The energy crisis and environmental pollution have forced scientists to explore alternative energy conversion and storage devices. The anodic reactions of these devices are all oxygen evolution ...reactions (OER), so the development of efficient OER electrocatalysts is of great significance. At the same time, understanding the reaction mechanism of OER is conducive to the rational design of efficient OER electrocatalysts. In general, catalytic active centers play a direct role in OER performance. In this paper, a series of stable bimetallic metal–organic frameworks (MOFs, named as Fe3‐Con‐X2, n=2, 3 and X=F, Cl, Br) with similar structure were synthesized by changing the halogen coordinated with the cobalt metal active center, aiming to investigate the influence of halogen substitution effect on OER performance. It was found that the OER activity of Fe3‐Co3‐F2 is much better than Fe3‐Co2‐Cl2 and Fe3‐Co2‐Br2, indicating that the regulation of the electronegativity change of the coordination halogen atom can regulate the coordination electron structure of the metal active center, thereby achieving effective regulation of OER performance.
Under the influence: Construction of a series of similar MOFs by halogen substitution was carried out, in order to study the impact of electric structure of the catalytic active sites on OER.
Little is known about the role of association between ABO blood type and risk of pancreatic cancer develops through effects on hepatitis B viral (HBV) infection. Our study aimed to determine whether ...joint ABO blood type and HBV infection could increase the risk for pancreatic cancer. A total of 645 patients with pancreatic adenocarcinoma and 711 age‐ and sex‐matched individuals who had nonmalignant diseases treated at the Sun Yat‐sen University Cancer Center in China were retrospectively analyzed. Blood samples were tested for ABO blood type and hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti‐HBs), hepatitis B e antigen (HBeAg), hepatitis B e antibody (anti‐HBe) and hepatitis B core antibody (anti‐HBc). Multivariable unconditional logistic regression analysis was used to estimate adjusted odds ratios AORs and 95% confidence interval CI. Multivariable analysis with adjustment for risk factors showed that A blood type, HBsAg‐positive/anti‐HBc‐positive, anti‐HBs‐positive/anti‐HBc‐positive were significantly associated with pancreatic cancer. The estimated AORs (95% CI) were as follows: A blood type, 1.425 (1.071–1.894), HBsAg‐positive/anti‐HBc‐positive, 1.610 (1.125–2.304), anti‐HBs‐positive/anti‐HBc‐positive, 1.526 (1.159–2.011). The effect of A blood type significantly modified the risk of pancreatic cancer among subjects with anti‐HBc‐positive (AORs = 1.882, 95% CI, 1.284–2.760). In our study, we reported an association between A blood type, infection with HBV and pancreatic cancer risk. Moreover, we found a synergism between A blood type and HBV infection in the development of pancreatic cancer.
Traumatic brain injury (TBI) induced the gastrointestinal inflammation that is associated with TBI-related morbidity and mortality. Carbon monoxide-releasing molecule (CORM)-3 is a water-soluble ...exogenous carbon monoxide that exerts protective effects against inflammation-induced pyroptosis. We investigated the gastrointestinal inflammation in a rodent model of traumatic brain injury (TBI) with subsequent hemorrhagic shock and resuscitation (HSR), as well as effects of CORM-3 using an intestinal injection on both gut and brain.
Following exposure to TBI plus HSR, rats were administrated with CORM-3 (8 mg/kg) through an intestinal injection after resuscitation immediately. The pathological changes and pyroptosis in the gut were measured at 24 h and 30 day post-trauma. We also assessed the intestinal and cortical CO content, as well as IL-1β and IL-18 levels in the serum within 48 h after trauma. We then explored pathological changes in the ventromedial prefrontal cortex (vmPFC) and neurological behavior deficits on 30 day post-trauma.
After TBI + HSR exposure, CORM-3-treated rats presented significantly decreased pyroptosis, more CO content in the jejunum, and lower IL-1β, IL-18 levels in the serum at 24 h after trauma. Moreover, the rats treated with CORM-3 exerted ameliorated jejunal and vmPFC injury, enhanced learning/memory ability and exploratory activity, improved anxiety-like behaviors than the TBI + HSR-treated rats on 30 day post-trauma.
These experimental data demonstrated and bidirectional gut–brain interactions after TBI, anti-inflammatory effects of CORM-3, which may improve late outcomes after brain injury.
•TBI plus HSR caused increased pyroptosis in the vmPFC and jejunum in the acute stage.•TBI plus HSR caused degeneration in morphopathological changes in the jejunum and vmPFC in the late stage.•CORM-3 via intestinal injection provided protection against TBI plus HSR via a bidirectional gut–brain communication.
Aim
Hepatocellular carcinoma (HCC) is common and causes many deaths worldwide. The aim of this study is to explore the mechanism by which long non‐coding RNA FGD5‐AS1 regulates HCC cell proliferation ...and stemness.
Methods
Tumor and normal adjacent tissues were harvested from HCC patients. Real‐time quantitative reverse transcription‐PCR was applied to examine the expression of FGD5‐AS1, miR‐223, Epithelial cell transforming sequence 2 (ECT2) and FAT1. The protein levels of ECT2, FAT1, proliferating cell nuclear antigen (PCNA), OCT4, CD133 and CD90 were analyzed by western blot. The localization of FGD5‐AS1 was examined by Fluorescence in situ hybridization. Cell proliferation was analyzed with CCK‐8 and colony formation assays. Spheroid formation was used for analyzing cell stemness. Gene interaction was examined by RNA immunoprecipitation and luciferase activity assays. A subcutaneous xenograft mouse model was established to analyze HCC growth and stemness in vivo. Immunohistochemistry staining was used to analyze the expression PCNA and OCT4 in subcutaneous tumors.
