Fringe-Field Switching (FFS) 모드는 모든 고화질 액정디스플레이에 적용되고 있다. FFS 모드의 전기광학 특성은 전극 구조, 위상지연값, 러빙각, 셀갭, 액정의 유전율 이방성 (Δε) 크기 및 부호와 같은 셀 및 액정 변수에 따라 크게 의존한다. 본 연구에서는 FFS 모드에서 유전율 이방성의 부호가 다르지만 크기가 동일한 조건에서 ...FFS모드의 전기광학 특성을 연구하였다. 연구 결과에 의하면 전압 인가시 Δε 절대값이 같더라도 유전율 이방성이 음인 액정의 경우가 탄성변형이 용이해 유전율 이방성 양인 액정에 비해 구동 전압이 약 10% 정도 낮은 결과를 보여주었다. 이러한 결과는 FFS모드의 본질을 이해하는데 큰 도움을 준다고 확신한다.
Recently, fringe field switching (FFS) mode in liquid crystal displays is mainly used for high image quality liquid crystal displays (LCDs). Electro-optic characteristics of FFS-LCDs liquid crystal (LC) depend on many cell parameters such as electrode structure, retardation, rubbing angle, cell gap and sign and magnitude of dielectric anisotropy. In this study, we have investigated electro-optic characteristics of the FFS mode as a function of a sign of dielectric anisotropy while keeping the magnitude of dielectric anisotropy of liquid crystals and other cell parameters to be the same. The results show that for the LC with negative dielectric anisotropy (-LC) shows lower operating voltage than that of a LC with positive dielectric anisotropy by about 10%, owing to easier elastic deformation responding to applied voltage in a -LC. The result will help understand the intrinsic switching behavior of the FFS mode.
Despite the importance of glucose and amino acids for energy metabolism, interactions between the two nutrients are not well understood. We provide evidence for a role of leucyl-tRNA synthetase 1 ...(LARS1) in glucose-dependent control of leucine usage. Upon glucose starvation, LARS1 was phosphorylated by Unc-51 like autophagy activating kinase 1 (ULK1) at the residues crucial for leucine binding. The phosphorylated LARS1 showed decreased leucine binding, which may inhibit protein synthesis and help save energy. Leucine that is not used for anabolic processes may be available for catabolic pathway energy generation. The LARS1-mediated changes in leucine utilization might help support cell survival under glucose deprivation. Thus, depending on glucose availability, LARS1 may help regulate whether leucine is used for protein synthesis or energy production.
Demand on the practical synthetic approach to the high performance electrocatalyst is rapidly increasing for fuel cell commercialization. Here we present a synthesis of highly durable and active ...intermetallic ordered face-centered tetragonal (fct)-PtFe nanoparticles (NPs) coated with a “dual purpose” N-doped carbon shell. Ordered fct-PtFe NPs with the size of only a few nanometers are obtained by thermal annealing of polydopamine-coated PtFe NPs, and the N-doped carbon shell that is in situ formed from dopamine coating could effectively prevent the coalescence of NPs. This carbon shell also protects the NPs from detachment and agglomeration as well as dissolution throughout the harsh fuel cell operating conditions. By controlling the thickness of the shell below 1 nm, we achieved excellent protection of the NPs as well as high catalytic activity, as the thin carbon shell is highly permeable for the reactant molecules. Our ordered fct-PtFe/C nanocatalyst coated with an N-doped carbon shell shows 11.4 times-higher mass activity and 10.5 times-higher specific activity than commercial Pt/C catalyst. Moreover, we accomplished the long-term stability in membrane electrode assembly (MEA) for 100 h without significant activity loss. From in situ XANES, EDS, and first-principles calculations, we confirmed that an ordered fct-PtFe structure is critical for the long-term stability of our nanocatalyst. This strategy utilizing an N-doped carbon shell for obtaining a small ordered-fct PtFe nanocatalyst as well as protecting the catalyst during fuel cell cycling is expected to open a new simple and effective route for the commercialization of fuel cells.
