In this paper, the damage initiation/propagation mechanisms and failure modes of open-hole carbon fiber-reinforced thermoplastic composites and thermosetting composites with tension, compression, and ...bearing loads are investigated, respectively, by experiments and finite element simulations. The experimental evaluations are performed on the specimens using the Combined Loading Compression (CLC) test method, the tensile test method, and the single-shear test method. The differences in macroscopic damage initiation, evolution mode, and damage characteristics between thermoplastic composite materials and thermosetting composite material open-hole structures are obtained and analyzed under compressive load. Based on scanning electron microscope SEM images, a comparative analysis is conducted on the micro-failure modes of fibers, matrices, and fiber/matrix interfaces in the open-hole structures of thermoplastic and thermosetting composites under compressive load. The differences between thermoplastic and thermosetting composites were analyzed from the micro-failure mechanism. Finally, based on continuum damage mechanics (CDM), a damage model is also developed for predicting the initiation and propagation of damage in thermoplastic composites. The model, which can capture fiber breakage and matrix crack, as well as the nonlinear response, is used to conduct virtual compression tests, tensile test, and single-shear test, respectively. Numerical simulation results are compared with the extracted experimental results. The displacement-load curve and failure modes match the experimental result, which indicates that the finite element model has good reliability.
Monodisperse poly(acrylic acid)‐modified Fe3O4 (PAA@Fe3O4) hybrid microspheres with dual responses (magnetic field and pH) were successfully fabricated. The PAA polymer was encapsulated into the ...inner cavity of Fe3O4 hollow spheres by a vacuum‐casting route and photo‐initiated polymerization. TEM images show that the samples consist of monodisperse porous spheres with a diameter around 200 nm. The Fe3O4 spheres, after modification with the PAA polymer, still possess enough space to hold guest molecules. We selected doxorubicin (DOX) as a model drug to investigate the drug loading and release behavior of as‐prepared composites. The release of DOX molecules was strongly dependent on the pH value due to the unique property of PAA. The HeLa cell‐uptake process of DOX‐loaded PAA@Fe3O4 was observed by confocal laser scanning microscopy (CLSM). After being incubated with HeLa cells under magnet magnetically guided conditions, the cytotoxtic effects of DOX‐loaded PAA@Fe3O4 increased. These results indicate that pH‐responsive magnetic PAA@Fe3O4 spheres have the potential to be used as anticancer drug carriers.
Dual response: Monodisperse poly(acrylic acid)‐modified Fe3O4 (PAA@Fe3O4) hybrid microspheres with dual responses (magnetic field and pH) were successfully fabricated (see figure). The drug release behavior was strongly dependent on pH value due to the unique properties of PAA. Furthermore, doxorubicin (DOX)‐loaded PAA@Fe3O4 composites show an enhanced magnetically guided anticancer effect.
The carotenoids, including lycopene, lutein, astaxanthin, and zeaxanthin belong to the isoprenoids, whose basic structure is made up of eight isoprene units, resulting in a C40 backbone, though some ...of them are only trace components in Euglena. They are essential to all photosynthetic organisms due to their superior photoprotective and antioxidant properties. Their dietary functions decrease the risk of breast, cervical, vaginal, and colorectal cancers and cardiovascular and eye diseases. Antioxidant functions of carotenoids are based on mechanisms such as quenching free radicals, mitigating damage from reactive oxidant species, and hindering lipid peroxidation. With the development of carotenoid studies, their distribution, functions, and composition have been identified in microalgae and higher plants. Although bleached or achlorophyllous mutants of Euglena were among the earliest carotenoid-related microalgae under investigation, current knowledge on the composition and biosynthesis of these compounds in Euglena is still elusive. This review aims to overview what is known about carotenoid metabolism in Euglena, focusing on the carotenoid distribution and structure, biosynthesis pathway, and accumulation in Euglena strains and mutants under environmental stresses and different culture conditions. Moreover, we also summarize the potential applications in therapy preventing carcinogenesis, cosmetic industries, food industries, and animal feed.
