Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic ...burden caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction and biological processes such as cell proliferation, apoptosis and metabolism. According to reports, it regulates neurotoxicity and mediates the survival of neurons through different substrates such as forkhead box protein Os (FoxOs), glycogen synthase kinase-3β (GSK-3β), and caspase-9. Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K/AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs. This article reviews the relationship between AKT signaling pathway and AD and PD, and discusses the potential natural products based on the PI3K/AKT signaling pathway to treat two diseases in recent years, hoping to provide guidance and reference for this field. Further development of Chinese herbal medicine is needed to treat these two diseases.
Virtual reality (VR) is the use of computer technology to create an interactive three-dimensional (3D) world, which gives users a sense of spatial presence. In nursing education, VR has been used to ...help optimize teaching and learning processes.
The purpose of this study was to evaluate the effectiveness of VR in nursing education in the areas of knowledge, skills, satisfaction, confidence, and performance time.
We conducted a meta-analysis of the effectiveness of VR in nursing education based on the Cochrane methodology. An electronic literature search using the Cochrane Library, Web of Science, PubMed, Embase, and CINAHL (Cumulative Index to Nursing and Allied Health Literature), up to December 2019 was conducted to identify studies that reported the effectiveness of VR on knowledge, skills, satisfaction, confidence, and performance time. The study selection and data extraction were carried out by two independent reviewers. The methodological quality of the selected studies was determined using the Cochrane criteria for risk-of-bias assessment.
A total of 12 studies, including 821 participants, were selected for the final analysis. We found that VR was more effective than the control conditions in improving knowledge (standard mean difference SMD=0.58, 95% CI 0.41-0.75, P<.001, I
=47%). However, there was no difference between VR and the control conditions in skills (SMD=0.01, 95% CI -0.24 to 0.26, P=.93, I
=37%), satisfaction (SMD=0.01, 95% CI -0.79 to 0.80, P=.99, I
=86%), confidence (SMD=0.00, 95% CI -0.28 to 0.27, P=.99, I
=0%), and performance time (SMD=-0.55, 95% CI -2.04 to 0.94, P=.47, I
=97%).
The results of this study suggest that VR can effectively improve knowledge in nursing education, but it was not more effective than other education methods in areas of skills, satisfaction, confidence, and performance time. Further rigorous studies with a larger sample size are warranted to confirm these results.
Alzheimerʼs disease (AD), an age‐related neurodegenerative disease, is a striking global health problem. Ferroptosis is a newly discovered form of cell death characterized by iron‐dependent lipid ...peroxidation products and the accumulation of lethal reactive oxygen species. Strict regulation of iron metabolism is essential to ensure neuronal homeostasis. Excess and deficiency of iron are both associated with neurodegeneration. Studies have shown that oxidative stress caused by cerebral iron metabolism disorders in the body is involved in the process of AD, ferroptosis may play an important role in the pathogenesis of AD, and regulating ferroptosis is expected to be a new direction for the treatment of AD. Various organelles are closely related to ferroptosis: mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosome are involved in the regulation of ferroptosis from the aspects of iron metabolism and redox imbalance. In this review, the relationship between AD and the dysfunction of organelles (including mitochondria, endoplasmic reticulum, lysosome, and Golgi apparatus) and the role of organelles in ferroptosis of AD were reviewed to provide insights for understanding the relationship between organelles and ferroptosis in AD and the treatment of AD.
Regulation of ferroptosis is expected to be a new direction for the treatment of Alzheimer's disease. And organelles play a role in different cellular interactions with ferroptosis. Targeting organelle metabolic pathways and redox responses may be an effective strategy for disease treatment.
An overview of the sensing nanomaterials of wearable glucose sensors including carbon, metals, conducting polymers and so on was summarized and highlighted.
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The metabolic disorder of ...glucose in human body will cause diseases such as diabetes and hyperglycemia. Hence the determination of glucose content is very important in clinic diagnosing. In recent years, researchers have proposed various non-invasive wearable sensors for rapid and real-time glucose monitoring from human body fluids. Unlike those reviews which discussed performances, detection environments or substrates of the wearable glucose sensor, this review focuses on the sensing nanomaterials since they are the key elements of most wearable glucose sensors. The sensing nanomaterials such as carbon, metals, and conductive polymers are summarized in detail. And also the structural characteristics of different sensing nanomaterials and the corresponding wearable glucose sensors are highlighted. Finally, we prospect the future development requirements of sensing nanomaterials for wearable glucose sensors. This review would give some insights to the further development of wearable glucose sensors and the modern medical treatment.
Autophagy is a degradative pathway that delivers cellular components to the lysosome for degradation. The role of autophagy in cell differentiation is poorly understood. Here we show that CaMKII can ...directly phosphorylate Beclin 1 at Ser90 to promote K63-linked ubiquitination of Beclin 1 and activation of autophagy. Meanwhile, CaMKII can also promote K63-linked ubiquitination of inhibitor of differentiation 1/2 (Id-1/2) by catalyzing phosphorylation of Id proteins and recruiting TRAF-6. Ubiquitinated Id-1/Id-2 can then bind to p62 and be transported to autolysosomes for degradation. Id degradation promotes the differentiation of neuroblastoma cells and reduces the proportion of stem-like cells. Our study proposes a mechanism by which autophagic degradation of Id proteins can regulate cell differentiation. This suggests that targeting of CaMKII and the regulation of autophagic degradation of Id may be an effective therapeutic strategy to induce cell differentiation in neuroblastoma.
