Schizophrenia is a severe psychiatric disorder with high premature mortality rates. This is a meta-analysis and systematic review of the prevalence of suicidal ideation (SI) and suicide plan (SP) ...among people with schizophrenia. PubMed, Web of Science, Embase, and PsycINFO were systematically searched from their respective inception to October 10, 2020. Data on prevalence of SI and/or SP were synthesized using the random effects model. Twenty-six studies covering 5079 people with schizophrenia were included for meta-analysis. The lifetime and point prevalence of SI were 34.5% (95% CI: 28.2-40.9%), and 29.9% (95% CI: 24.2-35.6%), respectively. The lifetime prevalence of SP was 44.3% and the point prevalence of SP ranged between 6.4 and 13%. Subgroup and meta-regression analyses revealed that source of patients, survey countries, and sample size were significantly associated with the point prevalence of SI, while male proportion and quality assessment scores were significantly associated with the lifetime and point prevalence of SI. Survey time and mean age were significantly associated with lifetime prevalence of SI. Both SI and SP are common in people living with schizophrenia, especially in males and inpatients. Routine screening and effective interventions for SI and SP should be implemented in this population.
Auxetic materials have recently emerged as new types of advanced materials with unique material properties that conventional materials do not possess. In this paper, we examine the effect of in-plane ...negative Poisson’s ratio (NPR) on the thermal postbuckling behavior of graphene-reinforced metal matrix composite (GRMMC) laminated cylindrical shells. The shell consists of GRMMC layers arranged in a piece-wise functionally graded (FG) pattern and is subjected to a uniform thermal load surrounded by an elastic medium. Based on the molecular dynamics simulation results, it is noted that the temperature-dependent material properties of GRMMCs can be expressed as a nonlinear function of temperature. The thermal postbuckling problem of shells is modeled under the framework of the Reddy’s third order shear deformation theory and solved by using a singular perturbation technique in conjunction with a two-step perturbation approach. Numerical investigations are carried out for the postbuckling of (10/-10/10/-10/10)S and (10/-10/10)S shells with in-plane NPR. It is found that the FG-X pattern can enhance the buckling temperature and the thermal postbuckling strength of the shells. The anomaly is that the thermal buckling load and postbuckling strength of UD (10/-10/10)S shell are slightly higher than those of UD (10/-10/10/-10/10)S GRMMC laminated cylindrical shell.
•Both piece-wise FG configurations and in-plane NPRs are considered.•Temperature dependent material properties for both graphene reinforcements and metal matrix are considered.•Buckling temperatures of UD (10/-10/10)S shell are slightly higher than those of UD (10/-10/10/-10/10)S shell.•Thermal postbuckling load–deflection curves of UD (10/-10/10)S shell are higher than those of UD (10/-10/10/-10/10)S shell.
Examine the real-world clinical impact of adopting less invasive surfactant administration (LISA) as the primary surfactant administration method in extremely preterm infants.
Single-center pre-post ...cohort study conducted over a 4-year period comparing outcomes of spontaneously breathing inborn infants 24
-28
weeks gestational age (GA) receiving surfactant via endotracheal tube (pre-cohort, n = 154) or LISA via thin catheter (post-cohort, n = 70). Primary outcome was need for invasive mechanical ventilation (IMV, ≥2 h) ≤72 h of age. Secondary outcomes were a composite of mortality, bronchopulmonary dysplasia, intraventricular hemorrhage ≥grade 3 or necrotizing enterocolitis, and its individual components. Groups were compared using propensity score methods, including covariates: GA, birth weight, sex, small for GA, SNAP II ≥20, premature rupture of membranes, maternal hypertension/diabetes, and C-section.
GA and birth weight were 27.1 (26, 28.1) weeks and 914 (230) g, and 27.1 (26.1, 28.1) weeks and 920 (236) g for pre- and post-cohorts, respectively. Pre-cohort had higher C-section rates, (67% vs. 51%, p = 0.03). After adjustment for covariates, LISA was associated with reduced IMV exposure AOR (95% CI) 0.07 (0.04, 0.11), lower odds of the composite clinical outcome 0.49 (0.33, 0.73), and most of its individual components.
Real-world experience favors LISA as the primary method in extremely preterm infants with established spontaneous respiration.
