Here we present a novel hyperpolarization method, Chemical Reaction-Induced Multi-molecular Polarization (CRIMP), which could be applied to the study of several in vivo processes simultaneously ...including glycolysis, TCA cycle, fatty acid synthesis and pH mapping. Through the use of non-enzymatic decarboxylation, we generate four hyperpolarized imaging agents from hyperpolarized 1,2-(13)C pyruvic acid.
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, ...an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin “burn propagation” into surrounding cold fuel, enabling the possibility of high energy gain. While “scientific breakeven” (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this work reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion.
On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding ..."scientific breakeven" (or G_{target}>1) where 2.05 MJ of 351 nm laser light produced 3.1 MJ of total fusion yield, a result which significantly exceeds the Lawson criterion for fusion ignition as reported in a previous NIF implosion H. Abu-Shawareb et al. (Indirect Drive ICF Collaboration), Phys. Rev. Lett. 129, 075001 (2022)PRLTAO0031-900710.1103/PhysRevLett.129.075001. This achievement is the culmination of more than five decades of research and gives proof that laboratory fusion, based on fundamental physics principles, is possible. This Letter reports on the target, laser, design, and experimental advancements that led to this result.
The third US Naval Observatory (USNO) CCD Astrograph Catalog, UCAC3, was released at the IAU General Assembly on 2009 August 10. It is the first all-sky release in this series and contains just over ...100 million objects, about 95 million of them with proper motions, covering about R = 8-16 mag. Current epoch positions are obtained from the observations with the 20 cm aperture USNO Astrograph's 'red lens,' equipped with a 4k X 4k CCD. Proper motions are derived by combining these observations with over 140 ground- and space-based catalogs, including Hipparcos/Tycho and the AC2000.2, as well as unpublished measures of over 5000 plates from other astrographs. For most of the faint stars in the southern hemisphere, the Yale/San Juan first epoch plates from the Southern Proper Motion (SPM) program (YSJ1) form the basis for proper motions. These data are supplemented by all-sky Schmidt plate survey astrometry and photometry obtained from the SuperCOSMOS project, as well as 2MASS near-IR photometry. Major differences of UCAC3 data as compared with UCAC2 include a completely new raw data reduction with improved control over systematic errors in positions, significantly improved photometry, slightly deeper limiting magnitude, coverage of the north pole region, greater completeness by inclusion of double stars, and weak detections. This of course leads to a catalog which is not as 'clean' as UCAC2 and problem areas are outlined for the user in this paper. The positional accuracy of stars in UCAC3 is about 15-100 mas per coordinate, depending on magnitude, while the errors in proper motions range from 1 to 10 mas yr--1 depending on magnitude and observing history, with a significant improvement over UCAC2 achieved due to the re-reduced SPM data and inclusion of more astrograph plate data unavailable at the time of UCAC2.
The present work is focused on the direct manufacturing of a hand splint using free-open access software and a low-cost three-dimensional printer (3DP). The hand digital model was created using ...panoramic photos by a common mobile phone camera. The photos were used as input to the "3DF-Zephyr" free software for creating the hand surface model. Then, the hand surface model was transferred into the "Autodesk fusion 360" free software and the surface model of the hand splint was generated and modified according to the design requirements. Sequentially, both hand and hand splint were translated to Stereolithography (STL) files and transferred to open access "MakerBot" 3D printing software in order to prepare the G-codes for 3D printing. A low cost 3D printer was used for building the models while Polylactic acid (PLA) was the material of the customized 3D physical models.
UCAC4 is an updated version of UCAC3 with about the same number of stars also covering all-sky. Bugs were fixed, Schmidt plate survey data were avoided, and precise five-band photometry was added for ...about half the stars. Astrograph observations have been supplemented for bright stars by FK6, Hipparcos, and Tycho-2 data to compile a UCAC4 star catalog complete from the brightest stars to about magnitude R = 16. Epoch 1998-2004 positions are obtained from observations with the 20 cm aperture USNO Astrograph's "red lens," equipped with a 4k by 4k CCD. Mean positions and PMs are derived by combining these observations with over 140 ground- and space-based catalogs, including Hipparcos/Tycho and the AC2000.2, as well as unpublished measures of over 5000 plates from other astrographs. These data are supplemented by 2MASS near-IR photometry for about 110 million stars and five-band (B, V, g. r, i) APASS data for over 51 million stars.
