Curiosity investigated active eolian sands near linear dunes during Phase 2 of the Bagnold Dunes campaign in Gale crater, Mars. Ogunquit Beach, a sample scooped from a large‐ripple trough within the ...Mount Desert Island ripple field and delivered to the Chemistry and Mineralogy (CheMin) X‐ray diffraction instrument, is dominated by basaltic igneous minerals and X‐ray amorphous materials. CheMin mineralogy of the Gobabeb sample acquired at a large‐ripple crest on the Namib barchan dune during Phase 1 is similar to Ogunquit Beach. Ogunquit Beach, however, contains more plagioclase and Gobabeb contains more olivine. Compact Reconnaissance Imaging Spectrometer for Mars (CRISM)‐based estimates of mineralogy at the optical surface of Namib Dune and Mount Desert Island demonstrate that surface sands are enriched in olivine and depleted in plagioclase over Mount Desert Island relative to Namib Dune. Differences between CheMin‐derived and CRISM‐derived mineralogies suggest sorting by grain size on bedform to dune field scales. Crystal chemistry from CheMin suggests contributions from multiple igneous sources and the local bedrock.
Plain Language Summary
Remote sensing data from orbit indicate that wind‐blown sands in the Bagnold Dune Field in Gale crater, Mars, are sorted by their composition. The Mars Science Laboratory Curiosity rover studied the Bagnold Dune Field at two locations to investigate the chemical and mineral composition of the sands and why they are sorted across the dune field. Data from Curiosity show distinct differences between the minerals in the upwind portion of the dune field compared to the downwind portion, but these differences are not the same as those observed from orbit. The scale and location of the sampling by Curiosity compared to orbiters explains the discrepancy between the two techniques. Results from both techniques suggest subtle differences in mineralogy within a single dune and across the dune field that can be explained by sorting from wind and contribution from the erosion of local bedrock.
Key Points
The mineralogy of active eolian sands were measured by the Curiosity rover at two locations in the Bagnold Dune Field in Gale crater, Mars
X‐ray diffraction data from the CheMin instrument of two sand samples indicate differences in plagioclase and olivine abundances
The mineralogy derived from CheMin and CRISM can be used in concert to characterize sediment sorting and sources across the Bagnold Dunes
This article provides an overview of current efforts in reducing energy consumption in passive optical access networks. Both ITU-T and IEEE standardized PONs are considered. The current solutions ...proposed by standardization authorities, industry, and academia are classified based on the layer they address in the standardized architectures: physical layer, data link layer, and hybrid. Then, the article provides answers to major questions, such as where, when, and how to reduce PON energy consumption in TDM PONs by means of a quantitative evaluation. Results show that to reduce energy consumption, ONUs must be provided with physical devices that are not only power-efficient but also provide improved services (e.g., fast synchronization) to upper layers. For this latter purpose, novel physical ONU architectures are proposed to speed up the synchronization process and enable effective data link layer solutions. Finally, the feasibility of switching ONUs to low power mode in idle slots is assessed through a testbed implementation.
In response to invading microorganisms, macrophages engage in phagocytosis and rapidly release reactive oxygen species (ROS), which serve an important microbicidal function. However, how phagocytosis ...induces ROS production remains largely unknown. CARD9, a caspase-recruitment domain (CARD)-containing protein, is important for resistance to fungal and bacterial infection. The mechanism of CARD9-mediated bacterial clearance is still mostly unknown. Here we show that CARD9 is required for killing intracellular bacteria in macrophages. CARD9 associated with the GDP-dissociation inhibitor LyGDI in phagosomes after bacterial and fungal infection and binding of CARD9 suppressed LyGDI-mediated inhibition of the GTPase Rac1, thereby leading to ROS production and bacterial killing in macrophages. Thus, our studies identify a key pathway that leads to microbe-elicited ROS production.
BACKGROUND
AABB requires that red blood cells (RBCs) are maintained at 1 to 10°C during transport. Historically, blood banks used the 30‐minute rule for returned RBCs transported outside of validated ...containers. The implications of this policy have not been previously reported in a real‐life hospital setting.
