Highlights • Regional and network functional changes could be seen in the early stage of SCI. • Functional changes were associated with clinical symptom severity in SCI patients. • Functional ...reorganization may reflect a compensatory role in the recovery of SCI.
In the Kondo insulator samarium hexaboride (SmB6), strong correlation and band hybridization lead to an insulating gap and a diverging resistance at low temperature. The resistance divergence ends at ...about 3 kelvin, a behavior that may arise from surface conductance. We used torque magnetometry to resolve the Fermi surface topology in this material. The observed oscillation patterns reveal two Fermi surfaces on the (100) surface plane and one Fermi surface on the (101) surface plane. The measured Fermi surface cross sections scale as the inverse cosine function of the magnetic field tilt angles, which demonstrates the two-dimensional nature of the conducting electronic states of SmB6.
In metals, orbital motions of conduction electrons on the Fermi surface are quantized in magnetic fields, which is manifested by quantum oscillations in electrical resistivity. This Landau ...quantization is generally absent in insulators. Here, we report a notable exception in an insulator-ytterbium dodecaboride (YbB
). The resistivity of YbB
, which is of a much larger magnitude than the resistivity in metals, exhibits distinct quantum oscillations. These unconventional oscillations arise from the insulating bulk, even though the temperature dependence of the oscillation amplitude follows the conventional Fermi liquid theory of metals with a large effective mass. Quantum oscillations in the magnetic torque are also observed, albeit with a lighter effective mass.
The molecular mechanism underlying gastric cancer (GC) invasion and metastasis is still poorly understood. In this study, we tried to investigate the roles of CXCR4 and CXCR2 signalings in gastric ...cancer metastasis. A highly invasive gastric cancer cell model was established. Chemokines receptors were profiled to search for the accountable ones. Then the underlying molecular mechanism was investigated using both in vitro and in vivo techniques, and the clinical relevance of CXCR4 and CXCR2 expression was studied in gastric cancer samples. CXCR4 and CXCR2 were highly expressed in a high invasive gastric cancer cell model and in gastric cancer tissues. Overexpression of CXCR4 and CXCR2 was associated with more advanced tumor stage and poorer survival for GC patients. CXCR4 and CXCR2 expression strongly correlated with each other in the way that CXCR2 expression changed accordingly with the activity of CXCR4 signaling and CXCR4 expression also changed in agreement with CXCR2 activity. Further studies demonstrated CXCR4 and CXCR2 can both activated NF-κB and STAT3 signaling, while NF-κBp65 can then transcriptionally activate CXCR4 and STAT3 can activate CXCR2 expression. This crosstalk between CXCR4 and CXCR2 contributed to EMT, migration and invasion of gastric cancer. Finally, Co-inhibition of CXCR4 and CXCR2 is more effective in reducing gastric cancer metastasis. Our results demonstrated that CXCR4 and CXCR2 cross-activate each other to promote the metastasis of gastric cancer.
Overview of Cold Resistance in Plants Chen, L.‐J; Xiang, H.‐Z; Miao, Y ...
Journal of agronomy and crop science (1986),
August 2014, Letnik:
200, Številka:
4
Journal Article
Recenzirano
Cold is a typical environmental stress factor that limits the geographical distribution and growth of various plants. It affects crop quality and productivity. In the contemporary years, with the ...plant cold‐resistant genetic engineering development, great progress was obtained in this field. This paper gave a general statement about the development of plant cold resistantance on the level of unsaturated fatty acids, protective enzymes, functional genes and regulation genes, aiming to provide some useful information and ideas to researchers who work on plant cold breeding and the mechanism of cold resistance. As research continues, we could develop further multiple resistant plant species.
Highly energetic electrons are trapped in the magnetic field of Earth’s radiation belts. The physical mechanisms driving the dynamics of the Van Allen belts can be understood from the electron’s ...energy spectrum, which is believed to be steeply falling with increasing energy. This view has been prevalent for the past 60 years since the energy spectra were first measured. Here, we report the observation of a reversed energy spectrum with abundant high-energy and fewer low-energy electrons spanning from hundreds of keV to around two MeV in electron energy in data collected with NASA’s Van Allen Probes. We find that this spectrum dominates inside the plasmasphere—a dense cold plasma region co-rotating with the Earth. Using two-dimensional Fokker–Planck diffusion simulations with a time-dependent, data-driven model of hiss waves in the plasmasphere, we demonstrate that the formation of the reversed spectrum is explained by the scattering of hiss waves. The results have important implications for understanding the distributions of charged particles and wave–particle interactions in magnetized plasmas throughout the solar system and beyond.Observations reveal that electrons in Earth’s outer radiation belt possess a spectrum that partially rises with increasing energy, contrary to common beliefs. Plasma hiss waves scattered off electrons are found to be the origin of this phenomenon.
Quantum oscillations in transport and thermodynamic parameters at high magnetic fields are an unambiguous signature of the Fermi surface, the defining characteristic of a metal. Recent observations ...of quantum oscillations in insulating SmB6 and YbB12, therefore, have been a big surprise—despite the large charge gap inferred from the insulating behaviour of the resistivity, these compounds seemingly host a Fermi surface at high magnetic fields. However, the nature of the ground state in zero field has been little explored. Here, we report the use of low-temperature heat-transport measurements to discover gapless, itinerant, charge-neutral excitations in the ground state of YbB12. At zero field, sizeable linear temperature-dependent terms in the heat capacity and thermal conductivity are clearly resolved in the zero-temperature limit, indicating the presence of gapless fermionic excitations with an itinerant character. Remarkably, linear temperature-dependent thermal conductivity leads to a spectacular violation of the Wiedemann–Franz law: the Lorenz ratio is 104–105 times larger than that expected in conventional metals, indicating that YbB12 is a charge insulator and a thermal metal. Moreover, we find that these fermions couple to magnetic fields, despite their charge neutrality. Our findings expose novel quasiparticles in this unconventional quantum state.
PDF
