Abstract
A quantum thermal machine is an open quantum system coupled to hot and cold thermal baths. Thus, its dynamics can be well understood using the concepts and tools from non-Hermitian quantum ...systems. A hallmark of non-Hermiticity is the existence of exceptional points where the eigenvalues of a non-Hermitian Hamiltonian or a Liouvillian superoperator and their associated eigenvectors coalesce. Here, we report the experimental realization of a single-ion heat engine and demonstrate the effect of Liouvillian exceptional points on the dynamics and the performance of a quantum heat engine. Our experiments have revealed that operating the engine in the exact- and broken-phases, separated by a Liouvillian exceptional point, respectively during the isochoric heating and cooling strokes of an Otto cycle produces more work and output power and achieves higher efficiency than executing the Otto cycle completely in the exact phase where the system has an oscillatory dynamics and higher coherence. This result opens interesting possibilities for the control of quantum heat engines and will be of interest to other research areas that are concerned with the role of coherence and exceptional points in quantum processes and in work extraction by thermal machines.
Salt substitutes with reduced sodium levels and increased potassium levels have been shown to lower blood pressure, but their effects on cardiovascular and safety outcomes are uncertain.
We conducted ...an open-label, cluster-randomized trial involving persons from 600 villages in rural China. The participants had a history of stroke or were 60 years of age or older and had high blood pressure. The villages were randomly assigned in a 1:1 ratio to the intervention group, in which the participants used a salt substitute (75% sodium chloride and 25% potassium chloride by mass), or to the control group, in which the participants continued to use regular salt (100% sodium chloride). The primary outcome was stroke, the secondary outcomes were major adverse cardiovascular events and death from any cause, and the safety outcome was clinical hyperkalemia.
A total of 20,995 persons were enrolled in the trial. The mean age of the participants was 65.4 years, and 49.5% were female, 72.6% had a history of stroke, and 88.4% a history of hypertension. The mean duration of follow-up was 4.74 years. The rate of stroke was lower with the salt substitute than with regular salt (29.14 events vs. 33.65 events per 1000 person-years; rate ratio, 0.86; 95% confidence interval CI, 0.77 to 0.96; P = 0.006), as were the rates of major cardiovascular events (49.09 events vs. 56.29 events per 1000 person-years; rate ratio, 0.87; 95% CI, 0.80 to 0.94; P<0.001) and death (39.28 events vs. 44.61 events per 1000 person-years; rate ratio, 0.88; 95% CI, 0.82 to 0.95; P<0.001). The rate of serious adverse events attributed to hyperkalemia was not significantly higher with the salt substitute than with regular salt (3.35 events vs. 3.30 events per 1000 person-years; rate ratio, 1.04; 95% CI, 0.80 to 1.37; P = 0.76).
Among persons who had a history of stroke or were 60 years of age or older and had high blood pressure, the rates of stroke, major cardiovascular events, and death from any cause were lower with the salt substitute than with regular salt. (Funded by the National Health and Medical Research Council of Australia; SSaSS ClinicalTrials.gov number, NCT02092090.).
An automated computational methodology to extract agricultural crop fields from 30m Web Enabled Landsat data (WELD) time series is presented. The results for three 150×150km WELD tiles encompassing ...rectangular, circular (center-pivot irrigation) and irregularly shaped fields in Texas, California and South Dakota are presented and compared to independent United States Department of Agriculture (USDA) National Agricultural Statistics Service (NASS) cropland data layer (CDL) classifications. Coherent fields that are visually apparent were extracted with relatively limited apparent errors of omission or commission compared to the CDL classifications. This is due to several factors. First, the use of multi-temporal Landsat data, as opposed to single Landsat acquisitions, that enables crop rotations and inter-annual variability in the state of the vegetation to be accommodated for and provides more opportunities for cloud-free, non-missing and atmospherically uncontaminated surface observations. Second, the adoption of an object-based approach, namely the variational region-based geometric active contour method that enables robust segmentation with only a small number of parameters and that requires no training data. Third, the use of a watershed algorithm to decompose connected segments belonging to multiple fields into coherent isolated field segments and a geometry-based algorithm to detect and associate parts of circular fields together. A preliminary validation is presented to gain quantitative insights into the field extraction accuracy and to prototype a validation protocol including new geometric measures that quantify the accuracy of individual field objects. Implications and recommendations for future research and large-area applications are discussed.
