To investigate the clinical and imaging characteristics of computed tomography (CT) in novel coronavirus pneumonia (NCP) caused by SARS-CoV-2.
A retrospective analysis was performed on the imaging ...findings of patients confirmed with COVID-19 pneumonia who had chest CT scanning and treatment after disease onset. The clinical and imaging data were analyzed.
Fifty patients were enrolled, including mild type in nine, common in 28, severe in 10 and critically severe in the rest three. Mild patients (29 years) were significantly (P<0.03) younger than either common (44.5 years) or severe (54.7) and critically severe (65.7 years) patients, and common patients were also significantly (P<0.03) younger than severe and critically severe patients. Mild patients had low to moderate fever (<39.1 °C), 49 (98%) patients had normal or slightly reduced leukocyte count, 14 (28%) had decreased counts of lymphocytes, and 26 (52%) patients had increased C-reactive protein. Nine mild patients were negative in CT imaging. For all the other types of NCP, the lesion was in the right upper lobe in 30 cases, right middle lobe in 22, right lower lobe in 39, left upper lobe in 33 and left lower lobe in 36. The lesion was primarily located in the peripheral area under the pleura with possible extension towards the pulmonary hilum. Symmetrical lesions were seen in 26 cases and asymmetrical in 15. The density of lesion was mostly uneven with ground glass opacity as the primary presentation accompanied by partial consolidation and fibrosis.
CT imaging presentations of NCP are mostly patchy ground glass opacities in the peripheral areas under the pleura with partial consolidation which will be absorbed with formation of fibrotic stripes if improved. CT scanning provides important bases for early diagnosis and treatment of NCP.
•Chitosan/cellulose-based sorbents designed for heavy metals removal from drink water.•The sorbents combined with renewability, biocompatibility and magnetic property.•The sobents had micro/nano pore ...structure and operational convenience.•Magnetic microspheres displayed superior adsorption and desorption capabilities.
Development of highly cost-effective, highly operation-convenient and highly efficient natural polymer-based adsorbents for their biodegradability and biocompatibility, and supply of safe drinking water are the most threatening problems in water treatment field. To tackle the challenges, a new kind of efficient recyclable magnetic chitosan/cellulose hybrid microspheres was prepared by sol–gel method. By embedding magnetic γ-Fe2O3 nanoparticles in chitosan/cellulose matrix drops in NaOH/urea aqueous solution, it combined renewability and biocompatibility of chitosan and cellulose as well as magnetic properties of γ-Fe2O3 to create a hybrid system in heavy metal ions removal.
•Underwater superoleophobic cotton fabric was prepared by a mussel-inspired method.•The underwater superoleophobic cotton fabric is efficient in oil/water separation.•The underwater superoleophobic ...cotton fabric exhibited outstanding mechanical resistance.•The underwater superoleophobic cotton fabric showed excellent chemical resistance.
Superhydrophilic and underwater superoleophobic textiles exhibit excellent oil/water separation performance but are limited by the poor stability and environmental incompatibility. Inspired by strong adhesion of marine mussels, we designed and fabricated a stable and eco-friendly superhydrophilic and underwater superoleophobic cotton fabric (CF) from all renewable resources through in-situ surface deposition of polydopamine (PDA) particles followed by adsorption of hydrophilic chitosan via dip coating at room temperature. The as-prepared superhydrophilic and underwater superoleophobic CF exhibited outstanding oil/water separation performance with separation efficiency and water flux higher than 99 % and 15,000 L m−2 h-1, respectively. Moreover, it not only showed excellent resistance to mechanical abrasion and ultrasound treatment but also had outstanding superwetting stability against acid/alkali/salt erosion. We believed that the eco-friendly superhydrophilic and underwater superoleophobic CF would exhibit great potential in oil/water separation especially under harsh conditions.
Poly(lactic acid) (PLA) is regarded as one of the most promising biobased and biodegradable polymers due its various advantages including high mechanical strength, easy processability, high melting ...temperature, renewability, biodegradability, and biocompatibility. However, the inherent brittleness significantly restricts its wide application. Therefore, toughening PLA has attracted more and more attention and various materials have been used to blend with PLA for toughening. Considering the fact that the use of petroleum-based species to toughen PLA would partially sacrifice the sustainability, various renewable polymers have recently been employed to toughen PLA. A series of important achievements have been obtained but not reviewed. This article aims to review progress in toughening PLA with renewable polymers. The toughening theories and compatibilization strategies are also briefly introduced.
The climatology, trends and leading modes of land surface latent heat flux (LHF) and sensible heat flux (SHF) as well as their responses to monsoon and precipitation in global land monsoon domains ...are presented. During the past three decades, LHF and SHF have generally undergone a rising and decreasing trend (that is, (LHF+, SHF-)), respectively, in Asian, North African, Austrian, and South American monsoon domains. Moreover, the increasing rate of LHF was higher than the decreasing rate of SHF, which causes a decreased trend in Bowen ratio. Two other dominant trend patterns, (LHF-, SHF-) and (LHF+, SHF+), are observed in South African and South American monsoon domains, respectively. The trends in LHF and SHF are closely linked to increasing global monsoon intensity and precipitation, especially for the monsoon domain that has annual precipitation lower than 1300 mm yr
. Singular value decomposition (SVD) analyses show that monsoon strength explains 25.2% and 22.2% total covariance of LHF and SHF respectively in the first modes, and that precipitation slightly raises the percentages up to 27.8% and 24% respectively. The increasing monsoon and precipitation on one hand favor more land surface available energy being converted into LHF; on the other hand they enhance the LHF by increasing the land surface net radiation. Moreover, remarkable phase shifts in LHF and SHF are observed for monsoon domains during late-1990s, which are in phase with those of precipitation and monsoon strength. The intensifying LHF and precipitation indicate the acceleration of hydrological cycle in global terrestrial monsoon domains.
