Abstract Background The role of surgical resection for synchronous hepatic metastases arising from gastric adenocarcinoma has not been established. This study was designed to explore the ...clinicopathologic features and surgical results of these patients. Methods Twenty-five (4.8%) of 526 patients diagnosed with synchronous hepatic metastatic gastric cancer received hepatectomy and gastrectomy at the same time; 2 cases underwent repeat hepatectomy after intrahepatic recurrence. Clinicopathologic parameters of the hepatic metastases and the surgical results for all 25 patients were analysed. Results The 1-, 3-, and 5-year overall survival (OS) and recurrence-free survival (RFS) rates after resection were 96.0%, 70.4%, and 29.4%, respectively, and 56.0%, 22.3%, and 11.1%, respectively. Five patients survived for more than 5 years after surgery, and no mortality has occurred within 30 days after resection. Univariate analysis revealed that patients with multiple hepatic metastases suffered poorer OS ( P = 0.026) and RFS ( P = 0.035) than those with solitary hepatic metastasis. Postoperative adjuvant chemotherapy was a significant indicator of a favourable OS ( P = 0.022). Number of metastatic lesions remained significant in the multivariate analysis of OS and RFS ( P = 0.039, P = 0.049, respectively). None of variables of the primary lesion was a significant prognostic factor for those patients. Conclusions Gastric cancer patients with a solitary synchronous liver metastasis may be good candidates for hepatic resection. Postoperative adjuvant chemotherapy may provide a benefit by aiding in OS.
Abstract
The microstructure and mechanical properties of 7065 alloy was investigate in this present work. The main intermetallic phases of the 7065 alloy identified by EDS analysis were (Mg,Cu)
2
Zn, ...Al
2
Cu and Al
7
Cu
2
Fe. The microstructure of the 7065 alloy after hot rolling mainly consists elongated fibrous grains containing sub-grains, indicating that dynamic recovery is the primarily mechanism during hot rolling. The 7065 alloy has lower quench-sensitive and higher mechanical properties than that of the 7050 alloy.
The influence of grinding pressure on the removal behaviours of rail material was investigated using a rail grinding simulation testing apparatus. Grinding tests were performed at three types of ...section radius of rail head. The results indicated that with the increase in the grinding pressure, the grinding efficiency was obviously improved and the grinding amount and chip thickness were increased. However, the surface quality became worse and residual stresses were increased. Furthermore, surface burn occurred when the grinding pressure was larger than 1600 N at R13, 1800 N at R80, and 2000 N at R300, respectively. The grinding debris was composed of curled chips, lump chips, and spherical debris. In addition, the wear mechanism of abrasive grains presented macro fracture.
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•A testing apparatus was developed to investigate the interaction on the rail/stone interface.•The influence of grinding pressure on grinding performance at three types of rail head was explored.•The increase in grinding pressure improved the grinding efficiency but lower the surface quality.
The mitochondrion is an important subcellular target of environmental toxicants. With environmental stress, a series of toxic effects on mitochondria are induced, which originate from the dynamic ...changes of mitochondrial fusion and fission, structure/membrane damage, and respiratory chain dysfunction. The toxic effects of various toxicants on mitochondrial morphology and intact membranes, and their determination of cell fate, have already been broadly studied and reported on. However, their effects on the integrity and function of the mitochondrial respiratory chain (RC) remain incompletely understood. Recently, Fan
et al.
and Yu
et al.
approached this topic by closely examining the mitochondrial toxicities, including the effect on the respiratory chain, induced by organic arsenical chemical 2-methoxy-4-(((4-(oxoarsanyl)phenyl)imino)methyl)phenol and thiourea gold(
i
) complexes (AuTuCl). Obviously, toxicant-induced dysfunction of the respiratory chain can hinder ATP production, and may elevate ROS generation. The increased ROS can further damage mtDNA, and consequently leads to inactivation of some RC protein-encoding mtDNA, generating a vicious circle of amplifying mitochondrial damage. We hope that these studies focused on RC structure and activity will broaden our view of mitochondrial toxicology and draw forth more profound mechanistic studies on the respiratory chain toxicity of environmental toxicants and their application in risk assessment.
The mitochondrion is an important subcellular target of environmental toxicants.