•Fully automated crop field extraction method applicable to large areas•Object-based crop field extraction•Uses multi-temporal WELD data•High qualitative correspondence of field extractions with U.S. National Agricultural Statistical Service cropland data layer products.•New geometric measures to quantify the accuracy of individual field objects demonstrated.
One of the outstanding challenges to information processing is the eloquent suppression of energy consumption in the execution of logic operations. The Landauer principle sets an energy constraint in ...deletion of a classical bit of information. Although some attempts have been made to experimentally approach the fundamental limit restricted by this principle, exploring the Landauer principle in a purely quantum mechanical fashion is still an open question. Employing a trapped ultracold ion, we experimentally demonstrate a quantum version of the Landauer principle, i.e., an equality associated with the energy cost of information erasure in conjunction with the entropy change of the associated quantized environment. Our experimental investigation substantiates an intimate link between information thermodynamics and quantum candidate systems for information processing.
Stalling during translation triggers ribosome quality control (RQC) to maintain proteostasis. Recently, stalling has also been linked to the activation of integrated stress response (ISR) by Gcn2. ...How the two processes are coordinated is unclear. Here, we show that activation of RQC by Hel2 suppresses that of Gcn2. We further show that Hel2 and Gcn2 are activated by a similar set of agents that cause ribosome stalling, with maximal activation of Hel2 observed at a lower frequency of stalling. Interestingly, inactivation of one pathway was found to result in the overactivation of the other, suggesting that both are activated by the same signal of ribosome collisions. Notably, the processes do not appear to be in direct competition with each other; ISR prefers a vacant A site, whereas RQC displays no preference. Collectively, our findings provide important details about how multiple pathways that recognize stalled ribosomes coordinate to mount the appropriate response.
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•Hel2 attenuates Gcn2-mediated activation of integrated stress response and vice versa•Gcn2 is activated in response to conditions that promote ribosome collisions•Stalling-induced integrated stress response prefers ribosomes with empty A sites•Hel2-mediated ubiquitination is more sensitive to stalling relative to Gcn2 activation
Ribosome stalling activates ribosome quality control (RQC) and integrated stress response, but how the two process are coordinated is unclear. Yan and Zaher show that although both processes are activated in response to ribosome collisions, RQC is more sensitive to changes to translation dynamics and responds quickly to lower collision frequency.
Most nonequilibrium processes in thermodynamics are quantified only by inequalities; however, the Jarzynski relation presents a remarkably simple and general equality relating nonequilibrium ...quantities with the equilibrium free energy, and this equality holds in both the classical and quantum regimes. We report a single-spin test and confirmation of the Jarzynski relation in the quantum regime using a single ultracold ^{40}Ca^{+} ion trapped in a harmonic potential, based on a general information-theoretic equality for a temporal evolution of the system sandwiched between two projective measurements. By considering both initially pure and mixed states, respectively, we verify, in an exact and fundamental fashion, the nonequilibrium quantum thermodynamics relevant to the mutual information and Jarzynski equality.
