The High Energy Modular Ensemble of Satellites (HERMES) project is aimed to realize a modular X/gamma-ray monitor for transient events, to be placed on-board of a nano-satellite bus (e.g. CubeSat). ...This expandable platform will achieve a significant impact on Gamma Ray Burst (GRB) science and on the detection of Gravitational Wave (GW) electromagnetic counterparts: the recent LIGO/VIRGO discoveries demonstrated that the high-energy transient sky is still a field of extreme interest. The very complex temporal variability of GRBs (experimentally verified up to the millisecond scale) combined with the spatial and temporal coincidence between GWs and their electromagnetic counterparts suggest that upcoming instruments require sub-microsecond time resolution combined with a transient localization accuracy lower than a degree. The current phase of the ongoing HERMES project is focused on the realization of a technological pathfinder with a small network (3 units) of nano-satellites to be launched in mid 2020. We will show the potential and prospects for short and medium-term development of the project, demonstrating the disrupting possibilities for scientific investigations provided by the innovative concept of a new “modular astronomy” with nano-satellites (e.g. low developing costs, very short realization time). Finally, we will illustrate the characteristics of the HERMES Technological Pathfinder project, demonstrating how the scientific goals discussed are actually already reachable with the first nano-satellites of this constellation. The detector architecture will be described in detail, showing that the new generation of scintillators (e.g. GAGG:Ce) coupled with very performing Silicon Drift Detectors (SDD) and low noise Front-End-Electronics (FEE) are able to extend down to few keV the sensitivity band of the detector. The technical solutions for FEE, Back-End-Electronics (BEE) and Data Handling will be also described.
We present a spectroscopic system constituted by a Silicon Drift Detector (SDD) coupled to a CMOS charge sensitive preamplifier, named SIRIO, specifically designed to reach ultimate low noise levels. ...The SDD, with an active area of 13 mm 2 , has been manufactured by optimizing the production processes in order to reduce the anode current, successfully reaching current densities between 17 pA/cm 2 and 25 pA/cm 2 at + 20 ° C for drift fields ranging from 100 V/cm to 500 V/cm. The preamplifier shows minimum intrinsic noise levels of 1.27 and 1.0 electrons r.m.s. at +20 ° C and -30 ° C, respectively. At room temperature (+ 20 ° C) the 55 Fe 5.9 keV and the pulser lines have 136 eV and 64 eV FWHM, respectively, corresponding to an equivalent noise charge of 7.4 electrons r.m.s.; the noise threshold is at 165 eV. The energy resolution, as measured on the pulser line, ranges from 82 eV FWHM (9.4 electrons r.m.s.) at + 30 ° C down to 29 eV FWHM (3.3 electrons r.m.s.) at - 30 ° C.
A Forbush decrease (FD) is a sudden drop of cosmic-ray intensity arising as an effect of coronal mass ejection (CME) propagation in interplanetary space. The different physical properties of each CME ...cause variability in the FDs observed by scientific instruments. A comprehensive study of both phenomena is required to properly understand the processes involved in FDs. Most of the current studies in this field use experimental data obtained by ground-based apparatus that measure the flux of cosmic rays via their interaction with Earth’s atmosphere. Direct measurements in space of FDs are rather rare. In this work, we present the results obtained by the spacecraft-borne experiment
Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics
(PAMELA). The experiment took data from 15 June 2006 until January 2016. A series of FDs during the period 2006 – 2013 were studied. Only significant events with amplitude ≥ 10% for the proton flux
R
=
1.1
– 2.9 GV were taken into account. The dependencies of the recovery times on the particle rigidity were obtained for FD events generated by halo-type CMEs.
Abstract
The results of a collaborative development activity aimed to the realization of multi-cell detectors based on monolithic SDD pixel technology will be described. Two kind of detection ...systems, skilled for the light lines at synchrotrons, have been brought to high levels of finalization and integration; a 64 cells detection system dedicated to absorption spectroscopy (XAFS) and a 32 cells detector for the X-ray microscopy (TwinMic). The main targets of this effort, led in a tight collaboration with the beam lines scientists, were large sensitive area, high rate capabilities, state of the art efficiency and energy resolution. The aim is to reduce the beam time demand for each single measurement while delivering a cutting edge analytical power.
All basic elements of those detection systems, from the detector’s design and production to the front-end and read-out electronics including the final engineering of the integrated system were customized to the specific use addressed.
The FAMU experiment aims to measure for the first time the hyperfine splitting of the muonic hydrogen ground state. From this measurement the proton Zemach radius can be derived and this will shed ...light on the determination of the proton charge radius. In this paper, we describe the scientific goal, the method and the detailed preparatory work. This includes the outcome of preliminary measurements, subsequent refined simulations and the evaluation of the expected results. The experimental setup being built for the measurement of the hyperfine splitting to be performed at the RAL laboratory muon facility is also described.
