Ionogels have gained increasing attentions as a flexible conductive material. However, it remains a big challenge to integrate multiple functions into one gel that can be widely applied in various ...complex scenes. Herein, a kind of multifunctional ionogels with a combination of desirable properties, including transparency, high stretchability, solvent and temperature resistance, recyclability, high conductivity, underwater self‐healing ability, and underwater adhesiveness is reported. The ionogels are prepared via one‐step photoinitiated polymerization of 2,2,2‐trifluoroethyl acrylate and acrylamide in a hydrophobic ionic liquid. The abundant noncovalent interactions including hydrogen bonding and ion–dipole interactions endow the ionogels with excellent mechanical strength, resilience, and rapid self‐healing capability at room temperature, while the fluorine‐rich polymeric matrix brings in high tolerance against water and various organic solvents, as well as tough underwater adhesion on different substrates. Wearable strain sensors based on the ionogels can sensitively detect and differentiate large body motions, such as bending of limbs, walking and jumping, as well as subtle muscle movements, such as pronunciation and pulse. It is believed that the designed ionogels will show great promises in wearable devices and ionotronics.
A physically crosslinked multifunctional ionogel is designed and prepared via a simple one‐step photoinitiated polymerization of a fluorinated monomer and a hydrogen bond enabling comonomer in a hydrophobic ionic liquid. The ionogels possess excellent comprehensive performance, including high transparency, robust mechanical properties, self‐healing and self‐adhesion in air/underwater, easy recyclability, solvent tolerance, and sensitive and reliable strain sensing.
Single-pixel imaging uses a single-pixel detector, rather than a focal plane detector array, to image a scene. It provides advantages for applications such as multi-wavelength, three-dimensional ...imaging. However, low frame rates have been a major obstacle inhibiting the use of computational ghost imaging technique in wider applications since its invention one decade ago. To address this problem, a computational ghost imaging scheme, which utilizes an LED-based, high-speed illumination module is presented in this work. At 32 × 32 pixel resolution, the proof-of-principle system achieved continuous imaging with 1000 fps frame rate, approximately two orders larger than those of other existing ghost imaging systems. The proposed scheme provides a cost-effective and high-speed imaging technique for dynamic imaging applications.
Bacteria preferentially accumulating in tumor microenvironments can be utilized as natural vehicles for tumor targeting. However, neither current chemical nor genetic approaches alone can fully ...satisfy the requirements on both stability and high efficiency. Here, we propose a strategy of "charging" bacteria with a nano-photocatalyst to strengthen their metabolic activities. Carbon nitride (C
N
) is combined with Escherichia coli (E. coli) carrying nitric oxide (NO) generation enzymes for photo-controlled bacterial metabolite therapy (PMT). Under light irradiation, photoelectrons produced by C
N
can be transferred to E. coli to promote the enzymatic reduction of endogenous NO
to cytotoxic NO with a 37-fold increase. In a mouse model, C
N
loaded bacteria are perfectly accumulated throughout the tumor and the PMT treatment results in around 80% inhibition of tumor growth. Thus, synthetic materials-remodeled microorganism may be used to regulate focal microenvironments and increase therapeutic efficiency.
Since December 2019, an epidemic caused by novel coronavirus (2019-nCoV) infection has occurred unexpectedly in China. As of 8 pm, 31 January 2020, more than 20 pediatric cases have been reported in ...China. Of these cases, ten patients were identified in Zhejiang Province, with an age of onset ranging from 112 days to 17 years. Following the latest
National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCoV
(the 4th edition) and current status of clinical practice in Zhejiang Province, recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health, the National Children’s Regional Medical Center, Children’s Hospital, Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV.
Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year survival rate of ...< 5%. Angiogenesis, namely, the formation of new blood vessels from pre-existing vessels, is an important event in tumor growth and hematogenous metastasis. It is a dynamic and complex process involving multiple mechanisms and is regulated by various molecules. Inhibition of angiogenesis has been an established therapeutic strategy for many solid tumors. However, clinical outcomes are far from satisfying for pancreatic cancer patients receiving anti-angiogenic therapies. In this review, we summarize the current status of angiogenesis in pancreatic cancer research and explore the reasons for the poor efficacy of anti-angiogenic therapies, aiming to identify some potential therapeutic targets that may enhance the effectiveness of anti-angiogenic treatments.
