•Unique restoration process of irradiation-induced metastable magnetic states of FeRh.•Significantly effect of ion fluence on magnetic restoration temperature.•Relations between ferromagnetic nature ...of FeRh and lattice defects.
The restoration process of irradiation-induced metastable magnetic states of FeRh thin films during the heat treatments at 373–1073 K was investigated by measuring the magnetization-magnetic field (M−H) curves and the magnetization-temperature (M−T) curves for the FeRh thin films irradiated with 50 keV Ar ions to various fluences. The recovery of lattice structures accompanying the magnetic restoration was also examined by an x-ray diffraction (XRD) measurement. For the ferromagnetic state induced by low fluence irradiation, the magnetic restoration to the thermal equilibrium antiferromagnetic state occurs during the heat treatment. Whereas for the paramagnetic state induced by high fluence irradiation, it once changes to the ferromagnetic state, and then, is restored to the antiferromagnetic (i.e., thermal equilibrium) state during the heat treatment. The above magnetic transformation occurs by the heat treatments at higher temperatures for the higher fluence irradiation. Moreover, the magnetic transition temperature from the antiferromagnetic state, which has been thermally restored from the irradiation induced ferromagnetic or paramagnetic state, to the ferromagnetic state decreases with increasing the irradiation fluence. This result implies that the antiferromagnetic state with larger amount of lattice defects is more unstable against the thermal vibration of lattice atoms.
SAMURAI spectrometer for RI beam experiments Kobayashi, T.; Chiga, N.; Isobe, T. ...
Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms,
12/2013, Letnik:
317
Journal Article
Recenzirano
A large-acceptance multiparticle spectrometer SAMURAI has been constructed at the RIKEN RI Beam Factory (RIBF) for RI beam experiments. It was designed primarily for kinematically complete ...experiments such as the invariant-mass spectroscopy of particle-unbound states in exotic nuclei, by detecting heavy fragments and projectile-rapidity nucleons in coincidence. The system consists of a superconducting dipole magnet, beam line detectors, heavy fragment detectors, neutron detectors, and proton detectors. The SAMURAI spectrometer was commissioned in March 2012, and a rigidity resolution of about 1/1500 was obtained for RI beams up to 2.4GeV/c.
Myristoylated Alanine-Rich C Kinase Substrate (MARCKS), a substrate of protein kinase C, is a key regulatory molecule controlling mucus granule secretion by airway epithelial cells as well as ...directed migration of leukocytes, stem cells and fibroblasts. Phosphorylation of MARKCS may be involved in these responses. However, the functionality of MARCKS and its related phosphorylation in lung cancer malignancy have not been characterized. This study demonstrated elevated levels of MARCKS and phospho-MARCKS in highly invasive lung cancer cell lines and lung cancer specimens from non-small-cell lung cancer patients. siRNA knockdown of MARCKS expression in these highly invasive lung cancer cell lines reduced cell migration and suppressed PI3K (phosphatidylinositol 3'-kinase)/Akt phosphorylation and Slug level. Interestingly, treatment with a peptide identical to the MARCKS N-terminus sequence (the MANS peptide) impaired cell migration in vitro and also the metastatic potential of invasive lung cancer cells in vivo. Mechanistically, MANS peptide treatment resulted in a coordination of increase of E-cadherin expression, suppression of MARCKS phosphorylation and AKT/Slug signalling pathway but not the expression of total MARCKS. These results indicate a crucial role for MARCKS, specifically its phosphorylated form, in potentiating lung cancer cell migration/metastasis and suggest a potential use of MARCKS-related peptides in the treatment of lung cancer metastasis.
