In recent years, increasing studies have been reported on characterization and detection of microplastics (MPs), and their interactions with organic pollutants (OPs) and heavy metals (HMs) in soils. ...However, a comprehensive review on the characteristics and factors that influence MPs distribution in soils, the sorption characteristics and mechanisms of soil contaminants by MPs, especially the interactions of MPs and their complexes with pollutants in the soil-plant systems remains rarely available at present. This review focuses on the sorption features and mechanisms of pollutants by MPs in soil and discussed the effects of MPs and their complexing with pollutants on soil properties, microbe and plants. The polarity of MPs significantly influenced the sorption of OPs, and different sorption mechanisms are involved for the hydrophobic and hydrophilic OPs. The sorption of OPs on MPs in soils is different from that in water. Aging of MPs can promote the sorption and migration of contaminants. The enhanced effects of biofilm in microplastisphere on the sorption of pollutants by MPs are critical, and interactions of soil environment-MPs-microbe-HMs-antibiotics increase the potential pathogens and larger release of resistance genes. The coexistence of HMs and MPs affected the growth of plants and the uptake of HMs and MPs by the plants. Moreover, the type, dose, shape and particle size of MPs have important influences on their interactions with pollutants and subsequent effects on soil properties, microbial activities and plant growth. This review also pointed out some knowledge gaps and constructive countermeasures to promote future research in this field.
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•Aging of microplastics (MPs) promote sorption and migration of soil pollutants.•Soil organism, tillage, organic matter, texture affect MPs' vertical distribution.•Polarity of MPs significantly influences their sorption of organic pollutants.•MPs can be carrier of soil heavy metals (HMs) and alter the bioavailability of HMs.•Type, dose, shape and size of MPs influence their effects on soil-plant system.
To explore and utilize abundant soil microbes and their beneficial functions, the bacterial and fungal compositions in rhizospheres between red- and yellow-fruited tomato varieties were analyzed ...using high-throughput sequencing technique. Our results indicated that different soil microbes in rhizospheres of tomatoes were exactly recruited by different color fruit tomatoes. For the reasons as not only soil bacterial community, but also soil fungal compositions were all different between red and yellow fruit tomatoes. For example, Nocardioides, norank_f_norank_o_Vicinamibacterales, norank_f_norank_o_norank_c_KD4-96, norank_f_Birii41, norank_f_norank_o_S085 and Bradyrhizobium were the specific dominant soil bacterial genera, and Lecythophora, Derxomyces and unclassified_f_Pyronemataceae were the dominant soil fungal genera in the rhizospheres of red tomato varieties. By contrast, unclassified_f__Micromonsporaceae, Acidipila, Roseisolibacter, Gaiella and norank_f_Xanthobacteraceae were the unique dominant soil bacterial genera in the rhizospheres of yellow tomato varieties. And unclassified_o__Onygenales, Trichocladium, unclassified_c__Sordariomycetes, Pseudogymnoascus, Acremonium, Oidiodendron, Phialemonium, Penicillium, Phialosimplex were the unique dominant soil fungal genera in rhizospheres of yellow tomato varieties. Moreover, a higher abundance of specific soil bacterial and fungal genera in the rhizosphere was found in rhizospheres of the yellow than those of the red tomato varieties. Soil bacterial and fungal compositions in rhizospheres between red- and yellow-fruited tomato varieties were found significantly different which growing in the same environment under the identical managements. It suggested that different soil microbes in rhizospheres exactly were recruited by different phenotypes tomato varieties related to fruit color formation.
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•A Janus membrane modified with few materials to resist membrane wetting for 48 h.•Modification of the membrane by combining UiO-66-NH2 with GO.•The anti-wetting mechanism of ...UiO-66-NH2/GO composite membrane was elaborated.
