We report the first measurement of monoenergetic muon neutrino charged current interactions. MiniBooNE has isolated 236 MeV muon neutrino events originating from charged kaon decay at rest ...(K^{+}→μ^{+}ν_{μ}) at the NuMI beamline absorber. These signal ν_{μ}-carbon events are distinguished from primarily pion decay in flight ν_{μ} and νover ¯_{μ} backgrounds produced at the target station and decay pipe using their arrival time and reconstructed muon energy. The significance of the signal observation is at the 3.9σ level. The muon kinetic energy, neutrino-nucleus energy transfer (ω=E_{ν}-E_{μ}), and total cross section for these events are extracted. This result is the first known-energy, weak-interaction-only probe of the nucleus to yield a measurement of ω using neutrinos, a quantity thus far only accessible through electron scattering.
The pathogenesis of coma in severe Plasmodium falciparum malaria remains poorly understood. Obstruction of the brain microvasculature because of sequestration of parasitized red blood cells (pRBCs) ...represents one mechanism that could contribute to coma in cerebral malaria. Quantitative postmortem microscopy of brain sections from Vietnamese adults dying of malaria confirmed that sequestration in the cerebral microvasculature was significantly higher in patients with cerebral malaria (CM; n = 21) than in patients with non-CM (n = 23). Sequestration of pRBCs and CM was also significantly associated with increased microvascular congestion by infected and uninfected erythrocytes. Clinicopathological correlation showed that sequestration and congestion were significantly associated with deeper levels of premortem coma and shorter time to death. Microvascular congestion and sequestration were highly correlated as microscopic findings but were independent predictors of a clinical diagnosis of CM. Increased microvascular congestion accompanies coma in CM, associated with parasite sequestration in the cerebral microvasculature.
The TIGRFAMs database of protein families Haft, Daniel H.; Selengut, Jeremy D.; White, Owen
Nucleic acids research,
01/2003, Letnik:
31, Številka:
1
Journal Article
Recenzirano
Odprti dostop
TIGRFAMs is a collection of manually curated protein families consisting of hidden Markov models (HMMs), multiple sequence alignments, commentary, Gene Ontology (GO) assignments, literature ...references and pointers to related TIGRFAMs, Pfam and InterPro models. These models are designed to support both automated and manually curated annotation of genomes. TIGRFAMs contains models of full-length proteins and shorter regions at the levels of superfamilies, subfamilies and equivalogs, where equivalogs are sets of homologous proteins conserved with respect to function since their last common ancestor. The scope of each model is set by raising or lowering cutoff scores and choosing members of the seed alignment to group proteins sharing specific function (equivalog) or more general properties. The overall goal is to provide information with maximum utility for the annotation process. TIGRFAMs is thus complementary to Pfam, whose models typically achieve broad coverage across distant homologs but end at the boundaries of conserved structural domains. The database currently contains over 1600 protein families. TIGRFAMs is available for searching or downloading at www.tigr.org/TIGRFAMs.
ABSTRACT
We present the data analysis pipeline, commissioning observations, and initial results from the greenburst fast radio burst (FRB) detection system on the Robert C. Byrd Green Bank Telescope ...(GBT) previously described by Surnis et al., which uses the 21-cm receiver observing commensally with other projects. The pipeline makes use of a state-of-the-art deep learning classifier to winnow down the very large number of false-positive single-pulse candidates that mostly result from radio frequency interference. In our observations, totalling 156.5 d so far, we have detected individual pulses from 20 known radio pulsars that provide an excellent verification of the system performance. We also demonstrate, through blind injection analyses, that our pipeline is complete down to a signal-to-noise threshold of 12. Depending on the observing mode, this translates into peak flux sensitivities in the range 0.14–0.89 Jy. Although no FRBs have been detected to date, we have used our results to update the analysis of Lawrence et al. to constrain the FRB all-sky rate to be $1150^{+200}_{-180}$ per day above a peak flux density of 1 Jy. We also constrain the source count index α = 0.84 ± 0.06, which indicates that the source count distribution is substantially flatter than expected from a Euclidean distribution of standard candles (where α = 1.5). We discuss this result in the context of the FRB redshift and luminosity distributions. Finally, we make predictions for detection rates with greenburst, as well as other ongoing and planned FRB experiments.
