Introducción: el infarto del miocardio agudo se define como la privación del aporte de oxígeno al corazón durante un período de tiempo suficiente para producir alteraciones estructurales y necrosis ...del miocardio, constituye una de las principales causas de muerte en los países industrializados y ocupa el primer lugar en la población adulta. Objetivo: caracterizar las variables ergométricas en pacientes con infarto del miocardio agudo, sometidos o no al tratamiento con estreptoquinasa recombinante. Métodos: estudio observacional, analítico de caso-control, en el Hospital Provincial “Dr. Antonio Luces Iraola” en el periodo de enero 2013 a enero de 2015 seleccionándose 67 de los 212 pacientes que presentaron infarto de miocardio agudo donde se valoraron las variables clínicas y ergométricas que revelan función ventricular. Resultados: se obtuvieron mejores resultados en los pacientes que fueron trombolizados, el dolor y el infradesnivel del segmento ST predominaron en los pacientes no trombolizados; los reingresos y fallecimientos por causas asociadas fueron del grupo que no recibió terapia trombolítica. Las variables que miden función ventricular siempre fueron superiores en el grupo de pacientes trombolizados, estas disminuyeron con la edad, pero siempre arrojaron mejores resultados en los tratados con estreptoquinasa recombinante. Conclusiones: la terapia trombolítica con estreptoquinasa recombinante es efectiva para el pronóstico y calidad de vida de los pacientes que sufren infarto del miocardio agudo en todos los grupos de edades.
Introducción: el infarto del miocardio agudo se define como la privación del aporte de oxígeno al corazón durante un período de tiempo suficiente para producir alteraciones estructurales y necrosis ...del miocardio, constituye una de las principales causas de muerte en los países industrializados y ocupa el primer lugar en la población adulta. Objetivo: caracterizar las variables ergométricas en pacientes con infarto del miocardio agudo, sometidos o no al tratamiento con estreptoquinasa recombinante. Métodos: estudio observacional, analítico de caso-control, en el Hospital Provincial “Dr. Antonio Luces Iraola” en el periodo de enero 2013 a enero de 2015 seleccionándose 67 de los 212 pacientes que presentaron infarto de miocardio agudo donde se valoraron las variables clínicas y ergométricas que revelan función ventricular. Resultados: se obtuvieron mejores resultados en los pacientes que fueron trombolizados, el dolor y el infradesnivel del segmento ST predominaron en los pacientes no trombolizados; los reingresos y fallecimientos por causas asociadas fueron del grupo que no recibió terapia trombolítica. Las variables que miden función ventricular siempre fueron superiores en el grupo de pacientes trombolizados, estas disminuyeron con la edad, pero siempre arrojaron mejores resultados en los tratados con estreptoquinasa recombinante. Conclusiones: la terapia trombolítica con estreptoquinasa recombinante es efectiva para el pronóstico y calidad de vida de los pacientes que sufren infarto del miocardio agudo en todos los grupos de edades.
We have purified and characterized pig and bovine milk lactadherins. Studies by circular dichroism spectroscopy indicate that the two proteins present a similar folding pattern. Results have been ...discussed in terms of their affinity for pig zona pellucida in order to use these proteins as analogs of pig sperm lactadherin in gamete studies.
enterica is an important foodborne pathogen. Commercial poultry are the main reservoirs of
enterica, leading to the contamination of food and outbreaks in humans. The vaccination of chickens is one ...of the most important strategies to reduce the number of
in poultry farms. Unfortunately, commercial vaccines have not been fully effective in controlling the spread and do not contain all the
serovars that circulate on farms. In this study, we evaluate a new, cochleate-based, trivalent injectable vaccine against
Enteritidis,
Typhimurium and
Infantis, describing the vaccine security, capacity to induce specific anti-
serovar IgY and the gene expression of immune markers related to CD4 and CD8 T-cell-mediated immunity. Efficacy was evaluated through oral challenges performed separately for each
serotype. The efficacy and safety of the trivalent vaccine was proven under controlled conditions. The vaccine has no local or systemic reactions or adverse effects on poultry performance related to the vaccine. The vaccine provided significantly increased serum IgY titer levels, significantly reduced
CFU/g present in the cecum and an increased CD4+/CD8+ ratio in vaccinated animals when challenged with
Infantis,
Enteritidis and
Typhimurium. These results indicate that this new trivalent vaccine does not generate adverse effects in poultry and produces an increase in neutralizing antibodies against the three
serovars.
