This paper presents a stochastic model for the long-term solution of security-constrained unit commitment (SCUC). The proposed approach could be used by vertically integrated utilities as well as the ...ISOs in electricity markets. In this model, random disturbances, such as outages of generation units and transmission lines as well as load forecasting inaccuracies, are modeled as scenario trees using the Monte Carlo simulation method. For dual optimization, coupling constraints among scenarios are relaxed and the optimization problem is decomposed into deterministic long-term SCUC subproblems. For each deterministic long-term SCUC, resource constraints represent fuel and emission constraints (in the case of vertically integrated utilities) and energy constraints (in the case of electricity markets). Lagrangian relaxation is used to decompose subproblems with long-term SCUC into tractable short-term MIP-based SCUC subproblems without resource constraints. Accordingly, penalty prices (Lagrangian multipliers) are signals to coordinate the master problem and small-scale subproblems. Computational requirements for solving scenario-based optimization models depend on the number of scenarios in which the objective is to minimize the weighted-average generation cost over the entire scenario tree. In large scale applications, the scenario reduction method is introduced for enhancing a tradeoff between calculation speed and accuracy of long-term SCUC solution. Numerical simulations indicate the effectiveness of the proposed approach for solving the stochastic security-constrained unit commitment
This letter provides a tighter piecewise linear approximation of generating units' quadratic cost curves (QCCs) for unit commitment (UC) problems. In order to facilitate the UC optimization process ...with efficient mixed-integer linear programing (MILP) solvers, QCCs are piecewise linearized for converting the original mixed-integer quadratic programming (MIQP) problem into an MILP problem. Traditionally, QCCs are piecewise linearized by evenly dividing the entire real power region into segments. This letter discusses a rigorous segment partition method for obtaining a set of optimal segment points by minimizing the difference between chord and arc lengths, in order to derive a tighter piecewise linear approximation of QCCs and, in turn, a better UC solution as compared to the equipartition method. Numerical test results show the effectiveness of the proposed method on a tighter piecewise linear approximation for better UC solutions.
This paper presents tighter formulations and dynamic global cutting plane solution approaches for accelerating network-constrained unit commitment (NCUC) problems, as the computational bottleneck of ...NCUC problems is always a concern to independent system operators (ISOs)/regional transmission owners (RTOs). Specifically, this paper explores tighter mixed-integer linear programming (MILP)-based NCUC formulations, via locally ideal reformulation for piece-wise linear cost functions of generators and valid cover inequalities by linking system load balance/power flow constraints with generation capacity limits. The paper also discusses an enhanced solution approach by dynamically generating global cutting planes at infeasible/suboptimal nodes of the branch-and-cut (BAC) tree, which would prevent similar infeasible/suboptimal nodes from being explored repeatedly. Since the major computational complexity of NCUC is caused by the large number of binary UC variables, the proposed strategies, being directly related to binary UC variables, could quickly identify infeasible/suboptimal binary solutions, reduce the search space in the BAC tree, and in turn improve the computational performance. Numerical case studies show that the proposed approach could significantly reduce the overall computational time as compared to the traditional NCUC approach.
This study investigates the role of dynamic capabilities in the resource-based view framework, and also explores the relationships among different resources, different dynamic capabilities and firm ...performance. Employing samples of top 1000 Taiwanese companies, the findings show that dynamic capabilities can mediate the firm's valuable, rare, inimitable and non-substitutable (VRIN) resources to improve performance. On the contrary, non-VRIN resources have an insignificant mediating effect. Among three types of dynamic capabilities, dynamic learning capability most effectively mediates the influence of VRIN resources on performance. Furthermore, the important role of VRIN resources is addressed because of their direct effects on performance based on RBV, as well as their indirect effect via the mediation of dynamic capabilities.
Background This study aimed to investigate the incidence and long-term survival outcomes of occult lung cancer between 2004 and 2015. Methods A total of 2958 patients were diagnosed with occult lung ...cancer in the 305,054 patients with lung cancer. The entire cohort was used to calculate the crude incidence rate. Eligible 52,472 patients (T1-xN0M0, including 2353 occult lung cancers) were selected from the entire cohort to perform survival analyses after translating T classification according to the 8th TNM staging system. Cancer-specific survival curves for different T classifications were presented. Results The crude incidence rate of occult lung cancer was 1.00 per 100 patients, and it was reduced between 2004 and 2015 1.4 per 100 persons in 2004; 0.6 per 100 persons in 2015; adjusted risk ratio = 0.437, 95% confidence interval (CI) 0.363-0.527. In the survival analysis, there were 2206 death events in the 2353 occult lung cancers. The results of the multivariable analysis revealed that the prognoses with occult lung cancer were similar to patients with stage T3N0M0 (adjusted hazard ratio = 1.054, 95% CI 0.986-1.127, p = 0.121). Adjusted survival curves presented the same results. In addition, adjusted for other confounders, female, age less than or equai to 72 years, surgical treatment, radiotherapy, adenocarcinoma, and non-squamous and non-adenocarcinoma non-small cell carcinoma were independent protective prognostic factors (all p < 0.05). Conclusions Occult lung cancer was uncommon. However, the cancer-specific survival of occult lung cancer was poor, therefore, we should put the assessment of its prognoses on the agenda. Timely surgical treatment and radiotherapy could improve survival outcomes for those patients. Besides, we still need more research to confirm those findings. Keywords: Occult lung cancer, Incidence, Survival, Surveillance, Epidemiology, And end results database
Recent articles have presented inconsistent findings on the impact of Mediterranean diet in the occurrence of cognitive disorders; therefore, we performed an updated systematic review and ...meta-analysis to evaluate the potential association and dose-response pattern with accumulating evidence. We searched the PubMed and the Embase for the records relevant to this topic. A generic inverse-variance method was used to pool the outcome data for continuous variable, and categories of high vs. low, median vs. low of Mediterranean diet score with a random-effects model. Generalized least-squares trend estimation model was used to estimate the potential dose-response patterns of Mediterranean diet score on incident cognitive disorders. We identified 9 cohort studies involving 34,168 participants. Compared with the lowest category, the pooled analysis showed that the highest Mediterranean diet score was inversely associated with the developing of cognitive disorders, and the pooled RR (95% CI) was 0.79 (0.70, 0.90). Mediterranean diet score of the median category was not significantly associated with cognitive disorders. Dose-response analysis indicated a trend of an approximately linear relationship of the Mediterranean diet score with the incident risk of cognitive disorders. Further studies of randomized controlled trials are warranted to confirm the observed association in different populations.