STUDY DESIGN AND METHODS
A 2‐year, retrospective review of RBC units returned outside of qualified containers was conducted. During the first year, the 30‐minute rule was used to accept RBCs back into inventory. Sequentially, the following year, a temperature‐based approach was implemented using a thermometer with an accuracy of ±1°C. Time out of the blood bank, temperature upon return, wastage, and transfusion reactions associated with the reissued RBCs were analyzed.
RESULTS
In our practice, the 30‐minute rule would have accepted 15.2% of RBC units outside of the allowed temperature. Compared to the 30‐minute rule, temperature‐based acceptance was associated with a 13% increase in wastage (p < 0.001). During the 30‐minute rule period, transfusion of returned and subsequently reissued RBCs was associated with a nonsignificant trend toward a higher transfusion reaction rate compared to the overall RBC transfusion reaction rate (1.4% vs. 0.6%, p = 0.084). During the temperature period, transfusion of returned and subsequently reissued RBCs had the same transfusion reaction rate compared to the overall RBC transfusion reaction rate (0.5% vs. 0.5%, p = 1.0).
CONCLUSION
Temperature‐based acceptance of returned RBCs is associated with significantly higher wastage compared to the 30‐minute rule. A temperature‐based acceptance practice mitigates the risk of accepting RBCs with unacceptable temperatures returned within 30 minutes of issue.
Corticotomy-assisted and osteotomy-assisted tooth movement involves surgical incisions through the alveolar bone. To ascertain whether teeth move by distraction osteogenesis or by regional ...accelerated phenomenon (RAP), we randomly assigned 30 Sprague-Dawley rats to one of 5 experimental groups: corticotomy alone, corticotomy-assisted tooth movement, osteotomy alone, osteotomy-assisted tooth movement, or tooth movement alone. Each animal was imaged by microtomography immediately after surgery, after 21 days, and after 2 months. After 21 days, regional accelerated phenomenon was observed in the alveolar bone of the corticotomy-treated animals and distraction osteogenesis in the osteotomy-assisted tooth movement animals. Pixel count data were analyzed by nested ANOVA for 5 experimental groups, split-mouth controls, 3 levels along the root, and 5 sites per level. The most demineralized sites after 21 days differed for each of the experimental groups. Our study indicates that osteotomies and corticotomies induce different alveolar bone reactions, which can be exploited for tooth movement.
Adenomyosis and risk of preterm delivery Juang, C‐M; Chou, P; Yen, M‐S ...
BJOG : an international journal of obstetrics and gynaecology,
February 2007, Letnik:
114, Številka:
2
Journal Article
Recenzirano
Objective To evaluate the risk of preterm delivery in patients with adenomyosis.
Design A 1:2 nested case–control study.
Setting Tertiary‐care institution.
Population A base cohort population of ...2138 pregnant women who attended routine prenatal check‐up between July 1999 and June 2005.
Methods From this base cohort population, gravid women with singleton pregnancy who delivered prior to the completion of 37 weeks of gestation were identified and formed the study group. Singleton gravid women who had term delivery and who matched with age, body mass index, smoking, and status of previous preterm delivery were recruited concurrently and served as control group. Preterm delivery cases were further divided into spontaneous preterm delivery and preterm premature rupture of membranes (PPROM) cases.
Main outcome measures Risk analysis of preterm delivery between gravid women with and without adenomyosis.
Results One‐hundred and four preterm delivery case subjects and 208 control subjects were assessed. Overall, gravid women with adenomyosis were associated with significantly increased risk of preterm delivery (adjusted odds ratio 1.96, 95% CI 1.23–4.47, P = 0.022). For subgroup analysis, gravid women with adenomyosis had an adjusted 1.84‐fold risk of spontaneous preterm delivery (95% CI 1.32–4.31, P = 0.012) and an adjusted 1.98‐fold risk of PPROM (95% CI 1.39–3.15, P = 0.017).
