Willow branch-shaped MoS2/CdS heterojunctions are successfully synthesized for the first time by a facile one-pot hydrothermal method. The as-prepared samples were characterized by X-ray diffraction, ...X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, nitrogen adsorption-desorption measurements, diffuse reflectance spectroscopy, and photoelectrochemical and photoluminescence spectroscopy tests. The photocatalytic hydrogen evolution activities of the samples were evaluated under visible light irradiation. The resulting MoS2/CdS heterojunctions exhibit a much improved photocatalytic hydrogen evolution activity than that obtained with CdS and MoS2. In particular, the optimized MC-5 (5 at.% MoS2/CdS) photocatalyst achieved the highest hydrogen production rate of 250.8 μmol h-1, which is 28 times higher than that of pristine CdS. The apparent quantum efficiency (AQE) at 420 nm was 3.66%. Further detailed characterizations revealed that the enhanced photocatalytic activity of the MoS2/CdS heterojunctions could be attributed to the efficient transfer and separation of photogenerated charge carriers resulting from the core-shell structure and the close contact between MoS2 nanosheets and CdS single-crystal nanorods, as well as to increased visible light absorption. A tentative mechanism for photocatalytic H2 evolution by MoS2/CdS heterojunctions was proposed. This work will open up new opportunities for developing more efficient photocatalysts for water splitting.
Novel willow branch-shaped MoS2/CdS heterojunctions synthesized via a one-pot hydrothermal method show excellent photocatalytic H2 evolution activity.
In diabetes mellitus, the excessive rate of glucose production from the liver is considered a primary contributor for the development of hyperglycemia, in particular, fasting hyperglycemia. In this ...study, we investigated whether kaempferol, a flavonol present in several medicinal herbs and foods, can be used to ameliorate diabetes in an animal model of insulin deficiency and further explored the mechanism underlying the anti-diabetic effect of this flavonol. We demonstrate that oral administration of kaempferol (50 mg/kg/day) to streptozotocin-induced diabetic mice significantly improved hyperglycemia and reduced the incidence of overt diabetes from 100% to 77.8%. This outcome was accompanied by a reduction in hepatic glucose production and an increase in glucose oxidation in the muscle of the diabetic mice, whereas body weight, calorie intake, body composition, and plasma insulin and glucagon levels were not altered. Consistently, treatment with kaempferol restored hexokinase activity in the liver and skeletal muscle of diabetic mice while suppressed hepatic pyruvate carboxylase activity and gluconeogenesis. These results suggest that kaempferol may exert antidiabetic action via promoting glucose metabolism in skeletal muscle and inhibiting gluconeogenesis in the liver.
Promoting wind power is a long-term strategy of China to respond to both energy shortage and environmental pollution. Stimulated by various incentive policies, wind power generation in China has ...achieved tremendous growth. However, the China's wind power industry is still in its early development stage and various problems have emerged, seriously challenging the healthy functioning of the industry. Based on micro-data on wind power listed companies, the four-stage Data Envelopment Analysis (DEA) model is used to measure the technical efficiency of China's wind power enterprises and sketch the development of the wind power industry at the micro level. The results show that there exist non-efficiency problems arising from the diseconomies of scale in China's wind power industry during 2011–2015. The average value of the efficiency of wind power enterprises is 32.5%. According to the subsample analysis, large-scale enterprises, private-owned enterprises and enterprises taking wind farm conduction and operation as their main business, as well as enterprises located in the three northern area, have the highest efficiency in their respective categories. Drawn on this analysis, conclusions and policy implications are provided at the end of the paper.
•Reviewed literature on the efficiency of China's wind power industry systematically.•Used the four-stage DEA method to analyze micro-data on wind power listed companies with the goal of delineating the efficiency of the development of China's wind power industry.•Analyzed wind power enterprises from the following four aspects: the scale of enterprises, their regions, nature, and the upstream and downstream of their industrial chain.•Made policy recommendations for the development of China's wind power industry.