Less invasive surfactant administration (LISA) is associated with a reduction in respiratory morbidity, but real-world data of routine use among extremely preterm infants are limited. LISA is associated with reduced frequency of exposure to and duration of IMV in both ≤72 h after birth and during hospital stay. LISA is associated with a reduction in mortality, and most other major morbidities including bronchopulmonary dysplasia, and interventricular hemorrhage. Data from a large North American center providing real-world clinical outcomes following LISA as the primary method of surfactant administration.
Bovine respiratory disease complex (BRDC) involves multiple pathogens, shows diverse lung lesions, and is a major concern in calves. Pathogens from 160 lung samples of dead cattle from 81 cattle ...farms in Northeast China from 2016 to 2021 were collected to characterize the molecular epidemiology and risk factors of BRDC and to assess the major pathogens involved in bovine suppurative or caseous necrotizing pneumonia. The BRDC was diagnosed by autopsy, pathogen isolation, PCR, or reverse transcription-PCR detection, and gene sequencing. More than 18 species of pathogens, including 491 strains of respiratory pathogens, were detected. The positivity rate of bacteria in the 160 lung samples was 31.77%, including Trueperella pyogenes (9.37%), Pasteurella multocida (8.35%), Histophilus somni (4.48%), Mannheimia haemolytica (2.44%), and other bacteria (7.13%). The positivity rate of Mycoplasma spp. was 38.9%, including M. bovis (7.74%), M. dispar (11.61%), M. bovirhinis (7.94%), M. alkalescens (6.11%), M. arginini (0.81%), and undetermined species (4.68%). Six species of viruses were detected with a positivity rate of 29.33%, including bovine herpesvirus-1 (BoHV-1; 13.25%), bovine respiratory syncytial virus (BRSV; 5.50%), bovine viral diarrhea virus (BVDV; 4.89%), bovine parainfluenza virus type-3 (BPIV-3; 4.28%), bovine parainfluenza virus type-5 (1.22%), and bovine coronavirus (2.24%). Mixed infections among bacteria (73.75%), viruses (50%), and M. bovis (23.75%) were the major features of BRDC in these cattle herds. The risk analysis for multi-pathogen co-infection indicated that BoHV-1 and H. somni; BVDV and M. bovis, P. multocida, T. pyogenes, or Mann. haemolytica; BPIV-3 and M. bovis; BRSV and M. bovis, P. multocida, or T. pyogenes; P. multocida and T. pyogenes; and M. bovis and T. pyogenes or H. somni showed co-infection trends. A survey on molecular epidemiology indicated that the occurrence rate of currently prevalent pathogens in BRDC was 46.15% (6/13) for BoHV-1.2b and 53.85% (7/13) for BoHV-1.2c, 53.3% (8/15) for BVDV-1b and 46.7% (7/15) for BVDV-1d, 29.41% (5/17) for BPIV-3a and 70.59% (12/17) for BPIV-3c, 100% (2/2) for BRSV gene subgroup IX, 91.67% (33/36) for P. multocida serotype A, and 8.33% (3/36) for P. multocida serotype D. Our research discovered new subgenotypes for BoHV-1.2c, BRSV gene subgroup IX, and P. multocida serotype D in China's cattle herds. In the BRDC cases, bovine suppurative or caseous necrotizing pneumonia was highly related to BVDV odds ratio (OR) = 4.18; 95% confidence interval (95% CI): 1.6–10.7, M. bovis (OR = 2.35; 95% CI: 1.1–4.9), H. somni (OR = 8.2; 95% CI: 2.6–25.5), and T. pyogenes (OR = 13.92; 95% CI: 5.8–33.3). The risk factor analysis found that dairy calves <3 mo and beef calves >3 mo (OR = 5.39; 95% CI: 2.7–10.7) were more susceptible to BRDC. Beef cattle were more susceptible to bovine suppurative or caseous necrotizing pneumonia than dairy cattle (OR = 2.32; 95% CI: 1.2–4.4). These epidemiological data and the new pathogen subgenotypes will be helpful in formulating strategies of control and prevention, developing new vaccines, improving clinical differential diagnosis by necropsy, predicting the most likely pathogen, and justifying antimicrobial use.
