Summary
Background
Currently there is no consensus about the association between psoriasis and human leucocyte antigen (HLA)‐B.
Objectives
To clarify the association between psoriasis and HLA‐B.
...Methods
Articles were selected, following predefined criteria, from case–control studies on the association between psoriasis and HLA‐B published between 1 January 1972 and 11 November 2012, and included in the PubMed and ISI Web of Knowledge databases.
Results
Thirty‐seven eligible articles covering 16 206 participants (14 644 white and 1562 Asian) were included. Sixty HLA‐B alleles were reported, among which 26 were associated with susceptibility to disease, 24 were protective and 10 were unassociated. For unspecific psoriasis, there were three strongly susceptible alleles (OR ≥ 3·0) in white and four in Asian subjects, with HLA‐B*57 and HLA‐B*13 common to both races; there were four strongly protective (OR ≤ 0·3) alleles in white and seven in Asian subjects, with HLA‐B*07 common to both. For psoriasis vulgaris, nine alleles were strongly associated with susceptibility in white subjects and five in Asians, with HLA‐Bw*37 and HLA‐B*57 in both; three alleles were strongly protective in white subjects and one in Asians, with none in common. Cases of psoriatic arthritis and guttate psoriasis were reported only in white subjects, with eight and seven strongly susceptible alleles, and two and three strongly protective alleles, respectively. Analyses of onset age showed that praecox patients with family history were significantly more susceptible to HLA‐B*13 and HLA‐B*57 than tardive ones.
Conclusions
A significant association was identified between psoriasis and 50 HLA‐B alleles. The association varied in terms of race, and clinical type and onset age of psoriasis.
What's already known about this topic?
Various alleles of human leucocyte antigen (HLA)‐B have been reported to be associated with psoriasis, but studies of the alleles have been carried out mostly in small populations and the results from different studies are not consistent.
What does this study add?
This study is the first meta‐analysis on the association between HLA‐B and psoriasis.
This study has indentified 26 susceptibility alleles, 24 protective ones and 10 unassociated alleles out of the 60 psoriasis‐associated HLA‐B alleles reported before.
The HLA‐B alleles associate with psoriasis to different degrees in different races and clinical types.
We developed a saturated iron-core type 35 kV/90 MVA superconductive fault current limiter and installed the device in a transmission network at Puji substation of China Southern Power Grid for ...live-grid operation. Innovative design in the iron-core configuration ensures that the device has low impedance in normal power transmission and sufficiently high impedance for a fault current limiting action. A magnetization control circuit allows the iron-core to be saturated or de-saturated depending upon the functional requirements. An energy release and voltage-surge protection unit can promptly discharge the magnetic energy accumulated in the iron-core and suppress the induced and surge voltages of the dc circuit in a current limiting event. This device has been designed to reduce the magnitude of a fault current by about 50%, which will prevent the breaking capacity of the existing circuit breakers in the transmission network from being exceeded in the predictable future. This article presents structural and functional specifications and reports up-to-date live-grid operation data of the device.
