Maintenance of dental health has attracted attention of researchers at present. Various materials have been constructed and applied for curing different dental diseases, although limitation of ...biocompatibility and safety is still a big challenge. To overcome these limitations, nanomaterials with unique properties are incorporated into various dental treatment materials used in dental applications, including endodontic treatment, periodontal treatment, implant treatment, oral surgery, and restorative treatment, etc. Especially, reactive oxygen species-based nanomaterials equipped with nanoscale properties and reactive oxygen activities can be used as sterilization agents in dentistry, along with being used as good fillers in the dental field. This review concludes the common reactive oxygen species (ROS) nanomaterials and reviews the utilization of ROS in dentistry, highlighting the potential application and safety in clinical treatment. The future prospect will also be proposed to conduct the clinic dental cure.
When the skin is damaged, accelerating the repair of skin trauma and promoting the recovery of tissue function are crucial considerations in clinical treatment. Previously, we isolated and identified ...an active peptide (livisin) from the skin secretion of the frog
. Livisin exhibited strong protease inhibitory activity, water solubility, and stability, yet its wound-healing properties have not yet been studied. In this study, we assessed the impact of livisin on wound healing and investigated the underlying mechanism contributing to its effect. Our findings revealed livisin effectively stimulated the migration of keratinocytes, with the underlying mechanisms involved the activation of CaSR as a peptide calcium mimetic. This activation resulted in the stimulation of the CaSR/E-cadherin/EGFR/ERK signaling pathways. Moreover, the therapeutic effects of livisin were partially reduced by blocking the CaSR/E-cadherin/EGFR/ERK signaling pathway. The interaction between livisin and CaSR was further investigated by molecular docking. Additionally, studies using a mouse full-thickness wound model demonstrated livisin could accelerate skin wound healing by promoting re-epithelialization and collagen deposition. In conclusion, our study provides experimental evidence supporting the use of livisin in skin wound healing, highlighting its potential as an effective therapeutic option.
Heavy metal pollution is a serious environmental problem, and adsorption is regarded as an effective technology for metal ions removal. A new absorbent triethylene tetramine (TETA)-modified ...crosslinked polyacrylonitrile (TETA-modified XL-PAN) was prepared by photo-induced precipitation polymerization of acrylonitrile in water at room temperature using FeC
2
O
4
as photoinitiator and
N
,
N′
-methylenebisacrylamide as crosslinking agent. The TETA provided amidogens, to bond Cu(II) ions and the crosslinking agent was used to improve the stability of adsorbent. FTIR, SEM, BET, and TG were used to characterize the TETA-modified XL-PAN. The FTIR results demonstrate that the XL-PAN was successfully modified by TETA. The SEM images show that TETA-modified XL-PAN powders were agglomerated from 100 to 200 nm spherical particles. TETA-modified XL-PAN was used as an adsorbent to remove Cu(II) ion from wastewater. The effects of contact time, pH, Cu(II) concentration, temperature, and reuse cycles on adsorption were investigated, respectively. Experimental results showed that the adsorption isotherms agreed well with the Langmuir model and a chemical adsorption between TETA-modified XL-PAN and Cu(II) was inferred. After optimizing the experimental conditions, the maximum adsorption capacity of TETA-modified XL-PAN for Cu(II) was 46.6 mg/g with an adsorption time of 8 h. Furthermore, the TETA-modified XL-PAN adsorbent can be well regenerated by acid solutions. After eight regeneration and adsorption processes, the adsorption capacity still reached more than 90% of the first adsorption capacity. These results demonstrated the potential use of TETA-modified XL-PAN as an effective adsorbent for Cu(II) ions removal from wastewater.
The high voltage application of the LiNi0.5Co0.2Mn0.3O2 cathode is still hindered by its unstable surficial structure and poor capacity retention. Surface coating has been proved to be an effective ...strategy to deal with these problems. However, previous multistep surface coating approaches greatly complicate the synthesis procedure. In this work, a simple and large-scale solid-state approach is developed to prepare lanthanum-based oxides co-coated LiNi0.5Co0.2Mn0.3O2 cathode materials. Electrochemical tests indicate that the co-coated samples exhibit superior cycle life and higher rate performance than those of the pristine sample. Further studies reveal that the enhanced interface stability and facilitated electron transportation can be attributed to the synergetic contribution provided by the lanthanum-based oxides co-coating layer. The present work demonstrates that our approach can achieve cathode synthesis and surface coating synchronously, and shows great potential to apply on a large scale and extent to all Ni-rich cathodes.