ABSTRACT Solar magnetic activity varies with time in the two hemispheres in different ways. The hemispheric interconnection of solar activity phenomena provides an important clue to understanding the ...dynamical behavior of solar dynamo actions. In this paper, several analysis approaches are proposed to analyze the systematic regularity of hemispheric asynchronism and amplitude asymmetry of long-term sunspot areas during solar cycles 9-24. It is found that, (1) both the hemispheric asynchronism and the amplitude asymmetry of sunspot areas are prevalent behaviors and are not anomalous, but the hemispheric asynchronism exhibits a much more regular behavior than the amplitude asymmetry; (2) the phase-leading hemisphere returns back to the identical hemisphere every 8 solar cycles, and the secular periodic pattern of hemispheric phase differences follows 3 (south leading) + 5 (north leading) solar cycles, which probably corresponds to the Gleissberg cycle; and (3) the pronounced periodicities of (absolute and normalized) asymmetry indices and lines of synchronization (LOSs) are not identical: the significant periodic oscillations are 80.65 6.31, 20.91 0.40, and 13.45 0.16 years for the LOS values, and 51.34 2.48, 8.83/8.69 0.07, and 3.77 0.02 years for the (absolute and normalized) asymmetry indices. The analysis results improve our knowledge on the hemispheric interrelation of solar magnetic activity and may provide valuable constraints for solar dynamo models.
Objectives
Patients with COVID‐19 may present with respiratory syndromes indistinguishable from common viruses. This poses a challenge for early detection during triage in the emergency department ...(ED). Over a 3‐month period, our ED aimed to minimize nosocomial transmission by using broader suspect case criteria for better detection and using appropriate personal protective equipment (PPE) for health care workers (HCWs).
Methods
All ED admissions with respiratory syndromes over a 3‐month period were tested for COVID‐19. The sensitivity and specificity of screening criteria in detecting COVID‐19 were assessed. A risk‐stratified approach was adopted for PPE usage in the ED, based on high‐risk “fever areas” and lower‐risk zones. When a case of COVID‐19 was confirmed, surveillance was conducted for potentially exposed patients and HCWs.
Results
A total of 1,841 cases presenting with respiratory syndromes required admission over the study period. Among these, 70 cases of COVID‐19 were subsequently confirmed. The majority (84.2%, 59/70) were detected at ED triage because they fulfilled suspect case criteria. Of these, 34 met the official screening criteria; an additional 25 were detected by the broader internal screening criteria. Over the 12‐week period, the cumulative sensitivity of internal screening criteria was 84.3% (95% confidence interval CI = 73.6% to 91.9%), whereas the sensitivity of the official screening criteria was 48.6% (95% CI = 36.4% to 60.8%). Given the broadened internal criteria, the preexisting ED “fever area” was insufficient and had to be expanded. However, there were no cases of nosocomial transmission from intra‐ED exposure, despite extensive surveillance.
Conclusion
Frontline physicians need to be given leeway to decide on the disposition of cases based on clinical suspicion during an ongoing outbreak of COVID‐19. If a broader criterion is used at ED triage, ED facilities and isolation facilities need to be readied to accommodate a surge of suspect cases. Usage of appropriate PPE is essential in minimizing nosocomial transmission.
Intrauterine insemination (IUI) is the first-line treatment for non-tubal infertility. Injectable gonadotropins are often chosen as adjunctive stimulation to promote the growth of ovarian follicles ...in IUI cycles. The growing follicles produce estrogen, which induces endometrial proliferation and increased endometrial stripe thickness (EST). The association between EST and pregnancy outcome in gonadotropin stimulated IUI is not well studied. The objective of this study is to determine if EST can predict pregnancy outcome in gonadotropin-stimulated IUI cycles.
A retrospective review was conducted of all exclusively gonadotropin-stimulated IUI cycles performed between 2012 and 2015 at an academic fertility clinic. Mean endometrial thickness was compared in positive versus negative cycles using Student T-test. Peak EST values were then divided into four groups of < 7 mm, 7.0-10.4 mm, 10.5-13.9 mm, and ≥ 14 mm. Multiple logistic regression analysis adjusted for potential confounders was conducted to assess the impact of peak EST on cycle outcome.
Our sample consisted of 1065 IUI cycles representing 548 patients with a 16.9% clinical pregnancy rate and 20.5% conception rate. No significant differences in mean peak EST were observed between cycles that achieved clinical pregnancy or conception and those that did not. Division of peak EST into four groups showed a non-linear relationship between peak EST and cycle outcome, with highest rates of positive outcomes between 10.5-13.9 mm. The odds of clinical pregnancy and conception increased by 38 and 44% respectively with each subsequent peak EST category up to 10.5-13.9 mm, following which they declined.