The role of the Na(+)/H(+) exchanger in ischemia, reperfusion, and preconditioning was investigated in isolated perfused rat hearts. Contractile function, Na(+)(i), and pH(i) were measured; ischemic ...damage was assessed by the recovery of developed pressure (DP) on reperfusion. After 30 minutes of ischemia, DP recovered to only 14+/-4% of preischemic control. In contrast, after preconditioning (3x5-minute periods of ischemia) followed by 30 minutes of ischemia, DP recovered to 75+/-4%. Hearts treated with the Na(+)/H(+) exchange inhibitor 5-(N-methyl-N-isobutyl)amiloride (MIA) also showed an enhanced recovery after ischemia (DP 62+/-9%). Treatment with a low concentration of tetrodotoxin (TTX, 100 nmol/L), which blocks the persistent component of the Na(+) current, had a small beneficial effect on recovery (DP 37+/-8%). Thirty minutes of ischemia caused a small Na(+)(i) rise (3.2+/-0.9 mmol/L); reperfusion resulted in a further Na(+)(i) increase (+11.9+/-2.5 mmol/L), which partially recovered over 30 minutes. Preconditioning did not change the Na(+)(i) rise during ischemia but abolished the large Na(+)(i) rise on reperfusion, and Na(+)(i) instead fell (-3.6+/-1.3 mmol/L). In the presence of MIA, the Na(+)(i) rise was unchanged from ischemia only; on reperfusion, Na(+)(i) fell (-3.7+/-0.9 mmol/L), similar to the preconditioned hearts. TTX abolished the Na(+)(i) rise during ischemia (+0.3+/-0.7 mmol/L), and the increase on reperfusion was similar to ischemia only. We conclude that the rise of Na(+)(i) during ischemia is caused by Na(+) entry through persistent Na(+) channels. The rise of Na(+)(i) on reperfusion is caused by activation of the Na(+)/H(+) exchanger and is blocked by MIA and by preconditioning. It is known that the Na(+)/H(+) exchanger is inhibited during ischemia; the present result suggests that this inhibition is prolonged into the early part of reperfusion by preconditioning. To test this hypothesis, we measured the time course of pH(i) recovery after ischemia and preconditioning. Preconditioning slowed the rate of pH(i) recovery after ischemia, providing further support for the hypothesis that preconditioning inhibits the Na(+)/H(+) exchanger during early reperfusion. This inhibition of the Na(+)/H(+) exchanger during reperfusion prevents Na(+) entry, and therefore Ca(2+) loading, and is part of the protective pathway involved in preconditioning.
To explore the expression and roles of nucleolin in cardiac injury in septic mice.
C57BL/6 mice (WT mice) and myocardium-specific expression of nucleolin transgenic mice (TG mice) were randomly ...divided into sham group (
10, sham-operated) and sepsis group (
15, animal model). Cecal ligation and puncture (CLP) was adopted to produce animal models of sepsis. The expression of nucleolin was detected by Western blotting analysis at 0, 12, 24, 48 hours after the operation. The 7-day survival rate, haemodynamic measurement, levels of isoenzyme of creatinekinase-MB (CK-MB) and cardiac troponin I (cTnI) in serum and levels of reactive oxygen species (ROS) and malondlaldehyde (MDA) in myocardium were evaluated 24 hours after the operation. The data were compared between groups with
test.
The expression of nucleolin in myocardium up-regulated significantly in WT+CLP group when compared with that in the WT+Sham group(2.57±0.34 vs 1.00±0.15,
7.468,
0.01). Compared with those in the WT+Sham group, the survival rate decrea
Objectives
The study was designed to evaluate the effectiveness of the combination of chemonucleolysis and psoas compartment block (PCB) for the treatment of lumbar disc herniations (LDHs) and to ...explore the role of PCB in managing postoperative pain of collagenase injection.
Methods
Two groups of patients (N = 192) were treated in different ways, respectively. Group A (N = 95) was treated with chemonucleolysis only (the injection of oxygen–ozone combined with collagenase into the lumbar disc and the epidural space); group B (N = 97) was treated with chemonucleolysis and PCB. After the treatment, the patients were followed‐up, and the therapeutic effect was assessed at 1 week, 1 month, 3 months, and 6 months by the relative pain reduction, visual analog scale (VAS) pain scores, and the Oswestry Disability Index (ODI) scores.
Results
In group A, treatment success rate was 64.2% (61 of 95), 82.1% (78 of 95), 84.2% (80 of 95), and 86.3% (82 of 95) at 1 week, 1 month, 3 months, and 6 months, respectively. In group B, treatment success rate was 86.5% (84 of 97), 89.6% (87 of 97), 93.8% (91 of 97), and 91.7% (89 of 97) at 1 week, 1 month, 3 months, and 6 months, respectively. There was statistically significant difference in outcome between two groups at 1 week, but there were no statistically significant difference in outcome between two groups at 1 month, 3 months, and 6 months. VAS scores and ODI were significantly decreased in both group A and group B, when compared with the baseline values in the same group at all points of follow‐up. Group B produced a significant reduction in the VAS scores and ODI when compared with group A at: 1‐week, 1‐month, 3‐month, 6‐month follow‐up.