Eccrine porocarcinoma (EPC) is a rare skin adnexal malignancy with a high potential for metastases. The most common metastatic sites are the lymph nodes and lungs. CCutaneous metastasis is extremely ...rare, particularly the zosteriform variant, with fewer than 5 cases reported in the literature. Here, we report a unique case of EPC in a 71-year-old male, clinically presenting with multiple clusters of ulcerated nodules distributing as a zosteriform pattern throughout his upper left limb, along with draining lymphatic metastases and lymphedema.
Whale optimization algorithm (WOA) is a swarm intelligence optimization algorithm inspired by humpback whale hunting behavior. WOA has many similarities with other swarm intelligence algorithms (PSO, ...GWO, etc.). WOA’s unique search mechanism enables it to have a strong global search capability while taking into account the strong global search capabilities. In this work, considering the the deficiency of WOA in local search mechanism, combined with the optimization methods of other group intelligent algorithms, perceptual perturbation mechanism is introduced, which makes the agent perform more detailed searches near the local extreme point. At the same time, since the WOA uses a logarithmic spiral curve, the agent cannot fully search all the spaces within its search range, even though the introduction of the perturbation mechanism may still lead to the algorithm falling into a local optimum. Therefore, the equal pitch Archimedes spiral curve is chosen to replace the classic logarithmic spiral curve. In order to fully verify the effect of the search path on the performance of the algorithm, several other spiral curves have been chosen for experimental comparison. By utilizing the 23 benchmark test functions, the simulation results show that WOA (PDWOA) with perceptual perturbation significantly outperforms the standard WOA. Then, based on the PDWOA, the effect of the search path on the performance of the algorithm has been verified. The simulation results show that the equal pitch of the Archimedean spiral curve is best.
Cyclodextrin (CD)‐based polyrotaxanes (PR) are widely used to construct high‐mechanical‐performance materials because of the high degree of conformational freedom. However, strong hydrogen bonds ...between CDs greatly limit the application of CD‐PR in the preparation of ductile neutral hydrogels. In this work, spiropyrane (SP) into α‐CD‐based PR is introduced to “visualize” the segment motion of the network in neutral water. The aggregation‐induced cohesion and critical factors for the force transmission are disclosed. This system offers a new approach for the fundamental research for the complicated topologically cross‐linked structures, which is important for the design of CD‐PR‐based biocompatible soft materials.
A chromic mechanophore is incorporated into cyclodextrin‐based polyrotaxane (CD‐PR) gels to “visualize” the microstructure evolution of CD‐PR in water. The solvent‐induced cohesion and the mechanism of force conduction are revealed. This work lays a fundamental basis for the design of highly ductile CD‐PR hydrogels, which can broaden the application of mechanically interlocked polymers in biocompatible soft materials.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), which has become a public health emergency of international concern
. ...Angiotensin-converting enzyme 2 (ACE2) is the cell-entry receptor for severe acute respiratory syndrome coronavirus (SARS-CoV)
. Here we infected transgenic mice that express human ACE2 (hereafter, hACE2 mice) with SARS-CoV-2 and studied the pathogenicity of the virus. We observed weight loss as well as virus replication in the lungs of hACE2 mice infected with SARS-CoV-2. The typical histopathology was interstitial pneumonia with infiltration of considerable numbers of macrophages and lymphocytes into the alveolar interstitium, and the accumulation of macrophages in alveolar cavities. We observed viral antigens in bronchial epithelial cells, macrophages and alveolar epithelia. These phenomena were not found in wild-type mice infected with SARS-CoV-2. Notably, we have confirmed the pathogenicity of SARS-CoV-2 in hACE2 mice. This mouse model of SARS-CoV-2 infection will be valuable for evaluating antiviral therapeutic agents and vaccines, as well as understanding the pathogenesis of COVID-19.