Conclusions Gravid women with adenomyosis were associated with increased risk of both spontaneous preterm delivery and PPROM. A common pathophysiological pathway may exist in these two disorders. Further in‐depth biochemical and molecular studies are necessary to explore this phenomenon.
Clay minerals provide indicators of the evolution of aqueous conditions and possible habitats for life on ancient Mars. Analyses by the Mars Science Laboratory rover Curiosity show that ~3.5-billion ...year (Ga) fluvio-lacustrine mudstones in Gale crater contain up to ~28 weight % (wt %) clay minerals. We demonstrate that the species of clay minerals deduced from x-ray diffraction and evolved gas analysis show a strong paleoenvironmental dependency. While perennial lake mudstones are characterized by Fe-saponite, we find that stratigraphic intervals associated with episodic lake drying contain Al-rich, Fe
-bearing dioctahedral smectite, with minor (3 wt %) quantities of ferripyrophyllite, interpreted as wind-blown detritus, found in candidate aeolian deposits. Our results suggest that dioctahedral smectite formed via near-surface chemical weathering driven by fluctuations in lake level and atmospheric infiltration, a process leading to the redistribution of nutrients and potentially influencing the cycling of gases that help regulate climate.
Diabetes mellitus has been a threat to humans for many years. Amongst the different diabetes types, type 2 diabetes mellitus is the most common, and this is due to drastic changes in human lifestyle ...such as lack of exercise, stressful life and so on. There are a large number of conventional treatment methods available for type 2 diabetes mellitus. However, most of these methods are curative and are only applicable when the patient is highly symptomatic. Effective treatment strategies should be geared towards interfering with cellular and bio molecular mechanisms associated with the development and sustenance of the disease. In recent years, research into the medical potential of nanoparticles has been a major endeavor within the pharmaceutical industries. Nanoparticles display unique and tuneable biophysical characteristics which are determined by their shape and size. Nanoparticles have been used to manifest the properties of drugs, and as carriers for drug and vaccine delivery. Notwithstanding, there are further opportunities for nanoparticles to augment the treatment of a wide range of life threatening diseases that are yet to be explored. This review article seeks to highlight the application of potential nano-formulations in the treatment of type 2 diabetes mellitus. In addition, the activity of nanomedicine supplements in reversing insulin resistance is also discussed.
Mechanical strain provides an anti-adipogenic, pro-osteogenic stimulus to mesenchymal stem cells (MSC) through generating intracellular signals and via cytoskeletal restructuring. Recently, mTORC2 ...has been shown to be a novel mechanical target critical for the anti-adipogenic signal leading to preservation of β-catenin. As mechanical activation of mTORC2 requires focal adhesions (FAs), we asked whether proximal signaling involved Src and FAK, which are early responders to integrin-FA engagement. Application of mechanical strain to marrow-derived MSCs was unable to activate mTORC2 when Src family kinases were inhibited. Fyn, but not Src, was specifically required for mechanical activation of mTORC2 and was recruited to FAs after strain. Activation of mTORC2 was further diminished following FAK inhibition, and as FAK phosphorylation (Tyr-397) required Fyn activity, provided evidence of Fyn/FAK cooperativity. Inhibition of Fyn also prevented mechanical activation of RhoA as well as mechanically induced actin stress fiber formation. We thus asked whether RhoA activation by strain was dependent on mTORC2 downstream of Fyn. Inhibition of mTORC2 or its downstream substrate, Akt, both prevented mechanical RhoA activation, indicating that Fyn/FAK affects cytoskeletal structure via mTORC2. We then sought to ascertain whether this Fyn-initiated signal pathway modulated MSC lineage decisions. siRNA knockdown of Fyn, but not Src, led to rapid attainment of adipogenic phenotype with significant increases in adipocyte protein 2, peroxisome proliferator-activated receptor gamma, adiponectin, and perilipin. As such, Fyn expression in mdMSCs contributes to basal cytoskeletal architecture and, when associated with FAs, functions as a proximal mechanical effector for environmental signals that influence MSC lineage allocation.
PDF