The observation of neutrino oscillations is clear evidence for physics beyond the standard model. To make precise measurements of this phenomenon, neutrino oscillation experiments, including ...MiniBooNE, require an accurate description of neutrino charged current quasielastic (CCQE) cross sections to predict signal samples. Using a high-statistics sample of nu_(mu) CCQE events, MiniBooNE finds that a simple Fermi gas model, with appropriate adjustments, accurately characterizes the CCQE events observed in a carbon-based detector. The extracted parameters include an effective axial mass, M_(A)(eff)=1.23+/-0.20 GeV, that describes the four-momentum dependence of the axial-vector form factor of the nucleon, and a Pauli-suppression parameter, kappa=1.019+/-0.011. Such a modified Fermi gas model may also be used by future accelerator-based experiments measuring neutrino oscillations on nuclear targets.
In Spain, Social Educators, similar to both social workers and educators in the United States, help coordinate social change through educational interventions and mobilization of social groups to ...benefit marginalized people and overall societal welfare. They are trained to work with diverse populations, and it is important that they have awareness and training on gender and transgender issues given the extensive discrimination that transgender people endue. Research has begun to identify the important role that knowledge and attitudes of health and educational professionals may play in providing a supportive, healing context to combat the harmful effects of this discrimination and how educational trainings may foster improved knowledge and attitudes in helping professions. This study describes a program to improve knowledge and positive attitudes toward gender and especially transgender people in university students who study Social Education. The researchers measured knowledge and attitudes toward gender and transgender people issues of 64 students before and after receiving a 4-month interactive training. They used the Short Form of the Genderism and Transphobia Scale, a 12-item scale of transphobia and gender ideology variables. The researchers also asked participants about their knowledge of gender and transgender issues before and after training. The methodological experience "Creative Factory" was employed as an interactive training program. The main goal of this methodology is to enable students in a formative context to analyze social realities to generate discussion and innovate ideas to design successful practices. After 4 months of training with a weekly session on gender and transgender learning, students showed improvements in knowledge and attitudes toward both gender and transgender people. Specifically, students demonstrated more knowledge about gender and transgender issues and more positive attitudes toward transgender people. The study demonstrates that training in gender education using the Creative Factory methodology improved knowledge and attitudes in students.
We experimentally investigate the effects of phase noise on the resonant and non-resonant dynamics of the atom-optics kicked rotor. Employing sinusoidal phase modulation at various frequencies, ...resonances are found corresponding to periodic phase shifts, resulting in the effective transformation of quantum anti-resonances into resonances and vice-versa. The stability of the resonance is analysed, with the aid of experiments, ϵ-classical theory and numerical simulations, and is found to be surprisingly robust against phase noise. Finally we look into the effects of phase noise on dynamical localization and discuss the destruction of the localization in terms of decoherence.
Researchers have begun to explore the mental health and social support experiences of rural transgender and gender nonconforming (TGNC) Americans.
This systematic review included 16 qualitative ...studies.
The studies are current and of moderate to high quality. Themes included: (a) exploring identity, (b) coping with bullying and isolation, (c) passing, (d) building relationships, and (e) developing resilience in the face of barriers.
While some rural TGNC adults wrestle with negative coping mechanisms, many have found ways to thrive. Further research is needed to develop more targeted prevention and intervention strategies.
Contentious issues in calf rearing include milk feeding level and single versus group housing. The current study was performed on a high‐producing 170 Holstein cow dairy farm to investigate the ...impact of nutrition and housing on disease incidence. Calves (n=100) were allocated in birth order to one of two commonly used feeding strategies. Group A calves were group housed from birth and fed ad libitum milk replacer (MR) via a computerised machine using a single teat, with weaning commencing at 63 days. Group R calves were initially housed in individual pens receiving 2.5 litres of MR twice daily via a bucket until three weeks of age when they were group housed and fed 3 litres of MR twice daily via a group trough with weaning commencing at 56 days. In total, 80 (80 per cent) calves suffered from at least one incident of disease during the period from birth to 12 weeks. Group A calves had a greater risk of disease than group R calves (diarrhoea: OR 3.86 (95 per cent CI 1.67 to 8.9); pneumonia: OR 5.80 (95 per cent CI 2.33 to 14.44)). There was a 5.1 per cent incidence of failure of passive transfer of Ig assessed via measurement of plasma total protein concentrations at 48 hours of age. It is hypothesised that the increased diarrhoea risk in group A calves was most likely associated with group housing, while the increased pneumonia risk was associated with the use of a single teat allowing increased transmission of pathogens from calf to calf.
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