Despite the importance of stem cells in plant and animal development, the common mechanisms of stem cell maintenance in both systems have remained elusive. Recently, the importance of hydrogen ...peroxide (H2O2) signaling in priming stem cell differentiation has been extensively studied in animals. Here, we show that different forms of reactive oxygen species (ROS) have antagonistic roles in plant stem cell regulation, which were established by distinct spatiotemporal patterns of ROS‐metabolizing enzymes. The superoxide anion (O2·−) is markedly enriched in stem cells to activate WUSCHEL and maintain stemness, whereas H2O2 is more abundant in the differentiating peripheral zone to promote stem cell differentiation. Moreover, H2O2 negatively regulates O2·− biosynthesis in stem cells, and increasing H2O2 levels or scavenging O2·− leads to the termination of stem cells. Our results provide a mechanistic framework for ROS‐mediated control of plant stem cell fate and demonstrate that the balance between O2·− and H2O2 is key to stem cell maintenance and differentiation.
Synopsis
Superoxide regulates plant stem cell fate, and the balance between superoxide and H2O2 serves as a key switch for stem cell maintenance versus differentiation by antagonistically regulating expression of stem cell fate transcription factor WUSCHEL.
Superoxide specifically accumulates in plant stem cells to determine the stem‐cell fate.
H2O2 is enriched in the differentiating peripheral zone to promote plant stem cell differentiation.
Repression of superoxide dismutases and activation of peroxidases establishes the high superoxide and low H2O2 distribution patterns in plant stem cells.
H2O2 negatively regulates superoxide accumulation in stem cells by inhibiting key enzymes in superoxide anabolism.
The superoxide/H2O2 balance controls plant stem cell fate by antagonistically regulating WUSCHEL expression.
Superoxide regulates plant stem cell fate, and the balance between superoxide and H2O2 serves as a key switch for stem cell maintenance versus differentiation by antagonistically regulating expression of stem cell fate transcription factor WUSCHEL.
•ESP-FLUS model is developed to predict the urban growth and delineate the urban growth boundaries with a comprehensive consideration of ecological protection.•Random forest coupled with Gini ...importance are applied to identify the driving forces of land use change.•Urban growth simulation and urban growth boundaries delineation are conducted under different scenarios.•Local master plans and national policies are considered in advancing the optimal urban growth scenario.
Delineating urban growth boundaries (UGBs) has been proved as an effective approach to constrain urban encroachment and achieve sustainable urban development. However, so far, many studies have not fully taken account of the ecosystem integrity in simulating the urban growth as well as the corresponding UGBs delineation. To bridge this research gap, this paper proposes an ESP-FLUS model to predict the future land use pattern with a comprehensive consideration of ecological protection. In this paper, on the one hand, the ecological security pattern (ESP) is integrated from four ecological aspects (i.e., hydrology, geology, biodiversity, and recreation) and classified into three levels (i.e., basic ESP, intermediate ESP, and optimal ESP). On the other hand, drawing on historical records, random forest coupled with Gini importance are applied to identify the driving factors in shaping the land use variation. Taking the classified ESP as the spatial constraint allied with the identified driving factors into a FLUS model, this paper predicts the urban growth in 2035 in a multi-scenario manner. By analysing the multi-scenario simulation results at both region and district levels, the possible urban planning option under the requirements of local master plans is suggested for sustainable urban development. Against a backdrop of an increasingly severe environmental crisis, this paper develops a new research paradigm to incorporate ESP into UGBs delineation as a way to shed light for urban planners on reaching the balance between eco-environment protection and socio-economic development.
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we ...identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this study.
The substitution of petroleum-based self-healing elastomers with biobased counterparts is crucial to the global sustainable development of the rubber industry, which highly depends on the ease of the ...synthesis procedure. Herein, we show that highly stretchable, recyclable, and self-healable biobased elastomers were synthesized via condensation polymerization of succinic acid, adipic acid, sebacic acid, and 1,4-butanediol in the presence of a small amount of glycerol as a curing agent and 3,3′-dithiodipropionic acid as a dynamic covalent monomer. The macroscopic properties of our elastomers, including thermal, mechanical, stress relaxation, and self-healing performance, were finely regulated via microscopic chemical and topological structure. As such, a highly stretchable (up to ∼1700%), recyclable (almost without degradation of the mechanical performance over several repeats), rapid room temperature self-healable (in 20 min) biobased vitrimeric elastomer was achieved, which is the first aliphatic disulfide metathesis assisted self-healing polymer achieved at such low temperatures. The ease of the polycondensation with which the elastomers can be readily scaled up points to exciting opportunities for sustainable polymers with minimal environmental impact.
Narrow-sense heritability (h
) is an important genetic parameter that quantifies the proportion of phenotypic variance in a trait attributable to the additive genetic variation generated by all ...causal variants. Estimation of h
previously relied on closely related individuals, but recent developments allow estimation of the variance explained by all SNPs used in a genome-wide association study (GWAS) in conventionally unrelated individuals, that is, the SNP-based heritability (). In this Perspective, we discuss recently developed methods to estimate for a complex trait (and genetic correlation between traits) using individual-level or summary GWAS data. We discuss issues that could influence the accuracy of , definitions, assumptions and interpretations of the models, and pitfalls of misusing the methods and misinterpreting the models and results.
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