Membrane distillation (MD) is considered an emerging desalination technology. However, the presence of surfactants allows liquid to penetrate the membrane, resulting in membrane wetting, which hinders the commercialization of MD. In this study, we use very few modified materials to prepare novel Janus thin membranes that immobilize modified materials (graphene oxide (GO) and UiO-66-NH2) on polytetrafluoroethylene (PTFE) hydrophobic base membranes via crosslinkers. The composite thin membrane properties with eight different ratios and contents of GO and UiO-66-NH2 were fabricated and tested by a feed solution of sodium chloride containing a high concentration of sodium dodecyl sulfate. An optimal ratio of Janus membrane with high flux without affecting the effluent water quality was obtained. The Janus membrane exhibited excellent anti-wetting properties compared to the original PTFE membrane. A desalination rate of up to 99.9% was still available even under 48 h of long-term operating conditions by maintaining a flux of approximately 21.2 L/(m2·h). The anti-wetting mechanism of this membrane was further confirmed by the modified XDLVO model. It suggested that the novel Janus membrane could be a highly promising substitute to the MD process for the resource-based treatment of surfactant-containing wastewater, which played an important role in promoting its application.
AimStroke is the leading cause of disability and death in China. Ischaemic stroke accounts for about 60%–80% of all strokes. It is of considerable significance to carry out multidimensional ...management of ischaemic cerebrovascular diseases. This evidence-based guideline aims to provide the latest detailed and comprehensive recommendations on the diagnosis, treatment and secondary prevention of ischaemic cerebrovascular diseases.MethodsWe had performed comprehensive searches of MEDLINE (via PubMed) (before 30 June 2019), and integrated the relevant information into charts and distributed to the writing group. Writing group members discussed and determined the recommendations through teleconference. We used the level of evidence grading algorithm of Chinese Stroke Association to grade each recommendation. The draft was reviewed by the Guideline Writing Committee of Chinese Stroke Association Stroke and finalised. This guideline is fully updated every 3 years.ResultsThis evidence-based guideline is based on the treatment, care and prevention of ischaemic cerebrovascular diseases, which emphasises on pathogenesis evaluation, intravenous thrombolysis, endovascular therapy, antiplatelet therapy, prevention and treatment of complications, and risk factor management.ConclusionsThis updated guideline presents a framework for the management of ischaemic cerebrovascular diseases. Timely first-aid measures, professional care in the acute stage, and proactive secondary prevention will be helpful to patients.
The blood-brain barrier (BBB), as a crucial gate of brain-blood molecular exchange, is involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused by an imbalance ...between the production of reactive oxygen species (ROS) and the scavenger system. Since oxidative stress plays a significant role in the production and maintenance of the BBB, the cerebrovascular system is especially vulnerable to it. The pathways that initiate BBB dysfunction include, but are not limited to, mitochondrial dysfunction, excitotoxicity, iron metabolism, cytokines, pyroptosis, and necroptosis, all converging on the generation of ROS. Interestingly, ROS also provide common triggers that directly regulate BBB damage, parameters including tight junction (TJ) modifications, transporters, matrix metalloproteinase (MMP) activation, inflammatory responses, and autophagy. We will discuss the role of oxidative stress-mediated BBB disruption in neurological diseases, such as hemorrhagic stroke, ischemic stroke (IS), Alzheimer’s disease (AD), Parkinson’s disease (PD), traumatic brain injury (TBI), amyotrophic lateral sclerosis (ALS), and cerebral small vessel disease (CSVD). This review will also discuss the latest clinical evidence of potential biomarkers and antioxidant drugs towards oxidative stress in neurological diseases. A deeper understanding of how oxidative stress damages BBB may open up more therapeutic options for the treatment of neurological diseases.
