This study explored the relationship between visceral adiposity index (VAI) and cervical arterial atherosclerosis in a total of 3688 residents aged ≥40 in northeast China. The VAI could be a ...practical indicator for cervical artery atherosclerosis, especially for carotid plaque and moderate‐to‐severe atherosclerosis (multiple plaques and stenosis). The correlations were more significant in non‐overweight or obese, non‐central obesity and non‐hypertriglyceridemic waist phenotype (HTWP) participants
Background and purpose
The burden of cervical arterial atherosclerosis, which is an important risk factor of stroke, is huge in China. The visceral adiposity index (VAI) is a convenient index that is related to a series of metabolic abnormalities and a variety of diseases, including cerebrovascular diseases. This study aimed to explore the relationship between VAI and cervical arterial atherosclerosis.
Methods
This cross‐sectional study used the multistage stratified random cluster sampling method to acquire a representative sample of residents aged ≥40 in the general population of northeast China. All participants completed a detailed questionnaire and provided blood samples. Cervical vascular ultrasound was performed by experienced ultrasound doctors. VAI was calculated by a well‐established formula and analyzed by quartiles (Q1–Q4).
Results
A total of 3688 people aged ≥40 years who underwent cervical arterial ultrasound were finally included, amongst whom 3.2% had increased intima‐media thickness (IMT), 48.6% had carotid plaque and 4.0% had cervical artery stenosis (CAS). After adjusting for several parameters, little statistical significance was found between VAI and increased IMT; compared with the VAI‐Q1 group, the VAI‐Q2, VAI‐Q3 and VAI‐Q4 groups were more likely to have CAS odds ratio (OR) 2.01, 95% confidence interval (CI) 1.17–3.43; OR 1.82, 95% CI 1.05–3.15; OR 1.79, 95% CI 1.03–3.12 and the VAI‐Q3 and VAI‐Q4 groups were at greater risk of carotid plaque (OR 1.30, 95% CI 1.05–1.62; OR 1.34, 95% CI 1.07–1.67).
Conclusions
The VAI was related to carotid plaque and CAS in the general population that is older than 40 years.
Erratic eating behavior disrupts the daily feeding and fasting pattern and leads to metabolic dysfunction and chronic diseases including cancer. In the present study, we tested the hypothesis that ...time-restricted feeding of a high-fat diet (HFD) to the dark phase does not enhance mammary tumorigenesis in MMTV-PyMT mice. Female mice were assigned to 3 groups and fed the standard AIN93G diet or an HFD with or without dark phase restricted feeding (12 hours). The duration of restricted feeding was 8 weeks. The HFD group had 24% more body fat mass than the AIN93G group; the body fat mass of the restricted group remained similar to that of the AIN93G group. Energy intake of the restricted group was similar to that of the HFD and AIN93G groups. The median mammary tumor latency was 5.8, 7.0, and 6.4 weeks for the AIN93G, HFD, and restricted groups, respectively. Mammary tumor progression was 241% higher in the HFD group than that in the AIN93G group; there was no significant difference in tumor progression between the restricted and AIN93G groups. Plasma concentrations of leptin, monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, angiopoietin-2, vascular endothelial growth factor, and hepatocyte growth factor were significantly higher in the HFD group than those in the control group; these measurements were similar between the restricted and control groups. In conclusion, feeding restricted to the dark phase mitigates the HFD-enhanced mammary tumorigenesis; this may be related to the lower body adiposity and associated inflammatory and angiogenic signals.
Oxidation and alkylation of nucleobases are known to disrupt their base-pairing properties within RNA. It is, however, unclear whether organisms have evolved general mechanism(s) to deal with this ...damage. Here we show that the mRNA-surveillance pathway of no-go decay and the associated ribosome-quality control are activated in response to nucleobase alkylation and oxidation. Our findings reveal that these processes are important for clearing chemically modified mRNA and the resulting aberrant-protein products. In the absence of Xrn1, the level of damaged mRNA significantly increases. Furthermore, deletion of LTN1 results in the accumulation of protein aggregates in the presence of oxidizing and alkylating agents. This accumulation is accompanied by Hel2-dependent regulatory ubiquitylation of ribosomal proteins. Collectively, our data highlight the burden of chemically damaged mRNA on cellular homeostasis and suggest that organisms evolved mechanisms to counter their accumulation.
The rest-frame ultraviolet properties of galaxies during the first three billion years of cosmic time (redshift z > 4) indicate a rapid evolution in the dust obscuration of such galaxies. This ...evolution implies a change in the average properties of the interstellar medium, but the measurements are systematically uncertain owing to untested assumptions and the inability to detect heavily obscured regions of the galaxies. Previous attempts to measure the interstellar medium directly in normal galaxies at these redshifts have failed for a number of reasons, with two notable exceptions. Here we report measurements of the forbidden C ii emission (that is, C II) from gas, and the far-infrared emission from dust, in nine typical star-forming galaxies about one billion years after the Big Bang (z ≈ 5-6). We find that these galaxies have thermal emission that is less than 1/12 that of similar systems about two billion years later, and enhanced C II emission relative to the far-infrared continuum, confirming a strong evolution in the properties of the interstellar medium in the early Universe. The gas is distributed over scales of one to eight kiloparsecs, and shows diverse dynamics within the sample. These results are consistent with early galaxies having significantly less dust than typical galaxies seen at z < 3 and being comparable in dust content to local low-metallicity systems.
