Viscous crustal flow can exhume once deeply buried rocks in postorogenic metamorphic core complexes (MCCs). While migmatite domes record the flow dynamics of anatectic crust, the mechanics and ...kinematics of solid‐state flow in the deep crust are poorly constrained. To address this issue, we studied a deeply eroded and particularly well‐exposed MCC in the southern Western Gneiss Region of Norway. The Gulen MCC formed during Devonian transtensional collapse of the Caledonian orogeny in the footwall of the Nordfjord‐Sogn detachment zone. We developed a semiquantitative mapping scheme for ductile strain to constrain micro‐ to megascale processes, which brought eclogite‐bearing crust from the orogenic root into direct contact with Devonian supradetachment basins. The Gulen MCC comprises different structural levels with distinct metamorphic evolutions. In the high‐grade core, amphibolite‐facies structures record fluid‐controlled eclogite retrogression and coaxial flow involving vast extension‐perpendicular shortening. Detachment mylonites formed during ductile‐to‐brittle noncoaxial deformation and wrap around the core. We present a sequential 3‐D reconstruction of MCC formation. In the detachment zone, the combined effects of simple shearing, incision/excision, and erosion thinned the upper crust. Internal necking of the ductile crust was compensated by extension‐perpendicular shortening within the deep crust and resulted in differential folding of distinct crustal levels. We identify this differential folding as the main mechanism that can redistribute material within solid‐state MCCs. Our interpretation suggests a continuum of processes from migmatite‐cored to solid‐state MCCs and has implications for postorogenic exhumation of (ultra‐)high‐pressure rocks.
Plain Language Summary
The Earth's crust has different layers with contrasting mechanics. Rocks in the upper crust tend to break, while higher temperatures at depth make rocks flow, although very slowly. This contrast is important when continents collide forming mountain belts but also when plates drift apart and mountain ranges collapse. In SW Norway, hundreds of million years of erosion have exposed rocks that once were deep below a large mountain range (the Caledonides). Today, glacier‐polished fjords reveal large dome structures that formed when the Caledonides collapsed. Inside such a dome, we find rocks originating from different levels of the crust. Rocks and structures in the core formed at high pressures and temperatures. Wrapped around, we find rocks that deformed while they cooled down, became more resistant to flow, and finally broke apart. Above the dome, we find remnants of the upper crust, which was broken up by faults, eroded, and deposited in sedimentary basins. We reconstruct how mechanical contrasts between crustal layers brought rocks from the root of the mountain belt in contact with sediments deposited at the surface. Understanding this process is important, because it can entirely transform the crust within a—geologically speaking—short period of time.
Key Points
A deeply eroded and particularly well‐exposed transtensional core complex reveals mechanisms of solid‐state viscous flow in the deep crust
Vertical metamorphic variations and lateral strain gradients lead to differential folding of distinct crustal levels
Solid‐state flow mechanisms are similar to anatectic crust and can contribute to postorogenic exhumation of (ultra‐)high‐pressure rocks
Extensional systems evolve through different stages due to changes in the rheological state of the lithosphere. It is crucial to distinguish ductile structures formed before and during rifting, as ...both cases have important but contrasting bearings on the structural evolution. To address this issue, we present the illustrative ductile‐to‐brittle structural history of a metamorphic core complex (MCC) onshore and offshore western Norway. Combining geological field mapping with newly acquired 3‐D seismic reflection data, we correlate two distinct onshore basement units (BU1 and BU2) to corresponding offshore basement seismic facies (SF1 and SF2). Our interpretation reveals two 40 km wide domes (one onshore and one offshore), which both show characteristic kilometer‐scale, westward plunging upright folds. The gneiss domes fill antiformal culminations in the footwall of a >100 km long, shallowly west dipping, extensional detachment. Overlying Caledonian nappes and Devonian supradetachment basins occupy saddles of the hyperbolic detachment surface. Devonian collapse of the Caledonian orogen formed dome and detachment geometries. During North Sea rifting, brittle reactivation of the MCC resulted in complex fault patterns deviating from N‐S strike dominant at the eastern margin of the rift. Around 61°N, only minor N‐S faults (<100 m throw) cut through the core of the MCC. Major rift faults (≤5 km throw), on the other hand, reactivated the detachment and follow the steep flanks of the MCC. This highlights that inherited ductile structures can locally alter the orientation of brittle faults formed during rifting.
