Unsafe medication practices and medication errors are a major cause of harm in healthcare systems around the world. This study aimed to explore the factors that influence the risk of medication and ...provide medication risk evaluation model for adults in Shanxi province, China.
The data was obtained from the provincial questionnaire from May to December 2022, relying on the random distribution of questionnaires and online questionnaires by four hospitals in Shanxi Province. Multiple linear regression analysis was used to explore the factors affecting the KAP score of residents. Univariate and multivariate logistic regression was used to determine the independent risk factors, and the nomogram was verified by receiver operating characteristic curve, calibration and decision curve analysis.
A total of 3,388 questionnaires were collected, including 3,272 valid questionnaires. The average scores of drugs KAP were 63.2 ± 23.04, 33.05 ± 9.60, 23.67 ± 6.75 and 33.16 ± 10.87, respectively. On the evaluation criteria of the questionnaire, knowledge was scored "fair", attitude and practice were scored "good". Sex, monthly income, place of residence, insurance status, education level, and employment were regarded as independent risk factors for medication and a nomogram was established by them.
Males, low-income, and low-educated people are important factors affecting the risk of medication. The application of the model can help residents understand the risk of their own medication behavior and reduce the harm of medication.
The citrus fruit fly Bactrocera (Tetradacus) minax is a major and devastating agricultural pest in Asian subtropical countries. Previous studies have shown that B. minax interacts with plant hosts ...via the efficient chemosensory system. However, the molecular components of the B. minax chemosensory system have not been well characterized. Herein, we identified a total of 25 putative odorant-binding receptors (OBPs), 4 single-copy chemosensory proteins (CSPs) and 53 candidate odorant receptors (ORs) using a newly generated whole-genome dataset for B. minax. This study significantly extended the chemosensation-related gene profiles (particularly, OBPs and ORs) in six other tephritid species. Comparative transcriptome analysis of adult B. minax and Bactrocera dorsalis showed that there were 14 highly expressed OBPs (FPKM > 100) in B. dorsalis and 7 highly expressed ones in B. minax. The expression level of CSP3 gene and CSP4 gene was higher in B. dorsalis than that in B. minax. Comparative genomic and transcriptomic analyses of chemosensory genes in the citrus fruit fly B. minax provided new insights for preventive control of this agriculture important pest and closely related species.
ABSTRACT Photometric and spectroscopic observations of a slowly declining, luminous Type Ia supernova (SN Ia) SN 2011hr in the starburst galaxy NGC 2691 are presented. SN 2011hr is found to peak at , ...with a postmaximum decline rate Δm15(B) = 0.92 0.03 mag. From the maximum-light bolometric luminosity, , we estimate the mass of synthesized 56Ni in SN 2011hr to be . SN 2011hr appears more luminous than SN 1991T at around maximum light, and the absorption features from its intermediate-mass elements (IMEs) are noticeably weaker than those of the latter at similar phases. Spectral modeling suggests that SN 2011hr has IMEs of ∼0.07 in the outer ejecta, which is much lower than the typical value of normal SNe Ia (i.e., 0.3-0.4 ) and is also lower than the value of SN 1991T (i.e., ∼0.18 ). These results indicate that SN 2011hr may arise from a Chandrasekhar-mass white dwarf progenitor that experienced a more efficient burning process in the explosion. Nevertheless, it is still possible that SN 2011hr may serve as a transitional object connecting the SN 1991T-like SNe Ia with a superluminous subclass like SN 2007if given that the latter also shows very weak IMEs at all phases.
We study the ground state phases of quasi-one-dimensional spin-orbit coupled spin-1 Bose-Einstein condensates trapped in harmonic potential. Based on variational analysis, the conditions of phase ...transition between magnetized and unmagnetized phases are obtained analytically for the first time, and the physical mechanism of inducing phase transition is revealed. The competition relationship among spin-independent interaction, spin-dependent interaction, spin-orbit (SO) coupling and harmonic potential for generating phase transition is discussed systematically. We predict that the spin-dependent interaction plays key role in ground state phase transition. Interestingly, the phase transition of the ground state degenerate to the single particle case in free space when spin-dependent interaction is absent. In addition, the harmonic potential strengthens the influence of atomic interactions on the phase boundary. Our results provide theoretical evidence for deep understanding the ground sate phase transition of the system.