Smart agricultural greenhouses provide well-controlled conditions for crop cultivation but require accurate prediction of environmental factors to ensure ideal crop growth and management efficiency. ...Due to the limitations of existing predictors in dealing with massive, nonlinear, and dynamic temporal data, this study proposes a bidirectional self-attentive encoder–decoder framework (BEDA) to construct the long-time predictor for multiple environmental factors with high nonlinearity and noise in a smart greenhouse. Firstly, the original data are denoised by wavelet threshold filter and pretreatment operations. Secondly, the bidirectional long short-term-memory is selected as the fundamental unit to extract time-serial features. Then, the multi-head self-attention mechanism is incorporated into the encoder–decoder framework to improve the prediction performance. Experimental investigations are conducted in a practical greenhouse to accurately predict indoor environmental factors (temperature, humidity, and CO2) from noisy IoT-based sensors. The best model for all datasets was the proposed BEDA method, with the root mean square error of three factors’ prediction reduced to 2.726, 3.621, and 49.817, and with an R of 0.749 for temperature, 0.848 for humidity, and 0.8711 for CO2 concentration, respectively. The experimental results show that the favorable prediction accuracy, robustness, and generalization of the proposed method make it suitable to more precisely manage greenhouses.
This study offers meta-analytic data on the potential association between epilepsy and depression especially for the prevalence of depression in epilepsy or vice versa.
The relevant studies were ...searched and identified from nine electronic databases. Studies that mentioned the prevalence and/or incidence of epilepsy and depression were included. Hand searches were also included. The search language was English and the search time was through May 2022. Where feasible, random-effects models were used to generate pooled estimates.
After screening electronic databases and other resources, 48 studies from 6,234 citations were included in this meta-analysis. The period prevalence of epilepsy ranged from 1% to 6% in patients with depression. In population-based settings, the pooled period prevalence of depression in patients with epilepsy was 27% (95% CI, 23-31) and 34% in clinical settings (95% CI, 30-39). Twenty studies reported that seizure frequency, low income, unemployment of the patients, perception of stigma, anxiety, being female, unmarried status, disease course, worse quality of life, higher disability scores, and focal-impaired awareness seizures were risk factors for depression.
Our study found that epilepsy was associated with an increased risk of depression. Depression was associated with the severity of epilepsy.
To compare radiofrequency ablation (RFA) with or without transcatheter arterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma (HCC).
A randomized controlled trial was ...conducted on 189 patients with HCC less than 7 cm at a single tertiary referral center between October 2006 and June 2009. Patients were randomly asssigned to receive TACE combined with RFA (TACE-RFA; n = 94) or RFA alone (n = 95). The primary end point was overall survival. The secondary end point was recurrence-free survival, and the tertiary end point was adverse effects.
At a follow-up of 7 to 62 months, 34 patients in the TACE-RFA group and 48 patients in the RFA group had died. Thirty-three patients and 52 patients had developed recurrence in the TACE-RFA group and RFA group, respectively. The 1-, 3-, and 4-year overall survivals for the TACE-RFA group and the RFA group were 92.6%, 66.6%, and 61.8% and 85.3%, 59%, and 45.0%, respectively. The corresponding recurrence-free survivals were 79.4%, 60.6%, and 54.8% and 66.7%, 44.2%, and 38.9%, respectively. Patients in the TACE-RFA group had better overall survival and recurrence-free survival than patients in the RFA group (hazard ratio, 0.525; 95% CI, 0.335 to 0.822; P = .002; hazard ratio, 0.575; 95% CI, 0.374 to 0.897; P = .009, respectively). There were no treatment-related deaths. On logistic regression analyses, treatment allocation, tumor size, and tumor number were significant prognostic factors for overall survival, whereas treatment allocation and tumor number were significant prognostic factors for recurrence-free survival.
TACE-RFA was superior to RFA alone in improving survival for patients with HCC less than 7 cm.
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