Plain Language Summary
The mechanical behavior of the lithosphere largely determines the style of crustal deformation. Therefore, many areas go successively through different modes of extension. In the case of a thick and warm crust, extension can form ductile domes below low‐angle normal faults, so‐called metamorphic core complexes (MCCs). Onshore West Norway, we observe a MCC formed during Devonian collapse of the Caledonian orogen. Offshore, new 3‐D seismic data reveal a second dome underneath rift basins in the northern North Sea. Both domes are connected through a 100 km long extensional high strain zone, which formed during Caledonian collapse. The combination of ductile and brittle processes formed a deformation zone with nonplanar geometry, which consists of a series of domes and saddles. About 140 Myr later, Permian‐Triassic rifting formed large normal faults, which exploited the inherited weakness of the deformation zone. This brittle reactivation resulted in strongly deviating rift fault orientations around 61°N.
Key Points
Field and 3‐D seismic data constrain Devonian metamorphic core complex onshore West Norway and underneath the northern North Sea rift
Onshore‐offshore correlation reveals 100 km long detachment with nonplanar geometry
Brittle reactivation of steep detachment segments strongly deviated Permian‐Triassic rift fault orientations around 61°N
The formation of low-angle detachments involves exhumation of previously ductile material and fault zone weakening. To better understand this relationship, we studied a deeply eroded metamorphic core ...complex, which formed in the core of the Bergen Arcs (W Norway) during Caledonian post-orogenic collapse. Multi-scale structural mapping in the Øygarden Complex constrains three structural levels characterized by localized shear (Upper Unit), distributed deformation (Middle Unit) and a migmatite double-dome (Lower Unit). All levels show retrogressive E-W stretching accompanied by extension-parallel recumbent folding, albeit, with opposing shear senses at upper and middle/lower levels. The systematic comparison of 23 shear zones constrains the ductile-to-brittle structural evolution. Initially, high temperatures and partial melting controlled pervasive deep crustal flow and ductile doming. During retrogressive shearing, lithological heterogeneity controlled strain localization and channelized fluid flow causing retrograde phyllosilicate growth. This established a feedback loop of fluid-flow, fabric weakening and progressive shear localization. The interconnection of inherited and newly formed weak, phyllosilicate-rich layers promoted the formation of bivergent detachments that rapidly exhumed a dome of previously ductile crust. Retrogressive weakening in a kilometer-wide ductile-to-brittle ‘processing zone’ may be essential for the formation of continental detachments.
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•Øygarden Complex (W Norway) represents deeply eroded dome in detachment footwall.•Core complex exhumed during Caledonian post-orogenic collapse (Early Devonian).•Multiscale structural analysis of ductile-to-brittle shear zone evolution.•Retrogressive fabric weakening through fluid-induced phyllosilicate growth.•Interconnection of weak layers promotes detachment formation.
Results regarding the association of thrombus length, stent retriever length, and recanalization success in patients with acute ischemic stroke are inconsistent. We hypothesized that the ratio of ...thrombus length to stent retriever length may be of particular relevance.
Patients with acute ischemic stroke undergoing stent retriever thrombectomy at our institution between January 2010 and December 2018 were reviewed retrospectively. Thrombus length was assessed by measuring the susceptibility vessel sign on SWI using a 1.5T or 3T MR imaging scanner. Multivariable logistic regression models were used to determine the association between thrombus length, stent retriever length, and thrombus length/stent retriever length ratio with first-pass recanalization, overall recanalization, and embolization in new territories. Results are shown as adjusted ORs with 95% CIs. Additional mediation analyses were performed to test for indirect effects on first-pass recanalization and overall recanalization success.