•Magnetized and non-magnetized phases of trapped SO coupled spin-1 BECs are studied.•The phase transition condition is obtained analytically for the first time.•The physical mechanism of inducing phase transition is revealed explicitly.•The spin-dependent interaction and trapping potential play key role in phase transition.•We provide theoretical evidence for manipulating the ground sate of the system.
Although popular users are more influential on social media, there may be a popularity fallacy in their public participation. We examined the relationship between the popularity of the most ...influential verified users (also known as "Big Vs") of Sina Weibo and their participation in 63 of the most salient public issues from 2013 to 2016. The results support the existence of the popularity fallacy for Big Vs. Although the popularity of Big Vs has an indirect positive impact on their public participation because of the mediation of public influence, their popularity also has a direct negative impact on their public participation. Overall, their popularity hurts their public participation. We further explain the findings from the perspective of Big Vs' occupational categories and impression management strategies. The results of this study shed light on our understanding of the limited role played by social media in influencing public participation.
Soil microbial communities play a crucial role in the accumulation and stabilization of soil organic carbon (SOC) through complex processes involving plant residue transformation and mineral ...interactions. These processes are influenced by plant inputs and modulated by soil properties that are mostly determined by the parent material. However, our understanding is limited regarding the manner in which vegetation and parent material affect microbial community structure, necromass accumulation, and their subsequent impact on SOC storage. To bridge this knowledge gap, we conducted an in-depth investigation focusing on the top-down influence of vegetation type and the bottom-up effect of parent material on microbial-mediated carbon transformation across soil profiles in a tropical region. Our study encompassed 42 sites on three parent materials (basalt, granite, and marine sediments) and four vegetation types (rubber, banana, areca plantations and uncultivated grassland). Soil samples were collected at 0–20, 20–40, 40–80, and 80–100 cm depth. Microbial community structure and necromass were quantified using microbial biomarkers of phospholipid fatty acids and amino sugars, respectively. In rubber plantations, we observed a trend toward higher microbial biomass that, though not significant when compared to other vegetation types, transformed to a significantly higher accumulation of microbial necromass. This increase in microbial necromass was linked to the accumulation of SOC facilitated by the presence of clay size minerals in clayey soils developed from basalt. In particular, basaltic soils were dominated by bacteria, which facilitated the accumulation of bacterial necromass that significantly bolstered its contribution to SOC. In contrast, in sandier soils developed from granite and marine sediments, fungal communities and necromass dominated due to the propensity of fungi for coarser soil environments. Overall, the main impact of vegetation on microbial communities and necromass accumulation was primarily demonstrated for the topsoil. Differences in soil texture arising from different parent materials exert significant effects on the fungal-to bacterial-biomass and necromass ratios, consequently influencing the contribution of fungal and bacterial necromass carbon to SOC across soil profiles. Our study underscores the pivotal role of parent material in governing tropical profile-scale soil carbon storage by shaping the structure of microbial communities and influencing the retention of microbial necromass.
•Soils in rubber plantations showed higher microbial necromass content than other vegetation types.•Parent material had a greater influence on microbial necromass retention than vegetation.•Clayey basaltic soils retain more microbial necromass and SOC, dominated by G+ bacteria.•Bacteria dominate basaltic soils, while fungi prevail in sandy granite and marine sediment soils.
