Abstract Environmental factors influence breast cancer incidence and progression. High body mass index (BMI) is associated with increased risk of post-menopausal breast cancer and with poorer outcome ...in those with a history of breast cancer. High BMI is generally interpreted as excess adiposity (overweight or obesity) and the World Cancer Research Fund judged that the associations between BMI and incidence of breast cancer were due to body fatness. Although BMI is the most common measure used to characterise body composition, it cannot distinguish lean mass from fat mass, or characterise body fat distribution, and so individuals with the same BMI can have different body composition. In particular, the relation between BMI and lean or fat mass may differ between people with or without disease. The question therefore arises as to what aspect or aspects of body composition are causally linked to the poorer outcome of breast cancer patients with high BMI. This question is not addressed in the literature. Most studies have used BMI, without discussion of its shortcomings as a marker of body composition, leading to potentially important misinterpretation. In this article we review the different measurements used to characterise body composition in the literature, and how they relate to breast cancer risk and prognosis. Further research is required to better characterise the relation of body composition to breast cancer.
Quantum-Enhanced Optical-Phase Tracking Yonezawa, Hidehiro; Nakane, Daisuke; Wheatley, Trevor A. ...
Science (American Association for the Advancement of Science),
09/2012, Letnik:
337, Številka:
6101
Journal Article
Recenzirano
Odprti dostop
Tracking a randomly varying optical phase is a key task in metrology, with applications in optical communication. The best precision for optical-phase tracking has until now been limited by the ...quantum vacuum fluctuations of coherent light. Here, we surpass this coherent-state limit by using a continuous-wave beam in a phase-squeezed quantum state. Unlike in previous squeezing-enhanced metrology, restricted to phases with very small variation, the best tracking precision (for a fixed light intensity) is achieved for a finite degree of squeezing because of Heisenberg's uncertainty principle. By optimizing the squeezing, we track the phase with a mean square error 15 ± 4% below the coherent-state limit.
Measurement underpins all quantitative science. A key example is the measurement of optical phase, used in length metrology and many other applications. Advances in precision measurement have ...consistently led to important scientific discoveries. At the fundamental level, measurement precision is limited by the number N of quantum resources (such as photons) that are used. Standard measurement schemes, using each resource independently, lead to a phase uncertainty that scales as 1/square root N-known as the standard quantum limit. However, it has long been conjectured that it should be possible to achieve a precision limited only by the Heisenberg uncertainty principle, dramatically improving the scaling to 1/N (ref. 3). It is commonly thought that achieving this improvement requires the use of exotic quantum entangled states, such as the NOON state. These states are extremely difficult to generate. Measurement schemes with counted photons or ions have been performed with N < or = 6 (refs 6-15), but few have surpassed the standard quantum limit and none have shown Heisenberg-limited scaling. Here we demonstrate experimentally a Heisenberg-limited phase estimation procedure. We replace entangled input states with multiple applications of the phase shift on unentangled single-photon states. We generalize Kitaev's phase estimation algorithm using adaptive measurement theory to achieve a standard deviation scaling at the Heisenberg limit. For the largest number of resources used (N = 378), we estimate an unknown phase with a variance more than 10 dB below the standard quantum limit; achieving this variance would require more than 4,000 resources using standard interferometry. Our results represent a drastic reduction in the complexity of achieving quantum-enhanced measurement precision.
It was recently argued (Wiseman and Gambetta 2012 Phys. Rev. Lett. 108 220402) that the stochastic dynamics (jumps or diffusion) of an open quantum system are not inherent to the system, but rather ...depend on the existence and nature of a distant detector. The proposed experimental tests involved homodyne detection, giving rise to quantum diffusion, and required efficiencies of well over 50%. Here we prove that this requirement ( ) is universal for diffusive-type detection, even if the system is coupled to multiple baths. However, this no-go theorem does not apply to quantum jumps, and we propose a test involving a qubit with jump-type detectors, with a threshold efficiency of only 37%. That is, quantum jumps are 'more quantum', and open the way to practical experimental tests. Our scheme involves a novel sort of adaptive monitoring scheme on a system coupled to two baths.
Using an operational definition we quantify the entanglement, E(P), between two parties who share an arbitrary pure state of N indistinguishable particles. We show that E(P)< or =E(M), where E(M) is ...the bipartite entanglement calculated from the mode-occupation representation. Unlike E(M), E(P) is superadditive. For example, E(P)=0 for any single-particle state, but the state |1>|1>, where both modes are split between the two parties, has E(P)=1/2. We discuss how this relates to quantum correlations between particles, for both fermions and bosons.
Images of the masses: Two‐dimensional molecular imaging of intact rat brain tissue under ambient conditions was achieved by using the mass spectrometric technique of desorption electrospray ...ionization (DESI). The distributions of specific lipids, such as sulfatide 24:1, reveal distinctive subanatomical features of the rat brain (cc=corpus callosum; aca=anterior part of anterior commissure) with spatial resolution of less than 500 μm.
Measurement of health-related quality of life (HRQL) is becoming increasingly valuable within veterinary preventative health care and chronic disease management, as well as in outcomes research. ...Initial reliability and validation of a 22 item shortened version of VetMetrica (VM), structured questionnaire instrument to measure HRQL in dogs via a mobile application was reported previously. Meaningful interpretation and presentation of the 4 domain scores comprising the HRQL profile generated by VM is key to its successful use in clinical practice and research. Study one describes transformation of domain scores from 0-6 to 0-100 and normalisation of these based on the healthy canine population in two age ranges, such that a score of 50 on a 0-100 scale represents the score for the age-related average healthy dog, and establishment of a threshold to assess domain-specific health status for individual dogs. This provides the clinician with a simple method of ascertaining the health status of an individual dog relative to the average healthy population in the same age group (norm-based scoring). Study two determines the minimum important difference (MID) in domain scores which represents the smallest improvement in score that is meaningful to the dog owner, thus providing the clinician with a means of recognising what is likely to be a significant improvement in scores for an individual dog over time. Visual representation of these guidelines for the purpose of interpreting VM profile scores is presented using case studies.
Abstract
As originally introduced, the Einstein, Podolsky and Rosen (EPR) phenomenon was the ability of one party (Alice) to steer, by her choice between two measurement settings, the quantum system ...of another party (Bob) into two distinct ensembles of pure states. As later formalized as a quantum information task, EPR-steering can be shown even when the distinct ensembles comprise mixed states, provided they are pure enough and different enough. Consider the scenario where Alice and Bob each have a qubit and Alice performs dichotomic projective measurements. In this case, the states in the ensembles to which she can steer form the surface of an ellipsoid
in Bob’s Bloch ball. Further, let the steering ellipsoid
have nonzero volume (as it must if the qubits are entangled). It has previously been shown that if Alice’s first measurement setting yields an ensemble comprising two pure states, then this, plus any one other measurement setting, will demonstrate EPR-steering. Here we consider what one can say if the ensemble from Alice’s first setting contains only one pure state
, occurring with probability
p
p
. Using projective geometry, we derive the necessary and sufficient condition analytically for Alice to be able to demonstrate EPR-steering of Bob’s state using this and some second setting, when the two ensembles from these lie in a given plane. Based on this, we show that, for a given
, if
p
p
is high enough
then any distinct second setting by Alice is sufficient to demonstrate EPR-steering. Similarly, we derive a
such that
is necessary for Alice to demonstrate EPR-steering using only the first setting and
some
other setting. Moreover, the expressions we derive are tight; for spherical steering ellipsoids, the bounds coincide:
.
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