BACKGROUND
Sphenoid mucoceles (SMCs) are unusual lesions, with about 130 cases reported in the literature. Although benign, they may involve the orbit and cause acute restrictive ophthalmoplegia, ...proptosis, and reduced visual acuity.
METHODS AND RESULTS
We present three cases (1 male, 2 females, aged 35, 36, and 46 years) of orbital involvement with acute decreased visual acuity by SMC. The lesions were promptly excised via a transnasal approach to decompress the optic nerve. After the decompression, the patients recovered completely.
CONCLUSION
We believe that immediate surgical drainage of the SMC and prolonged antibiotic therapy are necessary and resulted in recovery of visual acuity. Prompt microsurgical transsphenoidal decompression is simple, effective, safe, and is necessary for avoiding persistent visual loss. Antibiotic therapy alone usually results in a poor outcome. We discuss the etiology, clinical manifestations, and management of this rare condition in the light of 130 other cases in the literature.
To investigate the effect of splenectomy on lymphocyte subpopulations we monitored changes in serum concentrations of soluble suppressor/cytotoxic (sCD8) and soluble helper/inducer (sCD4) antigen in ...11 splenectomized patients. Indications for splenectomy were hereditary spherocytosis in 2, idiopathic thrombocytopenic purpura in 2, gastric carcinoma in 4, Hodgkin's disease in 2 and pancreatitis in 1 patient. Lymphocyte subpopulations were also analyzed by means of conventional immunophenotyping with monoclonal antibodies to CD4 and CD8. We consistently found an early postoperative drop of sCD8 and sCD4 levels within the first week after splenectomy, paralleling changes in the percentages of CD4+ and CD8+ lymphocytes. While alterations of lymphocyte subsets in the peripheral blood were completely reversible and sCD4 levels returned to preoperative values, sCD8 concentrations remained suppressed even 3 months after splenectomy. SCD8 levels at the nadir and those 3 months after splenectomy were significantly lower than preoperative values (P = 0.003, P = 0.149 respectively). Since sCD8 levels reflect suppressor/cytotoxic cell activity, we suggest that suppressor cell activity is reduced in splenectomized patients.
A NQR Study of γ-alumina Containing Chemisorbed Cl 2 Sharma, Virendra K.; Richarz, Werner; Sharma, Surendra ...
Zeitschrift für Naturforschung. A, A journal of physical sciences,
4/1990, Letnik:
45, Številka:
3-4
Journal Article
Recenzirano
Abstract
Cl
2
was adsorbed at 370 and 870 K on commercially available y-alumina, with BET surface area of 180m
2
/g, after dehydration at 850 K. NQR measurements were carried out between 55 and 6 ...MHz. The sample containing Cl
2
chemisorbed at 870 K showed the presence of a set of quite strong NQR signals with frequencies lower than 10.6 MHz, and another set of very weak NQR signals between 18.5 and 13.0 MHz. The stronger signals have been inferred as due to Al and have been assigned to Al in three distinct environments. The values of e
2
Qq/h and η determined for the signals are (1) 35.9 MHz, 0.53; (2) 35.7 MHz, 0.74; and (3) 35.3 MHz, 0.0 respectively. These values of e
2
Qq/h are found to be very high as compared to those estimated for
27
Al at distorted octahedral and tetrahedral sites of the alumina, viz. 3.5 and 4.0 MHz respectively, from MAS-NMR. Therefore, chemisorption causes
27
Al to exist in the surface region at sites with greater distortion than in the interior of the particles but much smaller than in the case of completely dehydrated samples for which no NQR signals could be observed. The weak signals have been tentatively attributed to
35
Cl. The present results demonstrate that the NQR technique can be used in studies of chemically bound species on heterogenous catalysts.
A NQR Study of γ-alumina Containing Chemisorbed Cl2 Sharma, Virendra K.; Richarz, Werner; Sharma, Surendra ...
Zeitschrift für Naturforschung. A, A Journal of physical sciences,
4/1990, Letnik:
45, Številka:
3
Journal Article, Conference Proceeding
Recenzirano
Odprti dostop
Cl
was adsorbed at 370 and 870 K on commercially available y-alumina, with BET surface area of 180m
/g, after dehydration at 850 K. NQR measurements were carried out between 55 and 6 MHz. The sample ...containing Cl
chemisorbed at 870 K showed the presence of a set of quite strong NQR signals with frequencies lower than 10.6 MHz, and another set of very weak NQR signals between 18.5 and 13.0 MHz. The stronger signals have been inferred as due to Al and have been assigned to Al in three distinct environments. The values of e
Qq/h and η determined for the signals are (1) 35.9 MHz, 0.53; (2) 35.7 MHz, 0.74; and (3) 35.3 MHz, 0.0 respectively. These values of e
Qq/h are found to be very high as compared to those estimated for
Al at distorted octahedral and tetrahedral sites of the alumina, viz. 3.5 and 4.0 MHz respectively, from MAS-NMR. Therefore, chemisorption causes
Al to exist in the surface region at sites with greater distortion than in the interior of the particles but much smaller than in the case of completely dehydrated samples for which no NQR signals could be observed. The weak signals have been tentatively attributed to
Cl. The present results demonstrate that the NQR technique can be used in studies of chemically bound species on heterogenous catalysts.
Non-linear elastic theory was applied to the problem of diastolic filling of the left ventricle, which was treated as a thick-walled sphere. The mathematical model was used to predict pressure-volume ...relationships for ventricles with various initial dimensions and myocardial elasticity constants. A resonable agreement was obtained with data reported in the literature. The results may provide a basis for the use of empirical compliance indices.
Glucocorticoid receptors (GR) have been suggested to have prognostic significance in patients with CLL treated with chemotherapy containing glucocorticoid. In this study, the GR levels in 65 patients ...with advanced CLL and immunocytoma (clinical stages III and IV according to Rai) were determined by means of a whole cell assay. The median GR-level was 1,920 bs/c with a range from 0 to 9591. The patients were subsequently treated according to a prospective, randomized trial with either a combination of chlorambucil and prednisolone, or with prednimustine. No significant difference in receptor levels was found between responders (median = 1940 bs/c; n = 47) and nonresponders (median = 1950 bs/c; n = 14). To assess the influence of receptor content on prognosis we have analyzed the relationship between GR content and survival time and duration of response. There was no significant difference in duration of response and in survival between those patients with high (greater than 1920 bs/c) and those with low GR levels (less than 1920 bs/c) (log-rank test). Our data suggest that determination of GR provides no reliable indicator for clinical response to regimens with glucocorticoid as a component in patients with CLL and immunocytoma.
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