The main analysis included 418 patients (mean age, 74.9 years). Increasing stent retriever length was associated with first-pass recanalization. Decreasing thrombus length and lower thrombus length/stent retriever length ratios were associated with first-pass recanalization and overall recanalization. Thrombus length and stent retriever length showed no association with first-pass recanalization or overall recanalization once thrombus length/stent retriever length ratio was factored in, while thrombus length/stent retriever length ratio remained a significant factor in both models (adjusted OR, 0.316 95% CI, 0.112-0.892;
= .030 and adjusted OR, = 0.366 95% CI, 0.194-0.689;
= .002). Mediation analyses showed that decreasing thrombus length and increasing stent retriever length had a significant indirect effect on first-pass recanalization mediated through thrombus length/stent retriever length ratio. The only parameter associated with embolization in new territories was an increasing thrombus length/stent retriever length ratio (adjusted OR, 5.079 95% CI, 1.332-19.362;
= .017).
Information about thrombus and stent length is more valuable when combined. High thrombus length/stent retriever length ratios, which may raise the risk of unsuccessful recanalization and embolization in new territories, should be avoided by adapting stent retriever selection to thrombus length whenever possible.
BACKGROUND AND PURPOSEThe frequency and clinical significance of the susceptibility vessel sign in patients with acute ischemic stroke remains unclear. We aimed to assess its prevalence in patients ...with acute ischemic stroke undergoing mechanical thrombectomy and to analyze its association with interventional and clinical outcome parameters in that group. MATERIALS AND METHODSSix hundred seventy-six patients with acute ischemic stroke and admission MR imaging were reviewed retrospectively. Of those, 577 met the eligibility criteria for further analysis. Imaging was performed using a 1.5T or 3T MR imaging scanner. Associations between baseline variables, interventional and clinical outcome parameters, and susceptibility vessel sign were determined with multivariable logistic regression models. Results are shown as adjusted ORs with 95% CIs. RESULTSThe susceptibility vessel sign was present in 87.5% (n = 505) of patients and associated with tandem occlusion (adjusted OR, 3.3; 95% CI, 1.1-10.0; P = .032) as well as successful reperfusion, defined as an expanded TICI score of ≥2b (adjusted OR, 2.4; 95% CI, 1.28-4.6; P = .007). The susceptibility vessel sign was independently associated with functional independence (mRS ≤ 2: adjusted OR, 2.1; 95% CI, 1.1-4.0; P = .028) and lower mortality (adjusted OR, 0.4; 95% CI, 0.2-0.7; P = .003) at 90 days, even after adjusting for successful reperfusion. The susceptibility vessel sign did not influence the number of passes performed during mechanical thrombectomy, the first-pass reperfusion, or the risk of peri- or postinterventional complications. CONCLUSIONSThe susceptibility vessel sign is an MR imaging phenomenon frequently observed in patients with acute ischemic stroke and is associated with successful reperfusion after mechanical thrombectomy. However, superior clinical functional outcome and lower mortality noted in patients showing the susceptibility vessel sign could not be entirely attributed to higher reperfusion rates.
The fungus Trichoderma virens is a ubiquitous soil saprophyte that has been applied as a biological control agent to protect plants from fungal pathogens. One mechanism of biocontrol is ...mycoparasitism, and T. virens produces antifungal compounds to assist in killing its fungal targets. Peptide synthetases produce a wide variety of peptide secondary metabolites in bacteria and fungi. Many of these are known to possess antibiotic activities. Peptaibols form a class of antibiotics known for their high α-aminoisobutyric acid content and their synthesis as a mixture of isoforms ranging from 7 to 20 amino acids in length. Here we report preliminary characterization of a 62.8-kb continuous open reading frame encoding a peptaibol synthetase from T. virens. The predicted protein structure consists of 18 peptide synthetase modules with additional modifying domains at the N- and C-termini. T. virens was shown to produce a mixture of peptaibols, with the largest peptides being 18 residues. Mutation of the gene eliminated production of all peptaibol isoforms. Identification of the gene responsible for peptaibol production will facilitate studies of the structure and function of peptaibol antibiotics and their contribution to biocontrol activity.