Straw return is an important management tool for tackling and promoting soil nutrient conservation and improving crop yield in Huang-Huai-Hai Plain, China. Although the incorporation of maize straw ...with deep plowing and rotary tillage practices are widespread in the region, only few studies have focused on rotation tillage. To determine the effects of maize straw return on the nitrogen （N） efficiency and grain yield of winter wheat （Triticum aestivum L.）, we conducted experiments in this region for 3 years. Five treatments were tested： （i） rotary tillage without straw return （RT）; （ii） deep plowing tillage without straw return （DT）; （iii） rotary tillage with total straw return （RS）; （iv） deep plowing tillage with total straw return （DS）; （v） rotary tillage of 2 years and deep plowing tillage in the 3rd year with total straw return （TS）. Treatments with straw return increased kernels no. ear-1, thousand-kernel weight （TKW）, grain yields, ratio of dry matter accumulation post-anthesis, and nitrogen （N） efficiency whereas reduced the ears no. ha-1 in the 2011-2012 and 2012-2013 growing seasons. Compared with the rotary tillage, deep plowing tillage significantly increased the grain yield, yield components, total dry matter accumulation, and N efficiency in 2013-2014. RS had significantly higher straw N distribution, soil inorganic nitrogen content, and soil enzymes activities in the 0-10 cm soil layer compared with the DS and TS. However, significantly lower values were ob- served in the 10-20 and 20-30 cm soil layers. TS obtained approximately equal grain yield as DS, and it also reduced the resource costs. Therefore, we conclude that TS is the most economical method for increasing grain yield and N efficiency of winter wheat in Huang-Huai-Hai Plain.
Dissipation is vital to any cyclic process in realistic systems. Recent research focus on nonequilibrium processes in stochastic systems has revealed a fundamental trade-off, called dissipation-time ...uncertainty relation, that entropy production rate associated with dissipation bounds the evolution pace of physical processes Phys. Rev. Lett. 125, 120604 (2020)PRLTAO0031-900710.1103/PhysRevLett.125.120604. Following the dissipative two-level model exemplified in the same Letter, we experimentally verify this fundamental trade-off in a single trapped ultracold ^{40}Ca^{+} ion using elaborately designed dissipative channels, along with a postprocessing method developed in the data analysis, to build the effective nonequilibrium stochastic evolutions for the energy transfer between two heat baths mediated by a qubit. Since the dissipation-time uncertainty relation imposes a constraint on the quantum speed regarding entropy flux, our observation provides the first experimental evidence confirming such a speed restriction from thermodynamics on quantum operations due to dissipation, which helps us further understand the role of thermodynamical characteristics played in quantum information processing.
We present multiwavelength observations of the tidal disruption event (TDE) iPTF15af, discovered by the intermediate Palomar Transient Factory survey at redshift z = 0.07897. The optical and ...ultraviolet (UV) light curves of the transient show a slow decay over 5 months, in agreement with previous optically discovered TDEs. It also has a comparable blackbody peak luminosity of . The inferred temperature from the optical and UV data shows a value of (3-5) × 104 K. The transient is not detected in X-rays up to within the first 5 months after discovery. The optical spectra exhibit two distinct broad emission lines in the He ii region, and at later times also H emission. Additionally, emission from N iii and O iii is detected, likely produced by the Bowen fluorescence effect. UV spectra reveal broad emission and absorption lines associated with high-ionization states of N v, C iv, Si iv, and possibly P v. These features, analogous to those of broad absorption line quasars (BAL QSOs), require an absorber with column densities cm−2. This optically thick gas would also explain the nondetection in soft X-rays. The profile of the absorption lines with the highest column density material at the largest velocity is opposite that of BAL QSOs. We suggest that radiation pressure generated by the TDE flare at early times could have provided the initial acceleration mechanism for this gas. Spectral UV line monitoring of future TDEs could test this proposal.
Background & Aims Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, have been implicated in diverticular complications. We examined the influence of aspirin and NSAID use on risk of ...diverticulitis and diverticular bleeding in a large prospective cohort. Methods We studied 47,210 US men in the Health Professionals Follow-up Study cohort who were 40–75 years old at baseline in 1986. We assessed use of aspirin, nonaspirin NSAIDs, and other risk factors biennially. We identified men with diverticulitis or diverticular bleeding based on responses to biennial and supplementary questionnaires. Results We documented 939 cases of diverticulitis and 256 cases of diverticular bleeding during a 22-year period of follow-up evaluation. After adjustment for risk factors, men who used aspirin regularly (≥2 times/wk) had a multivariable hazard ratio (HR) of 1.25 (95% confidence interval CI, 1.05–1.47) for diverticulitis and a HR of 1.70 (95% CI, 1.21–2.39) for diverticular bleeding, compared with nonusers of aspirin and NSAIDs. Use of aspirin at intermediate doses (2–5.9 standard, 325-mg tablets/wk) and frequency (4–6 days/wk) were associated with the highest risk of bleeding (multivariable HR, 2.32; 95% CI, 1.34–4.02, and multivariable HR, 3.13; 95% CI, 1.82–5.38, respectively). Regular users of nonaspirin NSAIDs also had an increased risk of diverticulitis (multivariable HR, 1.72; 95% CI, 1.40–2.11) and diverticular bleeding (multivariable HR, 1.74; 95% CI, 1.15–2.64), compared with men who denied use of these medications. Conclusions Regular use of aspirin or NSAIDs is associated with an increased risk of diverticulitis and diverticular bleeding. Patients at risk of diverticular complications should carefully consider the potential risks and benefits of using these medications.
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