First, to compare the quality of life (QL) and perceived self-competence of children and adolescents with anorectal malformations or Hirschsprung disease with that of reference groups. Second, to ...identify predictors of QL.
A total of 491 patients with anorectal malformations or Hirschsprung disease were sent a questionnaire, which assessed QL (mental, physical), disease-specific functioning (defecation-related), perceived self-competence (self-esteem, athletic competencies, school attitude), and demographic characteristics (sex, age). The clinical characteristics (disease severity, presence of congenital anomalies) were extracted from medical records.
More than 50% (316, 64%) of patients with anorectal malformations or Hirschsprung disease completed the questionnaire. On average, children and adolescents in both patient groups reported no differences in QL domains compared with the reference groups. However, standard deviations revealed considerable individual variation, indicating the presence of patients with high levels of QL as well as patients with low levels of QL. Children and adolescents in both patient groups reported psychosocial problems in all domains, compared with the reference groups. Females, older patients, and those with a severe form of the disease reported lower levels of perceived self-competence and global disease-specific functioning, which in turn predicted QL.
Our results should alert clinicians to patients who are at risk for QL problems and may therefore be in need of extra care. Our findings illustrate the importance of both global disease-specific functioning and perceived psychosocial competencies for enhancing the QL of these patients.
A series of tryptophan analogues has been introduced into the binding site regions of two ion channels, the ligand-gated nicotinic acetylcholine and serotonin 5-HT3A receptors, using unnatural amino ...acid mutagenesis and heterologous expression in Xenopus oocytes. A cation−π interaction between serotonin and Trp183 of the serotonin channel 5-HT3AR is identified for the first time, precisely locating the ligand-binding site of this receptor. The energetic contribution of the observed cation−π interaction between a tryptophan and the primary ammonium ion of serotonin is estimated to be approximately 4 kcal/mol, while the comparable interaction with the quaternary ammonium of acetylcholine is approximately 2 kcal/mol. The binding mode of nicotine to the nicotinic receptor of mouse muscle is examined by the same technique and found to differ significantly from that of the natural agonist, acetylcholine.
Myocardial injury after noncardiac surgery (MINS) was defined as prognostically relevant myocardial injury due to ischemia that occurs during or within 30 days after noncardiac surgery. The study's ...four objectives were to determine the diagnostic criteria, characteristics, predictors, and 30-day outcomes of MINS.
In this international, prospective cohort study of 15,065 patients aged 45 yr or older who underwent in-patient noncardiac surgery, troponin T was measured during the first 3 postoperative days. Patients with a troponin T level of 0.04 ng/ml or greater (elevated "abnormal" laboratory threshold) were assessed for ischemic features (i.e., ischemic symptoms and electrocardiography findings). Patients adjudicated as having a nonischemic troponin elevation (e.g., sepsis) were excluded. To establish diagnostic criteria for MINS, the authors used Cox regression analyses in which the dependent variable was 30-day mortality (260 deaths) and independent variables included preoperative variables, perioperative complications, and potential MINS diagnostic criteria.
An elevated troponin after noncardiac surgery, irrespective of the presence of an ischemic feature, independently predicted 30-day mortality. Therefore, the authors' diagnostic criterion for MINS was a peak troponin T level of 0.03 ng/ml or greater judged due to myocardial ischemia. MINS was an independent predictor of 30-day mortality (adjusted hazard ratio, 3.87; 95% CI, 2.96-5.08) and had the highest population-attributable risk (34.0%, 95% CI, 26.6-41.5) of the perioperative complications. Twelve hundred patients (8.0%) suffered MINS, and 58.2% of these patients would not have fulfilled the universal definition of myocardial infarction. Only 15.8% of patients with MINS experienced an ischemic symptom.
Among adults undergoing noncardiac surgery, MINS is common and associated with substantial mortality.
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