Expensive gold‐based catalysts are frequently used for electrochemical CO2 reduction into CO. A feasible approach to obtain low‐cost Au‐based catalysts is needed. Herein, a novel framework 1 ...assembled from Zr48Ni6 nano‐cages is prepared. It exhibits a high BET surface area of 1569 m2 g−1 and high solvents/pH stability. 1 can not only selectively extract AuCl4− from artificial electronic waste, but can then be transformed into low‐cost catalyst Au nanoparticle@1‐x (Au NPs@1‐x, x=1, 2, 3, 4) with tuneable Au NPs sizes. The CO2RR investigations revealed that the Au NPs@1‐3 displayed an excellent FECO of 95.2 % with a current density of 102.9 mA cm−2 at −1.1 V, and such high catalytic activity can be maintained for at least 15 h without obvious decrease because the confinement effect of Zr48Ni6 nano‐cages prevents Au NPs agglomeration. This work offers a facile strategy to obtain low‐cost and high‐performance Au‐based catalysts for various reactions activated by Au.
Novel metal‐organic framework 1 assembled from Zr48Ni6 nano‐cages is the first MOF that can not only extract gold from artificial electronic waste, but is then converted into an effective catalyst for the electroreduction of CO2 to CO. It offers a facile strategy to obtain low‐cost and high‐performance Au‐based catalysts.
Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome‐based nanoparticle (designated as LipoMB/CaO2) with O2 self‐sufficient property for dual‐stage ...light‐driven PDT is demonstrated to address this problem. Through a short time irradiation, 1O2 activated by the photosensitizer methylene blue (MB) can induce lipid peroxidation to break the liposome, and enlarge the contact area of CaO2 with H2O, resulting in accelerated O2 production. Accelerated O2 level further regulates hypoxic tumor microenvironment and in turn improves 1O2 generation by MB under another long time irradiation. In vitro and in vivo experiments also demonstrate the superior competence of LipoMB/CaO2 to alleviate tumor hypoxia, suppress tumor growth and antitumor metastasis with low side‐effect. The O2 self‐sufficient LipoMB/CaO2 nanoplatform with dual‐stage light manipulation is a successful attempt for PDT against hypoxic tumor.
A liposome‐based nanoparticle (desig‐nated as LipoMB/CaO2) with O2 self‐sufficient property is developed to combat hypoxic tumor. Through dual‐stage irradiation, O2 self‐sufficient LipoMB/CaO2 can alleviate tumor hypoxia and strongly suppress tumor growth with low side‐effect.
Interferon-α2b Treatment for COVID-19 Zhou, Qiong; Chen, Virginia; Shannon, Casey P ...
Frontiers in immunology,
05/2020, Letnik:
11
Journal Article
Recenzirano
Odprti dostop
The global pandemic of COVID-19 cases caused by infection with SARS-CoV-2 is ongoing, with no approved antiviral intervention. We describe here the effects of treatment with interferon (IFN)-α2b in a ...cohort of confirmed COVID-19 cases in Wuhan, China. In this uncontrolled, exploratory study, 77 adults hospitalized with confirmed COVID-19 were treated with either nebulized IFN-α2b (5 mU b.i.d.), arbidol (200 mg t.i.d.) or a combination of IFN-α2b plus arbidol. Serial SARS-CoV-2 testing along with hematological measurements, including cell counts, blood biochemistry and serum cytokine levels, and temperature and blood oxygen saturation levels, were recorded for each patient during their hospital stay. Treatment with IFN-α2b with or without arbidol significantly reduced the duration of detectable virus in the upper respiratory tract and in parallel reduced duration of elevated blood levels for the inflammatory markers IL-6 and CRP. These findings suggest that IFN-α2b should be further investigated as a therapy in COVID-19 cases.
The design of smart stimuli‐responsive photoluminescent materials capable of multi‐level encryption and complex information storage is highly sought after in the current information era. Here, a ...novel adamantyl‐capped CsPbBr3 (AD‐CsPbBr3) perovskite NCs, along with its supramolecular host‐guest assembly partner a modified β‐CD (mCD), mCD@AD‐CsPbBr3, are designed and prepared. By dispersing these two materials in different solvents, namely, AD‐CsPbBr3 in toluene, mCD@AD‐CsPbBr3 in toluene, and mCD@AD‐CsPbBr3 in methanol, the three solutions exhibit diverse photoluminescence (PL) turn‐on/off or PL discoloration response upon supramolecular stimulus. Based on these responses, a proof‐of‐principle programmable Multi‐Level Photoluminescence Encoding System (MPLES) is established. Three types of four‐level and three types of three‐level information encoding are achieved by the system. A layer‐by‐layer four‐level information encryption and decryption as well as a two‐level encrypted 3D code are successfully achieved.
Adamantyl‐capped AD‐CsPbBr3 perovskite nanorods and their cyclodextrin‐coated counterparts, mCD@AD‐CsPbBr3, display varied photoluminescent turn on/off or discoloration responses to four stimuli. This enables a sophisticated encoding system capable of multi‐level encryption and decryption, including intricate four‐layer encryption/decryption processes and a dual‐level 3D code.
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