The EMPOWER-Lung 1 trial showed that cemiplimab significantly prolongs the duration of progression-free survival and overall survival in advanced non-small cell lung cancer (NSCLC) patients with at ...least 50% programmed cell death receptor ligand-1 (PD-L1) positivity, yet the financial burden may limit its use. The aim of the present study was to evaluate the cost-effectiveness of cemiplimab versus chemotherapy in a US setting.
A Markov model, with three mutually exclusive health states, was used to compare the expected health outcomes and cost of cemiplimab with chemotherapy. Survival data and transition probabilities were collected from the EMPOWER-Lung 1 trial. Utility values and costs are publicly available from open sources. One-way and probabilistic sensitivity analyses were conducted in both the whole population and subgroups to test the robustness of the parameters and structure.
Treatment of NSCLC with cemiplimab yielded an extra 1.07 quality-adjusted life years (QALYs) at an additional cost of $98 211 compared with chemotherapy, associated with an incremental cost-effectiveness ratio of $91 891/QALY and an incremental net health benefit of 0.087 QALYs at a willingness to pay threshold of $100 000/QALY. The probabilistic sensitivity analysis indicated that cemiplimab provided an 83.2% probability of being cost-effective. One-way sensitivity analysis suggested that the price of cemiplimab was the chief driver in this model. A subgroup analysis showed that cemiplimab was the preferred incremental net health benefit in more than half of the subgroups, including patients with squamous type disease and metastases.
Cemiplimab is a cost-effective option in the first-line treatment of NSCLC in patients who are at least 50% PD-L1 positive from an American perspective.
•The first pharmacoeconomics analysis that compares the cost-effectiveness of cemiplimab and standard chemotherapy for advanced NSCLC patients.•For patients with at least 50% PD-L1 positivity, cemiplimab is more cost-effectiveness.•There is an unmeted need to further identify the characteristics of those specific populations to gain better economic outcomes of cemiplimab.
The single field-of-view (SFOV) sounder atmospheric product (SiFSAP) retrieval algorithm has been developed to address the need to retrieve high-spatial-resolution atmospheric data products from ...hyper-spectral sounders and ensure the radiometric consistency between the retrieved properties and measured spectral radiances. It is based on an integrated optimal-estimation inversion scheme that processes data from the satellite-based synergistic microwave (MW) and infrared (IR) spectral measurements from advanced sounders. The retrieval system utilizes the principal component radiative transfer model (PCRTM), which performs radiative transfer calculations monochromatically and includes accurate cloud-scattering simulations. SiFSAP includes temperature, water vapor, surface skin temperature and emissivity, cloud height and microphysical properties, and concentrations of essential trace gases for each SFOV at a native instrument spatial resolution. Error estimations are provided based on a rigorous analysis for uncertainty propagation from the top-of-atmosphere (TOA) spectral radiances to the retrieved geophysical properties. As a comparison, the spatial resolution for the traditional hyper-spectral sounder retrieval products is much coarser than the native resolution of the instruments due to the common use of the “cloud-clearing” technique to compensate for the lack of cloud-scattering simulation in the forward model. The degraded spatial resolution in traditional cloud-clearing sounder retrieval products limits their applications for capturing meteorological or climate signals at finer spatial scales. Moreover, a rigorous uncertainty propagation estimation needed for long-term climate trend studies cannot be given due to the lack of direct radiative transfer relationships between the observed TOA radiances and the retrieved geophysical properties. With the advantages of the higher spatial resolution; the simultaneous retrieval of atmospheric, cloud, and surface properties using all available spectral information; and the establishment of “radiance closure” in the sounder spectral measurements, the SiFSAP provides additional information needed for various weather and climate studies and applications using sounding observations. This paper gives an overview of the SiFSAP retrieval algorithm and assessment of SiFSAP atmospheric temperature, water vapor, clouds, and surface products derived from the Cross-track Infrared Sounder (CrIS) and Advanced Technology Microwave Sounder (ATMS) data.
Experimental, controlled, animal study.
To evaluate the effects of calcitriol on oxidative stress, apoptosis, autophagy and locomotor recovery in rats after spinal cord injury (SCI).
China.
