Aims
Diseases caused by pathogenic fungi was a major constrain in increasing productivity and improving quality of Panax notoginseng. The aim of this research was to evaluate the inhibitory activity ...of essential oils (EOs) from Asteraceae family, Chrysanthemum indicum and Laggera pterodonta, against pathogenic fungi of P. notoginseng.
Methods and Results
The antifungal activity was investigated using multiple methods, disclosing that the EOs from C. indicum and L. pterodonta are active against hypha growth of different fungi but with different degrees of potency. Checkerboard testing indicated that the combination of EOs with hymexazol had synergistic effect against Pythium aphanidermatum, and exhibited additive effects against bulk of targeted pathogenic fungi. Besides, we found that the baseline sensitivity of Fusarium oxysporum to L. pterodonta EOs was higher than those of C. indicum by means of mycelium growth rate method. Finally, the practicability of those EOs as plant pesticide was confirmed by in vivo model showing that EOs can significantly inhibit the occurrence of root rot of P. notoginseng caused by F. oxysporum.
Conclusion
Those studies suggest that the EOs from C. indicum and L. pterodonta had the potential to develop into new pollution‐free pesticides for the protection of precious Chinese herbal medicines.
Significance and Impact of the Study
This study provided a new way of biological control for overcoming the frequent diseases occurrence of P. notoginseng.
Using a novel method of isochronous mass spectrometry, the masses of ^{62}Ge, ^{64}As, ^{66}Se, and ^{70}Kr are measured for the first time, and the masses of ^{58}Zn, ^{61}Ga, ^{63}Ge, ^{65}As, ...^{67}Se, ^{71}Kr, and ^{75}Sr are redetermined with improved accuracy. The new masses allow us to derive residual proton-neutron interactions (δV_{pn}) in the N=Z nuclei, which are found to decrease (increase) with increasing mass A for even-even (odd-odd) nuclei beyond Z=28. This bifurcation of δV_{pn} cannot be reproduced by the available mass models, nor is it consistent with expectations of a pseudo-SU(4) symmetry restoration in the fp shell. We performed ab initio calculations with a chiral three-nucleon force (3NF) included, which indicate the enhancement of the T=1 pn pairing over the T=0 pn pairing in this mass region, leading to the opposite evolving trends of δV_{pn} in even-even and odd-odd nuclei.
Background
To test the efficacy of electroacupuncture for patients with refractory functional dyspepsia (FD).
Methods
A 24‐week, 2‐arm, single‐blind, randomized controlled trial was conducted at ...three hospitals in China. Patients with refractory FD were randomly assigned to receive 20 sessions of authentic or sham electroacupuncture in a treatment duration of 4 weeks. The primary outcome was complete absence of dyspeptic symptoms at 16 weeks after initiation of acupuncture (week 16). The secondary outcomes included adequate relief of dyspeptic symptoms, Leeds Dyspepsia Questionnaire (LDQ), Nepean Dyspepsia Index (NDI), and adverse events. Intention‐to‐treat analysis was performed.
Key Results
Two hundred patients were included, of which 196 (98%) completed follow‐up data at week 24. At week 16, 17 (17%) patients in the authentic electroacupuncture group vs 6 (6%) patients in the sham group achieved the primary outcome (P = .014). Sixty‐two (62%) patients had adequate relief in the authentic electroacupuncture group, as compared to 22 (22%) in the sham group (P = .001). The scores of LDQ and NDI were significantly improved in both groups at week 16, and patients in the authentic electroacupuncture group have more improvements (LDQ, mean difference, −2.2, 95% confidence interval, −2.3 to −2.1, P < .001; NDI, −7.3, −10.5 to −4.2, P < .001). Results were similar for all the outcomes assessed at week 24. No serious adverse events were reported in both groups.
Conclusion
Acupuncture efficaciously improves dyspeptic symptoms in patients with refractory FD.
The efficacy of acupuncture in treating refractory functional dyspepsia is unknown. We found that electroacupuncture is efficacious and safe for this population.