Background
Activated eosinophils release extracellular traps (EETs), which contribute to airway inflammation in severe asthma (SA). However, the role of EETs in innate immunity has not yet been ...completely determined. The present study aimed to demonstrate the mechanism of airway inflammation in SA mediated by EETs.
Methods
Peripheral counts of EET+ eosinophils and type 2 innate lymphoid cells (ILC2s) were evaluated in patients with SA (n = 13), nonsevere asthma (NSA, n = 17), and healthy control subjects (HC, n = 8). To confirm the effect of EETs, airway hyperresponsiveness (AHR) and adapted/innate immune responses were assessed in mice. Furthermore, the effects of anti‐IL‐33/TSLP antibody were tested.
Results
The numbers of EET+ eosinophils and ILC2s were significantly elevated in SA, with a positive correlation between these two cells (r = .539, P < .001). When mice were injected with EETs, we observed significant increases in epithelium‐derived cytokines (IL‐1α, IL‐1β, CXCL‐1, CCL24, IL‐33, and TSLP) and eosinophil/neutrophil count in bronchoalveolar lavage fluid (BALF) as well as an increased proportion of IL‐5‐ or IL‐13‐producing ILC2s in the lungs. When Rag1−/− mice receiving ILC2s were treated with EETs, increased AHR and IL‐5/IL‐13 levels in BALF were noted, which were effectively suppressed by anti‐IL‐33 or anti‐TSLP antibody.
Conclusion
EETs could enhance innate and type 2 immune responses in SA, in which epithelium‐targeting biologics (anti‐IL‐33/TSLP antibody) may have a potential benefit.
The numbers of EET+ eosinophils and type 2 innate lymphoid cells (ILC2s) are significantly elevated in severe asthma. EETs treatment in mice induces significant increase of epithelium‐derived cytokines (IL‐1α, IL‐1β, CXCL‐1, CCL24, IL‐33, and TSLP) and eosinophil/neutrophil count in bronchoalveolar lavage fluid. EETs activate IL‐5 or IL‐13‐producing ILC2s through stimulating airway epithelium.Abbreviations: EETs, Eosinophil extracellular traps; TSLP, Thymic stromal lymphopoietin
In patients with acute myocardial infarction receiving potent antiplatelet therapy, the bleeding risk remains high during the maintenance phase. We sought data on a uniform unguided de-escalation ...strategy of dual antiplatelet therapy (DAPT) from ticagrelor to clopidogrel after acute myocardial infarction.
In this open-label, assessor-masked, multicentre, non-inferiority, randomised trial (TALOS-AMI), patients at 32 institutes in South Korea with acute myocardial infarction receiving aspirin and ticagrelor without major ischaemic or bleeding events during the first month after index percutaneous coronary intervention (PCI) were randomly assigned in a 1:1 ratio to a de-escalation (clopidogrel plus aspirin) or active control (ticagrelor plus aspirin) group. Unguided de-escalation without a loading dose of clopidogrel was adopted when switching from ticagrelor to clopidogrel. The primary endpoint was a composite of cardiovascular death, myocardial infarction, stroke, or bleeding type 2, 3, or 5 according to Bleeding Academic Research Consortium (BARC) criteria from 1 to 12 months. A non-inferiority test was done to assess the safety and efficacy of de-escalation DAPT compared with standard treatment. The hazard ratio (HR) for de-escalation versus active control group in a stratified Cox proportional hazards model was assessed for non-inferiority by means of an HR margin of 1·34, which equates to an absolute difference of 3·0% in the intention-to-treat population and, if significant, a superiority test was done subsequently. To ensure statistical robustness, additional analyses were also done in the per-protocol population. This trial is registered at ClinicalTrials.gov, NCT02018055.
