The singly Cabibbo-suppressed decay Lambda(+)(c) -> n pi(+) e is observed for the first time with a statistical significance of 7.3 sigma by using 3.9 fb(-1) of e(+)e(-) collision data collected ...at center-of-mass energies between 4.612 and 4.699 GeV with the BESIII detector at BEPCII. The branching fraction of Lambda(+)(c) -> n pi(+) is measured to be (6.6 +/- 1.2(stat) 0.4(syst)) x 10(-4). By taking the upper limit of branching fractions of Lambda(+)(c) -> n pi(+) from the Belle experiment, the ratio of branching fractions between Lambda(+)(c) -> n pi(+) and Lambda(+)(c) -> p pi(0) is calculated to be larger than 7.2 at the 90% confidence level, which disagrees with most predictions of the available phenomenological models. In addition, the branching fractions of the Cabibbo-favored decays Lambda(+)(c) -> Lambda pi(+) and Lambda(+)(c)-> Sigma(0)(pi+) are measured to be (1.31 +/- 0.08(stat) +/- 0.05(syst)) x 10(-2) and (1.22 +/- 0.08(stat) +/- 0.07(syst)) x 10(-2), respectively, which are consistent with previous results.
A
bstract
Using 1310
.
6 × 10
6
J/ψ
and 448
.
1 × 10
6
ψ
(3686) events collected with the BESIII detector, the branching fractions of
J/ψ
decays to Σ
+
Σ
¯
−
is measured to be (10
.
61 ± 0
.
04 ± 0
.
...36) × 10
−
4
, which is significantly more precise than the current world average. The branching fractions of
ψ
(3686) decays to Σ
+
Σ
¯
−
is measured to be (2
.
52 ± 0
.
04 ± 0
.
09) × 10
−
4
, which is consistent with the previous measurements. In addition, the ratio of
B
(
ψ
(3686) → Σ
+
Σ
¯
−
)
/
B
(
J/ψ
→ Σ
+
Σ
¯
−
) is determined to be (23
.
8 ± 1
.
1)% which violates the “12% rule”.
Using data samples with a total integrated luminosity of 20.1 fb−1 collected by the BESIII detector operating at the BEPCII collider, the cross section of the process e+ e− → π+ π− ψ ( 3686 ) is ...measured at center-of-mass energies between 4.0076 and 4.6984 GeV. The measured cross section is consistent with previous results, and with much improved precision. A fit to the measured energy-dependent cross section, which includes three Breit-Wigner functions and a nonresonant contribution, confirms the existence of the charmonium-like states Y (4220), Y (4390), and Y (4660). This is the first observation of the Y (4660) at the BESIII experiment.
Increasing evidence has shown the aberrant expression of inflammasome-related proteins in Alzheimer's disease (AD) brain; these proteins, including NLRP1 inflammasome, are implicated in the execution ...of inflammatory response and pyroptotic death. Although current data are associated NLRP1 genetic variants with AD, the involvement of NLRP1 inflammasome in AD pathogenesis is still unknown. Using APPswe/PS1dE9 transgenic mice, we found that cerebral NLRP1 levels were upregulated. Our in vitro studies further showed that increased NLRP1-mediated caspase-1-dependent 'pyroptosis' in cultured cortical neurons in response to amyloid-β. Moreover, we employed direct in vivo infusion of non-viral small-interfering RNA to knockdown NLRP1 or caspase-1 in APPswe/PS1dE9 brain, and discovered that these NLRP1 or caspase-1 deficiency mice resulted in significantly reduced neuronal pyroptosis and reversed cognitive impairments. Taken together, our findings indicate an important role for NLRP1/caspase-1 signaling in AD progression, and point to the modulation of NLRP1 inflammasome as a promising strategy for AD therapy.
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