The process e^{+}e^{-}→D_{s}^{*+}D_{s}^{*-} is studied with a semi-inclusive method using data samples at center-of-mass energies from threshold to 4.95 GeV collected with the BESIII detector ...operating at the Beijing Electron Positron Collider. The Born cross sections of the process are measured for the first time with high precision in this energy region. Two resonance structures are observed in the energy-dependent cross sections around 4.2 and 4.4 GeV. By fitting the cross sections with a coherent sum of three Breit-Wigner amplitudes and one phase-space amplitude, the two significant structures are assigned masses of (4186.8±8.7±30) and (4414.6±3.4±6.1) MeV/c^{2}, widths of (55±15±53) and (122.5±7.5±8.1) MeV, where the first errors are statistical and the second ones are systematic. The inclusion of a third Breit-Wigner amplitude is necessary to describe a structure around 4.79 GeV.
The global carbon budget 1959–2011 Le Quéré, C; Andres, R. J; Boden, T ...
Earth system science data,
05/2013, Letnik:
5, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Accurate assessments of anthropogenic carbon dioxide (CO sub(2)) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere is important to better understand the global ...carbon cycle, support the climate policy process, and project future climate change. Present-day analysis requires the combination of a range of data, algorithms, statistics and model estimates and their interpretation by a broad scientific community. Here we describe datasets and a methodology developed by the global carbon cycle science community to quantify all major components of the global carbon budget, including their uncertainties. We discuss changes compared to previous estimates, consistency within and among components, and methodology and data limitations. CO sub(2) emissions from fossil fuel combustion and cement production (E sub(FF)) are based on energy statistics, while emissions from Land-Use Change (E sub(LUC)), including deforestation, are based on combined evidence from land cover change data, fire activity in regions undergoing deforestation, and models. The global atmospheric CO sub(2) concentration is measured directly and its rate of growth (G sub(ATM)) is computed from the concentration. The mean ocean CO sub(2) sink (S sub(OCEAN)) is based on observations from the 1990s, while the annual anomalies and trends are estimated with ocean models. Finally, the global residual terrestrial CO sub(2) sink (S sub(LAND)) is estimated by the difference of the other terms. For the last decade available (2002-2011), E sub(FF) was 8.3 plus or minus 0.4 PgC yr super(-1), E sub(LUC) 1.0 plus or minus 0.5 PgC yr super(-1), G sub(ATM) 4.3 plus or minus 0.1PgC yr super(-1), S sub(OCEAN) 2.5 plus or minus 0.5 PgC yr super(-1), and S sub(LAND) 2.6 plus or minus 0.8 PgC yr super(-1). For year 2011 alone, E sub(FF) was 9.5 plus or minus 0.5 PgC yr super(-1), 3.0 percent above 2010, reflecting a continued trend in these emissions; E sub(LUC) was 0.9 plus or minus 0.5 PgC yr super(-1), approximately constant throughout the decade; G sub(ATM) was 3.6 plus or minus 0.2 PgC yr super(-1), S sub(OCEAN) was 2.7 plus or minus 0.5 PgC yr super(-1), and S sub(LAND) was 4.1 plus or minus 0.9 PgC yr super(-1). G sub(ATM) was low in 2011 compared to the 2002-2011 average because of a high uptake by the land probably in response to natural climate variability associated to La Nina conditions in the Pacific Ocean. The global atmospheric CO sub(2) concentration reached 391.31 plus or minus 0.13 ppm at the end of year 2011. We estimate that E sub(FF) will have increased by 2.6% (1.9-3.5%) in 2012 based on projections of gross world product and recent changes in the carbon intensity of the economy. All uncertainties are reported as plus or minus 1 sigma (68% confidence assuming Gaussian error distributions that the real value lies within the given interval), reflecting the current capacity to characterise the annual estimates of each component of the global carbon budget. This paper is intended to provide a baseline to keep track of annual carbon budgets in the future. All data presented here can be downloaded from the Carbon Dioxide Information Analysis Center (doi:10.3334/CDIAC/GCP_V2013).
Background and purpose:
Recent studies have shown that resveratrol increased endothelial progenitor cells (EPCs) numbers and functional activity. However, the mechanisms remain to be determined. ...Previous studies have demonstrated that increased EPC numbers and activity were associated with the inhibition of EPC senescence, which involves activation of telomerase. Therefore, we investigated whether resveratrol inhibits the onset of EPC senescence through telomerase activation, leading to potentiation of cellular activity.
Experimental approach:
After prolonged in vitro cultivation, EPCs were incubated with or without resveratrol. The senescence of EPCs were determined by acidic β‐galactosidase staining. The bromo‐deoxyuridine incorporation assay or a modified Boyden chamber assay were employed to assess proliferative or migratory capacity, respectively. To further examine the underlying mechanisms of these effects, we measured telomerase activity and the phosphorylation of Akt by western blotting.