•Lanthanum-based oxide co-coated LiNi0.5Co0.2Mn0.3O2 is prepared via a simple route.•The smart route achieves cathode synthesis and surface coating simultaneously.•The co-coated LiNi0.5Co0.2Mn0.3O2 shows superior electrochemical performance.•The co-coating layers enhance the de-lithiation kinetic and conductivity.•The co-coating layers suppress electrochemical degradation.
This work develops a halophilic biocarriers-MBR for saline pharmaceutical wastewater treatment. The system has effectively treated the ampicillin-containing saline wastewater for 32 days, when the ...ampicillin concentration is lower than 20 mg/L. The system can tolerate the saline organic wastewater with a reasonable biodegradability (removals of COD over 75%) when the ampicillin concentration is 50 mg/L. The system has a bad performance in biodegradation (COD removals around 60–70%) and fouled within 16 days at a high ampicillin concentration of 100 mg/L. At high transmembrane pressures over 30 KPa, some ampicillin molecules may permeate through the membrane causing decreases in the ampicillin removal. The concentrations of protein and carbohydrate in EPS and SMP have increased over time and with increasing the ampicillin concentration. The method of biofouling control in MBR for the ampicillin situations has been proposed based on monitoring the concentrations of EPS and SMP. The drying-assisted monitoring of membrane biofoulants has showed a better efficiency than the monitoring of transmembrane pressure for membrane anti-biofouling in the treatment of pharmaceutical saline wastewaters where a spectroscopic detection can be hardly applied. This work may benefit relative research works for the control of biodegradation performance and membrane biofouling to better treat saline pharmaceutical wastewaters.
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•The ampicillin-containing wastewaters were treated in a halophilic biocarriers-MBR.•An acclimation process was observed at a ampicillin concentration of 20 mg/L.•The system could tolerate an ampicillin concentration no more than 50 mg/L.•The ratio of protein over carbohydrate in EPS and SMP varied from 1 to 3.•A drying-assisted monitoring of biofoulants was proposed for membrane antifouling.
Compound 3d R = p-Cl, IC50 =3.12 ± 1.25 μM.
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A series of (Z)-3-(2-(1,3,4-thiadiazol-2-yl)hydrazono)-1-substituted indolin-2-ones derivatives (3a-3m) were designed and synthesized. All ...newly synthesized compounds were evaluated for their a-glucosidase inhibitory activity with resveratrol as positive control in vitro. Except for 3i and 3j, all of the compounds showed a potent inhibitory activity against a-glucosidase with IC50 values in the range of 3.12 ± 1.25 to 45.95 ± 1.26 μM and the purity of these compounds was greater than 95%. The IC50 values were being compared to the standard resveratrol (IC50 = 22.00 ± 1.15 μM) and it was found that compounds 3b, 3d-3h were found to be more active than resveratrol. Specifically, (Z)-3-(2-(1,3,4-thiadiazol-2-yl)hydrazono)-1-(4-chlorobenzyl)indolin-2-one (3d) exhibited the most potent a-glucosidase inhibitory activity with IC50 value of 3.12 ± 1.25 μM. The kinetic analysis revealed that compound (3d) is noncompetitive inhibitor. Structure activity relationship has been established for all compounds. Furthermore, the binding interactions of compound 3d with the active site of a-glucosidase were confirmed through molecular docking. This study has identified a new class of potent a-glucosidase inhibitors for further investigation.