From Feb 26, 2014, to Dec 31, 2018, from 2901 patients screened, 2697 patients were randomly assigned: 1349 patients to de-escalation and 1348 to active control groups. At 12 months, the primary endpoints occurred in 59 (4·6%) in the de-escalation group and 104 (8·2%) patients in the active control group (pnon-inferiority<0·001; HR 0·55 95% CI 0·40–0·76, psuperiority=0·0001). There was no significant difference in composite of cardiovascular death, myocardial infarction, or stroke between de-escalation (2·1%) and the active control group (3·1%; HR 0·69; 95% CI 0·42–1·14, p=0·15). Composite of BARC 2, 3, or 5 bleeding occurred less frequently in the de-escalation group (3·0% vs 5·6%, HR 0·52; 95% CI 0·35–0·77, p=0·0012).
In stabilised patients with acute myocardial infarction after index PCI, a uniform unguided de-escalation strategy significantly reduced the risk of net clinical events up to 12 months, mainly by reducing the bleeding events.
ChongKunDang Pharm, Medtronic, Abbott, and Boston Scientific.
The hippocampus and parahippocampal region are essential for representing episodic memories involving various spatial locations and objects, and for using those memories for future adaptive behavior. ...The “dual‐stream model” was initially formulated based on anatomical characteristics of the medial temporal lobe, dividing the parahippocampal region into two streams that separately process and relay spatial and nonspatial information to the hippocampus. Despite its significance, the dual‐stream model in its original form cannot explain recent experimental results, and many researchers have recognized the need for a modification of the model. Here, we argue that dividing the parahippocampal region into spatial and nonspatial streams a priori may be too simplistic, particularly in light of ambiguous situations in which a sensory cue alone (e.g., visual scene) may not allow such a definitive categorization. Upon reviewing evidence, including our own, that reveals the importance of goal‐directed behavioral responses in determining the relative involvement of the parahippocampal processing streams, we propose the Goal‐directed Interaction of Stimulus and Task‐demand (GIST) model. In the GIST model, input stimuli such as visual scenes and objects are first processed by both the postrhinal and perirhinal cortices—the postrhinal cortex more heavily involved with visual scenes and perirhinal cortex with objects—with relatively little dependence on behavioral task demand. However, once perceptual ambiguities are resolved and the scenes and objects are identified and recognized, the information is then processed through the medial or lateral entorhinal cortex, depending on whether it is used to fulfill navigational or non‐navigational goals, respectively. As complex sensory stimuli are utilized for both navigational and non‐navigational purposes in an intermixed fashion in naturalistic settings, the hippocampus may be required to then put together these experiences into a coherent map to allow flexible cognitive operations for adaptive behavior to occur.
Background: The aim of this study was to examine the effects of the critical pathway for the admitted patients with type 2 diabetes mellitus on glycemic control, the knowledge on the disease, and the ...length of hospital stay. Methods: 89 diabetic in-patients were applied with the 1 week critical pathway which was consisted of intensive education program for self-management of diabetes mellitus such as glucose monitoring, excercise prescription, diet control, self-adjustment of the drugs and so on. The results were compared with 22 diabetic inpatients who were treated with conventional way. We assessed the effects of critical pathway on the degree of glycemic control, the knowledge on the disease, and the length of hospital stay. Results: Although fasting and postprandial 2 hours blood glucose levels did not showed statistically significant difference between critical pathway group and conventional group on discharge, HbA1c was significantly decreased in critical pathway group compared with the conventional group (7.5±1.8% vs 9.1±2.6%) on 3 months after discharge. Knowledge on the disease tended to increase in critical pathway group compared with the conventional group on discharge. The Length of hospital stay was significantly decreased in critical pathway group compared with the conventional group (8.4±2.8day vs 11.0±3.9day). Conclusion: These results showed that critical pathway for the patients with diabetes mellitus might be a useful way for improving the long term glycemic control through motivation, enhancing the knowledge on the disease as well as reducing the length of hospital stay.
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