Results
FGD5‐AS1 was upregulated in HCC and its high expression indicated poor prognosis of patients. High expression of FGD5‐AS1 enhanced HCC cell proliferation and stemness. Knockdown of FGD5‐AS1 restrained tumor growth and stemness in mice. FGD5‐AS1 directly sponged miR‐223 and promoted the expression of ECT2 and FAT1 in HCC. Both knockdown of miR‐223 and overexpression of ECT2 and FAT1 reversed FGD5‐AS1 silencing‐mediated suppression of HCC cell proliferation and stemness.
Conclusion
FGD5‐AS1 directly sponged miR‐223 and promoted the expression of ECT2 and FAT1 in HCC, thus enhancing HCC cell proliferation and stemness. Our study identifies potential prognostic biomarkers and therapeutic targets for HCC.
This study aimed to investigate and compare the effects of two widely used nonfusion posterior dynamic stabilization (NPDS) devices, pedicle screw‐based dynamic stabilizer (PSDS) and interspinous ...process spacer (IPS), on biomechanics of the implanted lumbar spine under static and vibration loadings. The finite element model of healthy human lumbosacral segment was modified to incorporate NPDS device insertion at L4–L5 segment. Bioflex and DIAM were used as PSDS‐based and IPS‐based NPDS devices, respectively. As a comparison, lumbar interbody fusion with rigid stabilization was also simulated at L4–L5. For static loading, segmental range of motion (ROM) of the models under moments of four physiological motions was computed using hybrid testing protocol. For vibration loading, resonant modes and dynamic stress of the models under vertical excitation were extracted through random response analysis. The results showed that compared with the rigid fusion model, ROM of the nonfusion models was higher at L4–L5 level but lower at adjacent levels (L1– L2, L2–L3, L3–L4, L5–S1). Compared with the Bioflex model, the DIAM model produced higher ROM at L4–L5 level but lower ROM at adjacent levels, especially under lateral bending and axial rotation; resonant frequency of the DIAM model was slightly lower; dynamic response of nucleus stress at L4–L5 level was slightly higher for the DIAM model, and the dynamic stress at adjacent levels was no obvious difference between the nonfusion models. This study reveals biomechanical differences between the Bioflex and DIAM systems, which may provide references for selecting surgical approaches in clinical practice.
This finite element study presents a comparison between two nonfusion dynamic stabilization devices, Bioflex and DIAM. The results indicate that under the static loading, the DIAM model produces higher range of motion (ROM) at implanted level but lower ROM at adjacent levels than the Bioflex model, indicating that DIAM could better preserve mobility of the implanted segment and might lessen the probability of adjacent segment degeneration; under the vibration loading, the Bioflex and DIAM models have similar stress response values.
Steric effects in chemical reactionsAlthough steric (orientation-dependent) effects in reactive scattering are well known to exist in the theory of chemical dynamics, there is a need for combined ...experimental-theoretical studies that rigorously explore these effects at the most fundamental level. Using polarized stimulated Raman pumping to prepare the hydrogen-deuterium (HD) molecules with the HD bond axis aligned either parallel or perpendicular to the H atom velocity, Wang et al. obtained high-quality stereodynamical data for the H + HD→H2 + D reaction. These measurements demonstrate that the HD orientation has a substantial effect on this most fundamental chemical reaction, and is further supported by excellent agreement with quantum mechanical calculations. The present work is an important milestone in the field of reaction dynamics. —YS
Highly accurate potential energy surfaces are critically important for chemical reaction dynamics. The large number of degrees of freedom and the intricate symmetry adaption pose a big challenge to ...accurately representing potential energy surfaces (PESs) for polyatomic reactions. Recently, our group has made substantial progress in this direction by developing the fundamental invariant-neural network (FI-NN) approach. Here, we review these advances, demonstrating that the FI-NN approach can represent highly accurate, global, full-dimensional PESs for reactive systems with even more than 10 atoms. These multi-channel reactions typically involve many intermediates, transition states, and products. The complexity and ruggedness of this potential energy landscape present even greater challenges for full-dimensional PES representation. These PESs exhibit a high level of complexity, molecular size, and accuracy of fit. Dynamics simulations based on these PESs have unveiled intriguing and novel reaction mechanisms, providing deep insights into the intricate dynamics involved in combustion, atmospheric, and organic chemistry.
Object detection is one of the most fundamental yet challenging research topics in the domain of computer vision. Recently, the study on this topic in aerial images has made tremendous progress. ...However, complex background and worse imaging quality are obvious problems in aerial object detection. Most state-of-the-art approaches tend to develop elaborate attention mechanisms for the space-time feature calibrations with arduous computational complexity, while surprisingly ignoring the importance of feature calibrations in channel-wise. In this work, we propose a simple yet effective calibrated-guidance (CG) scheme to enhance channel communications in a feature transformer fashion, which can adaptively determine the calibration weights for each channel based on the global feature affinity correlations. Specifically, for a given set of feature maps, CG first computes the feature similarity between each channel and the remaining channels as the intermediary calibration guidance. Then, rerepresenting each channel by aggregating all the channels weighted together via the guidance operation. Our CG is a general module that can be plugged into any deep neural networks, which is named as CG-Net. To demonstrate its effectiveness and efficiency, extensive experiments are carried out on both oriented object detection task and horizontal object detection task in aerial images. Experimental results on two challenging benchmarks ( i . e ., DOTA and HRSC2016) demonstrate that our CG-Net can achieve the new state-of-the-art performance in accuracy with a fair computational overhead. The source code has been open sourced at https://github.com/WeiZongqi/CG-Net .
PDF
