We demonstrate the facile, rational synthesis of monodispersedly sized zinc oxide (ZnO) nanowires from randomly sized seeds by hydrothermal growth. Uniformly shaped nanowire tips constructed in ...ammonia-dominated alkaline conditions serve as a foundation for the subsequent formation of the monodisperse nanowires. By precisely controlling the sharp tip formation and the nucleation, our method substantially narrows the distribution of ZnO nanowire diameters from σ = 13.5 nm down to σ = 1.3 nm and controls their diameter by a completely bottom-up method, even initiating from randomly sized seeds. The proposed concept of sharp tip based monodisperse nanowires growth can be applied to the growth of diverse metal oxide nanowires and thus paves the way for bottom-up grown metal oxide nanowires-integrated nanodevices with a reliable performance.
Catalytic Asymmetric allylation of aldehydes with functionalized allylic reagents represents an important process in synthetic organic chemistry because the resulting chiral homoallylic alcohols are ...valuable building blocks in diverse research fields. Despite the obvious advantages of allyl halides as allylation reagent under Barbier-type conditions, catalytic asymmetric version using functionalized allyl halides remains largely underdeveloped. Here, we addressed this issue by employing a chromium-catalysis system. The use of readily available allyl bromides with γ substitutions including trimethylsilyl, fluorinated methyl and phenylthio groups provided an efficient and convenient method to introduce those privileged functionalities into homoallylic alcohols. Good yields, high anti-diastereo- and excellent enantioselectivities were achieved under mild reaction conditions.
High requirements are put forward for the settlement control of metro tunnel to ensure the normal and safe operation of adjacent metro line during the process of deep foundation pit construction. ...Monitoring and predicting could constantly monitor the settlement of the tunnel and make safety early-warning, and massive data to be processed is collected by sensors in this process. In the study, an improved clustering method based on Gaussian mixture model (GMM) is proposed to deal with a large amount of monitoring data. Four initial eigenvalues are defined and the initial core points of clustering are selected by grouping monitoring sensors based on the characteristics of the project site and sensors. An improved method is utilized to the metro tunnel of Metro Line 9 near Xujiahui station. Compared with the traditional clustering method, the improved method has more reliable results, and reduces the operation time by 57.9%. Representative monitoring sensors are selected from each cluster to predict based on Long Short-Term Memory (LSTM) neural network. The prediction results well agree with the measured value and the prediction accuracy is reaching to 99.3%. Compared with other sensor selection ways, the data of representative sensors exhibits good representativeness and effectiveness. Finally, the prediction result after data update is more consistent with the monitoring data than the prediction result without data update. Increasing the data update frequency improves the accuracy of the prediction results in practical engineering application.
In situ fabrication of well-defined bridging nanostructures is an interesting and unique approach to three-dimensionally design nanosensor structures, which are hardly attainable by other methods. ...Here, we demonstrate the significant effect of edge-topological regulation on in situ fabrication of ZnO bridging nanosensors. When employing seed layers with a sharp edge, which is a well-defined structure in conventional lithography, the bridging angles and electrical resistances between two opposing electrodes were randomly distributed. The stochastic nature of bridging growth direction at the sharp edges inherently causes such unintentional variation of structural and electrical properties. We propose an edgeless seed layer structure using a two-layers resist method to solve the above uncontrollability of bridging nanosensors. Such bridging nanosensors not only substantially improved the uniformity of structural and electrical properties between two opposing electrodes but also significantly enhanced the sensing responses for NO2 with the smaller variance and the lower limit of detection via in situ controlled electrical contacts.
Click reactions (e.g., Huisgen cycloaddition) on metal oxide nanostructures offer a versatile and robust surface molecular modification for various applications because they form strong covalent ...bonds in a wide range of molecular substrates. This study reports a rational strategy to maximize the conversion rate of surface click reactions on single-crystalline ZnO nanowires by monitoring the reaction progress. p-Polarized multiple-angle incidence resolution spectrometry (pMAIRS) and Fourier-transformed infrared (FT-IR) spectroscopy were employed to monitor the reaction progress of an azide-terminated self-assembled monolayer (SAM) on single-crystalline ZnO nanowires. Although various reaction parameters including the concentration of Cu(I) catalysts, triazolyl ligands, solvents, and target alkynes were systematically examined for the surface click reactions, 10–30% of terminal azide on the nanowire surface remained unreacted. Temperature-dependent FT-IR measurements revealed that such unreacted residual azides deteriorate the thermal stability of the nanowire molecular layer. To overcome this observed conversion limitation of click reactions on nanostructure surfaces, we considered the steric hindrance around the closely packed SAM reaction points, then experimented with dispersing the azide moiety into a methyl-terminated SAM. The mixed-SAM method significantly improved the azide conversion rate to almost 100%. This reaction method enables the construction of spatially patterned molecular surface modifications on metal oxide nanowire arrays without detrimental unreacted azide groups.
