By performing a full analysis of the projected local density of states (LDOS) in a photonic crystal waveguide, we show that phase plays a crucial role in the symmetry of the light-matter interaction. ...By considering a quantum dot (QD) spin coupled to a photonic crystal waveguide (PCW) mode, we demonstrate that the light-matter interaction can be asymmetric, leading to unidirectional emission and a deterministic entangled photon source. Further we show that understanding the phase associated with both the LDOS and the QD spin is essential for a range of devices that can be realized with a QD in a PCW. We also show how suppression of quantum interference prevents dipole induced reflection in the waveguide, and highlight a fundamental breakdown of the semiclassical dipole approximation for describing light-matter interactions in these spin dependent systems.
This paper describes a soil moisture data set from the 82,000 km2 Murrumbidgee River Catchment in southern New South Wales, Australia. Data have been archived from the Murrumbidgee Soil Moisture ...Monitoring Network (MSMMN) since its inception in September 2001. The Murrumbidgee Catchment represents a range of conditions typical of much of temperate Australia, with climate ranging from semiarid to humid and land use including dry land and irrigated agriculture, remnant native vegetation, and urban areas. There are a total of 38 soil moisture‐monitoring sites across the Murrumbidgee Catchment, with a concentration of sites in three subareas. The data set is composed of 0–5 (or 0–8), 0–30, 30–60, and 60–90 cm average soil moisture, soil temperature, precipitation, and other land surface model forcing at all sites, together with other ancillary data. These data are available on the World Wide Web at http://www.oznet.org.au.
Key Points
Soil moisture data set from 82,000 square km Murrumbidgee Catchment, Australia
Data from 2001 and ongoing at 38 soil moisture monitoring sites
Sub‐hourly data at 4 depths for each site available at http://www.oznet.org.au
Tumours are comprised of a highly heterogeneous population of cells, of which only a small subset of stem-like cells possess the ability to regenerate tumours in vivo. These cancer stem cells (CSCs) ...represent a significant clinical challenge as they are resistant to conventional cancer therapies and play essential roles in metastasis and tumour relapse. Despite this realization and great interest in CSCs, it has been difficult to develop CSC-targeted treatments due to our limited understanding of CSC biology. Here, we present evidence that specific histone deacetylases (HDACs) play essential roles in the CSC phenotype. Utilizing a novel CSC model, we discovered that the HDACs, HDAC1 and HDAC7, are specifically over-expressed in CSCs when compared to non-stem-tumour-cells (nsTCs). Furthermore, we determine that HDAC1 and HDAC7 are necessary to maintain CSCs, and that over-expression of HDAC7 is sufficient to augment the CSC phenotype. We also demonstrate that clinically available HDAC inhibitors (HDACi) targeting HDAC1 and HDAC7 can be used to preferentially target CSCs. These results provide actionable insights that can be rapidly translated into CSC-specific therapies.
Inertial confinement fusion implosions must achieve high in-flight shell velocity, sufficient energy coupling between the hot spot and imploding shell, and high areal density (ρR=∫ρdr) at stagnation. ...Asymmetries in ρR degrade the coupling of shell kinetic energy to the hot spot and reduce the confinement of that energy. We present the first evidence that nonuniformity in the ablator shell thickness (∼0.5% of the total thickness) in high-density carbon experiments is a significant cause for observed 3D ρR asymmetries at the National Ignition Facility. These shell-thickness nonuniformities have significantly impacted some recent experiments leading to ρR asymmetries on the order of ∼25% of the average ρR and hot spot velocities of ∼100 km/s. This work reveals the origin of a significant implosion performance degradation in ignition experiments and places stringent new requirements on capsule thickness metrology and symmetry.
In Alligator mississippiensis the spinal dura is surrounded by a venous sinus; pressure waves can propagate in the spinal venous blood, and these spinal venous pressures can be transmitted to the ...spinal cerebrospinal fluid (CSF). This study was designed to explore pressure transfer between the spinal venous blood and the spinal CSF. At rest the cardiac-related CSF pulsations are attenuated and delayed, while the ventilatory-related pulsations are amplified as they move from the spinal venous blood to the spinal CSF. Orthostatic gradients resulted in significant alterations of both cardiac- and ventilatory-related CSF pulsations. Manual lateral oscillations of the alligator's tail created pressure waves in the spinal CSF that propagated, with slight attenuation but no delay, to the cranial CSF. Oscillatory pressure pulsations in the spinal CSF and venous blood had little influence on the underlying ventilatory pulsations, though the same oscillatory pulsations reduced the ventilatory- and increased the cardiac-related pulsations in the cranial CSF. In Alligator the spinal venous anatomy creates a more complex pressure relationship between the venous and CSF systems than has been described in humans.