At over 40years, the Landsat satellites provide the longest temporal record of space-based land surface observations, and the successful 2013 launch of the Landsat-8 is continuing this legacy. ...Ideally, the Landsat data record should be consistent over the Landsat sensor series. The Landsat-8 Operational Land Imager (OLI) has improved calibration, signal to noise characteristics, higher 12-bit radiometric resolution, and spectrally narrower wavebands than the previous Landsat-7 Enhanced Thematic Mapper (ETM+). Reflective wavelength differences between the two Landsat sensors depend also on the surface reflectance and atmospheric state which are difficult to model comprehensively. The orbit and sensing geometries of the Landsat-8 OLI and Landsat-7 ETM+ provide swath edge overlapping paths sensed only one day apart. The overlap regions are sensed in alternating backscatter and forward scattering orientations so Landsat bi-directional reflectance effects are evident but approximately balanced between the two sensors when large amounts of time series data are considered. Taking advantage of this configuration a total of 59 million 30m corresponding sensor observations extracted from 6317 Landsat-7 ETM+ and Landsat-8 OLI images acquired over three winter and three summer months for all the conterminous United States (CONUS) are compared. Results considering different stages of cloud and saturation filtering, and filtering to reduce one day surface state differences, demonstrate the importance of appropriate per-pixel data screening. Top of atmosphere (TOA) and atmospherically corrected surface reflectance for the spectrally corresponding visible, near infrared and shortwave infrared bands, and derived normalized difference vegetation index (NDVI), are compared and their differences quantified. On average the OLI TOA reflectance is greater than the ETM+ TOA reflectance for all bands, with greatest differences in the near-infrared (NIR) and the shortwave infrared bands due to the quite different spectral response functions between the sensors. The atmospheric correction reduces the mean difference in the NIR and shortwave infrared but increases the mean difference in the visible bands. Regardless of whether TOA or surface reflectance are used to generate NDVI, on average, for vegetated soil and vegetation surfaces (0≤NDVI≤1), the OLI NDVI is greater than the ETM+ NDVI. Statistical functions to transform between the comparable sensor bands and sensor NDVI values are presented so that the user community may apply them in their own research to improve temporal continuity between the Landsat-7 ETM+ and Landsat-8 OLI sensor data. The transformation functions were developed using ordinary least squares (OLS) regression and were fit quite reliably (r2 values>0.7 for the reflectance data and >0.9 for the NDVI data, p-values<0.0001).
•National-scale 30m Landsat 7 ETM+ Landsat 8 OLI data comparison•Characterization of sensor reflectance and NDVI differences•Statistical functions to transform between comparable sensor bands and NDVI
Reliable satellite monitoring of agriculture is often difficult because surface variations occur rapidly compared to the cloud-free satellite observation frequency. Harmonic time series models, i.e., ...superimposed sequences of sines and cosines, have an established provenance for fitting satellite vegetation index time series to coarse resolution satellite data, but their application to medium resolution Landsat data for crop monitoring has been limited. Non-linear harmonic models have been shown to perform well over agricultural sites using single-year Moderate Resolution Imaging Spectroradiometer (MODIS) time series, but have not been explored with Landsat data. The 2017 availability of Landsat Analysis Ready Data (ARD) over the United States provides the opportunity to investigate the utility of temporally rich Landsat data for 30 m pixel-level crop monitoring. In this paper, the capability of 5- and 7-parameter linear harmonic models and a 5-parameter non-linear harmonic model applied to a year of Landsat 5 Thematic Mapper (TM) and Landsat 7 Enhanced Thematic Mapper Plus (ETM+) ARD is investigated. The analysis is undertaken over six sites, each defined by a 5000 × 5000 30 m pixel ARD tile, that together include the major conterminous United States (CONUS) crops identified by inspection of the United States Department of Agriculture (USDA) Cropland Data Layer (CDL). The model fits are evaluated as the root mean square difference (RMSD) between the fitted and the observed Landsat data. Considering locations with at least 21 annual Landsat observations, the 7-parameter linear harmonic model (tile mean crop NDVI RMSD values ranging from 0.052 to 0.072) and the 5-parameter non-linear harmonic model (tile mean crop NDVI RMSD values ranging from 0.054 