Approximately 10% of active galactic nuclei exhibit relativistic jets, which are powered by the accretion of matter onto supermassive black holes. Although the measured width profiles of such jets on ...large scales agree with theories of magnetic collimation, the predicted structure on accretion disk scales at the jet launch point has not been detected. We report radio interferometry observations, at a wavelength of 1.3 millimeters, of the elliptical galaxy M87 that spatially resolve the base of the jet in this source. The derived size of 5.5 ± 0.4 Schwarzschild radii is significantly smaller than the innermost edge of a retrograde accretion disk, suggesting that the M87 jet is powered by an accretion disk in a prograde orbit around a spinning black hole.
Use of heterologous prime-boost COVID-19 vaccine schedules could facilitate mass COVID-19 immunisation. However, we have previously reported that heterologous schedules incorporating an adenoviral ...vectored vaccine (ChAdOx1 nCoV-19, AstraZeneca; hereafter referred to as ChAd) and an mRNA vaccine (BNT162b2, Pfizer–BioNTech; hereafter referred to as BNT) at a 4-week interval are more reactogenic than homologous schedules. Here, we report the safety and immunogenicity of heterologous schedules with the ChAd and BNT vaccines.
Com-COV is a participant-blinded, randomised, non-inferiority trial evaluating vaccine safety, reactogenicity, and immunogenicity. Adults aged 50 years and older with no or well controlled comorbidities and no previous SARS-CoV-2 infection by laboratory confirmation were eligible and were recruited at eight sites across the UK. The majority of eligible participants were enrolled into the general cohort (28-day or 84-day prime-boost intervals), who were randomly assigned (1:1:1:1:1:1:1:1) to receive ChAd/ChAd, ChAd/BNT, BNT/BNT, or BNT/ChAd, administered at either 28-day or 84-day prime-boost intervals. A small subset of eligible participants (n=100) were enrolled into an immunology cohort, who had additional blood tests to evaluate immune responses; these participants were randomly assigned (1:1:1:1) to the four schedules (28-day interval only). Participants were masked to the vaccine received but not to the prime-boost interval. The primary endpoint was the geometric mean ratio (GMR) of serum SARS-CoV-2 anti-spike IgG concentration (measured by ELISA) at 28 days after boost, when comparing ChAd/BNT with ChAd/ChAd, and BNT/ChAd with BNT/BNT. The heterologous schedules were considered non-inferior to the approved homologous schedules if the lower limit of the one-sided 97·5% CI of the GMR of these comparisons was greater than 0·63. The primary analysis was done in the per-protocol population, who were seronegative at baseline. Safety analyses were done among participants receiving at least one dose of a study vaccine. The trial is registered with ISRCTN, 69254139.
Between Feb 11 and Feb 26, 2021, 830 participants were enrolled and randomised, including 463 participants with a 28-day prime-boost interval, for whom results are reported here. The mean age of participants was 57·8 years (SD 4·7), with 212 (46%) female participants and 117 (25%) from ethnic minorities. At day 28 post boost, the geometric mean concentration of SARS-CoV-2 anti-spike IgG in ChAd/BNT recipients (12 906 ELU/mL) was non-inferior to that in ChAd/ChAd recipients (1392 ELU/mL), with a GMR of 9·2 (one-sided 97·5% CI 7·5 to ∞). In participants primed with BNT, we did not show non-inferiority of the heterologous schedule (BNT/ChAd, 7133 ELU/mL) against the homologous schedule (BNT/BNT, 14 080 ELU/mL), with a GMR of 0·51 (one-sided 97·5% CI 0·43 to ∞). Four serious adverse events occurred across all groups, none of which were considered to be related to immunisation.
Despite the BNT/ChAd regimen not meeting non-inferiority criteria, the SARS-CoV-2 anti-spike IgG concentrations of both heterologous schedules were higher than that of a licensed vaccine schedule (ChAd/ChAd) with proven efficacy against COVID-19 disease and hospitalisation. Along with the higher immunogenicity of ChAd/BNT compared with ChAD/ChAd, these data support flexibility in the use of heterologous prime-boost vaccination using ChAd and BNT COVID-19 vaccines.
UK Vaccine Task Force and National Institute for Health Research.
Aims. Our aim is to characterize the polarized continuum emission properties including intensity, polarization position angle, and polarization percentage of Sgr A* at ~100 (3.0 mm), ~230 (1.3 mm), ...~345 (0.87 mm), ~500 (0.6 mm), and ~700 GHz (0.43 mm). Methods. We report continuum emission properties of Sgr A* at the above frequency bands, based on the Atacama Large Millimeter Array (ALMA) observations. We measured flux densities of Sgr A* from ALMA single pointing and mosaic observations. We performed sinusoidal fittings to the observed (XX-YY)/I intensity ratios, to derive the polarization position angles and polarization percentages. Results. We successfully detect polarized continuum emission from all observed frequency bands. We observed lower Stokes I intensity at ~700 GHz than that at ~500 GHz, which suggests that emission at ≳500 GHz is from the optically thin part of a synchrotron emission spectrum. Both the Stokes I intensity and the polarization position angle at our highest observing frequency of ~700 GHz, may vary with time. However, as yet we do not detect variation in the polarization percentage at >500 GHz. The polarization percentage at ~700 GHz is likely lower than that at ~500 GHz. By comparing the ~500 GHz and ~700 GHz observations with the observations at lower frequency bands, we suggest that the intrinsic polarization position angle of Sgr A* varies with time. This paper also reports the measurable polarization properties from the observed calibration quasars. Conclusions. Future simultaneous multi-frequency polarization observations are required to clarify the time and frequency variation of the polarization position angle and polarization percentage.