A crystal growth of hydrothermal ZnO nanowires essentially requires a concentration control within so-called "concentration window", where the anisotropic crystal growth of ZnO nanowires ...preferentially occurs. Although understanding what exactly determines the width of "concentration window" is important to tailor the anisotropic crystal growth process, the fundamental knowledge as to "concentration window" is still scarce. Here we report the effect of ammonia addition on the width of "concentration window" using conventional hydrothermal ZnO nanowire growth. We found that the ammonia addition substantially narrows the width of "concentration window". Within the narrow range of zinc complex concentration, we found a significant increase of growth rate (up to 2000 nm/h) of ZnO nanowires. The narrowed "concentration window" and the resultant increased growth rate by the ammonia addition can be understood in terms of synchronized effects of both (1) a reduction of zinc hydroxide complex (precursor) concentration and (2) a fast rate limiting process of ligand exchange between different zinc complexes. Thus, the present knowldege as to "concentration window" will accelerate further tailoring an anisotropic crystal growth of hydrothermal ZnO nanowires.
Role of T cells in liver metastasis Wu, Kejia; Zhang, Guozhu; Shen, Changbing ...
Cell death & disease,
05/2024, Letnik:
15, Številka:
5
Journal Article
Recenzirano
Odprti dostop
The liver is a major metastatic site (organ) for gastrointestinal cancers (such as colorectal, gastric, and pancreatic cancers) as well as non-gastrointestinal cancers (such as lung, breast, and ...melanoma cancers). Due to the innate anatomical position of the liver, the apoptosis of T cells in the liver, the unique metabolic regulation of hepatocytes and other potential mechanisms, the liver tends to form an immunosuppressive microenvironment and subsequently form a pre-metastatic niche (PMN), which can promote metastasis and colonization by various tumor cells(TCs). As a result, the critical role of immunoresponse in liver based metastasis has become increasingly appreciated. T cells, a centrally important member of adaptive immune response, play a significant role in liver based metastases and clarifying the different roles of the various T cells subsets is important to guide future clinical treatment. In this review, we first introduce the predisposing factors and related mechanisms of liver metastasis (LM) before introducing the PMN and its transition to LM. Finally, we detail the role of different subsets of T cells in LM and advances in the management of LM in order to identify potential therapeutic targets for patients with LM.
Groundwater seepage significantly affects the temperature field of a cold region tunnel. Laboratory model tests are carried out to evaluate its effects, yielding four main results. First, groundwater ...seepage can increase tunnel air temperature and decrease the thickness and length of the tunnel insulation layer. Second, groundwater seepage and tunnel ventilation exert a coupling effect on the surrounding rock temperature. This effect is related to the surrounding rock depth. Third, the influence of the groundwater seepage velocity on the temperature of the interface between the lining and surrounding rock demonstrates a spatial difference, and the groundwater seepage leads to an uneven temperature distribution at the interface between the lining and surrounding rock. Furthermore, under groundwater seepage, the shape and size of the tunnel cross section have significant effects on the interface temperature. Fourth, the cold region tunnel has an antifreezing capability that is mainly related to the frost heaving of the surrounding rock and the groundwater seepage velocity. This capability should be fully utilized in the design of cold region tunnels. The experimental data presented can be used to verify the reliability of the theoretical calculation model for tunnel temperatures in cold regions.
An impurity doping in semiconductors is an important irreversible process of manipulating the electrical properties of advanced electron devices. Here, we report an unusual reversible dopant ...activation/deactivation phenomenon, which emerges at an interface between indium tin oxide (ITO) and single-crystalline oxide channel. We found that the interface electrical resistance between ITO electrodes and single-crystalline oxide nanowire channel can be repeatedly switched between a metallic state and a near-insulative state by applying thermal treatments in air or vacuum. Interestingly, this electrical switching phenomenon disappears when the oxide nanowire changes from the single-crystalline structure to the lithography-defined polycrystalline structure. Atmosphere-controlled annealing experiments reveal that atmospheric oxygen induces repeatable change in the interfacial electrical resistance. Systematic investigations on metal cation species and channel crystallinity demonstrate that the observed electrical switching is related to an interface-specific reversible Sn-dopant activation/deactivation of ITO electrode in contact with a single-crystalline oxide channel.
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