Cancer immunotherapy restores or enhances the effector function of T cells in the tumor microenvironment, but the efficacy of immunotherapy has been hindered by therapeutic resistance. Here, we ...identify the proto-oncogene serine/threonine protein kinase PIM2 as a novel negative feedback regulator of IFNγ-elicited tumor inflammation, thus endowing cancer cells with aggressive features. Mechanistically, IL1β derived from IFNγ-polarized tumor macrophages triggered PIM2 expression in cancer cells via the p38 MAPK/Erk and NF-κB signaling pathways. PIM2+ cancer cells generated by proinflammatory macrophages acquired the capability to survive, metastasize, and resist T-cell cytotoxicity and immunotherapy. A therapeutic strategy combining immune checkpoint blockade (ICB) with IL1β blockade or PIM2 kinase inhibition in vivo effectively and successfully elicited tumor regression. These results provide insight into the regulatory and functional features of PIM2+ tumors and suggest that strategies to influence the functional activities of inflammatory cells or PIM2 kinase may improve the efficacy of immunotherapy.
Cross-talk between T cells and macrophages regulates cancer cell PIM2 expression to promote cancer aggressiveness, revealing translational approaches to improve response to ICB in hepatocellular carcinoma.
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•Designed new luotonin A-derived scaffold with flexible skeleton.•Demonstrating potent anti-proliferation and Topo I inhibition.•Inhibiting the Topo I via a mode differ from those of ...CPT and luteolin.•Showing weak DNA damage effect and low genotoxicity compared with CPT.•Displaying potent antitumor efficiency in vivo with low toxicity.
Conventional topoisomerase (Topo) inhibitors typically usually exert their cytotoxicity by damaging the DNAs, which exhibit high toxicity and tend to result in secondary carcinogenesis risk. Molecules that have potent topoisomerase inhibitory activity but involve less DNA damage provide more desirable scaffolds for developing novel chemotherapeutic agents. In this work, we broke the rigid pentacyclic system of luotonin A and synthesized thirty-three compounds as potential Topo inhibitors based on the devised molecular motif. Further investigation disclose that two compounds with the highest antiproliferation activity against cancer cells, 5aA and 5dD, had a distinct Topo I inhibitory mechanism different from those of the classic Topo I inhibitors CPT or luteolin, and were able to obviate the obvious cellular DNA damage typically associated with clinically available Topo inhibitors. The animal model experiments demonstrated that even in mice treated with a high dosage of 50 mg/kg 5aA, there were no obvious signs of toxicity or loss of body weight. The tumor growth inhibition (TGI) rate was 54.3 % when 20 mg/kg 5aA was given to the T24 xenograft mouse model, and 5aA targeted the cancer tissue precisely without causing damage to the liver and other major organs.
Abstract
Linearly homomorphic signatures (LHSs) allow any entity to linearly combine a set of signatures and to provide authentication service for the corresponding (combined) data. The public key of ...the current known LHSs from lattices in the standard model requires $O(l)$ matrices and $O(k)$ vectors, where $l$ is the length of file identifier and $k$ is the maximum data set size that linear functions support. In this paper, we construct two lattice-based LHS schemes with provable security in the standard model and both schemes can authenticate vectors defined over finite field. First, we present a basic LHS scheme satisfying selective security, based on the full-rank difference hash functions. Second, we modify the chameleon hash function constructed by (Cash, D., Hofheinz, D., Kiltz, E. and Peikert, C. (2010) Bonsai Trees, or How to Delegate a Lattice Basis. In Proc. EUROCRYPT 10, Monaco/French Riviera, May 30 to June 3, pp. 523–552. Springer, Berlin) to construct a linearly homomorphic chameleon hash function (LHCHF), which can be applied to all transformations from selectively secure LHS scheme that authenticates vectors defined over finite field $\mathbb{F}_{p}$ ($p=poly(n)$) to fully secure one, except for a new one that authenticates vectors defined over a small field. Starting from LHCFH and the basic scheme as above, we obtain a fully secure LHS scheme. Both schemes can be used to sign multiple files and have relatively short public keys consisting of $O(1)$ matrices and $O(k)$ vectors.
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