This is the largest study to date evaluating the effect of peak EST on gonadotropin-stimulated IUI cycles exclusively. The lack of significant difference in peak EST between positive and negative outcomes cycles may be due to the non-linear relationship between cycle outcomes and peak EST. Peak EST in the range of 10.5-13.9 mm was associated with significantly higher conception rates and a trend towards higher clinical pregnancy rates. This non-linearity is likely one of the reasons that EST in isolation was found to be a poor predictor of IUI outcomes, and therefore is not appropriate to be used as the sole indicator for cycle cancellation.
•Nonlinear vibration of FG-GRMMC laminated plates in the pre- and post-buckling states under different load conditions.•Consideration of negative in-plane Poisson's ratio and temperature dependent ...material properties of FG-GRMMA plates.•First observation of buckled vibration phenomenon of auxetic GRMMC plate different from that of nonauxetic one.
The nonlinear vibration of a laminated plate constituting of graphene reinforced metal matrix composite (GRMMC) materials possessing in-plane negative Poisson’s ratio in pre- and post-buckled status is investigated in this work. The volume fraction of graphene remains constant in each layer but changes along the thickness direction of the plate to obtain functionally graded (FG) patterns. The plate rests on a Pasternak-type foundation and the post-buckling state of the plate is only caused by the thermal load or the compressive edge load. The nonlinear motion equations of the plate with the effect of the out-of-plane shear deformation are established and then solved by a two-step perturbation approach. The perturbation solutions provide a platform to study the influences of the FG arrangement, volume fraction of graphene and foundation stiffness on the post-buckled vibration of FG-GRMMC laminated plates. As the GRMMC material properties are dependent on temperature, the thermal effect on the linear and nonlinear frequencies of the plates for compressive post-buckling is also investigated. The numerical results of the linear and nonlinear frequencies of post-buckled FG GRMMC laminated plates under thermal and compressive loads are respectively illustrated and discussed in detail.
The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). It is believed that Aβ deposited in the brain originates from the brain tissue itself. ...However, Aβ is generated in both brain and peripheral tissues. Whether circulating Aβ contributes to brain AD-type pathologies remains largely unknown. In this study, using a model of parabiosis between APPswe/PS1dE9 transgenic AD mice and their wild-type littermates, we observed that the human Aβ originated from transgenic AD model mice entered the circulation and accumulated in the brains of wild-type mice, and formed cerebral amyloid angiopathy and Aβ plaques after a 12-month period of parabiosis. AD-type pathologies related to the Aβ accumulation including tau hyperphosphorylation, neurodegeneration, neuroinflammation and microhemorrhage were found in the brains of the parabiotic wild-type mice. More importantly, hippocampal CA1 long-term potentiation was markedly impaired in parabiotic wild-type mice. To the best of our knowledge, our study is the first to reveal that blood-derived Aβ can enter the brain, form the Aβ-related pathologies and induce functional deficits of neurons. Our study provides novel insight into AD pathogenesis and provides evidence that supports the development of therapies for AD by targeting Aβ metabolism in both the brain and the periphery.
We report a simple self-assembled synthesis of hierarchical CuO particles with various morphologies such as leaf, shuttle, flower, dandelion, and caddice clew. The morphologies can be easily tailored ...by adjusting the pH value. The synthesis is based on dehydration and re-crystallization of precursor Cu(OH)
2 nanowires. Cu(NH
3)
4
2+ and OH
− in the solutions are considered as the key factors to influence the assembling manner of CuO. The obtained hierarchical CuO particles serve as a good model system for the study as anodes for lithium ion batteries. Various morphologies of CuO particles result in different electrochemical performances of electrodes. Compared to others, dandelion-like and caddice clew-like CuO exhibit reversible discharge capacities of 385
mAh
g
−1 and 400
mAh
g
−1 at 0.1
C, 340
mAh
g
−1 and 374
mAh
g
−1 at 0.5
C after 50 cycles, respectively. The higher discharge capacities and better cycling performances are attributed to their larger surface area and porosity, leading to better contact between CuO and electrolyte and shorter diffusion length of lithium ions.
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