Down syndrome (DS) is one of the main genetic abnormalities of newborns. Therefore, prenatal diagnosis of this syndrome is of paramount importance to the family and the community. The microbiota ...system is important in early brain development. We tried to study and compare gut microbiota (GM) composition in pregnancies that resulted in DS neonates with pregnancies that resulted in healthy children. The study population consisted of 21 pregnant women having delivered DS newborns (group 1) and 22 pregnant women who had given birth to healthy newborns (group 2). The GM composition was determined and compared between the two groups. There were no significant age and gestational age differences between the two groups (p>0.005 both). Regarding GM analysis, microorganisms of the families
Clostridiaceae
and
Pasteurellaceae
were more abundant in the group of women having delivered DS neonates than the group of women having delivered healthy newborns (p<0.05). The results of our pilot study showed that the GM system might have a role in the pathophysiology of DS. The GM changes may be used in the prenatal diagnosis and prevention of this syndrome. Further studies are needed in this field.
Objective
The aim of this study was to determine whether the timing of prophylactic antibiotics at cesarean delivery influences maternal and neonatal infectious morbidity.
Study design
This was a ...prospective, randomized trial. Four hundred patients that underwent elective cesarean section between June and December 2007 formed the study population. Eleven patients were excluded from the study because they needed transfusion during the cesarean section. The population was divided into two groups: Group A, antibiotic prophylaxis was applied to 194 women before skin incision and Group B, antibiotic prophylaxis was applied to 195 women after umbilical cord clamping. The occurrence of endomyometritis/endometritis, wound infection, febrile morbidity, total infectious morbidity, and neonatal complications were compared.
Results
There were 389 patients enrolled. No demographic differences were observed between groups. No significant difference was found between the groups for total infectious morbidity relative risk (RR) 1.39, 95% confidence interval (CI) 0.71–2.69 and endometritis (RR 1.40, 95% CI 0.43–4.51). There was no increase in neonatal sepsis (RR 1.47, 95% CI 0.61–3.53), sepsis workup (RR 1.35, 95% CI 0.75–2.42), need for neonatal intensive care (RR 1.77, 95% CI 0.51–6.16), and intensive care stay period (
P
= 0.16).
Conclusions
Time of antibiotic prophylaxis application does not change maternal infectious morbidity in cesarean section deliveries. Preoperative prophylaxis application does not affect neonate morbidity rates as stated in literature.
Down syndrome (DS) is one of the main genetic abnormalities of newborns. Therefore, prenatal diagnosis of this syndrome is of paramount importance to the family and the community. The microbiota ...system is important in early brain development. We tried to study and compare gut microbiota (GM) composition in pregnancies that resulted in DS neonates with pregnancies that resulted in healthy children. The study population consisted of 21 pregnant women having delivered DS newborns (group 1) and 22 pregnant women who had given birth to healthy newborns (group 2). The GM composition was determined and compared between the two groups. There were no significant age and gestational age differences between the two groups (p>0.005 both). Regarding GM analysis, microorganisms of the families Clostridiaceae and Pasteurellaceae were more abundant in the group of women having delivered DS neonates than the group of women having delivered healthy newborns (p<0.05). The results of our pilot study showed that the GM system might have a role in the pathophysiology of DS. The GM changes may be used in the prenatal diagnosis and prevention of this syndrome. Further studies are needed in this field. Key words: Brain; Down syndrome; Microbiota; Pregnancy; Outcome; Screening Downov sindrom (DS) je jedna od glavnih genetskih nenormalnosti kod novorodencadi, stoga je prenatalna dijagnostika ovoga sindroma od velike vaznosti za obitelj, kao i za drustvo. Sustav mikrobiote ima vaznu ulogu u ranom razvoju mozga. U ovom istrazivanju ispitali smo i usporedili sastav crijevne mikrobiote (CM) u trudnocama iz kojih su rodena djeca s DS i u trudnocama iz kojih su rodena zdrava djeca. Istrazivana populacija obuhvatila je 21 trudnicu koje su rodile djecu s DS (1. skupina) i 22 trudnice koje su rodile zdravu djecu (2. skupina). Sastav CM utvrden je i usporeden medu dvjema skupinama. Nije bilo razlike u dobi i gestacijskoj dobi izmedu skupina (p>0,005 oboje). Analiza CM je pokazala da su mikroorganizmi iz porodica Clostridiaceae i Pasteurellaceae zastupljenije u skupini zena koje su rodile djecu s DS u usporedbi sa skupinom zena koje su rodile zdravu djecu (p<0,05). Rezultati naseg probnog ispitivanja pokazuju da bi sustav CM mogao imati ulogu u patofziologiji DS. Promjene u CM mogle bi se rabiti u prenatalnoj dijagnostici i prevenciji ovoga sindroma. Potrebna su daljnja istrazivanja u ovom podrucju. Kljucne rijeci: Mozak; Downov sindrom; Mikrobiota; Trudnoca; Ishod; Probir
Downov sindrom (DS) je jedna od glavnih genetskih nenormalnosti kod novorođenčadi, stoga je prenatalna dijagnostika
ovoga sindroma od velike važnosti za obitelj, kao i za društvo. Sustav mikrobiote ...ima važnu ulogu u ranom razvoju mozga. U
ovom istraživanju ispitali smo i usporedili sastav crijevne mikrobiote (CM) u trudnoćama iz kojih su rođena djeca s DS i u
trudnoćama iz kojih su rođena zdrava djeca. Istraživana populacija obuhvatila je 21 trudnicu koje su rodile djecu s DS (1.
skupina) i 22 trudnice koje su rodile zdravu djecu (2. skupina). Sastav CM utvrđen je i uspoređen među dvjema skupinama.
Nije bilo razlike u dobi i gestacijskoj dobi između skupina (p>0,005 oboje). Analiza CM je pokazala da su mikroorganizmi
iz porodica Clostridiaceae i Pasteurellaceae zastupljenije u skupini žena koje su rodile djecu s DS u usporedbi sa skupinom žena
koje su rodile zdravu djecu (p<0,05). Rezultati našeg probnog ispitivanja pokazuju da bi sustav CM mogao imati ulogu u
patofiziologiji DS. Promjene u CM mogle bi se rabiti u prenatalnoj dijagnostici i prevenciji ovoga sindroma. Potrebna su
daljnja istraživanja u ovom području.