Key results:
Resveratrol dose dependently prevented the onset of EPCs senescence and increased the proliferation and migration of EPCs. The effect of resveratrol on senescence could not be abolished by eNOS inhibitor or by an oestrogenic receptor antagonist. Resveratrol significantly increased telomerase activity and Akt phosphorylation. Pre‐treatment with the PI3K inhibitor, LY294002, significantly attenuated resveratrol‐induced telomerase activity.
Conclusions and implications:
Resveratrol delayed the onset of EPC senescence and this effect was accompanied by activation of telomerase through the PI3K‐Akt signalling pathway. The inhibition of EPCs senescence by resveratrol might protect EPCs against dysfunction induced by pathological factors in vivo and improve EPC functional activities in a way that may be important for cell therapy.
British Journal of Pharmacology (2008) 155, 387–394; doi:10.1038/bjp.2008.272; published online 30 June 2008
We report the measurement of the inclusive cross sections for e^{+}e^{-}→nOCH (where nOCH denotes non-open charm hadrons) with improved precision at center-of-mass (c.m.) energies from 3.645 to ...3.871 GeV. We observe three resonances: R(3760), R(3780), and R(3810) with significances of 8.1σ, 13.7σ, and 8.8σ, respectively. The R(3810) state is observed for the first time, while the R(3760) and R(3780) states are observed for the first time in the nOCH cross sections. Two sets of resonance parameters describe the energy-dependent line shape of the cross sections well. In set I set II, the R(3810) state has mass (3805.7±1.1±2.7) (3805.7±1.1±2.7) MeV/c^{2}, total width (11.6±2.9±1.9) (11.5±2.8±1.9) MeV, and an electronic width multiplied by the nOCH decay branching fraction of (10.9±3.8±2.5) (11.0±3.4±2.5) eV. In addition, we measure the branching fractions BR(3760)→nOCH=(25.2±16.1±30.4)%(6.4±4.8±7.7)% and BR(3780)→nOCH=(12.3±6.6±8.3)%(10.4±4.8±7.0)% for the first time. The R(3760) state can be interpreted as an open-charm (OC) molecular state, but containing a simple four-quark state component. The R(3810) state can be interpreted as a hadrocharmonium state.
Using (10087±44)×10^{6} J/ψ events collected with the BESIII detector, numerous Ξ^{-} and Λ decay asymmetry parameters are simultaneously determined from the process J/ψ→Ξ^{-}Ξover ...¯^{+}→Λ(pπ^{-})π^{-}Λover ¯(nover ¯π^{0})π^{+} and its charge-conjugate channel. The precisions of α_{Λ0} for Λ→nπ^{0} and αover ¯_{Λ0} for Λover ¯→nover ¯π^{0} compared to world averages are improved by factors of 4 and 1.7, respectively. The ratio of decay asymmetry parameters of Λ→nπ^{0} to that of Λ→pπ^{-}, ⟨α_{Λ0}⟩/⟨α_{Λ-}⟩, is determined to be 0.873±0.012_{-0.010}^{+0.011}, where the first and the second uncertainties are statistical and systematic, respectively. The ratio is smaller than unity more than 5σ, which signifies the existence of the ΔI=3/2 transition in Λ for the first time. Besides, we test for CP symmetry in Ξ^{-}→Λπ^{-} and in Λ→nπ^{0} with the best precision to date.
Based on data samples collected with the BESIII detector at the BEPCII collider, the process e^{+}e^{-}→Σ^{+}Σover ¯^{-} is studied at center-of-mass energies sqrts=2.3960, 2.6454, and 2.9000 GeV. ...Using a fully differential angular description of the final state particles, both the relative magnitude and phase information of the Σ^{+} electromagnetic form factors in the timelike region are extracted. The relative phase between the electric and magnetic form factors is determined to be sinΔΦ=-0.67±0.29(stat)±0.18(syst) at sqrts=2.3960 GeV, ΔΦ=55°±19°(stat)±14°(syst) at sqrts=2.6454 GeV, and 78°±22°(stat)±9°(syst) at sqrts=2.9000 GeV. For the first time, the phase of the hyperon electromagnetic form factors is explored in a wide range of four-momentum transfer. The evolution of the phase along with four-momentum transfer is an important input for understanding its asymptotic behavior and the dynamics of baryons.
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