Electroredox of organics provides a promising and green approach to producing value‐added chemicals. However, it remains a grand challenge to achieve high selectivity of desired products ...simultaneously at two electrodes, especially for non‐isoelectronic transfer reactions. Here a porous heterostructure of Mo2C@Co‐NC is successfully fabricated, where subnanometre β‐Mo2C clusters (<1 nm, ≈10 wt%) are confined inside porous Co, N‐doped carbon using metalorganic frameworks. It is found that Co species not only promote the formation of β‐Mo2C but also can prevent it from oxidation by constructing the heterojunctions. As noted, the heterostructure achieves >96% yield and 92% Faradaic efficiency (FE) for aldehydes in anodic alcohol oxidation, as well as >99.9% yield and 96% FE for amines in cathodal nitrocompounds reduction in 1.0 M KOH. Precise control of the reaction kinetics of two half‐reactions by the electronic interaction between β‐Mo2C and Co is a crucial adjective. Density functional theory (DFT) gives in‐depth mechanistic insight into the high aldehyde selectivity. The work guides authors to reveal the electrooxidation nature of Mo2C at a subnanometer level. It is anticipated that the strategy will provide new insights into the design of highly effective bifunctional electrocatalysts for the coproduction of more complex fine chemicals.
A porous heterostructure of Mo2C@Co‐NC is successfully fabricated with a high loading of surface Mo2C species templated by MOFs. The porous Co‐NC can effectively prompt the formation of β‐Mo2C to fabricate the heterojunction and keep the adjacent β‐Mo2C from deactivation. The heterostructure achieves high yield and Faradaic efficiency of desired products from two non‐isoelectronic transfer reactions at two electrodes.
A star-shaped 1,3,5-triazine/cyano hybrid molecule CN-T2T was designed and synthesized as a new electron acceptor for efficient exciplex-based OLED emitter by mixing with a suitable electron donor ...(Tris-PCz). The CN-T2T/Tris-PCz exciplex emission shows a high ΦPL of 0.53 and a small ΔE T‑S = −0.59 kcal/mol, affording intrinsically efficient fluorescence and highly efficient exciton up-conversion. The large energy level offsets between Tris-PCz and CN-T2T and the balanced hole and electron mobility of Tris-PCz and CN-T2T, respectively, ensuring sufficient carrier density accumulated in the interface for efficient generation of exciplex excitons. Employing a facile device structure composed as ITO/4% ReO3:Tris-PCz (60 nm)/Tris-PCz (15 nm)/Tris-PCz:CN-T2T(1:1) (25 nm)/CN-T2T (50 nm)/Liq (0.5 nm)/Al (100 nm), in which the electron–hole capture is efficient without additional carrier injection barrier from donor (or acceptor) molecule and carriers mobilities are balanced in the emitting layer, leads to a highly efficient green exciplex OLED with external quantum efficiency (EQE) of 11.9%. The obtained EQE is 18% higher than that of a comparison device using an exciplex exhibiting a comparable ΦPL (0.50), in which TCTA shows similar energy levels but higher hole mobility as compared with Tris-PCz. Our results clearly indicate the significance of mobility balance in governing the efficiency of exciplex-based OLED. Exploiting the Tris-PCz:CN-T2T exciplex as the host, we further demonstrated highly efficient yellow and red fluorescent OLEDs by doping 1 wt % Rubrene and DCJTB as emitter, achieving high EQE of 6.9 and 9.7%, respectively.
Affine motion compensation (AMC) is a promising coding tool in Joint Exploration Model (JEM) developed by the Joint Video Exploration Team. AMC in JEM employs a 4-parameter affine model between the ...current block and its reference block. With this model, the motion vectors (MV) of each sub-block can be derived from the MVs at two control points. In this paper, we present a practical framework to further improve the AMC in JEM. First, we introduce a multi-model AMC approach, which allows the encoder to select either the 4-parameter affine model or the 6-parameter affine model adaptively. Second, we improve the affine inter-mode in two aspects. For the normative part, we present an efficient affine motion coding method, which replaces the affine MV Prediction (MVP) candidates in JEM with more accurate but simpler ones, and employs a second-order MVP. For the non-normative part, we enhance the motion estimation process for AMC, by regulating the optimization algorithm. Finally, we propose to unify the affine merge-mode and the normal merge-mode into a unified merge-mode, which combine affine merge candidates and normal merge candidates in a single merge candidate list. Partial of these methods have been adopted into the next generation video coding standard named Versatile Video Coding. Simulation results show that the proposed methods can achieve 1.67% BD rate savings in average for the random access configurations.