Poly(L-lactide-co-caprolactone)(85-15)P(LLA-CL)(85-15) was synthesized from high purity L-lactide and
ɛ
-caprolactone using tin octoate as initiator by ring-opening polymerization, and characterized ...by infrared spectrum and
1
H-NMR spectrum. The synthesized P(LLA-CL)(85-15) is a random copolymer. The influences of polymerization temperature, polymerization time, dosage of initiator and polymerization pressure on the weight average molecular weight and the polydispersity index of P(LLA-CL)(85-15) were investigated. The optimum preparation conditions of P(LLA-CL) (85-15) are: the polymerization pressure is less than 0.5 Pa, the polymerization temperature is 130 °C, the
n
(M)/
n
(I) ratio is 8 000/1, and the polymerization time is 36 h. Under the condition, the weight-average molecular weight of prepared P(LLA-CL)(85-15) is 65.6×10
4
, and molecular weight distribution coefficient is 1.15.
A series of Eu(III) complexes of α-thenoyltrifluoroacetone(HTTA) with trioctylphosphine oxide(TPPO) and benzoic acid(BA) or its two derivatives,
p-toluic acid(PTA) and
p-methoxybenzoic acid(POA) were ...synthesized and were characterized with elemental analysis, IR spectroscopy, scanning electronic microscopy and fluorescent spectra. The complexes were revealed to be Eu(BA)(TTA)
2TPPO
2, Eu(PTA)(TTA)
2TPPO
2 and Eu(POA)(TTA)
2TPPO
2. The excitation and absorption spectra of the complex Eu(POA)(TTA)
2TPPO
2 in MeOH solution were investigated in detail. The experimental result showed that relatively cheap materials with sharp red luminescence could be prepared, when benzoic acid or its two derivatives were added in Eu(III) complexes of α-thenoyltrifluoroacetone with trioctylphosphine oxide. The relative fluorescence intensity of the Eu(III) complexes decreased in the following order: Eu(POA)(TTA)
2TPPO
2> Eu(PTA)(TTA)
2TPPO
2>Eu(BA)(TTA)
2TPPO
2.
Cryopreservation has been a key technology in medical science, food preservation, and many other fields. In a freezing process, the formation of ice crystals may cause significant damage to the ...frozen samples. In order to reduce the damage, many cryoprotectants (CPAs) have been developed and added in cryopreservation processes for reduced ice volume, decreased ice size, proper ice shaping, and cell protection. According to the material characteristics, the CPAs are either impermeable (i.e., antifreeze protein, polyampholytes, and polyvinyl alcohol) or permeable (i.e., dimethyl sulfoxide, proline, and glycerol) to cell membranes. The typical CPAs are introduced in this work with their material characteristics, antifreeze mechanisms, and applications. Antifreeze mechanisms for different CPAs involve molecular adsorption on the ice surface, hydrogen bonding to ice, bending the ice surface, lowering the freezing point, inhibiting ice recrystallization, protecting cell membranes, reducing dehydration of cells, and breaking hydrogen bonds among ice crystals to reduce the size of ice crystals. In practice, different CPAs can be used together with their cryopreservation properties functioning synergetically. This study reviews the recent applications of CPAs in food, biology and medicine, and agriculture. Future works for CPAs are suggested in improving efficiency, revealing mechanisms, broadening application, and finding new CPAs.
Solid state dodecyl perylene diimide (DDPDI) fluorescent materials (DDPDI/MCM-41) with strong fluorescence were successfully prepared by incorporating the DDPDI molecules into the nanopores of MCM-41 ...in toluene solution with subsequent ultrasonic treatment. The solid materials were characterized by small-angle X-ray diffraction (SAXRD), high-resolution transmission electron microscopy (HRTEM), ultraviolet-visible spectroscopy (DR UV-vis), fluorescence spectroscopy, and elemental analysis. The results indicated that the DDPDI molecules were incorporated into the mesopores of MCM-41 in the monomeric or dimeric state after ultrasonic treatment, and the DDPDI content was 41.0 (mg g −1 ). In addition, the Stokes shift of the DDPDI in MCM-41 decreased to zero in contrast to that in toluene solution. Emission of DDPDI/MCM-41 composites split into two peaks at 543 nm and 551 nm in water, indicating DDPDI molecules attached at the internal and external surface of the pores of MCM-41. The difference of spectral shift was proportional to the permittivity of the solvent.
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