ABSTRACT
Obesity, which is often caused by adipocyte metabolism dysfunction, is rapidly becoming a serious global health issue. Studies in the literature have shown that camellia oil (Camellia ...oleifera Abel) exerted potential lipid regulation and other multiple biological activities. Here, we aimed to investigate the effects of camellia oil on obese mice induced by a high-fat diet and to explore gut microbiota alterations after camellia oil intervention. The results showed that oral administration of camellia oil dramatically attenuated the fat deposits, serum levels of the total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, fasting plasma glucose, the atherosclerosis index, the hepatic steatosis and inflammation in high-fat diet-induced obese mice. Meanwhile, the high-density lipoprotein cholesterol level in obese mice was enhanced after the camellia oil treatment. Furthermore, 16S rRNA analysis showed that certain aspects of the gut microbiota, especially the gut microbiota diversity and the relative abundance of Actinobacteria, Coriobacteriaceae, Lactobacillus and Anoxybacillus, were significantly increased by camellia oil treatment while the ratio of Firmicutes to Bacteroidetes was decreased. Taken together, our finding suggested that camellia oil was a potential dietary supplement and functional food for ameliorating fat deposits, hyperglycemia and fatty liver, probably by modifying the gut microbiota composition.
In the current study, we highlight an interesting pharmacological action of camellia oil against HFD-induced obesity in mice, mainly exerting its ability to slow down fat accumulation regulate hyperlipidemia and hamper liver steatosis and inflammation, with the mechanism probably by modifying the gut microbiota composition.
Atherosclerosis is the main cause of cardiovascular diseases, and healthy dietary habits are a feasible strategy to prevent atherosclerosis development. Camellia oil, an edible plant oil, exhibits ...multiple beneficial cardiovascular effects. Our previous study showed that oral administration of camellia oil attenuated hyperglycemia, fat deposits in the liver, and the atherosclerosis index in high-fat diet (HFD)-induced obese mice. Here, an atherosclerosis model of apolipoprotein E (ApoE)−/− mice induced by HFD was used to study the effect of camellia oil on atherosclerosis, and 16S rRNA gene sequencing was used to analyze the changes in gut microbiota composition. The results showed that camellia oil significantly inhibited the formation of atherosclerotic plaques in ApoE−/− mice, which were characterized by significantly reduced levels of serum total cholesterol and enhanced levels of serum high-density lipoprotein cholesterol. The aortic levels of interleukin-6 and tumor necrosis factor were decreased. The results of the 16S rRNA analysis showed that after camellia oil interventions, the intestinal flora of ApoE−/− mice changed significantly, with the diversity of intestinal flora especially increasing, the relative abundances of Bacteroides, Faecalibaculum, Bilophila, and Leuconostoc increasing, and the Firmicutes/Bacteroidetes ratio and Firmicutes abundance decreasing. Collectively, our findings confirmed the promising value of camellia oil in preventing the development of atherosclerosis in ApoE−/− mice. Mechanistically, this preventive effect of camellia oil was probably due to its lipid-lowering activity, anti-inflammatory effects, and alteration of the gut microbiota composition in the mice.
Optimal recovery rate, price decision and system efficiency of a closed-loop supply chain are analyzed under the competition of an online retailer and a traditional retailer based on game theory. The ...results show that, in the market structure dominated by the manufacturer, the manufacturer's profit is higher than that of the retailer being the leadership, and the benefits of the other members of the supply chain and the total system are small. In the market structure dominated by retailers, the benefits of retailers and consumers and the total system are higher than that of the manufacturer being the leadership.
Under different carbon regulatory policies, corporate social responsibility (CSR) activities will have different impacts on the environmental benefits of the supply chain and corporate carbon ...emission reduction decisions. In this study, we examine a dual-channel closed-loop supply chain consisting of a single manufacturer selling re-products generated from waste products and a single retailer selling new products and consider two settings: enforcing a carbon tax policy or enforcing a subsidy policy. Under each setting, we put CSR into account, construct two models for the retailer to implement or not implement CSR activities, and analyze the decisions obtained under optimal solutions. Through numerical simulation and comparative research, we observe that the carbon tax policy applies to the supply chain where CSR activities are implemented, while the subsidy policy applies to the supply chain where CSR activities are not implemented. Reasonable selection of CSR implementation methods with low-cost coefficients by the retailer is conducive to eliminating profit conflicts among supply chain members. The government should fully consider the decision-making thresholds of supply chain members to ensure the maximum effectiveness of the policy.
Copper(II) phthalocyanine tetrasulfonate (CuPcTs) sensitized nanocrystalline anatase TiO
2 photocatalyst was synthesized in situ at low temperature in a short time employing ultrasonic irradiation. ...The XRD patterns demonstrated that TiO
2 was anatase structured, and the TEM images displayed that the average particle sizes of the as-prepared powders were nanometric (50–60
nm). The DRS data indicated that the CuPcTs-sensitized TiO
2 had obvious absorption band in the visible light region, and the intensity of the monomeric CuPcTs absorption peak increased relative to the dimer due to the desorption or deaggregation of the dimeric after heat treatment below 200
°C. The results of photodecomposition of methyl orange revealed that CuPcTs–TiO
2 had much more photocatalytic activity than CuPcTs or pure TiO
2, and the monomeric CuPcTs-sensitized TiO
2 was more photocatalytic than the dimeric CuPcTs-sensitized TiO
2 under the visible light (
λ
>
450
nm). The stability investigation indicated that the oxidized state of CuPcTs could be reduced by methyl orange or other intermediate substances, which promoted the regeneration of CuPcTs dye.