Inertial confinement fusion seeks to create burning plasma conditions in a spherical capsule implosion, which requires efficiently absorbing the driver energy in the capsule, transferring that energy ...into kinetic energy of the imploding DT fuel and then into internal energy of the fuel at stagnation. We report new implosions conducted on the National Ignition Facility (NIF) with several improvements on recent work Phys. Rev. Lett. 120, 245003 (2018)PRLTAO0031-900710.1103/PhysRevLett.120.245003; Phys. Rev. E 102, 023210 (2020)PRESCM2470-004510.1103/PhysRevE.102.023210: larger capsules, thicker fuel layers to mitigate fuel-ablator mix, and new symmetry control via cross-beam energy transfer; at modest velocities, these experiments achieve record values for the implosion energetics figures of merit as well as fusion yield for a NIF experiment.
Relationships between plasma morphine concentrations and neonatal responses to endotracheal tube (ETT) suctioning are unknown in preterm neonates.
Ventilated preterm neonates (n=898) from 16 centres ...were randomly assigned to placebo (n=449) or morphine (n=449). After an i.v. loading dose (100 μg kg−1), morphine infusions 23–26 weeks postmenstrual age (PMA) 10 μg kg−1 h−1; 27–29 weeks 20 μg kg−1 h−1; and 30–32 weeks 30 μg kg−1 h−1 were established for a maximum of 14 days. Open-label morphine (20–100 μg kg−1) was given for pain or agitation. Morphine assay and neonatal response to ETT suctioning was measured at 20–28 and 70–76 h after starting the drug infusion and at 10–14 h after discontinuation of the study drug. The concentration–effect response was investigated using non-linear mixed effects models.
A total of 5119 data points (1598 measured morphine concentrations and 3521 effect measures) were available from 875 neonates for analysis. Clearance was 50% that of the mature value at 54.2 weeks PMA (CLmat50) and increased from 2.05 litre h−1 70 kg−1 at 24 weeks PMA to 6.04 litre h−1 70 kg−1 at 32 weeks PMA. The volume of distribution in preterm neonates was 190 litre 70 kg−1 (CV 51%) and did not change with age. There was no relationship between morphine concentrations (range 0–440 μg litre−1) and heart rate changes associated with ETT suctioning or with the Premature Infant Pain Profile.
A sigmoid curve describing maturation of morphine clearance is moved to the right in preterm neonates and volume of distribution is increased compared with term neonates. Morphine does not alter the neonatal response to ETT suctioning.
Sunscreen photoprotection and vitamin D status Passeron, T.; Bouillon, R.; Callender, V. ...
British journal of dermatology (1951),
November 2019, 2019-11-00, 20191101, Letnik:
181, Številka:
5
Journal Article
Recenzirano
Odprti dostop
Summary
Background
Global concern about vitamin D deficiency has fuelled debates on photoprotection and the importance of solar exposure to meet vitamin D requirements.
Objectives
To review the ...published evidence to reach a consensus on the influence of photoprotection by sunscreens on vitamin D status, considering other relevant factors.
Methods
An international panel of 13 experts in endocrinology, dermatology, photobiology, epidemiology and biological anthropology reviewed the literature prior to a 1‐day meeting in June 2017, during which the evidence was discussed. Methods of assessment and determining factors of vitamin D status, and public health perspectives were examined and consequences of sun exposure and the effects of photoprotection were assessed.
Results
A serum level of ≥ 50 nmol L−1 25(OH)D is a target for all individuals. Broad‐spectrum sunscreens that prevent erythema are unlikely to compromise vitamin D status in healthy populations. Vitamin D screening should be restricted to those at risk of hypovitaminosis, such as patients with photosensitivity disorders, who require rigorous photoprotection. Screening and supplementation are advised for this group.
Conclusions
Sunscreen use for daily and recreational photoprotection does not compromise vitamin D synthesis, even when applied under optimal conditions.
What's already known about this topic?
Knowledge of the relationship between solar exposure behaviour, sunscreen use and vitamin D is important for public health but there is confusion about optimal vitamin D status and the safest way to achieve this.
Practical recommendations on the potential impact of daily and/or recreational sunscreens on vitamin D status are lacking for healthy people.
What does this study add?
Judicious use of daily broad‐spectrum sunscreens with high ultraviolet (UV) A protection will not compromise vitamin D status in healthy people.
However, photoprotection strategies for patients with photosensitivity disorders that include high sun‐protection factor sunscreens with high UVA protection, along with protective clothing and shade‐seeking behaviour are likely to compromise vitamin D status.
Screening for vitamin D status and supplementation are recommended in patients with photosensitivity disorders.
Linked Comment: Bikle. Br J Dermatol 2019; 181:884.
Plain language summary available online
The QCD axion is a leading dark matter candidate that emerges as part of the solution to the strong-CP problem in the Standard Model. The coupling of the axion to photons is the most common ...experimental probe, but much parameter space remains unexplored. The coupling of the QCD axion to the Standard Model scales linearly with the axion mass; therefore, the highly motivated region 0.4–120 neV, corresponding to a GUT-scale axion, is particularly difficult to reach. This paper presents the design requirements for a definitive search for GUT-scale axions and reviews the technological advances needed to enable this program.
PDF