Surface air temperature is an important factor for the permafrost thermal state in the Northern Hemisphere. It is therefore necessary to understand the variations and regional differences in air ...temperature to determine the interactions between permafrost degradation and climate change. In this study, we used observational data from the National Centers for Environmental Information, the China Meteorological Administration, and the World Data Centre for Meteorology to quantitatively analyze the variations and regional differences in air temperature from 1980 to 2018. The results demonstrated that the annual mean air temperatures were low in continuous permafrost regions and high in sporadic and isolated permafrost regions, with a significant warming rate of 0.371 ± 0.086 °C/decade. Air temperatures warmed the slowest during the winter and fastest during the spring, and no “warming hiatus” was observed in the permafrost regions of the Northern Hemisphere. The spatial patterns of freezing degree-days (FDDs) and thawing degree-days (TDDs) had different spatial characteristics. The decreasing rate of FDDs was −6.97 °C·days/year, while the increasing rate of TDDs was 6.4 °C·days/year. The air temperatures and warming trends had largely regional differences with respect to high latitude, transitional, and high altitude permafrost regions. Air temperature and its warming trend was the highest in high altitude regions. In addition, air temperature warming trends gradually decreased from the continuous permafrost zone to the island permafrost zone. The FDDs had a significant decreasing trend from the continuous permafrost zone to the island permafrost zone, whereas TDDs exhibited the opposite trend. The results indicate that the air temperature warming rate in the permafrost regions was approximately 2.0 times that of the global warming rate, and 1.3 times the global land warming rate from 1980 to 2018. These findings offer a perspective on the differences in permafrost and its thermal state across different regions under climate change.
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•Air temperatures showed significant warming trend in different permafrost regions.•FDD and TDD have different variation trends in different permafrost regions.•Examined difference in air temperature in different permafrost regions and types•Discussed the possible reasons for these differences
•Literature where observed NO2 or UHI are reported together with population size is thin.•We estimate the effect of city size on NO2 concentration and heat island from literature data.•A 1 million ...inhabitants city is estimated to have a temperature gap with its surrounding of around 8 °C and a NO2 concentration of 36 μg/m3.•Each 10-fold increase in city size is estimated to lead to around 40 % increase in both hazards.•More evidence is needed across a wider set of small to large cities and comparable city definitions.
Urban heat island (UHI) and nitrogen dioxide (NO2) concentration in the air are two significant health hazards arising from urbanization. While much research has focused on the local urban context and micro-conditions for sources and exposures in particular case-studies, the effect of the overall level of urban agglomeration, as measured by population size, remains underreported. We compile the literature that explicitly discusses the relationship between UHI or NO2 and population size. We synthesize methods and findings qualitatively, then perform a quantified meta-analysis using comparable data from the corpus. We find that the corpus from which population size effects can be retrieved is very thin given the level of urbanization trends and the health impact. Despite a variety of functional specifications, data gathering processes, and metrics, the literature generally agrees on a significant effect of population size on both UHI and NO2. After pooling data we estimate that each 10-fold increase in population, increases the temperature gap between the city and countryside by almost 2 °C or a 40 % increase when cities get very large. We find that NO2 scales similarly, with a 40 % increase in concentration each time the city population is multiplied by 10. These numbers represent very important health threat given the current urbanization rate and the distribution of city population sizes. We also call for more studies to be conducted, across larger sets of cities, using observed data at higher resolution and comparable city definitions.
Intracerebral hemorrhage (ICH) is a severe, life-threatening subtype of stoke that constitutes a crucial health and socioeconomic problem worldwide. However, the current clinical treatment can only ...reduce the mortality of patients to a certain extent, but cannot ameliorate neurological dysfunction and has a high recurrence rate. Increasing evidence has demonstrated that mitochondrial dysfunction occurs in the early stages of brain injury and participates in all stages of secondary brain injury (SBI) after ICH. As the energy source of cells, various pathobiological processes that lead to SBI closely interact with the mitochondria, such as oxidative stress, calcium overload, and neuronal injury. In this review, we discussed the structure and function of mitochondria and the abnormal morphological changes after ICH. In addition, we discussed recent research on the involvement of mitochondrial dynamics in the pathological process of SBI after ICH and introduced the pathological variations and related molecular mechanisms of mitochondrial dysfunction in the occurrence of brain injury. Finally, we summarized the latest progress in mitochondrion-targeted agents for ICH, which provides a direction for the development of emerging therapeutic strategies targeting the mitochondria after ICH.
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•Mitochondria play a vital role in brain injury after intracerebral hemorrhage(ICH).•The regulation of mitochondrial dynamics affects mitochondrial function.•Mitochondrial dysfunction leads to multiple pathological mechanisms.•Targeted mitochondria therapy will be an emerging therapeutic strategy for ICH.
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