Our current knowledge of cosmic star-formation history during the first two billion years (corresponding to redshift z > 3) is mainly based on galaxies identified in rest-frame ultraviolet light
. ...However, this population of galaxies is known to under-represent the most massive galaxies, which have rich dust content and/or old stellar populations. This raises the questions of the true abundance of massive galaxies and the star-formation-rate density in the early Universe. Although several massive galaxies that are invisible in the ultraviolet have recently been confirmed at early epochs
, most of them are extreme starburst galaxies with star-formation rates exceeding 1,000 solar masses per year, suggesting that they are unlikely to represent the bulk population of massive galaxies. Here we report submillimetre (wavelength 870 micrometres) detections of 39 massive star-forming galaxies at z > 3, which are unseen in the spectral region from the deepest ultraviolet to the near-infrared. With a space density of about 2 × 10
per cubic megaparsec (two orders of magnitude higher than extreme starbursts
) and star-formation rates of 200 solar masses per year, these galaxies represent the bulk population of massive galaxies that has been missed from previous surveys. They contribute a total star-formation-rate density ten times larger than that of equivalently massive ultraviolet-bright galaxies at z > 3. Residing in the most massive dark matter haloes at their redshifts, they are probably the progenitors of the largest present-day galaxies in massive groups and clusters. Such a high abundance of massive and dusty galaxies in the early Universe challenges our understanding of massive-galaxy formation.
A four-component scattering model is proposed to decompose polarimetric synthetic aperture radar (SAR) images. The covariance matrix approach is used to deal with the nonreflection symmetric ...scattering case. This scheme includes and extends the three-component decomposition method introduced by Freeman and Durden dealing with the reflection symmetry condition that the co-pol and the cross-pol correlations are close to zero. Helix scattering power is added as the fourth component to the three-component scattering model which describes surface, double bounce, and volume scattering. This helix scattering term is added to take account of the co-pol and the cross-pol correlations which generally appear in complex urban area scattering and disappear for a natural distributed scatterer. This term is relevant for describing man-made targets in urban area scattering. In addition, asymmetric volume scattering covariance matrices are introduced in dependence of the relative backscattering magnitude between HH and VV. A modification of probability density function for a cloud of dipole scatterers yields asymmetric covariance matrices. An appropriate choice among the symmetric or asymmetric volume scattering covariance matrices allows us to make a best fit to the measured data. A four-component decomposition algorithm is developed to deal with a general scattering case. The result of this decomposition is demonstrated with L-band Pi-SAR images taken over the city of Niigata, Japan.
Lecticans are a family of chondroitin sulfate proteoglycans, encompassing aggrecan, versican, neurocan and brevican. These proteoglycans are characterized by the presence of a hyaluronan-binding ...domain and a C-type lectin domain in their core proteins. Through these domains, lecticans interact with carbohydrate and protein ligands in the extracellular matrix and act as linkers of these extracellular matrix molecules. In adult brain, lecticans are thought to interact with hyaluronan and tenascin-R to form a ternary complex. We propose that the hyaluronan-lectican-tenascin-R complex constitutes the core assembly of the adult brain extracellular matrix, which is found mainly in pericellular spaces of neurons as 'perineuronal nets'.
This paper describes an adaptive control to realize the desired steering characteristics on a vehicle. As is well known, the steering characteristics indicate handling performance on a vehicle and ...are important for safe driving. In this paper, a strategy to adjust it to a driver's preference easily using a steer-by-wire system is proposed. The control system including the proposed method intervenes only when the front tire cornering stiffness undergoes many changes. Then, the estimated self-aligning torque is fed back to the steering wheel so that a driver can feel reaction torque from the road. This is one of the remarkable features in the proposed steer-by-wire system. Numerical simulation and experiment are carried out to show the validity of the proposed method.
A four-component decomposition scheme of the coherency matrix is presented here for the analysis of polarimetric synthetic aperture radar (SAR) images. The coherency matrix is used to deal with ...nonreflection symmetric scattering case, which is an extension of covariance matrix approach. The same decomposition results have been obtained. The advantage of this approach is explicit expressions of four scattering powers in terms of scattering matrix elements, which serve the interpretation of polarimetric SAR data quantitatively
Breast milk is the most effective strategy to protect infants against necrotizing enterocolitis (NEC), a devastating disease that is characterized by severe intestinal necrosis. Previous studies have ...demonstrated that the lipopolysaccharide receptor Toll-like receptor 4 (TLR4) plays a critical role in NEC development via deleterious effects on mucosal injury and repair. We now hypothesize that breast milk protects against NEC by inhibiting TLR4 within the intestinal epithelium, and sought to determine the mechanisms involved. Breast milk protected against NEC and reduced TLR4 signaling in wild-type neonatal mice, but not in mice lacking the epidermal growth factor receptor (EGFR), whereas selective removal of EGF from breast milk reduced its protective properties, indicating that breast milk inhibits NEC and attenuates TLR4 signaling via EGF/EGFR activation. Overexpression of TLR4 in the intestinal epithelium reversed the protective effects of breast milk. The protective effects of breast milk occurred via inhibition of enterocyte apoptosis and restoration of enterocyte proliferation. Importantly, in IEC-6 enterocytes, breast milk inhibited TLR4 signaling via inhibition of glycogen synthase kinase-3β (GSK3β). Taken together, these findings offer mechanistic insights into the protective role for breast milk in NEC, and support a link between growth factor and innate immune receptors in NEC pathogenesis.
The glass state of matter represents a frozen state of an atomically disordered system with local order only. Instead of atoms, systems with glassy states of magnetic and electric dipole moments in ...solids are known as spin and dipole glasses, respectively. In these conventional glasses, slow dynamics, such as relaxation and memory phenomena, are characteristics of their magnetic/dielectric properties. Here we propose a new glassy state in solids, a 'toroidal glass', in which toroidal moments-vector-like electromagnetic multipole moments breaking both space inversion and time reversal symmetries, and producing a linear magnetoelectric coupling-are randomly oriented and frozen. We investigate the dynamics of a linear magnetoelectric effect in Ni0.4Mn0.6TiO3 and find that the magnetoelectric responses strongly depend on the magnetoelectric cooling history and show striking memory effects. These unusual magnetoelectric dynamical features can be explained in the framework of a toroidal glass in which the toroidal frozen state can be controlled magnetoelectrically.
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