome variation. Neither of these provided an unequivocal signal of phylogenetic relations or population intermixture proportions in the Pacific. Our analysis indicates the ancestors of Polynesians moved through Melanesia relatively rapidly and only intermixed to a very modest degree with the indigenous populations there.
We present an assessment of the impacts on atmospheric composition and radiative forcing of short‐lived pollutants following a worldwide decrease in anthropogenic activity and emissions comparable to ...what has occurred in response to the COVID‐19 pandemic, using the global composition‐climate model United Kingdom Chemistry and Aerosols Model (UKCA). Emission changes reduce tropospheric hydroxyl radical and ozone burdens, increasing methane lifetime. Reduced SO2 emissions and oxidizing capacity lead to a decrease in sulfate aerosol and increase in aerosol size, with accompanying reductions to cloud droplet concentration. However, large reductions in black carbon emissions increase aerosol albedo. Overall, the changes in ozone and aerosol direct effects (neglecting aerosol‐cloud interactions which were statistically insignificant but whose response warrants future investigation) yield a radiative forcing of −33 to −78 mWm−2. Upon cessation of emission reductions, the short‐lived climate forcers rapidly return to pre‐COVID levels; meaning, these changes are unlikely to have lasting impacts on climate assuming emissions return to pre‐intervention levels.
Plain Language Summary
As a result of the global COVID‐19 pandemic, unprecedented lockdown measures have been imposed worldwide to reduce the spread of the disease, causing huge reductions in economic activity and corresponding reductions in transport, industrial, and aircraft emissions. As well as lowering emissions of greenhouse gases, such as carbon dioxide, this has resulted in a dramatic reduction in the emissions of pollutants that also affect climate. In this study, we have used state‐of‐the‐art computer simulations to quantify how changes in these components are likely to impact the chemical make‐up of the atmosphere and the likely short‐term impacts on climate. Despite large decreases in nitrogen dioxide and atmospheric particles, we find these changes result in a very small impact on the energy balance of the atmosphere but one that would act to cool the planet, without considering the knock‐on impacts on clouds (which we cannot be confident about). However, these effects are all likely to be short‐lived if emissions return to pre‐lockdown levels.
Key Points
Emission reductions are likely to have led to a global reduction in short‐lived climate forcers and tropospheric oxidizing capacity
Reductions in O3 and aerosol from both lower emissions and decreased sulfate oxidation resulted in a net negative radiative forcing
The radiative impacts are small and short‐lived. Longer term climate impacts must come through future sustained emission reductions
Genetic Structure of Human Populations Rosenberg, Noah A.; Pritchard, Jonathan K.; Weber, James L. ...
Science (American Association for the Advancement of Science),
12/2002, Letnik:
298, Številka:
5602
Journal Article
Recenzirano
We studied human population structure using genotypes at 377 autosomal microsatellite loci in 1056 individuals from 52 populations. Within-population differences among individuals account for 93 to ...95% of genetic variation; differences among major groups constitute only 3 to 5%. Nevertheless, without using prior information about the origins of individuals, we identified six main genetic clusters, five of which correspond to major geographic regions, and subclusters that often correspond to individual populations. General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies.
As a ClinGen Expert Panel (EP) we set out to adapt the American College of Medical Genetics and Genomics (ACMG)/Association for Molecular Pathology (AMP) pathogenicity criteria for classification of ...RYR1 variants as related to autosomal dominantly inherited malignant hyperthermia (MH).
We specified ACMG/AMP criteria for variant classification for RYR1 and MH. Proposed rules were piloted on 84 variants. We applied quantitative evidence calibration for several criteria using likelihood ratios based on the Bayesian framework.
Seven ACMG/AMP criteria were adopted without changes, nine were adopted with RYR1-specific modifications, and ten were dropped. The in silico (PP3 and BP4) and hotspot criteria (PM1) were evaluated quantitatively. REVEL gave an odds ratio (OR) of 23:1 for PP3 and 14:1 for BP4 using trichotomized cutoffs of ≥0.85 (pathogenic) and ≤0.5 (benign). The PM1 hotspot criterion had an OR of 24:1. PP3 and PM1 were implemented at moderate strength. Applying the revised ACMG/AMP criteria to 44 recognized MH variants, 29 were classified as pathogenic, 13 as likely pathogenic, and 2 as variants of uncertain significance.
Curation of these variants will facilitate classification of RYR1/MH genomic testing results, which is especially important for secondary findings analyses. Our approach to quantitatively calibrating criteria is generalizable to other variant curation expert panels.
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