This paper presents a stochastic coordination of generation and transmission expansion planning model in a competitive electricity market. The Monte Carlo simulation method is applied to consider ...random outages of generating units and transmission lines as well as inaccuracies in the long-term load forecasting. The scenario reduction technique is introduced for reducing the computational burden of a large number of planning scenarios. The proposed model assumes a capacity payment mechanism and a joint energy and transmission market for investors' costs recovery. The proposed approach simulates the decision making behavior of individual market participants and the ISO. It is an iterative process for simulating the interactions among GENCOs, TRANSCOs and ISO. The iterative process might be terminated by the ISO based on a pre-specified stopping criterion. The case studies illustrate the applications of proposed stochastic method in a coordinated generation and transmission planning problem when considering uncertainties.
With increasing wind penetration, it is likely that wind power plant will be expected to provide frequency response in support of the power system, in particular some form of inertial response. In ...these circumstances it is important to accurately quantify the type of inertial response available from wind plant (typically a wind farm) and how it is affected by varying wind conditions. Two different control schemes to provide this "synthetic" inertial response are investigated. The benefits of the non-standard control scheme are demonstrated by comparing the response with the conventional "ideal" inertial control scheme that exactly emulates synchronous generators in terms of their provision of inertial response. This paper proposes a novel probabilistic approach for estimation of the aggregate inertial response available from a wind farm by using a Gaussian probability distribution to model wind turbulence. The aggregate inertial response calculated in this way has been examined at various mean wind speed levels and has the advantage that it automatically takes into account wind speed variations during the transient event itself.
This paper presents a model for calculating the cost of power system reliability based on the stochastic optimization of long-term security-constrained unit commitment. Random outages of generating ...units and transmission lines as well as load forecasting inaccuracy are modeled as scenario trees in the Monte Carlo simulation. Unlike previous reliability analyses methods in the literature which considered the solution of an economic dispatch problem, this model solves an hourly unit commitment problem, which incorporates spatial constraints of generating units and transmission lines, random component outages, and load forecast uncertainty into the reliability problem. The classical methods considered predefined reserve constraints in the deterministic solution of unit commitment. However, this study considers possible uncertainties when calculating the optimal reserve in the unit commitment solution as a tradeoff between minimizing operating costs and satisfying power system reliability requirements. Loss-of-load-expectation (LOLE) is included as a constraint in the stochastic unit commitment for calculating the cost of supplying the reserve. The proposed model can be used by a vertically integrated utility or an ISO. In the first case, the utility considers the impact of long-term fuel and emission scheduling on power system reliability studies. In the second case, fuel and emission constraints of individual generating companies are submitted as energy constraints when solving the ISO's reliability problem. Numerical simulations indicate the effectiveness of the proposed approach for minimizing the cost of reliability in stochastic power systems.
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012. Induced by iron overload and ROS ...accumulation, ferroptosis is modulated by various cellular metabolic and signaling pathways. The GSH-GPX4 pathway, the FSP1-CoQ10 pathway, the GCH1-BH4 pathway, the DHODH-CoQH2 system and the sex hormones suppress ferroptosis. Mitochondrial iron metabolism regulates ferroptosis and mitochondria also undergo a morphological change during ferroptosis, these changes include increased membrane density and reduced mitochondrial cristae. Moreover, mitochondrial energy metabolism changes during ferroptosis, the increased oxidative phosphorylation and ATP production rates lead to a decrease in the glycolysis rate. In addition, excessive oxidative stress induces irreversible damage to mitochondria, diminishing organelle integrity. ROS production, mitochondrial membrane potential, mitochondrial fusion and fission, and mitophagy also function in ferroptosis. Notably, some ferroptosis inhibitors target mitochondria. Ferroptosis is a major mechanism for cell death associated with the progression of cancer. Metastasis-prone or metastatic cancer cells are more susceptible to ferroptosis. Inducing ferroptosis in tumor cells shows very promising potential for treating drug-resistant cancers. In this review, we present a brief retrospect of the discovery and the characteristics of ferroptosis, then we discuss the regulation of ferroptosis and highlight the unique role played by mitochondria in the ferroptosis of cancer cells. Furthermore, we explain how ferroptosis functions as a double-edged sword as well as novel therapies aimed at selectively manipulating cell death for cancer eradication.
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