The development, characterization, and qualification testing of nuclear fuel at Idaho National Laboratory's Advanced Test Reactor (ATR) requires extensive design and analysis activities prior to the ...insertion of an irradiation experiment in-pile. Significant effort is made in the design and development phase of all in-pile experiments to ensure that the maximum feasible impacts of all necessary experimental requirements are satisfied. The advancement of fuel, cladding, and in-reactor materials technology in recent years has introduced complexities associated with the design and construct of in-pile experiments necessitating deeper understanding of boundary conditions and increasingly comprehensive observations resulting from the experiment. Each unique experiment must be assessed for neutronics response, thermal/hydraulic/hydrodynamic performance, and structural integrity. This is accomplished either analytically, computationally, or experimentally, or some combination thereof, prior to insertion into the ATR. The various effects are interrelated to various degrees, such as the case with the experiment temperature affecting the thermal cross section of the fuel or the increased temperature of the experiment's materials reducing the mechanical strength of the assemblies. Additionally, the feedback between the experiment's response to a reactor transient could alter the neutron flux profile of the reactor during the transient. Each experiment must therefore undergo a barrage of analyses to assure the ATR operational safety review committee that the insertion and irradiation of the experiment will not detrimentally affect the safe operational envelope of the reactor. In many cases, the nuclear fuel being tested can be double-encapsulated to ensure safety margins are adequately addressed, whereas failed fuel would be encased in a protective capsule. In other cases, the experiments can be inserted in a self-contained loop that passes through the reactor core, remaining isolated from the primary coolant. In the case of research reactor fuel, however, the fuel plates must be tested in direct contact with the reactor coolant, and being fuel designed for high neutron fluxes, they are inherently power-dense plates. The combination of plate geometry, high-power density, and direct contact with primary coolant creates a scenario where the neutronic/thermomechanic/hydrodynamic characteristics of the fuel plates are tightly coupled, necessitating as complete characterization as possible to support the safety and programmatic assessments, thus enabling a successful experiment. This paper explores the efforts of the U.S. High-Performance Research Reactor program to thermomechanically/hydromechanically characterize the program's wide variety of experiments, which range from stacks of miniplate capsules to full-sized, geometrically representative curved plates. Special attention is given to instances where the combination of experimental characterization and analytical assessment has reduced uncertainties of the safety margins, allowing experiments to be irradiated that would otherwise not have passed the rigorous qualification process for irradiation in the ATR. In some cases, the combined processes have exposed flow and heat transfer characteristics that would have been missed using historical methods, which allows for more accurate and representative postirradiation assessments.
The emergence of drug resistance is a major limitation of current antimalarials. The discovery of new druggable targets and pathways including those that are critical for multiple life cycle stages ...of the malaria parasite is a major goal for developing next-generation antimalarial drugs. Using an integrated chemogenomics approach that combined drug resistance selection, whole-genome sequencing, and an orthogonal yeast model, we demonstrate that the cytoplasmic prolyl-tRNA (transfer RNA) synthetase (PfcPRS) of the malaria parasite Plasmodium falciparum is a biochemical and functional target of febrifugine and its synthetic derivative halofuginone. Febrifugine is the active principle of a traditional Chinese herbal remedy for malaria. We show that treatment with febrifugine derivatives activated the amino acid starvation response in both P. falciparum and a transgenic yeast strain expressing PfcPRS. We further demonstrate in the Plasmodium berghei mouse model of malaria that halofuginol, a new halofuginone analog that we developed, is active against both liver and asexual blood stages of the malaria parasite. Halofuginol, unlike halofuginone and febrifugine, is well tolerated at efficacious doses and represents a promising lead for the development of dual-stage next-generation antimalarials.
“Plain question and plain answer make the shortest road out of most perplexities.” Mark Twain-
Life on the Mississippi
A new methodology for the measurement of the neural substrates of human social ...interaction is described. This technology, termed “Hyperscan,” embodies both the hardware and the software necessary to link magnetic resonance scanners through the internet. Hyperscanning allows for the performance of human behavioral experiments in which participants can interact with each other while functional MRI is acquired in synchrony with the behavioral interactions. Data are presented from a simple game of deception between pairs of subjects. Because people may interact both asymmetrically and asynchronously, both the design and the analysis must accommodate this added complexity. Several potential approaches are described.
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