The devastating consequences of climate change have resulted in the promotion of clean energies, being the wind energy the one with greater potential. This technology has been developed in recent ...years following different strategic plans, playing special attention to wind generation. In this sense, the use of bicomponent materials in wind generator blades and housings is a widely spread procedure. However, the great complexity of the process followed to obtain this kind of materials hinders the problem of detecting anomalous situations in the plant, due to sensors or actuators malfunctions. This has a direct impact on the features of the final product, with the corresponding influence in the durability and wind generator performance. In this context, the present work proposes the use of a distributed anomaly detection system to identify the source of the wrong operation. With this aim, five different one-class techniques are considered to detect deviations in three plant components located in a bicomponent mixing machine installation: the flow meter, the pressure sensor and the pump speed.
Abstract
In this study, a hybrid model based on intelligent techniques is developed to predict the active power generated in a bioclimatic house by a low power wind turbine. Contrary to other ...researches that predict the generated power taking into account the speed and the direction of the wind, the model developed in this paper only uses the speed of the wind, measured mainly in a weather station from the government meteorological agency (MeteoGalicia). The wind speed is measured at different heights, against the usual measurements in others researches, which uses the wind speed and the direction measured in a weather station on the wind turbine nacelle. The prediction is performed 30 minutes ahead, what ensures that the Building Management System knows the energy generated by the low power wind turbine 30 minutes before, and it can adapt the consumption of different equipment in the house to optimize the power use. The main objective is to allow the Building Management System to optimize the uses of energy, taking into account the predicted amount of energy that will be produced and the energy consumed in the house. The developed model uses a hybrid topology with four clusters to improve the prediction, achieving an error lower than 6.5% for Mean Absolute Error measured in a final test. To perform this test, part of the original dataset was isolated from the beginning of the training process to check the model with a dataset that is not used before, simulating the model as it is receiving new data.
Abstract
Closed-loop administration of propofol for the control of hypnosis in anesthesia has evidenced an outperformance when comparing it with manual administration in terms of drug consumption and ...post-operative recovery of patients. Unlike other systems, the success of this strategy lies on the availability of a feedback variable capable of quantifying the current hypnotic state of the patient. However, the appearance of anomalies during the anesthetic process may result in inaccurate actions of the automatic controller. These anomalies may come from the monitors, the syringe pumps, the actions of the surgeon or even from alterations in patients. This could produce adverse side effects that can affect the patient postoperative and reduce the safety of the patient in the operating room. Then, the use of anomaly detection techniques plays a significant role to avoid this undesirable situations. This work assesses different one-class intelligent techniques to detect anomalies in patients undergoing general anesthesia. Due to the difficulty of obtaining real data from anomaly situations, artificial outliers are generated to check the performance of each classifier. The final model presents successful performance.
INTRODUCCIÓN. La reciente pandemia provocada por la COVID-19 ha supuesto numerosos cambios en los protocolos de salud pública, así como un profundo impacto socioeconómico. Políticas como el ...distanciamiento social y los confinamientos han condicionado las relaciones interpersonales y derivado en consecuencias dramáticas para muchas empresas y trabajadores. Concretamente, en el marco educativo, las universidades se han visto obligadas a adaptar las metodologías docentes a causa de las políticas de control implantadas por las autoridades. Por ello, el uso de herramientas para la docencia online, combinadas con experiencias en docencia presencial (blended learning, BL), constituye un interesante enfoque dentro de este contexto. MÉTODO. BL permite la reducción de la ratio de estudiantes por aula, evitando la supresión total de la presencialidad, y permitiendo también aprovechar las ventajas de ambas modalidades. En este sentido, una interesante propuesta es la implementación de un entorno de simulación virtual para estudiantes de ingeniería, cuyo objetivo es la emulación de un sistema real de control de nivel de líquido, disponible en los laboratorios de la Escuela Politécnica de Ingeniería de Ferrol, de la Universidad de A Coruña. Con el objetivo de evaluar el efecto de la metodología BL en el rendimiento académico del alumnado, se compararon las calificaciones obtenidas en el trabajo tutelado en dos cursos académicos. RESULTADOS. Para llevar a cabo este trabajo, se propone una experiencia BL apoyada en un laboratorio virtual construido a partir de la integración de dos novedosas la frase correcta sería: “herramientas de software”. Factory I/O como sistema de virtualización y emulación de escenas y plantas industriales reales y Node-RED como entorno de programación para el diseño de sistemas de control y comunicación. Con base en los resultados académicos, se concluye que esta metodología tiene un efecto positivo en el rendimiento de los estudiantes. DISCUSIÓN. Este entorno realista de simulación y de visualización 3D en tiempo real aporta flexibilidad a los estudiantes facilitando la organización de sus tareas y les permite trabajar de forma autónoma aplicando los conceptos base de la ingeniería de control. Además, esta experiencia BL ayuda a los estudiantes a desarrollar competencias básicas (duras) y transferibles (blandas).