The TiO2/wood (TW) based on fast-growing poplar wood was in situ synthesized through one-step solvothermal method and then Ag-doped TiO2/wood (ATW)was also prepared via the solvothermal method. The ...morphologies, crystal structure, and chemical characteristics of the composites were carried out by SEM, XRD, XPS and FTIR. The results of XPS and FTIR showed that the nanoparticles (TiO2 and Ag) were chemically bonded to the wood surface through the combination of hydrogen groups. Spherical-like Ag nanoparticles (Ag-NPs) was about 66 nm diameter. What's more, the TW and ATW showed excellent antibacterial against Gram positive and negative bacterium under visible light irradiation and mould-resistance properties, which illustrated a significance and practical value in high added-value of wood.
With the development of economic globalization, the competition among enterprises is increasingly fierce. Therefore, companies need close information sharing to realize the integration of supply ...chain. This article aims to study the collaborative management and information sharing mechanism of supply chain inventory based on cloud computing and 5G Internet of Things. This article first introduces the theory and methods of collaborative supply chain management and the information exchange mechanism and then discusses the problem of information sharing in the supply chain, that is, the bullwhip phenomenon, and then from the demand forecast, supply chain structure, time lag, and shortage game, six aspects are analyzed. The cause of the bullwhip phenomenon is analyzed. Secondly, this article proposes a quantitative analysis of the bullwhip effect, establishes a mathematical model of the bullwhip effect in the supply chain, and uses quantitative analysis to analyze the value of information sharing in the supply chain. Finally, this article uses cloud computing technology to build a supply chain information collaboration system architecture and uses EPC Internet of Things to build a supply chain information sharing model and describes the entire operation process of the supply chain. The experimental results of this paper show that the application of cloud computing technology to supply chain management establishes a system platform for supply chain information sharing, improves the overall operational efficiency of supply chain management, and realizes supply chain information sharing and business collaboration. In addition, the operating costs and risks of each node enterprise in the supply chain are reduced by 12% compared with the nonsharing situation, which also shows that the overall benefits of the supply chain have been correspondingly improved and market competitiveness has been enhanced.
A novel method has been developed to synthesize anatase nano-photocatalyst of copper phthalocyanine tetrasulfonate (CuPcTs) in hydrothermal condition. When TiO
2 was synthesized by an in situ ...synchronous process, the surface of TiO
2 particles adsorbed sensitizers. The photocatalyst was characterized by XRD, TEM and UV–vis spectrophotometer techniques. It was found that TiO
2 powder could be sensitized to have wavelength beyond its intrinsic sensitivity using phthalocyanine. Its efficiency was tested with methyl orange (MO) under visible light by UV–vis spectrophotometer. All the photodegradations of MO must experience a dye-sensitized TiO
2 photocatalytic mechanism.
Although urban forests are important components of the urban tourism system, research on urban forests from the perspective of tourism is limited. This is particularly true for research on cherry ...blossom festivals held in urban areas in the context of China. This paper, for the first time, examined the similarities and differences between locals and tourists in their past experience, motivation, attitude, satisfaction, and loyalty as well as the interrelationships among these variables as they relate to the Taihu Lake International Cherry Blossom Festival (TLICBF) in Wuxi City, Jiangsu Province, China, based on data collected onsite in 2019 from 412 usable questionnaires. Results show that responses from locals and tourists were quite similar. Moreover, TLICBF attendees’ motivation of attending the festival significantly influenced their attitudes toward the festival, which significantly predicted their overall satisfaction with the festival. It is worth noting that it is the positive comparison, not the frequency of visits, that significantly influenced TLICBF attendees’ attitudes toward and overall satisfaction with the festival. In addition, motivations and benefits were also qualitatively examined, with a measure of 21 items for the former and 25 items for the latter being developed. Research implications, research limitations, and future research needs are discussed.
Recent studies have shown that increased syndecan-1 (SDC1) expression in human glioma is associated with higher tumor grades and poor prognoses, but its oncogenic functions and the underlying ...molecular mechanisms remain unknown. Here, we examined SDC1 expression in datasets from The Cancer Genome Atlas and the National Center for Biotechnology Information Gene Expression Omnibus. Elevated SDC1 expression in glioma was closely associated with increases in tumor progression and shorter survival. We also examined SDC1 expression and evaluated the effects of stable SDC1 knockdown in glioma cell lines. SDC1 knockdown attenuated proliferation and invasion by glioma cells and markedly decreased PCNA and MMP-9 mRNA and protein expression. In a xenograft model, SDC1 knockdown suppressed the tumorigenic effects of U87 cells in vivo. SDC1 knockdown decreased phosphorylation of the c-src/FAK complex and its downstream signaling molecules, Erk, Akt and p38 MAPK. These results suggest that SDC1 may be a novel therapeutic target in the treatment of glioma.
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