We report on the first proton-induced single proton- and neutron-removal reactions from the neutron-deficient ^{14}O nucleus with large Fermi-surface asymmetry S_{n}-S_{p}=18.6 MeV at ∼100 ...MeV/nucleon, a widely used energy regime for rare-isotope studies. The measured inclusive cross sections and parallel momentum distributions of the ^{13}N and ^{13}O residues are compared to the state-of-the-art reaction models, with nuclear structure inputs from many-body shell-model calculations. Our results provide the first quantitative contributions of multiple reaction mechanisms including the quasifree knockout, inelastic scattering, and nucleon transfer processes. It is shown that the inelastic scattering and nucleon transfer, usually neglected at such energy regime, contribute about 50% and 30% to the loosely bound proton and deeply bound neutron removal, respectively. These multiple reaction mechanisms should be considered in analyses of inclusive one-nucleon removal cross sections measured at intermediate energies for quantitative investigation of single-particle strengths and correlations in atomic nuclei.
The nuclear structure of 66Se, nucleus beyond the N=Z line on the proton-rich side of the valley of stability, was investigated by the neutron knock-out reaction 67Se(12C,X)66Se using a 12C target. ...The analysis of the singles spectrum of the γ-rays emitted during the de-excitation of the populated low-lying excited states revealed two previously detected (927(4) keV, 1460(32) keV) and three new (744(6) keV, 1210(17) keV, 1661(23) keV) transitions. The 744-keV, the 1210-keV, and the 1460-keV transitions were found to be in coincidence with the one at 927 keV. The spectrum coincident with the 927-keV transition showed a further possible transition at 299(35) keV, which was obscured by significant atomic background in the singles spectrum. This transition might correspond to a peak previously reported at 273(5) keV that could not be assigned to 66Se unambiguously. Based on a comparison of the experimental data to theoretical calculations, four new excited states are proposed which suggest that 66Se exhibits shape coexistence.
Coccygeal pad associated with neurosyphilis Yoneda, K.; Kubota, Y.
Journal of the European Academy of Dermatology and Venereology,
June 2016, Letnik:
30, Številka:
6
Journal Article
The molecular mechanisms underlying the promotion of colorectal carcinogenesis by a high-fat diet (HFD) remain unclear. We investigated the role of the insulin-signal pathway and the c-Jun N-terminal ...kinase (JNK) pathway, which reportedly play crucial roles in insulin resistance, during colorectal carcinogenesis in the presence of hyperinsulinaemia induced by a HFD.
Azoxymethane-induced aberrant crypt foci formation and cell proliferation in the colonic epithelium were compared between mice fed a normal diet (ND) and mice fed a HFD. A western blot analysis was performed to elucidate the mechanism affecting colorectal carcinogenesis by a HFD.
The number of aberrant crypt foci and the colonic epithelial cell proliferative activity were significantly higher in the HFD group than in the ND group. While the plasma insulin level was significantly higher in the HFD group than in the ND group, a western blot analysis revealed the inactivation of Akt, which is located downstream of the insulin receptor, in the colonic epithelia of the HFD group. On the other hand, JNK activity was significantly higher in the HFD group than in the ND group. A JNK specific inhibitor significantly suppressed the increase in epithelial cell proliferation only under a HFD, but not under a ND.
Colonic cell proliferation was promoted via the JNK pathway in the presence of a HFD but not in the presence of a ND. This novel mechanism may explain the involvement of the JNK pathway in the effect of dietary fat intake on colon carcinogenesis.
The nuclear structure of 66 Se, nucleus beyond the N=Z line on the proton-rich side of the valley of stability, was investigated by the neutron knock-out reaction 67 Se( 12 C,X) 66 Se using a 12 C ...target. The analysis of the singles spectrum of the γ-rays emitted during the de-excitation of the populated low-lying excited states revealed two previously detected (927(4) keV, 1460(32) keV) and three new (744(6) keV, 1210(17) keV, 1661(23) keV) transitions. The 744-keV, the 1210-keV, and the 1460-keV transitions were found to be in coincidence with the one at 927 keV. The spectrum coincident with the 927-keV transition showed a further possible transition at 299(35) keV, which was obscured by significant atomic background in the singles spectrum. This transition might correspond to a peak previously reported at 273(5) keV that could not be assigned to 66 Se unambiguously. Based on a comparison of the experimental data to theoretical calculations, four new excited states are proposed which suggest that 66 Se exhibits shape coexistence.
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