Conclusions
Computer tomography (CT)‐guided chemonucleolysis combined with PCB leads to rapid pain relief, fewer postoperative pain of collagenase injection happen, and should be regarded as a useful treatment for the management of LDH.
In this paper, Al/Cu laminated tubes were fabricated by strong staggered spinning at room temperature. The interface behavior and mechanical properties of the laminates with different thinning rates ...were studied. The results show that the laminated tubes have good deformation coordination, no obvious interface defects and good bonding. With the increase of thinning rate, the metals in the diffused layer decrease during the spinning process and transition to the new diffused layer interface, and the interface bonding strength is improved, the microstructure on both sides of the interface becomes finer and more uniform. The Cu side is dominated by fibrous texture and equiaaxial grains formed by recrystallization, forming strong shear Brass-R {111} texture. The Al side grains are mainly equiaxed, forming deformed Goss {110} texture. Due to the strong plastic strain exerted by the diffusion layer metal on the surrounding material and the occurrence of dynamic recrystallization (DRX), the average grain size on the Cu and Al sides near the interface decreased to 1.18 μm and 1.33 μm at a 70% thinning rate, respectively. With the increase of thinning rate, the yield strength (YS) and ultimate tensile strength (UTS) of laminated tube increase first and then decrease. Compared with the BM, YS (131.0 MPa) and UTS (180.9 MPa) of the sample with 50% thinning rate increase 50.4% and 64.0%. The increase in strength is attributed to work hardening and grain refinement. The fracture mechanism is brittle fracture on Cu side and ductile fracture on Al side.
The scrubbing tower plays an important role for gas dedusting in the industry. In this study, the VOF-DPM coupled model is applied to investigate the gas—liquid—solid three-phase flow process in the ...bottom water chamber of the scrubbing tower. Two gas intake modes of guide-pipe mode and tangential-horn mode are numerically compared. Near the outlet surface, the guide-pipe mode scrubber can obtain lower gas velocity and more uniformly distributed gas phase. This is a good protection for the column tray against being overturned. However, there exists a hydrostatic zone in the guide-pipe mode chamber, this may cause dust to accumulate near the wall. The tangential-horn mode chamber obtains a lower pressure drop and a smaller velocity maximum above liquid level. As a result, to a group of particles range from 50 to 1000 μm, the removal efficiency of the tangential-horn mode scrubber is 88.3%, higher than that of 82.0% of the guide-pipe mode scrubber. The tangential-horn mode performs better in lower pressure drop, higher antiblocking and dust removal ability but worse in protecting the column tray against being overturned. This study offers guidance for the research and design of the wet gas scrubbing chamber.
To manage steel-making slag (SS) produced as industrial waste and conserve ceramic raw material resources, it is significant and sustainable to develop new ways of using SS. In this study, a novel ...ceramic brick was prepared using SS and red clay. The influence of SS particle size and sintering temperature on the sintering process and final properties of the red clay ceramic bricks was investigated. The water absorption capacity and compressive strength of these samples were analyzed. The results showed that the water absorption rate of the samples decreased with decreasing slag particle size and that the compressive strength of the sample reached its peak value at a moderate SS particle size (<0.075 mm) and sintering temperature (1150°C). The effect of SS particle size on the properties of the red clay ceramic bricks was investigated by analyzing the liquid phase and crystal structure. In addition, the relationship between SS particle size and activation energy of the sintering reaction was established, which is expected to provide useful information for the design of a sintering schedule for red clay–SS ceramic tiles with a certain SS particle size. We demonstrated a process for preparing a new type of ceramic brick that exceeds the specifications for pedestrian paving applications, while minimizing problems related to waste SS disposal.
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