•Proposed a robust multiobjective control operation and risk decision-making model.•Introduced Conditional Value-at-Risk to approximate extreme flood damage.•Revealed mechanism of robust flood ...control operation in different flood events.•Reduced maximum reservoir release by 7.33% in adverse scenarios.
Forecast uncertainty in real-time flood forecasting is the primary source of risk regarding reservoir flood control operation, affecting both reliability and safety of the entire system. Informing reservoir operation for real-time flood control coping with forecast uncertainty encourages overall robust control of risk probability, vulnerability, and resilience of upstream and downstream protection areas. Current stochastic programming models or chance constrained programming models (CCP) focuses on reducing either risk loss or vulnerability, thereby failing to ensure systematic control. This study established a robust multiobjective operation and risk decision-making model to inform reservoir operations. The proposed model includes three modules. First, a copula function was applied to capture multidimensional temporal dependences of forecast uncertainties, following which stochastic inflow scenarios were generated. Second, a robust multiobjective optimization (RMOO) model was established with the objectives of minimizing the probability of risk events, Conditional Value-at-Risk of risk loss (vulnerability) and the maximum sequential duration for both upstream and downstream areas. Then, an adaptive reference multiobjective evolutionary algorithm was used to solve the model and obtain noninferior solutions. Finally, the TOPSIS multicriteria decision-making method was introduced to select the compromise solution. Methodologies were verified by application to Xianghongdian reservoir, China. The main findings were as follows. (1) The copula function effectively captured the multidimensional positive temporal dependences of forecast uncertainties. (2) RMOO provided more widely distributed noninferior solutions than CCP, and performed better in lowering vulnerability of the system. (3) RMOO reduced the maximum release by 135.6 m3/s (7.33%) by increasing prerelease before the occurrence of flood peak. The proposed methodologies provide insights for supporting robust control of real-time operations of a reservoir system through simultaneous control of flood risk probability, vulnerability, and resilience.
Double aortic arch (DAA) with subaortic left brachiocephalic vein (LBCV) and right‐side ductus arteriosus (RDA) was not reported before delivery, only in adults with anatomy course findings. We ...present a case of fetal DAA with subaortic LBCV and RDA using high‐definition (HD) flow render mode and spatiotemporal image correlation (STIC).
Background
Accurate delineation of cancer margins is critical for endoscopic curative resection. This study aimed to train and validate real-time fully convolutional networks for delineating the ...resection margin of early gastric cancer (EGC) under indigo carmine chromoendoscopy (CE) or white light endoscopy (WLE), and evaluated its performance and that of magnifying endoscopy with narrow-band imaging (ME-NBI).
Methods
We collected CE and WLE images of EGC lesions to train fully convolutional networks ENDOANGEL. ENDOANGEL was tested both on stationary images and endoscopic submucosal dissection (ESD) videos. The accuracy and reliability of ENDOANGEL and NBI-dependent delineation were further evaluated by a novel endoscopy–pathology point-to-point marking.
Results
ENDOANGEL had an accuracy of 85.7% in the CE images and 88.9% in the WLE images under an overlap ratio threshold of 0.60 in comparison with the manual markers labeled by the experts. In the ESD videos, the resection margins predicted by ENDOANGEL covered all areas of high-grade intraepithelial neoplasia and cancers. The minimum distance between the margins predicted by ENDOANGEL and the histological cancer boundary was 3.44 ± 1.45 mm which outperformed the resection margin based on ME-NBI.
Conclusions
ENDOANGEL has the potential to assist endoscopists in delineating the resection extent of EGC under CE or WLE during ESD.