Near a black hole, differential rotation of a magnetized accretion disk is thought to produce an instability that amplifies weak magnetic fields, driving accretion and outflow. These magnetic fields ...would naturally give rise to the observed synchrotron emission in galaxy cores and to the formation of relativistic jets, but no observations to date have been able to resolve the expected horizon-scale magnetic-field structure. We report interferometric observations at 1.3-millimeter wavelength that spatially resolve the linearly polarized emission from the Galactic Center supermassive black hole, Sagittarius A*. We have found evidence for partially ordered magnetic fields near the event horizon, on scales of ~6 Schwarzschild radii, and we have detected and localized the intrahour variability associated with these fields.
Age differences in emotion recognition from lexical stimuli and facial expressions were examined in a cross-sectional sample of adults aged 18 to 85 (
N
= 357). Emotion-specific response biases ...differed by age: Older adults were disproportionately more likely to incorrectly label lexical stimuli as happiness, sadness, and surprise and to incorrectly label facial stimuli as disgust and fear. After these biases were controlled, findings suggested that older adults were less accurate at identifying emotions than were young adults, but the pattern differed across emotions and task types. The lexical task showed stronger age differences than the facial task, and for lexical stimuli, age groups differed in accuracy for all emotional states except fear. For facial stimuli, in contrast, age groups differed only in accuracy for anger, disgust, fear, and happiness. Implications for age-related changes in different types of emotional processing are discussed.
Background
Hepatocellular carcinoma (HCC) patients undergo liver-directed therapy (LDT) to control tumor burden while awaiting liver transplantation with response impacting waitlist survival. In this ...study, we investigate the link between absolute lymphocyte count (ALC) and PD-1 expression with response to LDT and bridge-to-transplant survival.
Methods
Treatment-naïve HCC patients (
n
= 86) undergoing LDT were enrolled at a single center from August 2016–March 2020. Response to LDT was determined using mRECIST. Blood samples were collected on the day of LDT and at follow-up. Cells were analyzed for phenotype by flow cytometry. Outcomes were liver transplantation or tumor progression.
Results
Incomplete response to initial LDT was associated with tumor progression precluding liver transplantation (OR: 7.6, 1.7 – 33.3,
P
< 0.001). Univariate analysis of baseline
T
cell phenotypes revealed ALC (OR: 0.44, 0.24–0.85,
P
= 0.009) as well as intermediate expression of PD-1 on CD4 (OR: 3.3, 1.03–10.3,
P
= 0.034) and CD8
T
cells (OR: 3.0, 0.99–8.8
P
= 0.043) associated with incomplete response to LDT. Elevations in PD-1 expression were associated with increased risk of bridge-to-transplant tumor progression (HR: 3.2, 1.2–9.4). In patients successfully bridged to liver transplantation, pre-treatment peripheral PD-1 profile was associated with advanced tumor staging (
P
< 0.005) with 2/4 of patients with elevations in PD-1 having T3-T4 TNM staging compared to 0 with low PD-1 expression.
Conclusion
Low lymphocyte count or elevated expression of the PD-1 checkpoint inhibitor is associated with incomplete response to LDT and increased risk of bridge-to-transplant tumor progression. Patients with impaired
T
cell homeostasis may benefit from PD-1 immunotherapy to improve response to LDT and improve bridge-to-transplant outcomes.
The solvothermal reactions of Ti(OEt)4 with LnCl3 (Ln=La, Ce) produced new Ti28Ln cages, in which the Ln3+ ions are coordinated within a metallocrown arrangement, which represents the highest ...nuclearity cages of this type (see figure).
We present the Submillimeter Array 157 pointing mosaic in 0.86 mm dust continuum emission with 5".1 x 4".2 angular resolution, and the National Radio Astronomy Observatory Green Bank 100 m Telescope ...(GBT) observations of the CS/C super(34)S/ super(13)CS 1-0 and SiO 1-0 emission with < or =, slant20" x 18" angular resolution. The dust continuum image marginally resolves at least several tens of 10-10 super(2) M sub(middot in circle) dense clumps in the 5' field including the circumnuclear disk (CND) and the exterior gas streamers. There is very good agreement between the high resolution dust continuum map of the CND and all previous molecular line observations. As the dust emission is the most reliable optically thin tracer of the mass, free from most chemical and excitation effects, we demonstrate the reality of the abundant localized structures within the CND, and their connection to external gas structures. From the spectral line data, the velocity dispersions of the dense clumps and their parent molecular clouds are ~10-20 times higher than their virial velocity dispersions. This supports the idea that the CND and its immediate environment may not be stationary or stable structures. Some of the dense gas clumps are associated with 22 GHz water masers and 36.2 GHz and 44.1 GHz CH sub(3)OH masers. However, we do not find clumps that are bound by the gravity of the enclosed molecular gas. Hence, the CH sub(3)OH or H sub(2)O maser emission may be due to strong (proto)stellar feedback, which may be dispersing some of the gas clumps.
We present conductivity data for a newly synthesised metal-organic framework FeQ, Fe(C
14
H
6
O
4
).H
2
O demonstrating significant electronic transport. The electrical conductivity of the material ...is expected to be through the π-π interaction of the ligand-quinizarin and is measured to be 1.73 × 10
−2
Scm
−1
.
Its potential role as supercapacitor electrodes is discussed.
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