Abstract JSNS $$^2$$ 2 (J-PARC Sterile Neutrino Search at J-PARC Spallation Neutron Source) is an experiment that searches for sterile neutrinos via the observation of $$\bar{\nu }_{\mu } ...\rightarrow \bar{\nu }_{e}$$ ν ¯ μ → ν ¯ e appearance oscillations using muon decay-at-rest neutrinos. The JSNS $$^2$$ 2 experiment performed data taking from 2021. In this manuscript, a study of the accidental background is presented. The rate of the accidental background is ( $$9.29\pm 0.39) \times 10^{-8}$$ 9.29 ± 0.39 ) × 10 - 8 /spill with 0.75 MW beam power and comparable to the expected number of signal events.
The core fucosylation ( alpha 1,6-fucosylation) of glycoproteins is widely distributed in mammalian tissues, and is altered under pathological conditions. To investigate physiological functions of ...the core fucose, we generated alpha 1,6-fucosyltransferase (Fut8)-null mice and found that disruption of Fut8 induces severe growth retardation and death during postnatal development. Histopathological analysis revealed that Fut8 super(-/-) mice showed emphysema-like changes in the lung, verified by a physiological compliance analysis. Biochemical studies indicated that lungs from Fut8 super(-/-) mice exhibit a marked overexpression of matrix metalloproteinases (MMPs), such as MMP-12 and MMP-13, highly associated with lung-destructive phenotypes, and a down-regulation of extracellular matrix (ECM) proteins such as elastin, as well as retarded alveolar epithelia cell differentiation. These changes should be consistent with a deficiency in TGF- beta 1 signaling, a pleiotropic factor that controls ECM homeostasis by down-regulating MMP expression and inducing ECM protein components. In fact, Fut8 super(-/-) mice have a marked dysregulation of TGF- beta 1 receptor activation and signaling, as assessed by TGF- beta 1 binding assays and Smad2 phosphorylation analysis. We also show that these TGF- beta 1 receptor defects found in Fut8 super(-/-) cells can be rescued by reintroducing Fut8 into Fut8 super(-/-) cells. Furthermore, exogenous TGF- beta 1 potentially rescued emphysema-like phenotype and concomitantly reduced MMP expression in Fut8 super(-/-) lung. We propose that the lack of core fucosylation of TGF- beta 1 receptors is crucial for a developmental and progressive/destructive emphysema, suggesting that perturbation of this function could underlie certain cases of human emphysema.
In the GAMMA 10 tandem mirror, Magneto Hydro Dynamic (MHD) stabilization is kept with quadruple minimum-B anchor configuration. In the previous heating experiments, Ion-Cyclotron Range of Frequency ...(ICRF) antenna installed in the central cell was used for the anchor heating. Fast Alfvén wave excited in the central cell is partly converted to the slow wave in the nonaxisymmetric transition region between the central and the anchor cells, and heats ions in the minimum-B well. In order to produce higher performance plasmas in the central cell, the ion heating should be enhanced in the anchor cell. In this study, an experiment is carried out in the anchor cell to heat ions by ICRF waves without mode conversion. A bar-type antenna is installed in the anchor cell. Applied frequency is adjusted to ion-cyclotron resonance frequency in the minimum-B well. By the additional ion heating with the bar-type antenna, remarkable increase in the diamagnetic signal has been observed in the anchor cell. It is confirmed that the additional heating by the bar-type antenna can also keep MHD stabilization.
The recent molecular cloning of the complementary DNA encoding T cell--replacing factor (TRF) has demonstrated that a single molecule is responsible for B cell growth factor II (BCGF-II) activity and ...eosinophil differentiation activity. It has been proposed that this molecule be called interleukin 5 (IL-5). We previously reported that purified rIL-5 supports the terminal differentiation and proliferation of eosinophilic precursors. In this study, we examined the effects of IL-5 on functional activities of mature eosinophils. IL-5 maintained the viability of mature eosinophils obtained from peritoneal exudate cells of mice infected with parasites. It also induced superoxide anion production in a dose-dependent manner. The Boyden's chamber Millipore assay revealed that IL-5 had a marked chemokinetic effect on eosinophils in a dose-dependent manner. Moreover, IL-5 was found to be an eosinophil chemotactic factor by the checkerboard assay. In conclusion, IL-5 is suggested to play an important role in increasing the functional activities of eosinophils as well as their production in allergic and parasitic diseases.
Recent progress and near future plan of GAMMA 10 efforts are presented. With high power plug electron cyclotron heating (ECH) up to ~400 kW, the ion confining potential of more than 2 kV was ...confirmed. The drift type low frequency fluctuations were suppressed by the positive radial electric field produced by plug ECH. It is found that the efficient EC heating on mirror devices from a strong B field side requires the minimization of the stray microwave in addition to the 100% X-mode excitation to avoid the enhancement of the ion loss. The development of a gyrotron, the key tool of these ECH experiments, has been made in collaboration with NIFS (National Institute for Fusion Science), More than 1.5 MW for more than 1s has been demonstrated at 77GHz. The plan of the boundary plasma research program with modification of GAMMA 10 is in progress. The new program includes the physics and technology studies of the divertor and SOL plasmas and PWI relevant to torus plasmas like ITER. The high heat flux experiments using the open end mirror throat has been started and we have obtained successful preliminary data, which include the heat flux of 8 MW/m
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Development of a new in-ring beam monitor in the Rare-RI Ring Omika, S.; Yamaguchi, T.; Tadano, N. ...
Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms,
01/2020, Letnik:
463
Journal Article
Recenzirano
A beam monitor is developed at the Rare-RI Ring storage ring facility at the RI beam factory at RIKEN. Because the Rare-RI Ring stores only a single exotic ion according to the operation principle, ...conventional beam instruments cannot be employed. In the present study, we design a simple monitoring system to confirm particle storage. The system comprises a thin foil and scintillators with photon sensors. When an ion passes through the foil, secondary electrons, including δ-rays, are emitted and are detected by a set of scintillation detectors without any guiding field. A beam test using 78Ge with 175 MeV/nucleon successfully demonstrates the periodic revolution of the stored ions.
We investigated two families with Wilson disease in which siblings showed different clinical phenotypes and different ages at onset. In Family 1, the second and fourth male children demonstrated ...onset of the neurological type of Wilson disease at 16 and 28 years of age, respectively, and the first female child developed the hepatic type at 38 years of age. In Family 2, the second male child showed neurological symptoms at 32 years of age and was diagnosed as having the hepatoneurological type of Wilson disease; then the 35-year-old first female child was found to have the hepatic type by familial screening. We performed mutation analysis of the ATP7B gene for these patients, and found that the mutation was a compound heterozygote in both families. Previous reports of siblings with Wilson disease have shown an identical clinical phenotype and similar ages at onset. In addition, hepatic-type cases generally occur at lower ages compared with the neurological type. In the present investigation, however, younger patients showed neurological symptoms earlier than their older siblings, and clinical phenotypes differed among siblings in both families. These cases appear to be rare. Individual differences in copper accumulation in hepatic cells and intolerance to copper toxicity might be the reason for this phenomenon. Furthermore, there might be a difference in the dominance of the allele expressing ATP7B protein among these cases, resulting in different clinical phenotypes, because all patients of both families were found to be compound heterozygotes.
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