: This study aims to delineate the key characteristics of eyelid neoplasms in central and southern coastal China and to explore potential factors affecting tumour development.
: Retrospective ...multicenter observational study. A total of 1302 cases of eyelid neoplasms diagnosed in two tertiary hospitals were reviewed from January 2013 to May 2023. Histogenesis, pathological diagnosis, and potential risk factors were investigated, and the findings were compared with data from various regions and countries. Age- and gender-specific incidence rates, time trends, distributions across age groups, and the relationship with the Sociodemographic Index (SDI), latitude, and altitude were calculated.
: There were 1162 benign (89.2%) and 140 malignant (10.8%) cases, representing 63 pathological types. The median age of benign cases (50 years) was significantly lower than that of malignant cases (72 years) (P<0.05). The most common benign and malignant lesions were intradermal nevus (28.83%) and basal cell carcinoma (BCC) (74.29%). A relatively younger median age (68 years) for sebaceous gland carcinoma (SGC) was observed, with a male preponderance (gender ratio 2:1). Analyses of the proportions of BCC, SGC and squamous cell carcinoma (SCC) in eyelid malignancies revealed significant regression equations (P<0.05).
: The majority of eyelid neoplasms are of epithelial and melanocytic origin, with benign tumours being predominant. The regions with higher SDI exhibit a higher incidence of BCC and a lower incidence of SCC and SGC. BCC appears to have a higher incidence in regions located at higher latitudes.
To determine the reactivity of recombinant 52 and 60 kDa Ro(SSA) (Ro) proteins with sera from 3 subsets of patients with Ro autoantibody associated disease.
Complementary DNA (cDNA) clones that ...encode the human 52 and 60 kDa Ro autoantigens were isolated by the polymerase chain reaction and utilized to express recombinant glutathione S-transferase (GST) fusion proteins. Double immunodiffusion (ID) defined Ro positive autoimmune sera from 12 patients with neonatal lupus erythematosus (NLE), 16 with subacute cutaneous lupus erythematosus (SCLE) and 12 with primary Sjögren's syndrome (SS) were tested by enzyme linked immunosorbent assay (ELISA) against the recombinant 52 and 60 kDa Ro fusion proteins.
Seventy-five percent of NLE, 56% of SCLE and 83% of SS sera reacted with the 52 kDa fusion protein. Seventy-five percent of NLE, 63% of SCLE and 83% of SS sera reacted with the 60 kDa fusion protein. Seventeen percent of NLE sera, 25% of SCLE sera and 8% of SS sera were nonreactive to both full length fusion proteins. Eight (57%) of 14 ID defined Ro negative NLE, SCLE and SS sera were reactive with both Ro fusion proteins by ELISA: ELISA studies with recombinant 52 and 60 kDa Ro protein fragments revealed at least 2 major epitopes on each Ro protein. A fragment of the 52 kDa Ro protein that contains a putative leucine zipper motif reacted with 100% of ID defined Ro positive SS sera.
Our data demonstrate that the ID assay and the recombinant Ro ELISA together are more sensitive in detecting Ro antibodies than either assay alone, and that multiple epitopes are present on both Ro proteins.
Computerized data becomes more and more critical in todaypsilas digital life. With the help of redundant hardware and software, remote mirror can keep information systems alive by seamless service ...switching, even encountering site corruptions. Unfortunately, existing mirror systems have some limitations such as restrictions to specific storage devices and/or low level drivers. In this paper, we design a storage virtualization based asynchronous remote mirror system, named as SVAM (Storage Virtualization based Asynchronous Mirror). First, SVAM utilizes a logical volume structure, AMLV (Asynchronous Mirror Logic Volume), to provide data protection and make it the basic data container. This way, there is no device and driver dependency at all. Secondly, we present a server free mechanism to offload mirror related jobs to SAN IO nodes, therefore good performance can be expected. Finally, SVAM incorporates an advanced mirror protocol to support seamless service switching while keeping low network bandwidth overhead. Experiments and evaluation results demonstrate that SVAM has the ability to provide high reliability while only introduce little overhead: tolerated a site corruption while kept providing service, the cost was only 12.3% more time.
We present the second release of value-added catalogues of the LAMOST Spectroscopic Survey of the Galactic Anticentre (LSS-GAC DR2). The catalogues present values of radial velocity \(V_{\rm r}\), ...atmospheric parameters --- effective temperature \(T_{\rm eff}\), surface gravity log\(g\), metallicity Fe/H, \(\alpha\)-element to iron (metal) abundance ratio \(\alpha\)/Fe (\(\alpha\)/M), elemental abundances C/H and N/H, and absolute magnitudes \({\rm M}_V\) and \({\rm M}_{K_{\rm s}}\) deduced from 1.8 million spectra of 1.4 million unique stars targeted by the LSS-GAC since September 2011 until June 2014. The catalogues also give values of interstellar reddening, distance and orbital parameters determined with a variety of techniques, as well as proper motions and multi-band photometry from the far-UV to the mid-IR collected from the literature and various surveys. Accuracies of radial velocities reach 5kms\(^{-1}\) for late-type stars, and those of distance estimates range between 10 -- 30 per cent, depending on the spectral signal-to-noise ratios. Precisions of Fe/H, C/H and N/H estimates reach 0.1dex, and those of \(\alpha\)/Fe and \(\alpha\)/M reach 0.05dex. The large number of stars, the contiguous sky coverage, the simple yet non-trivial target selection function and the robust estimates of stellar radial velocities and atmospheric parameters, distances and elemental abundances, make the catalogues a valuable data set to study the structure and evolution of the Galaxy, especially the solar-neighbourhood and the outer disk.
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