Although domesticated tomato is cultivated by wild tomato, there are a lot of differences between cultivated tomato and wild tomato, such as shape, physiological function and life history. Many ...studies show that wild tomato has better salt resistance and drought resistance. In addition to, domesticated tomato's fruit is bigger and has more nutritious than wild tomato. The different features are closely related to differentially expressed genes. We identified 126 up-regulated differentially expressed genes and 87 down-regulated differentially expressed genes in cultivated tomato and wild tomato by RNA-Seq. These differentially expressed genes may be associated with salt resistance, drought resistance and fruit nutrition. These differentially expressed genes also further highlight the large-scale reconstruction between wild and cultivated species. In this paper, we mainly study GO enrichment analysis and pathway analysis of the differentially expressed genes. After GO and pathway enrichment analysis, a set of significantly enriched GO annotations and pathways were identified for the differentially expressed genes. What's more, we also identified long non-coding RNAs and mRNAs in the two species and analyzed its essential features. In addition to, we construct a co-expression network of long non-coding RNAs and mRNAs, and annotate mRNAs associated with long non-coding RNAs as target genes, and speculate the regulation function of long non-coding RNAs. In total, our results reveal the effects of artificial and natural selection on tomato's transcript, providing scientific basis for tomato's research in the future.
The “curse of dimensionality” is a major problem in dynamic programming (DP) algorithms for large-scale hydropower systems. This study proposes a parallel DP algorithm based on Spark (PDPoS) to ...alleviate the “curse of dimensionality”. Parallel computing experiments are formulated by varying the number of reservoirs, the number of discrete water levels and the number of CPU cores to analyze the quality and efficiency of PDPoS. The methodologies were applied to a cascade reservoir system made up of eight reservoirs in the Yuanshui River Basin in China. The results are as follows. (1) The number of discrete water levels is the dominant factor in the solution quality, while the number of reservoirs is the dominant factor in the solving efficiency. (2) The runtime of PDPoS is markedly affected by the calculational scale (determined by the number of reservoirs and discrete water levels), and the relationship between the number of CPU cores and the runtime is triphasic with increasing calculational scale. (3) The larger the calculational scale is, the better the parallel performance (i.e., the parallel speedup and parallel efficiency). The proposed PDPoS method has strong generality, high parallel performance, and high practical value.
The interface between 2D topological Dirac states and an s‐wave superconductor is expected to support Majorana‐bound states (MBS) that can be used for quantum computing applications. Realizing these ...novel states of matter and their applications requires control over superconductivity and spin‐orbit coupling to achieve spin‐momentum‐locked topological interface states (TIS) which are simultaneously superconducting. While signatures of MBS have been observed in the magnetic vortex cores of bulk FeTe0.55Se0.45, inhomogeneity and disorder from doping make these signatures unclear and inconsistent between vortices. Here superconductivity is reported in monolayer (ML) FeTe1–ySey (Fe(Te,Se)) grown on Bi2Te3 by molecular beam epitaxy (MBE). Spin and angle‐resolved photoemission spectroscopy (SARPES) directly resolve the interfacial spin and electronic structure of Fe(Te,Se)/Bi2Te3 heterostructures. For y = 0.25, the Fe(Te,Se) electronic structure is found to overlap with the Bi2Te3 TIS and the desired spin‐momentum locking is not observed. In contrast, for y = 0.1, reduced inhomogeneity measured by scanning tunneling microscopy (STM) and a smaller Fe(Te,Se) Fermi surface with clear spin‐momentum locking in the topological states are found. Hence, it is demonstrated that the Fe(Te,Se)/Bi2Te3 system is a highly tunable platform for realizing MBS where reduced doping can improve characteristics important for Majorana interrogation and potential applications.
Bulk FeTe0.55Se0.45 is a promising candidate for topological superconductivity but the inhomogeneity from doping raises doubts about the existence of Majorana modes. This work explores thin films of FeTe1‐ySey (Fe(Te,Se)) grown on Bi2Te3 that reveal superconductivity at the monolayer limit. Control over the interfacial electronic structure is demonstrated to maintain the spin‐momentum locking necessary for topological superconductivity with significantly less doping.
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