Abstract
Automatic control of physiological variables is one of the most active areas in biomedical engineering. This paper is centered in the prediction of the analgesic variables evolution in ...patients undergoing surgery. The proposal is based on the use of hybrid intelligent modelling methods. The study considers the Analgesia Nociception Index (ANI) to assess the pain in the patient and remifentanil as intravenous analgesic. The model proposed is able to make a one-step-ahead prediction of the remifentanil dose corresponding to the current state of the patient. The input information is the previous remifentanil dose, the ANI variable and the electromyogram signal. Modelling techniques used are Artificial Neural Networks and Support Vector machines for Regression combined with clustering methods. Both training and validation were done with a real dataset from different patients. Results obtained show the potential of this methodology to calculate the drug dose corresponding to a given analgesic state of the patient.
OBJECTIVES/SPECIFIC AIMS: Island communities face greater environmental risks creating challenges in their populations. A community and participatory qualitative research method aiming to understand ...community perspectives regarding the ecology and environmental risks of the island of Culebra was performed to develop a community-centered Information and Communications Technology (ICT) intervention (an app). The island of Culebra, a municipality from the archipelago of Puerto Rico is located 17 miles from the eastern coast of Puerto Rico’s main island. This ICT—termed mZAP (Zonas, Acción & Protección)—is part of a Translational Biomedical doctoral degree dissertation housed at the University of Rochester’s Clinical Translational Science Institute (CTSI) Informatics Core funded by an NIH Clinical Translational Science Award (CTSA). In September 2017, the island of Culebra faced 2 major category hurricanes 2 weeks apart. Hurricane Irma and Hurricane Maria devastated homes, schools, health clinics, and local businesses, disrupting an already-fragile ecological balance on the island. METHODS/STUDY POPULATION: These 2 storms catastrophically affected the archipelago of Puerto Rico. Culebra’s geographically isolated location, along with the inefficient response from authorities, exacerbated the stressors caused by these natural disasters, increasing the gap of social determinants of health, including the lack of potable water. Leveraging a community engagement partnership established before the hurricanes by the mZAP participatory research, which naturally halted once the hurricanes hit a new humanitarian objective formed to deliver aid. Along with another NIH funded RCMI Translational Research Network, or RTRN institution (University of Puerto Rico, Medical Science Campus) students and faculty, The Puerto Rico Testsite for Exploring Contamination Threats Program (PROTECT) an NIEHS Funded Grant, and the National Guard, a “people to people” approach was established to ascertain needs and an opportunity to meet those needs. A people-to-people approach brings humanitarian needs, identified directly by the community to the people who need it most; without intermediaries and bureaucratic delays that typically occur during catastrophes. RESULTS/ANTICIPATED RESULTS: The consumption of potable water in plastic bottles and subsequent accumulation of plastic material has proven to be collateral damage of a vulnerable water distribution system creating another environmental hazard on the island of Culebra. Therefore, this humanitarian partnership, worked to delivered community and family sized water filters, providing a safe environmental alternative to drinkable water for the island. The success of this approach, People to People for Puerto Rico (#p2p4PUR), demonstrated the power of genuine community engagement—arising from a previous clinical research partnership—and true established commitment with members of the community. DISCUSSION/SIGNIFICANCE OF IMPACT: Research partnerships can (and should, when needed) lead to humanitarian partnerships that extend beyond research objectives. Research may subsequently be adapted based on new realities associated with natural disasters and the altered nature of existing partnerships, allowing for a rapid response to communities need. Further, #p2p4PUR was not only able to channel a partnership humanitarian response but also created an opportunity to reflect on how the commitment between members of society and academia (researchers) can create beneficial bilateral relationships, always putting the community needs first. The resulting shared experience elevates community interest and engagement with researchers, and helps researchers see communities as true partners, rather than—simply—research subjects.
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