Ninety ...female rats were randomly divided into three groups. Laminectomy only was performed in the control group. The SCI group received laminectomy as well as spinal cord compression injury. In the calcitriol group, SCI rats received an intraperitoneal injection of calcitriol (2 μg kg(-1)day(-1)). Oxidative stress was assessed by the tissue superoxide dismutase (SOD) activity and the contents of glutathione (GSH) and malondialdehyde (MDA). The extent of apoptosis was assessed by immunohistochemistry for C-caspase3, TUNEL staining and western blotting for C-caspase3, Bax and Bcl2. Transmission electron microscopy was used to examine autophagosomes in the injured spinal cord of calcitriol-treated rats. Autophagy was detected by western blotting for LC3-II, Beclin1 and p62. Histological changes were assessed by haematoxylin and eosin staining and Nissl staining. Functional recovery was reflected by the Basso, Beattie and Bresnahan locomotion rating scale and the inclined plane test.
With calcitriol treatment, oxidative stress was decreased, SOD activity and GSH content were increased and MDA content was decreased. Moreover, apoptosis was inhibited in the SCI plus calcitriol group. However, a higher level of autophagy was detected in the lesions of the calcitriol group compared with the SCI group. Histological damage and neuron loss after SCI were reduced in calcitriol-treated rats, and functional recovery was significantly promoted in the calcitriol group compared with controls.
Calcitriol promotes locomotor recovery after SCI by reducing oxidative stress and inhibiting apoptosis, as well as promoting autophagy.
Transcranial direct current stimulation has been widely used in the clinical treatment of stroke. The purpose of this study was to perform a bibliometric analysis of scientific literature in this ...field.
Articles and reviews regarding transcranial direct current stimulation in stroke from January 01, 2004 to May 31, 2022 were identified from the Science Citation Index-Expanded of the Web of Science Core Collection database. CiteSpace 6.1.R2,
and the Bibliometric Online Analysis Platform were used to analyze data.
A total of 905 papers were obtained, with the highest number of publications coming from the USA. The institutions and authors with the most publications were Harvard Medical School and Fregni F respectively. Nitsche MA had the most co-citations, followed by Fregni F. Neurosciences was the most fruitful research area and Brain Stimulation had the highest H-index. The research topics could be divided into three sections: mechanisms of treatment, comparison of efficacy with transcranial magnetic stimulation, clinical application of post-stroke dysfunction. The field of "walking", "strength" and "virtual reality therapy" are the future research hotspots of transcranial direct current stimulation.
The overall research showed a slow growth trend, and the outstanding contribution of the USA in this field cannot be ignored. Relevant researchers are suggested to focus on international collaboration and actively conduct high-quality randomized controlled clinical trials on research hotspots and frontiers in order to identify the optimal stimulation paradigm for clinical purposes.
For patients with clinically early-stage localized prostate cancer, radiotherapy is another treatment that can achieve radical treatment in addition to radical prostatectomy. Despite this, there are ...still a large number of patients with prostate cancer who have a biochemical recurrence after undergoing radiotherapy, or even clinical recurrence, leading to treatment failure. Although the expression of the fructose-1,6-bisphosphatase 1 (FBP1) gene has been found to be absent in various tumors and is associated with a poor prognosis in tumor patients. However, the expression and role of FBP1 in prostate cancer are not clear. The purpose of this study was to investigate the role and mechanism of FBP1 in the radiotherapy resistance of prostate cancer. By analyzing the microarray data of prostate cancer radiotherapy resistant cells and parental cells (GSE53902), we found that FBP1 expression in DU145 radiotherapy resistant cells was significantly higher than in the DU145 parental cells. In addition, we searched for the expression of FBP1 in 492 prostate cancer samples from TCGA and found that its expression in prostate cancer was significantly higher than that in normal tissues. Knockdown of FBP1 expression significantly inhibited the proliferation of prostate cancer cells, promoted DNA damage-mediated apoptosis, and enhanced the sensitivity of prostate cancer cells to radiotherapy. Further mechanism analysis revealed that FBP1 knockdown could activate autophagy mediated by the AMPK-mTOR signaling pathway, while inhibition of the AMPK-mTOR signaling pathway could reverse FBP1 knockdown-mediated autophagy and apoptosis, as well as radiosensitization. In conclusion, this study clarified that FBP1 is an oncogene in prostate cancer, and the main mechanism for knockdown of FBP1 to increase radiosensitivity is to enhance autophagy mediated by the AMPK-mTOR signaling pathway. Therefore, FBP1 may be a potential target for enhancing prostate cancer radiotherapy.
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