STAT3 in Skeletal Muscle Function and Disorders Guadagnin, Eleonora; Mázala, Davi; Chen, Yi-Wen
International journal of molecular sciences,
08/2018, Letnik:
19, Številka:
8
Journal Article
Recenzirano
Odprti dostop
Signal transducer and activator of transcription 3 (STAT3) signaling plays critical roles in regulating skeletal muscle mass, repair, and diseases. In this review, we discuss the upstream activators ...of STAT3 in skeletal muscles, with a focus on interleukin 6 (IL6) and transforming growth factor beta 1 (TGF-β1). We will also discuss the double-edged effect of STAT3 activation in the muscles, including the role of STAT3 signaling in muscle hypertrophy induced by exercise training or muscle wasting in cachectic diseases and muscular dystrophies. STAT3 is a critical regulator of satellite cell self-renewal after muscle injury. STAT3 knock out affects satellite cell myogenic progression by impairing proliferation and inducing premature differentiation. Recent studies in STAT3 signaling demonstrated its direct role in controlling myogenic capacity of myoblasts and satellite cells, as well as the potential benefit in using STAT3 inhibitors to treat muscle diseases. However, prolonged STAT3 activation in muscles has been shown to be responsible for muscle wasting by activating protein degradation pathways. It is important to balance the extent of STAT3 activation and the duration and location (cell types) of the STAT3 signaling when developing therapeutic interventions. STAT3 signaling in other tissues and organs that can directly or indirectly affects skeletal muscle health are also discussed.
Resource-constrained firms rely on entrepreneurial bricolage to enhance innovative performance. In entrepreneurial bricolage, workers are considered intangible resources with which to construct new ...combinations. This study utilized labor inputs to identify the predictors of entrepreneurial bricolage and analyzed the relationship among the experiential resource-learning experience, human resource endowment, and entrepreneurial bricolage and the mediating role of creative self-efficacy. This study focused on small and medium-sized enterprises (SMEs) that have engaged in bricolage activities and presented products in cultural and creative parks. A questionnaire survey and structural equation modeling were used to verify the research framework. Experiential learning was positively associated with human resource endowment and positively influenced entrepreneurial bricolage. Moreover, creative self-efficacy mediated the relationship between human resource endowment and entrepreneurial bricolage. This study recommends that SMEs that intend to implement the bricolage strategy should invest some resources in experiments to gain experiential knowledge from learning workers and thus enhance their human resource endowment. Through such learning, employee confidence in their ability to create may increase. Managers or business owners should redesign work evaluation methods to support experimentation to promote knowledge accumulation. Organizations should create a creativity-friendly workplace to strengthen employees' belief in their ability to engage in creative work.
Thiacalix4arenes as a family of promising ligands have been widely used to construct polynuclear metal clusters, but scarcely employed in silver nanoclusters. Herein, an anion-templated Ag
...nanocluster (SD/Ag88a) built from p-tert-butylthiacalix4arene (H
TC4A) is reported. Single-crystal X-ray diffraction reveals that C
-symmetric SD/Ag88a resembles a metal-organic super calix comprised of eight TC4A
as walls and 88 silver atoms as base, which can be deconstructed to eight CrO
@Ag
(TC4A)(EtS)
(OAc) secondary building units arranged in an annulus encircling a CrO
in the center. Local and global anion template effects from chromates are individually manifested in SD/Ag88a. The solution stability and hierarchical assembly mechanism of SD/Ag88a are studied by using electrospray mass spectrometry. The Ag
nanocluster represents the highest nuclearity metal cluster capped by TC4A
. This work not only exemplify the specific macrocyclic effects of TC4A
in the construction of silver nanocluster but also realize the shape heredity of TC4A
to overall silver super calix.
ABSTRACT
Geotechnical seismic isolation (GSI) system involves the dynamic interaction between structure and low‐modulus foundation material, such as rubber‐soil mixtures (RSM). Whilst numerical ...studies have been carried out to demonstrate the potential benefits of GSI‐RSM system, experimental research is indispensable for confirming its isolation mechanism and effectiveness in reducing structural demand. In this regard, centrifuge modelling with an earthquake shaker under an acceleration field of 50 g adopted in this study can mimic the actual nonlinear dynamic response characteristics of RSM and subsoil in a coupled soil‐foundation‐structure system. This is the first time the performance of GSI‐RSM system was examined in a geotechnical centrifuge. It was found that an average of 40‐50% reduction of structural demand can be achieved. The increase in both the horizontal and rotation responses of the foundation was also evidenced. The unique augmented rocking mechanism with reversible foundation rotation was highlighted.