to 0.074) are shown to be able to fit annual Landsat NDVI time series for most CONUS crops, whereas the 5-parameter linear harmonic model cannot (tile mean crop NDVI RMSD values ranging from 0.072 to 0.099). If there are between 15 and 20 annual Landsat observations, the 5-parameter non-linear harmonic model is recommended for fitting annual NDVI crop time series, and if there are ≥21 observations, then either the 5-parameter non-linear or the 7-parameter linear model can be used. The 7-parameter model had marginally smaller mean NDVI RMSD values but larger standard deviations than the 5-parameter non-linear model, likely due to the relative robustness of the non-linear model to over-fitting and oscillations. None of the models could reliably fit crops with multiple stages, such as alfalfa, that are insufficiently sampled using combined Landsat 5 TM and Landsat 7 ETM+ time series. Given the utility of the growing season peak NDVI for crop yield applications, the date and magnitude of the model fitted peak NDVI are compared to quantify model reporting differences. The differences between the 7-parameter linear and the 5-parameter non-linear harmonic models are not large. For each ARD tile, the mean absolute differences in the estimated peak NDVI days varied from <2 days in the northern ARD tiles, which had short growing seasons and similar crops, to less than a week for the other tiles except for nearly 10 days for the California tile that had longer growing seasons and more diverse crops including crops with multiple stages. The paper concludes with a discussion and recommendations for future research.
•Harmonic model fitting on crops using single-year Landsat 5 and 7 time series•Landsat ARD data•First application of non-linear harmonic model to Landsat time series•NDVI models fitted per-pixel in six 5000 × 5000 30 m agricultural ARD tiles•Considered all major U.S. crop types
Quantum gates induced by geometric phases are intrinsically robust against noise due to the global properties of their evolution paths. Compared to conventional nonadiabatic geometric quantum ...computation, the recently proposed nonadiabatic noncyclic geometric quantum computation (NNGQC) works in a faster fashion while still remaining the robust feature of the geometric operations. Here, we experimentally implement the NNGQC in a single trapped ultracold 40Ca+ ion to verify the noise-resilient and fast feature. By performing unitary operations under imperfect conditions, we witness the advantages of the NNGQC with measured fidelities by quantum process tomography in comparison to other two quantum gates by conventional nonadiabatic geometric quantum computation and by straightforward dynamical evolution. Our results provide the first evidence confirming the possibility of accelerated quantum information processing with limited systematic errors even in an imperfect situation.
Patients with diverticular disease are frequently advised to avoid eating nuts, corn, popcorn, and seeds to reduce the risk of complications. However, there is little evidence to support this ...recommendation.
To determine whether nut, corn, or popcorn consumption is associated with diverticulitis and diverticular bleeding.
The Health Professionals Follow-up Study is a cohort of US men followed up prospectively from 1986 to 2004 via self-administered questionnaires about medical (biennial) and dietary (every 4 years) information. Men reporting newly diagnosed diverticulosis or diverticulitis were mailed supplemental questionnaires.
The study included 47,228 men aged 40 to 75 years who at baseline were free of diverticulosis or its complications, cancer, and inflammatory bowel disease and returned a food-frequency questionnaire.
Incident diverticulitis and diverticular bleeding.
During 18 years of follow-up, there were 801 incident cases of diverticulitis and 383 incident cases of diverticular bleeding. We found inverse associations between nut and popcorn consumption and the risk of diverticulitis. The multivariate hazard ratios for men with the highest intake of each food (at least twice per week) compared with men with the lowest intake (less than once per month) were 0.80 (95% confidence interval, 0.63-1.01; P for trend = .04) for nuts and 0.72 (95% confidence interval, 0.56-0.92; P for trend = .007) for popcorn. No associations were seen between corn consumption and diverticulitis or between nut, corn, or popcorn consumption and diverticular bleeding or uncomplicated diverticulosis.
In this large, prospective study of men without known diverticular disease, nut, corn, and popcorn consumption did not increase the risk of diverticulosis or diverticular complications. The recommendation to avoid these foods to prevent diverticular complications should be reconsidered.
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