Human papillomavirus (HPV) is widely known as a cause of cervical cancer (CC) and cervical intraepithelial neoplasia (CIN). HPVs related to cancer express two main oncogenes, i.e. E6 and E7, ...considered as tumorigenic genes; their integration into the host genome results in the abnormal regulation of cell cycle control. Due to their peculiarities, these oncogenes represent an excellent target for cancer immunotherapy. In this work the authors highlight the potential use of therapeutic vaccines as safe and effective pharmacological tools in cervical disease, focusing on vaccines that have reached the clinical trial phase. Many therapeutic HPV vaccines have been tested in clinical trials with promising results. Adoptive T-cell therapy showed clinical activity in a phase II trial involving advanced CC patients. A phase II randomized trial showed clinical activity of a nucleic acid-based vaccine in HPV16 or HPV18 positive CIN. Several trials involving peptide-protein-based vaccines and live-vector based vaccines demonstrated that these approaches are effective in CIN as well as in advanced CC patients. HPV therapeutic vaccines must be regarded as a therapeutic option in cervical disease. The synergic combination of HPV therapeutic vaccines with radiotherapy, chemotherapy, immunomodulators or immune checkpoint inhibitors opens a new and interesting scenario in this disease.
The General Antiparticle Spectrometer (GAPS) is an Antarctic balloon experiment designed for low-energy (0.1–0.3 GeV/n) cosmic antinuclei as signatures of dark matter annihilation or decay. GAPS is ...optimized to detect low-energy antideuterons, as well as to provide unprecedented sensitivity to low-energy antiprotons and antihelium nuclei. The novel GAPS antiparticle detection technique, based on the formation, decay, and annihilation of exotic atoms, provides greater identification power for these low-energy antinuclei than previous magnetic spectrometer experiments. This work reports the sensitivity of GAPS to detect antihelium-3 nuclei, based on full instrument simulation, event reconstruction, and realistic atmospheric influence simulations. The report of antihelium nuclei candidate events by AMS-02 has generated considerable interest in antihelium nuclei as probes of dark matter and other beyond the Standard Model theories. GAPS is in a unique position to detect or set upper limits on the cosmic antihelium nuclei flux in an energy range that is essentially free of astrophysical background. In three 35-day long-duration balloon flights, GAPS will be sensitive to an antihelium flux on the level of 1.3−1.2+4.5·10−6 m-2sr-1s-1(GeV/n)-1 (95% confidence level) in the energy range of 0.11–0.3 GeV/n, opening a new window on rare cosmic physics.
The General Antiparticle Spectrometer (GAPS) is an upcoming balloon mission to measure low-energy cosmic-ray antinuclei during at least three ∼35-day Antarctic flights. With its large geometric ...acceptance and novel exotic atom-based particle identification, GAPS will detect ∼500 cosmic antiprotons per flight and produce a precision cosmic antiproton spectrum in the kinetic energy range of ∼0.07−0.21GeV/n at the top of the atmosphere. With these high statistics extending to lower energies than any previous experiment, and with complementary sources of experimental uncertainty compared to traditional magnetic spectrometers, the GAPS antiproton measurement will be sensitive to dark matter, primordial black holes, and cosmic ray propagation. The antiproton measurement will also validate the GAPS antinucleus identification technique for the antideuteron and antihelium rare-event searches. This analysis demonstrates the GAPS sensitivity to cosmic-ray antiprotons using a full instrument simulation and event reconstruction, and including solar and atmospheric effects.
Background. Metabolic syndrome (MetS) and nephrolithiasis (NL) are quite common disorders. While some of the components of MetS have been proposed as precursors of NL in population studies, no data ...are available about the possible association between NL and MetS as such. The primary objective of the study was to evaluate the relationship between MetS and NL. The secondary outcome was to examine the relationship between MetS single constitutive elements and NL considering the strict correlation occurring among these factors. Methods. We studied 2132 Caucasian inpatients of the ‘Spinelli’ Hospital in southern Italy (males/females = 0.95; mean age 63.8 ± 15.8 years; body mass index 26.1 ± 3.9 kg/m2). The MetS diagnosis was performed according to the Heart Association/National Heart, Lung, and Blood Institute criteria. The presence of NL was assessed by ultrasound examination of the kidneys and upper urinary tract. Results. Seven hundred twenty-five subjects (34.0%) had a positive diagnosis of MetS. Two hundred twenty subjects (10.3%) had echographic evidence of NL, while 199 subjects reported a past history of NL (9.3%). The presence of MetS, as well as the male sex, and the occurrence of a previous episode of NL (in male subjects only) were each independently related to echographic evidence of NL. Among the individual components of MetS, high blood pressure and abdominal obesity (in female individuals only) were also independently related to echographic evidence of NL. Conclusions. MetS is significantly associated with echographic evidence of NL. A gender-related difference in the clinical expression of NL was also observed.
PDF