Antibiotics have become a critical concern worldwide due to the severe threats to human health and eco-environment. This review summarizes the fate of antibiotics and antibiotics resistance genes ...(ARGs) by biological treatment technologies and combined processes in wastewater treatment plants (WWTPs). Adsorption and biodegradation are the two major removal pathways for antibiotics. Adsorption is the main mechanism of antibiotics removal for Tetracyclines, Fluoroquinolones and Macrolides, while biodegradation is the pathway of antibiotics removal for Sulfonamides and β-Lactams. Additionally, the microbial co-metabolism process contributes to the biodegradation of antibiotics. In WWTPs, the antibiotics removal pathway and ARGs accumulation by different biological treatment technologies were provided. The ease of construction and set-up, simplicity of operation, flexibility in adapting to the fluctuations, capital and operating costs were discussed. Overall, the combined technologies should be further investigated as great application prospects in the treatment of antibiotics and alleviation of ARGs risk in the future.
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•The fate and removal of antibiotics and ARGs with different treatment processes are summarized.•Adsorption and biodegradation are the important removal mechanisms of antibiotics.•MBR, BES and CW as the promising processes showed higher performance of antibiotics removal.•MBR and BES could significantly reduce the accumulation of ARGs.•Combined technologies should be further investigated as good application prospects.
Kcnq1 overlapping transcript 1 (kcnq1ot1), an imprinted antisense lncRNA in the kcnq1 locus, acts as a potential contributor to cardiovascular disease, but its role in atherosclerosis remains ...unknown. The aim of this study was to explore the effects of kcnq1ot1 on atherogenesis and the underlying mechanism. Our results showed that kcnq1ot1 expression was significantly increased in mouse aorta with atherosclerosis and lipid-loaded macrophages. Lentivirus-mediated kcnq1ot1 overexpression markedly increased atherosclerotic plaque area and decreased plasma HDL-C levels and RCT efficiency in apoE
mice fed a Western diet. Upregulation of kcnq1ot1 also reduced the expression of miR-452-3p and ABCA1 but increased HDAC3 levels in mouse aorta and THP-1 macrophages. Accordingly, kcnq1ot1 overexpression inhibited cholesterol efflux and promoted lipid accumulation in THP-1 macrophages. In contrast, kcnq1ot1 knockdown protected against atherosclerosis in apoE
mice and suppressed lipid accumulation in THP-1 macrophages. Mechanistically, kcnq1ot1 enhanced HDAC3 expression by competitively binding to miR-452-3p, thereby inhibiting ABCA1 expression and subsequent cholesterol efflux. Taken together, these findings suggest that kcnq1ot1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the miR-452-3p/HDAC3/ABCA1 pathway.
The hippocampus is critical for contextual memory and has recently been implicated in various kinds of social memory. Traditionally, studies of hippocampal context coding have manipulated elements of ...the background environment, such as the shape and color of the apparatus. These manipulations produce large shifts in the spatial firing patterns, a phenomenon known as remapping. These findings suggest that the hippocampus encodes and differentiates contexts by generating unique spatial firing patterns for each environment a subject encounters. However, we do not know whether the hippocampus encodes social contexts defined by the presence of particular conspecifics. We examined this by exposing rats to a series of manipulations of the social context, including the presence of familiar male, unfamiliar male and female conspecifics, in order to determine whether remapping is a plausible mechanism for encoding socially-defined contexts. Because the dorsal and ventral regions of the hippocampus are thought to play different roles in spatial and social cognition, we recorded neurons in both regions. Surprisingly, we found little evidence of remapping in response to manipulation of the social context in either the dorsal or ventral hippocampus, although we saw typical remapping in response to changing the background color. This result suggests that remapping is not the primary mechanism for encoding different social contexts. However, we found that a subset of hippocampal neurons fired selectively near the cages that contained the conspecifics, and these responses were most prevalent in the ventral hippocampus. We also found a striking increase in the spatial information content of ventral hippocampal firing patterns. These results indicate that the ventral hippocampus is sensitive to changes in the social context and neurons that respond selectively near the conspecific cages could play an important, if not fully understood role in encoding the conjunction of conspecifics, their location and the environment.
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