According to physical property tests of lead-containing slag, the volatilisation behaviour of lead slag will have adverse impacts on test accuracy and further affect the control of chemical ...reactions, solidification and removal of inclusions during smelting. To analyse the volatilisation characteristics of lead slag, in this paper, four kinds of lead slags from lead direct reduction smelting with different PbO and ZnO content are taken. thermogravimetry, ISP-TOF were used. Additionally, the changes in volatiles and slag composition and phases were analysed with XRD and ICPS, and the volatilisation reaction mechanism was discussed. The results indicated that the volatilisation of lead slag can lead to a big weight loss of about to the slag with higher PbO content. The weight loss increases with the PbO content in slag increases. The volatile corresponding to the weight loss above 900 °C is mainly PbO and less ZnO. The higher the temperature is, the stronger the volatilisation is. With the increase in temperature and keeping time, most of the PbO can be evaporated and leaves little PbO in the residual slag. This will has great effect to physico-chemical property measurement of the slag with higher PbO content, especially to the property measurement that be kept at high temperature for a long time. Because the volatiles is trend to condense with the temperature decrease, mass spectrometer is limited by the condensation of volatiles, i.e., PbO, ZnO and so on, in the connection pipeline. The device should be modified for this use.
We explore, in the framework of linearized quantum gravity, the quantum gravitational quadrupole-quadrupole interaction between two entangled non point-like objects in the presence of both Dirichlet ...and Neumann boundaries. The results show that, compared to the case without boundaries, the interaction can be either enhanced or weakened depending on the geometrical arrangement of the objects with respect to the boundaries. In the limit when the two-object system is placed very close to the Dirichlet boundary, the near-regime interaction potential is larger than that of the pure vacuum case when the two objects are placed perpendicular to the boundary but smaller when parallel to it, while, in the far regime, such strong and weak relations between potentials are just opposite to that in the near regime. And, there exists a new
r
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2
far-regime behavior of the interaction potential under the perpendicular configuration. For the case of Neumann boundary, the strong and weak relations between the interaction potentials under perpendicular or parallel configurations and the case without boundary are opposite to the Dirichlet circumstance both in the near and far regimes. Besides, the novel
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2
far-regime behavior occurs for the parallel rather than perpendicular configuration in the presence of Neumann boundary.
The development of nanoscience and nanotechnology has inspired scientists to continuously explore new electrode materials for constructing an enhanced electrochemical platform for sensing. In this ...article, we proposed a new Pt nanoparticle (NP) ensemble-on-graphene hybrid nanosheet (PNEGHNs), a new electrode material, which was rapidly prepared through a one-step microwave-assisted heating procedure. The advantages of PNEGHNs modified glassy carbon electrode (GCE) (PNEGHNs/GCE) are illustrated from comparison with the graphenes (GNs) modified GCE for electrocatalytic and sensing applications. The electrocatalytic activities toward several organic and inorganic electroactive compounds at the PNEGHNs/GCE were investigated, all of which show a remarkable increase in electrochemical performance relative to GNs/GCE. Hydrogen peroxide (H2O2) and trinitrotoluene (TNT) were used as two representative analytes to demonstrate the sensing performance of PNEGHNs. It is found that PNEGHNs modified GCE shows a wide linear range and low detection limit for H2O2 and TNT detection. Therefore, PNEGHNs may be an attractive robust and advanced hybrid electrode material with great promise for electrochemical sensors and biosensors design.
Efficient anodic electrocatalysts are of great importance for the water and urea electrolysis to lower the overall potential for hydrogen generation. NiMoO4 is recently considered as a promising ...electrocatalyst towards water and urea oxidation reactions while its catalytic properties are still not comparable to the state-of-the-art catalysts. Herein, decorating CeO2 nanoparticles on NiMoO4 nanosheets is proposed and realized by the facile post-annealing treatment of NiMoO4 with absorbed Ce3+ ions. Due to the strong interaction between CeO2 and NiMoO4, the surface chemical states are modulated with more defects as catalytic sites. By optimizing the ratio of CeO2 to NiMoO4, the obtained catalyst of CeO2 modified NiMoO4 exhibited significantly enhanced activity with lower overpotentials and remarkable durability as compared with NiMoO4 for water and urea oxidation. Therefore, this facile method of post decorating CeO2 nanoparticles promoted the activity of NiMoO4, contributing to the robust anodes for low-cost and stable hydrogen generation.
The aim of the present study was to explore the underlying mechanisms involved in gastric cancer (GC) formation using data‐independent acquisition (DIA) quantitative proteomics analysis. We ...identified the differences in protein expression and related functions involved in biological metabolic processes in GC. Totally, 745 differentially expressed proteins (DEPs) were found in GC tissues vs. gastric normal tissues. Despite enormous complexity in the details of the underlying regulatory network, we find that clusters of proteins from the DEPs were mainly involved in 38 pathways. All of the identified DEPs involved in oxidative phosphorylation were down‐regulated. Moreover, GC possesses significantly altered biological metabolic processes, such as NADH dehydrogenase complex assembly and tricarboxylic acid cycle, which is mostly consistent with that in KEGG analysis. Furthermore the higher expression of UQCRQ, NDUFB7 and UQCRC2 were positively correlated with a better prognosis, implicating these proteins may as novel candidate diagnostic and prognostic biomarkers.
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